JP4555610B2 - Gas-liquid reaction unit and analyzer - Google Patents

Description

  The present invention relates to a gas-liquid reaction unit that reacts a gas and a liquid by directly contacting them without using a diaphragm or the like, and an analyzer using the same.

Conventionally, a diaphragm that passes only gas and does not allow liquid to pass through is used, and the gas outside the diaphragm is absorbed by the reaction liquid stored inside the diaphragm, and the gas component in the gas is detected from the change in properties of the reaction liquid. Quantification was done.
However, such a method using a diaphragm may cause a delay in response speed due to contamination of the diaphragm, that is, a detection error. In addition, it is difficult to meet the demand for micro-analysis of the analytical sensor due to the structure.

On the other hand, there has been reported a microchemical analysis chip in which a gas and a liquid are simultaneously flowed into a microchannel, and a component in the gas reacts with a component in the liquid in the microchannel (non-patent document). 1).
In the microchemical analysis chip of Non-Patent Document 1, the liquid and the gas are in direct contact with each other in a laminar flow state in the microchannel, and the components in the gas are transferred into the liquid at the gas-liquid interface. Therefore, it is possible to react the components in the gas and the components in the liquid without using a diaphragm.
Such a microchemical analysis chip is environmentally superior because it is easy to reduce reagents, waste, and energy consumption. Moreover, quick and highly sensitive measurement is possible. Furthermore, it also has an excellent function of being able to construct a small and lightweight analyzer.
“1. Basic study of micro chemical analysis chip using gas-liquid reaction”, Chemical Sensors, 2003, Volume 19 Supplement B, p1-3

However, with the microchemical analysis chip of Non-Patent Document 1, high-sensitivity measurement may be difficult. This is considered to be because the reaction between the component in the gas and the component in the liquid does not always proceed sufficiently, particularly when a reaction system having a slow reaction rate is used.
An object of the present invention is to provide a gas-liquid reaction unit in which a reaction between a component in a gas and a component in a liquid proceeds more rapidly. It is another object of the present invention to provide an analyzer capable of measuring a component in a gas with high sensitivity by allowing the reaction between the component in the gas and the component in the liquid to proceed rapidly.

The present invention includes the following aspects.
[1] It has one or more large flow paths and one or more small flow paths, and the large flow paths are the collection section, the introduction section existing on one end side of the collection section, and the outflow section existing on the other end side of the collection section. The small flow path consists of a collecting portion, an outflow portion existing on one end side of the collecting portion, and an introduction portion existing on the other end side of the collecting portion,
The large flow path collecting portion and the small flow path collecting portion are adjacent to each other so that the fluid inside can be in contact with each other, and the depth and cross-sectional area of the small flow path collecting portion are Smaller than the depth and cross-sectional area of the assembly,
The introduction part of the large flow path and the outflow part of the small flow path are juxtaposed without contacting each other,
The outflow part of the large flow path and the introduction part of the small flow path are juxtaposed without contacting each other,
A gas introduction port through which gas is introduced is provided in the introduction portion of the large flow path,
A liquid introduction port through which liquid is introduced is provided in the introduction portion of the small flow path,
The outflow part of the large flow path is provided with a gas outlet through which gas flows out,
The outflow part of the small flow path is provided with a liquid outlet through which liquid flows out ,
By introducing a gas into the gas inlet and introducing a liquid into the liquid inlet, the gas and the liquid are in contact with each other while flowing in the opposite direction in the large channel and the small channel. The gas- liquid reaction unit is configured so that gas flows out from the gas outlet and liquid flows out of the liquid outlet .
[2] The gas-liquid reaction unit according to [1], wherein a part or all of the inner surface of the small flow path is lyophilic with respect to the liquid introduced into the small flow path.
[3] An analyzer including the gas-liquid reaction unit according to [1] or [2], and a detection unit that detects a property of the liquid in the outflow portion of the small flow path .

According to the invention of the aspect of [1], the gas and the liquid flow in opposite directions while contacting each other at the gathering portion, so that the interface between the gas and the liquid is disturbed to some extent in the minute region and is continuous. Thus, fresh components are supplied to the interface. Therefore, the reaction between the component in the gas and the component in the liquid is promoted.
According to the invention of the aspect of [2], the lyophilic property of the liquid to the small channel increases, so that the liquid stably moves in the small channel while contacting the gas flowing from the opposite direction. .
According to the invention of the aspect of [3], the liquid in the outflow part of the small flow path has a property corresponding to the reaction with the component in the gas. Therefore, components in the gas can be detected or quantified by detecting the properties of the liquid. In the analyzer of this aspect, the component in the gas can be measured with high sensitivity by using the gas-liquid reaction unit in which the reaction between the component in the gas and the component in the liquid proceeds rapidly.

A gas-liquid reaction unit according to a first embodiment of the present invention and an analyzer using the same will be described with reference to FIGS. As shown in FIG. 1, the gas-liquid reaction unit of the present embodiment includes a large flow path 11 and a small flow path 12 provided in the substrate 1.
As a material of the substrate 1, for example, silicon, resin, glass, quartz or the like can be used. Among these materials, glass has high transparency, and is suitable when optical analysis is performed using this gas-liquid reaction unit. In particular, Pyrex (registered trademark) glass is preferable because of its high heat resistance and chemical resistance.
The substrate 1 may be composed of a single material or a combination of a plurality of materials. For example, a glass plate can be bonded to a silicon plate having a flow path formed by etching or the like to form a substrate. The substrate 1 is preferably flat.

The large flow path 11 includes a collecting portion 11a, an introduction portion 11b existing on the left side of the collecting portion 11a, and an outflow portion 11c existing on the right side of the collecting portion 11a. The small flow path 12 includes the collecting portion 12a and the collecting portion 12a. Is composed of an outflow portion 12b on the left side of the figure and an introduction part 12c on the right side of the gathering part 12a.
And the gathering part 11a of the large flow path 11 and the gathering part 12a of the small flow path 12 are adjacent to each other in a state in which the fluid inside can contact. Moreover, the introduction part 11b of the large flow path 11 and the outflow part 12b of the small flow path 12 are juxtaposed without contacting each other. Similarly, the outflow part 11c of the large flow path 11 and the introduction part 12c of the small flow path 12 are juxtaposed without contacting each other.

  In addition, a gas introduction port 13 that communicates with the outside of the substrate 1 and introduces gas is provided in the introduction portion 11 b of the large flow path 11. Further, a liquid introduction port 16 that communicates with the outside of the substrate 1 and into which liquid is introduced is provided in the introduction portion 12 c of the small flow path 12. In addition, the outflow portion 11c of the large flow path 11 is provided with a gas outlet 15 that communicates with the outside of the substrate 1 and through which gas flows out. In addition, the outflow portion 12b of the small flow path 12 is provided with a liquid outflow port 14 that communicates with the outside of the substrate 1 and from which the liquid flows out.

  The relationship between the large flow path 11 and the small flow path 12 will be described in more detail with reference to FIGS. FIG. 2A is a partially enlarged plan view in the vicinity of the boundary between the introduction part 11b of the large flow path 11 and the outflow part 12b of the small flow path 12, the collection part 11a, and the collection part 12a. FIG. 2B is a partially enlarged plan view of the collecting portion 11a and the collecting portion 12a of each of the large flow path 11 and the small flow path 12. FIG. 2C shows the vicinity of the boundary between the collecting portion 11a and the collecting portion 12a of the large flow channel 11 and the small flow channel 12, and the outflow portion 11c of the large flow channel 11 and the introducing portion 12c of the small flow channel 12. FIG. Further, FIG. 3 is an enlarged cross-sectional view of each of the aggregate portion 11a and the aggregate portion 12a of the large flow path 11 and the small flow path 12.

As shown in FIG. 3, the bottom surfaces of the respective channels are all arc-shaped. Further, the depth d2 of the collecting portion 12a of the small flow path 12 is shallower (smaller) than the depth d1 of the collecting section 11a of the large flow path 11. Further, the width w2 of the collective portion 12a is narrower (smaller) than the width w1 of the collective portion 11a. As a result, the cross-sectional area of the collecting portion 12a of the small flow path 12 is narrower (smaller) than the cross-sectional area of the collecting portion 11a of the large flow path 11.
The depth d1 is preferably 50 μm or more, and the width w1 is preferably about (d1 × 2 + 10) μm. The depth d2 is preferably less than 50 μm, and the width w2 is preferably about (d2 × 2 + 10) μm. The ratio between the depth d1 and the depth d2 is preferably around 3: 1.

Part or all of the inner surface of the small flow path 12 of the substrate 1 is preferably lyophilic. In particular, it is preferable that the gathering portion 12a is lyophilic. Here, lyophilic means that the liquid introduced from the introduction part 12c of the small flow path 12 is lyophilic, and when the liquid is aqueous, it is hydrophilic. When the liquid is oily, it means lipophilic.
On the other hand, it is preferable that part or all of the inner surface of the large flow path 11 of the substrate 1 has low lyophilicity. In particular, it is preferable that the portion of the collecting portion 11a is low lyophilic.
As means for making hydrophilic and lipophilic, known means such as chemical treatment, plasma treatment, and surface roughening treatment can be appropriately used.

In order to perform a gas-liquid reaction in the gas-liquid reaction unit of the present embodiment, gas is introduced into the large flow path 11 from the gas inlet 13. At the same time, the liquid is introduced from the liquid inlet 16 into the small flow path 12. The introduced liquid and gas flow in opposite directions while coming into contact with each other when they reach the collecting portions 11a and 12a.
Then, the gas and the liquid move in directions opposite to each other, the liquid flows to the outflow portion 12b of the small flow path 12, and the gas flows to the outflow section 11c of the large flow path 11. The liquid flows out from the liquid outlet 14 and the gas flows out from the gas outlet 15.
That is, in the collecting portions 11a and 12a, the gas and the liquid come into contact in a countercurrent state. Since the interface between the gas and the liquid is disturbed to some extent during this contact, the reaction between the component in the gas and the component in the liquid proceeds rapidly.

In order for gas and liquid to come out of the liquid outlet 14 and the gas outlet 15 after being brought into contact with each other in a countercurrent state, a gas-liquid interface between the collecting portion 11a and the collecting portion 12a is maintained to some extent. It needs to be in a lean state.
In order to achieve this interface state, both the liquid introduced from the gas inlet 13 and the gas introduced from the liquid inlet 16 need to have a pressure of a certain level or more. And in order to ensure this pressure, it is necessary to make both flow volume more than fixed.
The flow rate required to achieve this interface state depends on the cross-sectional area of the flow path. For example, the depth d1 is 90 μm, the width w1 is 190 μm, the depth d2 is 60 μm, and the width w2 is 60 μm. When an experiment was conducted using a phenolphthalein aqueous solution and air, it was confirmed that a good interface state was obtained under the following conditions.
That is, when the flow rate of liquid (phenolphthalein aqueous solution) is 1 μL / min, the flow rate of gas (air) is 0.5 to 2.5 mL / min, and the flow rate of gas is 1 mL / min, the flow rate of liquid When 0.1 was set to 0.1 to 5 μL / min, good interface states were obtained.

The analyzer using the gas-liquid reaction unit of the first embodiment includes a detector that detects the result of the gas-liquid reaction in addition to the gas-liquid reaction unit.
In the gas-liquid reaction unit, the properties of both liquid and gas can change as a result of the gas-liquid reaction. Therefore, the detector may be for either the liquid in the outflow portion 12b or the gas in the outflow portion 11c, but detection that detects the property of the liquid in the outflow portion 12b in terms of easy detection. It is preferable to provide a vessel.
Moreover, the property of the fluid in the outflow part of a gas-liquid reaction unit may be detected on the spot, or may be detected after outflow from the outflow part. That is, when detecting the property of the liquid in the outflow portion 12b, the liquid in the outflow portion 12b may be detected on the spot or after it has flowed out of the outflow portion 12b.

The properties of the fluid to be detected include, for example, the concentration of the compound generated by the gas-liquid reaction, the concentration of the compound transferred from the gas phase to the liquid phase, the conductivity linked to the concentration of these compounds, the physical properties such as pH, etc. Can be mentioned. Examples of the detection means include light detection means for detecting fluorescence, light absorption, etc., electrochemical detection means such as conductivity sensor, H ₂ O ₂ sensor, pH sensor, thermal lens microscope detection means, and the like.

As an example of a method of using the analyzer using the gas-liquid reaction unit of the first embodiment, a method for determining the concentration of ammonia gas in the gas will be described.
First, a gas as an object is introduced from the gas inlet 13. In addition, a phenolphthalein solution, which is a pH indicator, is introduced from the liquid inlet 16 as a reaction reagent. And the color development of the phenolphthalein solution in the outflow part 12b is detected with a thermal lens microscope. As a result, the pH change of the phenolphthalein solution due to the ammonia gas in the gas can be obtained, and the concentration of the ammonia gas in the gas can be obtained from this value.

  Next, a gas-liquid reaction unit according to a second embodiment of the present invention and an analyzer using the same will be described with reference to FIGS. As shown in FIG. 4, the gas-liquid reaction unit of the present embodiment includes a large flow path 21 and small flow paths 22 and 23 provided in the substrate 1. Since the material, shape, etc. of the substrate 1 are the same as those of the substrate 1 in the first embodiment, description thereof is omitted.

The large flow path 21 includes a collecting portion 21a, an introduction portion 21b on the left side of the collecting portion 21a in the drawing, and an outflow portion 21c on the right side of the collecting portion 21a. The small flow paths 22 and 23 include the collecting portion 22a, 23a, outflow portions 22b and 23b existing on the left side of the collecting portions 22a and 23a, and introduction portions 22c and 23c existing on the right side of the collecting portions 22a and 23a.
And the collection part 21a of the large flow path 21 and the collection part 22a of the small flow path 22 are adjacent to each other in a state in which the fluid inside can come into contact with each other. Similarly, the collecting portion 21a of the large flow channel 21 and the collecting portion 23a of the small flow channel 23 are adjacent to each other in a state in which the internal fluid can contact each other.
Moreover, the introduction part 21b of the large flow path 21 and the outflow parts 22b and 23b of the small flow paths 22 and 23 are juxtaposed without contacting each other. Similarly, the outflow part 21c of the large flow path 21 and the introduction parts 22c and 23c of the small flow paths 22 and 23 are juxtaposed without contacting each other.

  In addition, the introduction part 21b of the large flow path 21 is provided with a gas introduction port 24 that communicates with the outside of the substrate 1 and into which gas is introduced. In addition, the introduction part 22c of the small flow path 22 and the introduction part 23c of the small flow path 23 are respectively provided with liquid introduction ports 28 and 29 that communicate with the outside of the substrate 1 and into which liquid is introduced. The outflow portion 21c of the large flow path 21 is provided with a gas outlet 27 that communicates with the outside of the substrate 1 and through which gas flows out. In addition, the outflow portion 22b of the small flow path 22 and the outflow portion 23b of the small flow path 23 are provided with liquid outlets 25 and 26, respectively, which are in communication with the outside of the substrate 1 and from which liquid flows out.

  The relationship between the large flow path 21 and the small flow paths 22 and 23 will be described in more detail with reference to FIGS. FIG. 5A is a partially enlarged plan view in the vicinity of the boundary between the introduction portion 21b of the large flow channel 21 and the outflow portions 22b and 23b of each of the small flow channels 22 and 23 and the collection portions 21a, 22a and 23a. FIG. 5B is a partially enlarged plan view of the aggregated portions 21a, 22a, and 23a of the large flow channel 21 and the small flow channels 22 and 23, respectively. FIG. 5 (c) shows the collecting portions 21a, 22a, 23a of the large flow channel 21 and the small flow channels 22, 23, the outflow portion 21c of the large flow channel 21, and the introduction portions 22c of the small flow channels 22, 23, It is a partial enlarged plan view of the boundary vicinity with 23c. FIG. 6 is an enlarged cross-sectional view of each of the aggregate portions 21 a, 22 a, and 23 a of the large flow channel 21 and the small flow channels 22 and 23.

As shown in FIG. 6, the bottom surfaces of the respective channels are all arc-shaped. Further, the depths d4 and d5 of the collecting portions 22a and 23a of the small flow paths 22 and 23 are equal, and both are shallower (smaller) than the depth d3 of the collecting portion 21a of the large flow path 21. Further, the widths w4 and w5 of the collective portions 22a and 23a are equal, and both are narrower (smaller) than the width w3 of the collective portion 21a. As a result, the cross-sectional areas of the collecting portions 22a and 23a of the small flow paths 22 and 23 are both narrower (smaller) than the cross-sectional area of the collecting portion 21a of the large flow path 21.
The depth d3 is preferably 50 μm or more, and the width w3 is preferably about (d3 × 2 + 10) μm. The depths d4 and d5 are both preferably less than 50 μm, the width w4 is preferably around (d4 × 2 + 10) μm, and the width w5 is preferably around (d5 × 2 + 10) μm. The ratio between the depth d3 and the depth d4 (d5) is preferably around 3: 1.

Part or all of the inner surfaces of the small flow paths 22 and 23 of the substrate 1 are preferably lyophilic. In particular, it is preferable that the portions of the collecting portions 22a and 23a are lyophilic.
On the other hand, it is preferable that part or all of the inner surface of the large flow path 21 of the substrate 1 has low lyophilicity. In particular, it is preferable that the portion of the collecting portion 21a is low lyophilic.
The meaning of lyophilicity and the means for making it lyophilic are as described above.

In order to perform a gas-liquid reaction in the gas-liquid reaction unit of the present embodiment, gas is introduced into the large flow path 21 from the gas inlet 24. At the same time, the liquid is introduced into the small flow paths 22 and 23 from the liquid introduction ports 28 and 29. The introduced liquid and gas flow in opposite directions while coming into contact with each other when they reach the collecting portions 21a, 22a, and 23a.
Then, the gas and the liquid move in directions opposite to each other, the liquid introduced from the liquid introduction port 28 flows into the outflow portion 22b of the small flow path 22, and the liquid introduced from the liquid introduction port 29 flows into the small flow path. The gas flows to the outflow portion 23b of the large flow path 21 to the outflow portion 23b of the large flow path 21, respectively. The liquid flows out from the liquid outlets 25 and 26, and the gas flows out from the gas outlet 27.
That is, in the collecting portions 21a, 22a, and 23a, the gas and the liquid come into contact in a countercurrent state. Since the interface between the gas and each liquid is disturbed to some extent during this contact, the reaction between the component in the gas and the component in each liquid proceeds rapidly.

In order for gas and liquid to come out of liquid outlets 25 and 26 and gas outlet 27, respectively, after the gas and liquid are brought into contact with each other in a countercurrent state, the gas-liquid interface is maintained to some extent between 21a, 22a and 23a. It needs to be in a lean state.
In order to achieve this interface state, both the gas introduced from the gas inlet 24 and the liquid introduced from the liquid inlets 28 and 29 need to have a pressure of a certain level or more. And in order to ensure this pressure, it is necessary to make both flow volume more than fixed.
The flow rate necessary to achieve this interface state depends on the cross-sectional area of the flow path. For example, the depth d3 is 90 μm, the width w3 is 190 μm, the depths d4 and d5 are 60 μm, and the widths w4 and w5 are When the experiment was performed using a phenolphthalein aqueous solution and air for the case of 60 μm, it was confirmed that a good interface state was obtained under the following conditions.
That is, when the flow rate of liquid (phenolphthalein aqueous solution) is 1 μL / min and the flow rate of gas (air) is 0.5 to 2.5 mL / min, and the flow rate of gas is 1 mL / min, When the flow rates were 0.1 to 5 μL / min, good interface states were obtained.

The analyzer using the gas-liquid reaction unit of the second embodiment includes a detector that detects the result of the gas-liquid reaction in addition to the gas-liquid reaction unit.
Similar to the analyzer using the gas-liquid reaction unit of the first embodiment, the analyzer of the second embodiment also includes a detector that detects the properties of the liquid in the outflow portion 22b and / or the outflow portion 23b. preferable. In addition, when detecting the property of the liquid in the outflow portion 22b and / or 23b, the liquid outflowed from the outflow portion 22b and / or the outflow portion 23b even if the liquid in the outflow portion 22b and / or the outflow portion 23b is detected on the spot. It may be detected later. The properties of the fluid to be detected and the detection means are the same as in the first embodiment.

A method for determining the concentration of ammonia gas in the gas will be described as an example of a method for using the analyzer using the gas-liquid reaction unit of the second embodiment.
First, a gas as an object is introduced from the gas inlet 24. In addition, a phenolphthalein solution, which is a pH indicator, is introduced from the liquid inlets 28 and 29 as a reaction reagent. And the color development of the phenolphthalein solution in both or one of the outflow portions 22b and 23b is detected with a thermal lens microscope. As a result, the pH change of the phenolphthalein solution due to the ammonia gas in the gas can be obtained, and the concentration of the ammonia gas in the gas can be obtained from this value.

Next, a gas-liquid reaction unit according to a third embodiment of the present invention and an analyzer using the same will be described with reference to FIG. The gas-liquid reaction unit of this embodiment and the analyzer using the same are the same as the gas-liquid reaction unit according to the second embodiment, except that the cross-sectional shapes of the large channel 21 and the small channels 22, 23 are different. .
FIG. 7 is an enlarged cross-sectional view of each of the aggregate portions 21a, 22a, and 23a of the large flow channel 21 and the small flow channels 22 and 23 of the present embodiment.

  As shown in FIG. 7, the bottom surfaces of the respective channels are all horizontal and linear. Further, the depths d7 and d8 of the collecting portions 22a and 23a of the small flow paths 22 and 23 are equal, and both are shallower (smaller) than the depth d6 of the collecting portion 21a of the large flow path 21. In addition, the widths w7 and w8 of the aggregate portions 22a and 23a are equal, and both are narrower (smaller) than the width w6 of the aggregate portion 21a. As a result, the cross-sectional areas of the collecting portions 22a and 23a of the small flow paths 22 and 23 are both narrower (smaller) than the cross-sectional area of the collecting portion 21a of the large flow path 21.

Next, a gas-liquid reaction unit according to a fourth embodiment of the present invention and an analyzer using the same will be described with reference to FIG. The gas-liquid reaction unit of this embodiment and the analyzer using the same are also the same as the gas-liquid reaction unit according to the second embodiment except that the cross-sectional shapes of the large channel 21 and the small channels 22 and 23 are different. .
FIG. 8 is an enlarged cross-sectional view of each of the aggregate portions 21a, 22a, and 23a of the large flow path 21 and the small flow paths 22 and 23 of the present embodiment. As shown in FIG. 8, the bottom surface and the top surface of each channel are both arcuate.

In addition, although the number of the large flow path and the small flow path in each said embodiment is 1 or 2, respectively, all may be 3 or more. However, it is preferable that the large channel and the small channel are alternately arranged.
Further, in order to more reliably perform gas-liquid separation in the gathering portion, a partition wall that partially separates the gas phase and the liquid phase may be erected, for example, from the bottom surface of the gathering portion toward the upper surface.

It is a top view of the gas-liquid reaction unit concerning one embodiment of the present invention. FIG. 2 is a partially enlarged plan view of FIG. 1. It is a partial expanded sectional view of FIG. It is a top view of the gas-liquid reaction unit which concerns on 2 embodiment of this invention. FIG. 5 is a partially enlarged plan view of FIG. 4. It is a partial expanded sectional view of FIG. It is a partial expanded sectional view of the gas-liquid reaction unit which concerns on 3 embodiment of this invention. It is a partial expanded sectional view of the gas-liquid reaction unit which concerns on 4 embodiment of this invention.

Explanation of symbols

11, 21 .... Large flow path,
12, 22, 23... Small flow path,
11a, 12a, 21a, 22a, 23a,...
11b, 12c, 21b, 22c, 23c... Introduction part,
11c, 12b, 21c, 22b, 23b... Outflow part,
13, 24 ... Gas inlet,
16, 28, 29, ..., liquid inlet,
15, 27 ... Gas outlet,
14, 25, 26 ... Liquid outlet

Claims (3)

It has one or more large flow paths and one or more small flow paths, and the large flow path comprises a collecting portion, an introduction portion existing on one end side of the collecting portion, and an outflow portion existing on the other end side of the collecting portion. The small flow path comprises a collecting portion, an outflow portion existing on one end side of the collecting portion, and an introduction portion existing on the other end side of the collecting portion,
The large flow path collecting portion and the small flow path collecting portion are adjacent to each other so that the fluid inside can be in contact with each other, and the depth and cross-sectional area of the small flow path collecting portion are Smaller than the depth and cross-sectional area of the assembly,
The introduction part of the large flow path and the outflow part of the small flow path are juxtaposed without contacting each other,
The outflow part of the large flow path and the introduction part of the small flow path are juxtaposed without contacting each other,
A gas introduction port through which gas is introduced is provided in the introduction portion of the large flow path,
A liquid introduction port through which liquid is introduced is provided in the introduction portion of the small flow path,
The outflow part of the large flow path is provided with a gas outlet through which gas flows out,
The outflow part of the small flow path is provided with a liquid outlet through which liquid flows out ,
By introducing a gas into the gas inlet and introducing a liquid into the liquid inlet, the gas and the liquid are in contact with each other while flowing in the opposite direction in the large channel and the small channel. The gas- liquid reaction unit is configured so that gas flows out from the gas outlet and liquid flows out of the liquid outlet .   The gas-liquid reaction unit according to claim 1, wherein a part or all of the inner surface of the small flow path is lyophilic with respect to the liquid introduced into the small flow path. An analyzer comprising the gas-liquid reaction unit according to claim 1 and a detection means for detecting the property of the liquid in the outflow portion of the small flow path.

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