JP4522014B2 - Biosensor sheet, biosensor cartridge, and biosensor dispensing device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a biosensor sheet, a biosensor cartridge, and a biosensor dispensing device for quantifying a specific component in a biological sample with high accuracy, quickly and easily.
[0002]
[Prior art]
In recent years, various biosensors utilizing the specific catalytic action of enzymes have been developed and applied to clinical fields, and biosensors capable of measuring specific components in biological samples quickly and accurately have been put into practical use. ing.
[0003]
Taking a glucose sensor as an example, today's increase in the number of diabetic patients is remarkable, so that blood blood levels can be easily measured and managed, so that whole blood can be removed without the conventional complicated procedure of centrifuging blood and separating plasma. Japanese Patent Laid-Open No. 61-294351 proposes a sensor capable of measuring with the above. When this type of sensor is set in a dedicated measuring instrument, a predetermined voltage is supplied to the electrode system, the current flowing between the electrodes is measured, and the substrate concentration in the sample solution is calculated based on the current value. The value is displayed on the display unit.
[0004]
Japanese Patent Application Laid-Open No. 8-262026 describes a biosensor dispensing apparatus in which a biosensor cartridge in which a plurality of biosensors are set is loaded and biosensors are arranged one by one at a test position by a knob operation. ing. With the development of such biosensor dispensing devices, the sensor is accidentally dropped when it is attached to the measuring instrument body, inserted in the reverse direction, or even measured in the reverse direction. Problems that tend to occur in users such as diabetic patients who have many people have been improved.
[0005]
In the biosensor dispensing device 30 shown in FIGS. 6 to 7, a biosensor having a plurality of blood glucose sensors 34 enclosed in a sensor cavity 35 in a housing 33 including an upper case 31 and a lower case 32. A cartridge 36 is loaded. A data port connector (not shown) is provided on the rear portion 33a of the housing 33. Data can be input to electronic components on the printed wiring board in the housing 33 via the data port connector, or the printed wiring board can be used. The data stored in the electrical circuit is taken out to a monitoring device or a computer.
[0006]
In addition, by moving a sliding actuator (not shown) arranged in the upper case 31 from the standby position to the test position, the sensor 34 is released from one of the sensor cavities 35, and the contact on the sensor 34 becomes a housing. In addition to being coupled to the microprocessor and other data processing circuits of the printed wiring board 33 in the electrode contact portion 37, the test end of the sensor 34 projects from the test end 33 b of the housing 33.
[0007]
Therefore, by inserting the test end of the sensor 34 into the blood sample, blood sample data can be obtained and processed. The processing data is displayed or accumulated on the display screen 38 of the display unit. When the sliding actuator is moved to the standby position after the test, the used sensor 34 is ejected from the housing 33, the biosensor cartridge 36 is rotated by the latch 39, and a new sensor 34 is released from the sensor cavity 35. Located at the test location.
[0008]
[Problems to be solved by the invention]
However, in the conventional biosensor apparatus as described above, the sensor 34 to which a biological sample such as blood is attached must be disposed of after being exposed, and there is a sanitary problem. This is very inconvenient for the user.
The present invention solves the above-described problems, and it is an object of the present invention to be able to dispose biosensors one by one at a test position and to dispose of used biosensors in a sanitary and easy manner. .
[0009]
[Means for Solving the Problems]
In order to solve the above-described problems, the present invention provides a biosensor sheet in which a plurality of biosensors are arranged in a column, a biosensor cartridge in which the biosensor sheet is housed in a housing, and a biosensor dispensing apparatus in which the sensor cartridge is loaded. By configuring, the biosensor in the cartridge can be sent out and set at the measurement position, or the biosensor after measurement can be collected in the cartridge by simple manual operation using the lever or dial of the dispensing device. It is a thing. As a result, it has become possible to easily and easily perform biological value measurement a plurality of times.
[0010]
DETAILED DESCRIPTION OF THE INVENTION
The present invention according to claim 1 is a base sheet in which a plurality of biosensors for acquiring electrical data relating to a specific component in a biological sample are arranged in a column so that each test end faces the same direction; A biosensor sheet comprising a cover film that covers the surface and surrounds each biosensor so as to be peeled and bonded to the base sheet to individually seal each biosensor so that the test end of each biosensor precedes The biosensor can be sequentially arranged at the test position by peeling the cover film while feeding it along the longitudinal direction.
[0011]
Furthermore, in the present invention according to claim 1 , each biosensor has a rigidity in which a region near the test end is self-supporting, and each biosensor of the base sheet is formed at one end opposite to the test end. as a tongue continuous with other areas excluding the area where there, it was made form a flexible base sheet characterized in, when sending a biosensor sheet through some opening, Bio Since the sensor protrudes from the opening, the operation of spotting the biological sample on the test end can be easily performed. When the biosensor is formed integrally with the base sheet, it is possible to prevent the individual biosensors from falling off.
[0012]
According to a second aspect of the present invention, in the biosensor sheet according to the first aspect, the cover film is welded to the base sheet at an angle of 45 degrees or less with respect to the delivery direction. The peeling resistance of the film at the time of peeling with the sheet feeding operation can be reduced.
[0013]
Since the invention of claim 3, wherein, in the biosensor sheet according to claim 1, wherein, characterized in that one unit minute biosensor are stacked folded alternately, a storage form is constant It is possible to automatically laminate after collection.
[0014]
According to a fourth aspect of the present invention, there is provided a biosensor cartridge that houses the biosensor sheet according to the first aspect and supplies the biosensor one unit at a time, and is divided into a sensor supply chamber and a sensor recovery chamber by a partition, A housing in which a sensor delivery port that opens in the supply chamber and a sensor collection port that opens in the sensor collection chamber are formed in parallel to each other; and the biosensor sheet is placed between the sensor delivery port and the sensor collection port. held so as to pass through the outer, and progressive in the longitudinal direction, and supplies are protruded biosensor unused to the outside of the sensor delivery port, a biosensor already used into the housing from the sensor recovery port a sheet feeding means for recovering, said disposed in the housing in the vicinity of the sensor delivery port having a film peeling means for peeling the cover film of the biosensor sheet Intended to symptoms, it is possible to sequentially provide a biosensor, can clean recovered sensor collecting chamber biosensor already used.
[0015]
According to a fifth aspect of the present invention, in the biosensor cartridge according to the fourth aspect , the sheet feeding means winds the biosensor sheet and feeds the biosensor sheet toward the sensor outlet, and the biosensor sheet passing through the sensor recovery port And a take-up roller for taking up the biosensor, and the biosensor can be easily fed out.
[0016]
According to a sixth aspect of the present invention, in the biosensor cartridge according to the fourth aspect , the sheet feeding means is disposed on the downstream side of the sensor recovery port, sandwiches the biosensor sheet, and is stacked on the upstream side of the sensor feeding port. The biosensor sheet has a pull-in means for pulling and stacking the biosensor sheet on the downstream side. Since the biosensor is pulled in while being folded, the design can be designed without much considering the change in resistance applied to the pull-in means.
[0017]
According to a seventh aspect of the present invention, in the biosensor cartridge according to the fourth aspect of the present invention, the biosensor cartridge further includes a sealing member that seals the sensor outlet around the biosensor sheet. Each biosensor can be maintained in a certain environment.
[0018]
The present invention according to claim 8 is characterized in that in the biosensor cartridge according to claim 4 , a desiccant is provided in the casing to prevent deterioration of the characteristics of the reagent substance used in each biosensor. Can guarantee the performance.
[0019]
According to a ninth aspect of the present invention, in the biosensor cartridge according to the fourth aspect , the wall constituting the recovery path from the sensor delivery port to the sensor recovery port is disposed downstream of the biosensor formed in a tongue shape on the biosensor sheet. It is characterized in that it is arranged outside the housing with a gap that can be bent to the side, and the used biosensor enters the collection path while being folded with the attached part of the biological sample inside, so that the measurer It is possible to prevent the biological sample from adhering to the surface.
[0020]
According to a tenth aspect of the present invention, in the biosensor cartridge according to the fifth aspect , a supply roller for feeding out the biosensor sheet, a film take-up roller for taking up the cover film, and a take-up for taking up the used biosensor sheet. The roller is configured to have a sliding clutch with respect to its rotating shaft, and absorbs changes in the feed amount of the biosensor due to changes in the winding diameter depending on the number of biosensors used. it can.
[0021]
The present invention of claim 11 wherein the mounting the biosensor cartridge according to claim 4, drives the delivery of the bio-sensor sheet through the sheet feeding means, and processing the electrical data obtained by the biosensor A biosensor dispensing device for outputting a processing result, wherein a first side surface of a box in which the sensor delivery port is formed on the outer periphery of the main body of the device and a second side surface adjacent to the first side surface Biological data from a biological sample, characterized in that it has a recess that is accommodated so as to be exposed and that the first side surface and the second side surface are disposed substantially flush with the surrounding outer surface. It is possible to carry out a plurality of measurements in a simple, easy and continuous manner. Since the sensor outlet is located at the end of the apparatus main body, the operation of spotting the biological sample onto the biosensor is also easy.
[0022]
The present invention according to claim 12, in the biosensor dispensing device according to claim 11, the manual possible actuation actuator connected to the sheet feeding means of the biosensor cartridge, a first side surface of a box body of the biosensor cartridge and The biosensor supply operation is not hindered because the measurer does not cover the sensor supply port during operation because the measurer does not cover the sensor supply port during operation. In addition, it is possible to provide measurement value display means on both the outer surface of the apparatus main body in the direction along the first side surface of the box of the biosensor cartridge and the outer surface opposite to it.
[0023]
Hereinafter, embodiments of the present invention will be described with reference to the drawings.
(Embodiment 1)
1 is an external perspective view of a biosensor dispensing device including a biosensor cartridge. FIG. 2 is an exploded perspective view of a biosensor sheet, (b) a cross-sectional view, (c) a plan view, and FIG. AA sectional view of the biosensor cartridge, FIG. 4 is a sectional view of the vicinity of the supply part of the biosensor dispensing device of FIG.
[0024]
The biosensor dispensing device 1 relates to blood glucose, and is composed of a substantially rectangular box-shaped main body device 2 and a biosensor cartridge 3, and has a function of sequentially arranging the biosensors 4 at test positions. And a function of collecting blood glucose concentration data through the biosensor 4.
[0025]
The main body device 2 is formed with a recess 5 for accommodating the biosensor cartridge 3 at one end (hereinafter referred to as the front end 2a) along the longitudinal direction, and on the upper surface near the other end (hereinafter referred to as the rear end 2b). A display screen 6 of a liquid crystal display unit for displaying information related to the biosensor cartridge 3 and information related to the performed test is disposed. The concave portion 5 has a rectangular shape corresponding to the outer shape of the biosensor cartridge 3, and the front end side is open and open upward, and the biosensor cartridge 3 accommodated in the concave portion 5 is located on the upper surface of the surrounding main body device 2. Further, it is configured to be flush with the front end face.
[0026]
Two driving rollers 7 and 8 and an electrode arm 9 are erected on the upward bottom surface of the recess 5. A button 10 for engaging a latch (not shown) provided on the inner surface of the concave portion 5 with the latch concave portion 3a of the biosensor cartridge 3 is disposed on the upper surface of the main body device 2 in the vicinity of the concave portion 5. On the outer surface in the direction intersecting with the upper surface and the front end surface of the apparatus 2, the operation portion of the rotary disk-like (or slidable) operating actuator 11 connected to the drive rollers 7 and 8 is exposed.
[0027]
The electrode arm 9 is connected to a microprocessor or other data processing circuit (not shown) formed on a printed wiring board inside the main unit 2, and the rear end 2 b of the main unit 2 is connected to this data processing circuit. Are connected to manual buttons and data port connectors (not shown). Thus, by inputting information to the data processing circuit from the manual button, data generated by the biosensor 4 during the test operation is acquired, information related to the test being performed is processed and stored, and the stored information Can be displayed on the display screen 6 or output to an analysis device or computer device outside the apparatus via the data port connector.
[0028]
As shown in FIG. 2, the biosensor 4 has an enzyme reaction part 4a containing an enzyme and an electrode contact part 4b. The resin reaction part 12 is made of a resin sheet 12 such as polyethylene terephthalate (PET). A plurality of columns 4a and electrode contact portions 4b are formed in a column so that they are arranged in this order along the longitudinal direction. The resin sheet 12 is joined to a biosensor base 13 having substantially the same width on the lower surface thereof to constitute a biosensor sheet 14. The upper surface of the biosensor sheet 14 is covered with a laminate film 15.
[0029]
However, in the resin sheet 12, the region of the biosensor 4 from the enzyme reaction portion 4a slightly ahead to the electrode contact portion 4b is separated in a tongue shape by a U-shaped groove 4c having a circular arc shape on the front end side. It is tightly bonded to the biosensor base 13 in a region other than 4. For this reason, the individual biosensors 4 do not fall off and move forward toward the test end 3b of the biosensor cartridge 3 as the biosensor sheets 14 are sequentially fed. A capillary that sucks up the biological sample extends from the spotting part 4d at the front end of the biosensor 4 to the enzyme reaction part 4a.
[0030]
The laminate film 15 is welded to the biosensor sheet 14 in a V shape of 45 degrees or less, in front of the spotting portion 4a of each biosensor 4 and behind the electrode contact portion 4b. Continuously welded along its longitudinal edge, each biosensor 4 is isolated and sealed from each other. 15a is a welding line. For this reason, the enclosed biosensors 4 are kept in a dry state with no outside air coming in and out, and even if one biosensor 4 is opened, the other biosensors 4 are not affected.
[0031]
In the biosensor cartridge 3, as shown in FIG. 3, the inside of the box 16 is divided into a sensor supply chamber 18 and a sensor recovery chamber 19 by a partition wall 17. A sensor supply port 20 that opens to the sensor supply chamber 18 along the partition wall 17 and a sensor recovery port 21 that opens to the sensor recovery chamber 19 so as to be parallel to the sensor supply port 20 are formed in the box 16. Has been. A sensor guide wall 22 that covers the outer surface of the box 16 from the sensor supply port 20 to the sensor recovery port 21 with a predetermined gap 22 a is disposed outside the box 16.
[0032]
In the sensor supply chamber 18, a sensor supply roller 23 around which the biosensor sheet 14 covered with the laminate film 15 is wound, a release roller 24 that peels the laminate film 15 from the biosensor sheet 14, and the peeled laminate film 15. And a transmission roller 26 for transmitting the rotation of the sensor supply roller 23 to the film take-up roller 25. The sensor supply roller 23 and the film take-up roller 25 are rotated by engaging a rotating shaft with a gear or the like. ing. A flexible moisture-proof member 27 that can cover the sensor supply port 20 is disposed in the vicinity of the sensor supply port 20, and a desiccant 28 is disposed in the vicinity of the sensor supply roller 23.
[0033]
In the sensor collection chamber 19, the sensor collection roller 29 that winds the biosensor sheet 14 in conjunction with the sensor supply roller 23 and the film take-up roller 25, and the biosensor sheet 14 is sandwiched in the vicinity of the sensor collection port 21 to collect the sensor. A pair of guide rollers 30 for guiding to the rollers 29 are arranged.
[0034]
An opening (not shown) through which the electrode arm 9 of the main unit 2 can enter is formed in the vicinity of the sensor supply port 20, and the driving roller 7 of the main unit 2 is fitted into the sensor supply roller 23. It has become. In the initial state, the front end portion of the biosensor sheet 14 is peeled off from the laminate film 15 and wound around the sensor collection roller 29, and the front end portion of the laminate film 15 is separated by the separation roller 24 near the electrode arm 9. It is guided in a direction away from 17 and wound around the film take-up roller 25.
[0035]
Hereinafter, the operation of the biosensor dispensing apparatus 1 will be described.
When the biosensor cartridge 3 is mounted in the recess 5 of the main body device 2, the box 16 is set from above with the latch (above) on the inner surface of the recess 5 retracted by the button 10. As a result, the drive rollers 7 and 8 and the electrode arm 9 on the bottom surface of the concave portion 5 enter the box 16 of the biosensor cartridge 3, and the drive rollers 7 and 8 respectively move to the sensor supply roller 23 and the sensor collection roller 29. Insert. When the box 16 reaches the bottom surface of the recess 5, the latch on the inner surface of the recess 5 automatically engages with the latch recess 3a of the box 16 by the action of a spring or the like (or by operating the button 10), and the biosensor. The cartridge 3 is fixed.
[0036]
In the test, first, the operation actuator 11 is rotated (in the case of a slide type, it is operated to the front end 2a side of the main body device 2). As a result, the main unit 2 is set to the test mode, the drive rollers 7 and 8 are rotated by a predetermined amount, and the sensor supply roller 23 in the sensor supply chamber 18 that rotates with the rotation rotates the biosensor sheet 14. One unit is sent out along the partition wall 17. The laminate film 15 of the biosensor sheet 14 that has been sent out is peeled off by the turning roller 24 turning right before the electrode arm 9, and the spotted portion 4 d of the biosensor 4 exposed thereby is tested through the sensor supply port 20. It protrudes from the end 3b. The peeled laminate film 15 is taken up by a film take-up roller 25 that rotates along with the sensor supply roller 23.
[0037]
When the biosensor 4 is arranged at a test position protruding a predetermined length from the test end 3b, the electrode contact portion 4b of the biosensor 4 comes into contact with the electrode arm 9, and the printed wiring board arranged in the main body device 2 Electrically couples to the electronic circuit. At the same time, the display screen 6 of the liquid crystal display unit is activated to the display mode. The visual recognition from above on the display screen 6 is not hindered when the operation actuator 11 is operated.
[0038]
In this state, blood accumulated in, for example, a punctured finger is brought into contact with the spotting portion 4d of the biosensor 4 protruding from the test end 3b (sensor supply port 20) of the biosensor cartridge 3. As a result, blood in the spotting part 4d is sucked by capillary action and guided to the enzyme reaction part 4a in a sufficient amount, and glucose as a test target component in the blood chemically reacts with the reagent in the enzyme reaction part 4a. . As a result, an electrical signal corresponding to the blood glucose level is taken out to the electronic circuit of the printed wiring board in the main body device 2 through the electrode contact portion 4b and the electrode arm 9 and processed, and is displayed on the display screen 6 as the blood glucose level. Is displayed.
[0039]
When the test is completed and information acquisition and data transmission are completed, the actuator 11 is manually operated in the same manner as before the test. As a result, the sensor supply roller 23 and the sensor collection roller 29 rotate and the biosensor sheet 14 is sent out. The used biosensor 4 protruding from the sensor supply port 20 is folded back to the downstream side when drawn into the gap 22a between the box 16 and the sensor guide wall 22, and the surface to which the blood adheres It is recovered into the sensor recovery chamber 19 while being arranged inside.
[0040]
At that time, the biosensor sheet 14 is sent out by a certain amount by the operation of the operation actuator 11 (by a latch or the like not shown), and the used biosensor 4 is collected into the sensor collection chamber 19, The feeding is stopped once when the unused biosensor 4 remains in the sensor supply chamber 18. Accordingly, the main device 2 is turned off or in a standby state. When the test is continuously performed, the operation actuator 11 may be operated until the unused biosensor 4 is arranged at the test position. The position of the used biosensor 4 or the next used biosensor 4 can be confirmed on the display screen 6.
[0041]
In this manner, the biosensor 4 in the box 16 can be sequentially placed at the test position only by manually operating the operating actuator 11, and at the same time, the used biosensor 4 can be collected in the box 16. Therefore, not only can a plurality of tests be performed easily and easily, but also an unnecessary hygiene concern such as the user's hands getting dirty with blood can be reduced. If all the biosensors 4 in the biosensor sheet 14 are used up, the entire biosensor cartridge 2 may be discarded. Since the biosensor dispensing device itself can be configured relatively compactly, it can also be carried by the user.
[0042]
FIG. 5 shows a biosensor cartridge 3 that does not use the sensor supply roller 23 and the sensor collection roller 29 described above.
In this sensor cartridge 3 , a biosensor sheet 14 in which one unit of the biosensor 4 is alternately folded and stacked is used, and a sensor pull-in roller 31 that sandwiches and pulls the biosensor sheet 14 into the sensor collection chamber 19. The opposing member 32 parallel to it is arrange | positioned.
[0043]
Accordingly, by operating the sensor pull-in roller 31, the used biosensor 4 is guided by the guide roller 30, pulled one unit at a time, folded and stored, and accordingly, a new biosensor 4 is installed in the sensor supply chamber 18. Can be sent out one unit at a time.
[0044]
In the biosensor sheet 14 described above, the U-shaped groove 4c is formed so that the spotting portion 4d of each biosensor 4 protrudes from the sensor supply port 20. However, the spotting portion 4d is disposed outside the sensor supply port 20. As long as this is done, a biological sample can be spotted, and the biosensor sheet 14 may be in the form of a tape having no U-shaped groove 4c. Moreover, although demonstrated as what tests blood glucose, it is also possible to comprise for the other biological sample which can be analyzed using a reagent. In practice, it can be applied to any kind of chemical fluid other than biological samples.
[0045]
【The invention's effect】
As described above, according to the present invention, a biosensor sheet is configured by housing a plurality of biosensors arranged in series and sealed in a casing to form a biosensor cartridge, and the sensor cartridge is a main body having a measurement function and the like. Since the apparatus is loaded, the biosensor in the housing can be sent out and placed at the test position by a simple manual operation, the test data can be collected, and the used biosensor can be collected in the housing. This makes it possible to easily and easily perform biometric measurement a plurality of times, and can reduce the troublesomeness when setting or discarding the biosensor.
[Brief description of the drawings]
1 is an external perspective view of a biosensor dispensing apparatus including a biosensor cartridge according to an embodiment of the present invention. FIG. 2 is an exploded perspective view of a biosensor sheet housed in the biosensor cartridge of FIG. FIG. 3 is a cross-sectional view of the biosensor cartridge of FIG. 1 taken along the line AA. FIG. 4 is a cross-sectional view of the biosensor dispensing device in FIG. 5 is a cross-sectional view of another biosensor cartridge that can be loaded into the biosensor dispensing device of FIG. 1. FIG. 6 is an external perspective view of a conventional biosensor dispensing device. FIG. 7 is a perspective view of the biosensor dispensing device of FIG. Perspective view showing the inside 【Explanation of symbols】
DESCRIPTION OF SYMBOLS 1 Biosensor dispensing apparatus 2 Main body apparatus 3 Biosensor cartridge 4 Biosensor
4c U-shaped groove
4d Spotted part 5 Concave part
11 Actuator
12 Resin sheet
13 Biosensor base
14 Biosensor sheet
15 Laminate film
15a Welding line
16 box
17 Bulkhead
18 Sensor supply room
19 Sensor collection room
22 Sensor guide wall
23 Sensor supply roller
24 Peeling roller
25 Film take-up roller
27 Moisture-proof material
28 Desiccant
29 Sensor recovery roller
31 Sensor pull-in roller
32 Opposing member

Claims (12)

A base sheet in which a plurality of biosensors for acquiring electrical data relating to specific components in a biological sample are arranged in a column so that each test end faces the same direction;
A biosensor sheets constituting the respective biosensor peelably bonded to the base sheet so as to surround the respective biosensor covering the surface of the base sheet and cover film sealed separately,
Each of the biosensors has a rigidity in which a region in the vicinity of the test end is self-supporting, and at one end opposite to the test end, is continuous with other regions of the base sheet excluding the region where the biosensor is formed. A biosensor sheet formed on the flexible base sheet so as to have a tongue shape . The biosensor sheet according to claim 1 , wherein the cover film is welded to the base sheet at an angle of 45 degrees or less with respect to the delivery direction . The biosensor sheet according to claim 1, wherein one unit of the biosensor is alternately folded and stacked . A biosensor cartridge that stores the biosensor sheet according to claim 1 and supplies each biosensor one unit at a time,
A housing that is divided into a sensor supply chamber and a sensor recovery chamber by a partition wall, wherein a sensor delivery port that opens to the sensor supply chamber and a sensor recovery port that opens to the sensor recovery chamber are formed in parallel to each other;
The biosensor sheet is held between the sensor delivery port and the sensor collection port so as to pass outside the casing, and is fed in the longitudinal direction so that the unused biosensor is fed to the sensor. A sheet feeding means for supplying the used biosensor to the outside of the outlet and collecting the used biosensor into the housing from the sensor collection port;
Film peeling means for peeling the cover film of the biosensor sheet disposed in the casing near the sensor delivery port;
A biosensor cartridge . The sheet feeding means includes a supply roller that winds the biosensor sheet and feeds the biosensor sheet toward the sensor delivery port, and a take-up roller that winds the biosensor sheet through the sensor recovery port. of the biosensor cartridge. The sheet feeding means is disposed on the downstream side of the sensor recovery port, sandwiches the biosensor sheet, pulls in the biosensor sheet stacked on the upstream side of the sensor delivery port, and stacks on the downstream side The biosensor cartridge according to claim 4 , comprising: The biosensor cartridge according to claim 4 , further comprising a sealing member that seals the sensor delivery port around the biosensor sheet . The biosensor cartridge according to claim 4 , further comprising a desiccant in the housing . The wall constituting the recovery path extending from the sensor delivery port to the sensor recovery port is provided outside the casing by providing a gap in which the biosensor formed in a tongue shape on the biosensor sheet can be bent downstream. The biosensor cartridge according to claim 4 arranged . The supply roller for feeding out the biosensor sheet, the film take-up roller for taking up the cover film, and the take-up roller for taking up the used biosensor sheet have a slip clutch with respect to the rotation shaft thereof. The biosensor cartridge according to claim 5 configured as described above. A biosensor cartridge that is mounted with the biosensor cartridge according to claim 4 and that drives the feeding of the biosensor sheet of the biosensor cartridge, processes electrical data acquired by each biosensor, and outputs a processing result. A feeding device,
On the outer periphery of the apparatus body, the biosensor cartridge is accommodated so that the first side surface of the box in which the sensor delivery port is formed and the second side surface adjacent thereto are exposed, the first side surface and the A biosensor dispensing device having a recess that arranges the second side surface substantially flush with the surrounding outer surface . A manually operable actuator connected to the sheet feeding means of the biosensor cartridge is disposed on the outer surface of the apparatus main body in a direction intersecting the first side surface and the second side surface of the box of the biosensor cartridge. The biosensor dispensing device according to claim 11 .

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