JP4517173B2 - Resin film for opening formation - Google Patents

Description

  The present invention relates to an opening forming resin film capable of forming an opening by light irradiation.

  As a method of analyzing a sample, for example, there is a method of analyzing a reaction solution obtained by reacting a sample with a reagent by an optical method. Such an analysis is performed, for example, by attaching an analytical tool that provides a reaction field to an analysis apparatus that has constructed an optical system capable of irradiating and receiving light (for example, see Patent Document 1).

  The analysis tool disclosed in Patent Document 1 has sample processing chambers 90a and 90b, photometry chambers 91a and 91b, and a waste liquid reservoir 92 as shown in FIGS. 5 (a) and 5 (b) of the present application. These are connected to each other through flow paths 93a to 93d. Reagents 94 and 95 are held in the sample processing chambers 90 a and 90 b, and the sample processing chamber 90 a is connected to a sample receiving port 96. The waste liquid reservoir 92 is connected to the pump connection port 97. In the analysis tool 9, after the sample introduced from the sample receiving port 96 reacts with the reagent 94 in the sample processing chamber 90a, it is sequentially carried to the photometry chamber 91a and the sample processing chamber 90b by the suction force of the pump. The sample conveyed to the sample processing chamber 90b reacts with the reagent 95 in the sample processing chamber 90b, and then is sequentially transferred to the photometric chamber 91b and the waste liquid reservoir 92.

  In the analysis tool 9, the sample liquid receiving port 96 and the pump connection port 97 are opened. Therefore, depending on the types of the reagents 94 and 95, the reagents 94 and 95 may be exposed to moisture or the like. In order to suppress such a problem, the sample receiving port 96 and the pump connection port 97 are closed, and the sample receiving port 96 and the pump connection port 97 are opened at the time of analysis. . However, there is no technique for opening the sample receiving port 96 and the pump connection port 97 as necessary after closing the sample receiving port 96 and the pump connection port 97 with an inexpensive and simple configuration. Not only when the sample liquid receiving port 96 and the pump connection port 97 are opened, it is also conceivable that other parts need to be opened from the closed state during analysis.

  In addition, it is sometimes necessary to form a fine opening selectively in a specific region in other technical fields as well as the analysis tool 9 in the above situation. For example, in a container, it may be necessary to form a fine opening when the container seal is opened to take out the contents.

JP-A-8-114539

  This invention makes it a subject to provide the resin film which can form an opening cheaply and easily.

The opening forming resin film provided by the present invention includes a thermoplastic resin and light absorbing particles for actively absorbing light in the range of visible light to near infrared light, and irradiates light. The thermoplastic resin is a nylon-based polyamide resin having a melting point of 100 ° C. or lower and an ethylene-based resin film having a melting point of 100 ° C. or lower. The light-absorbing particles selected from polymers are phthalocyanine pigments, carbon pigments, anthraquinone pigments, perylene oil-soluble pigments, iron-chromium black, copper-iron black, iron black, cobalt green, and is at least one of titanium cobalt green, average particle size of the light absorbing particles 0.1~30μm der is, and the transmittance for the light is 10% or less DOO is characterized by, more specifically, as described below.

  Here, the light-absorbing particles having an average particle size in the above-described range are absorbed when a particle having an average particle size that is unduly small absorbs a sufficient amount of light to form an opening. On the other hand, if an average particle size is unreasonably large, the fluidity of the resin at the time of resin film formation deteriorates, making it difficult to form the desired resin film. It is. For the same reason, the content of the light absorbing particles is, for example, 1 to 30 parts by weight with respect to 100 parts by weight of the thermoplastic resin.

The kind of light-absorbing particle is selected according to the wavelength characteristic of the light which should be irradiated to a resin film. For example, when the resin film is irradiated with red light, a blue, black, green or blue-green pigment is used as the light-absorbing particles. As the blue light-absorbing particles, a phthalocyanine-based blue pigment can be used. The black light-absorbing particles typically include carbon black (C), copper-chromium black (CuO · Cr ₂ O ₃ ), copper-iron black (CuO · Fe ₂ O ₃ ), or iron black ( FeO ₄ ) can be used. As green light-absorbing particles, typically cobalt green (CoO ・ Al ₂ O ₃・ Cr ₂ O ₃ ), titanium ・ cobalt green (TiO ₂・ CoO ・ NiOZnO) can be used. Also, copper phthalocyanine pigments and perylene oil-soluble pigments can be used. An anthoraquinone blue-green pigment can be used as the blue-green light-absorbing particles. Of course, if the wavelength of the light applied to the resin film is different, the type of light-absorbing particles that can be used is different from that exemplified above.

  In addition to the light-absorbing particles, the opening-forming resin film of the present invention is for heat storage having a specific heat smaller than that of a thermoplastic resin for the purpose of efficiently increasing the temperature of the light irradiation site by suppressing the diffusion of light energy. A filler may be included. As the heat storage filler, a material made of a metal such as gold, silver, copper, nickel, or aluminum, or an inorganic compound such as glass can be used. The form of the heat storage filler is preferably, for example, particulate or fibrous. The content of the heat storage filler is, for example, 5 to 30 parts by weight with respect to 100 parts by weight of the thermoplastic resin so that the filling purpose can be effectively achieved without impairing the workability. Is used, the average particle size is 5 to 30 μm.

  The resin film for opening formation of the present invention may have a configuration in which a thermoplastic resin and light-absorbing particles are held on a mesh formed of a material having a small specific heat. As the mesh, for example, a synthetic resin fiber, natural fiber or glass fiber can be used.

  The heat storage filler and the mesh can be used for the purpose of improving the handleability of the resin film or reinforcing the resin film.

  As the thermoplastic resin, it is preferable to use a resin having a melting point of 100 ° C. or lower, more preferably from the viewpoint of effectively forming an opening while reducing the amount of light energy to be irradiated to the resin film. Of 70 ° C. or less is used. Practically, it is preferable to use a thermoplastic resin having a melting point of 50 to 70 ° C. If the melting point of the thermoplastic resin is unduly small, the resin film may be softened or melted during storage. On the other hand, if the melting point is unduly large, the light energy to be irradiated as described above. This is because the amount becomes large and the running cost is disadvantageous.

  The thermoplastic resin that can be used in the present invention may be selected as long as the object can be achieved, and is not limited to a homopolymer obtained by polymerizing a single monomer (straight polymer), but a copolymer (copolymer) or a polymer alloy should be used. Can do. In the case of a copolymer or polymer alloy, a thermoplastic resin having a target melting point can be formed by selecting the combination and blending ratio.

  As the homopolymer, for example, a low melting point (nylon-based) polyamide resin can be used. As the copolymer, an ethylene-based one is preferably used. For example, an ethylene-vinyl acetate copolymer or an ethylene ionomer can be used.

  In the ethylene-vinyl acetate copolymer, the higher the vinyl acetate content, the lower the melting point. For example, if the vinyl acetate content is 6%, the melting point is about 100 ° C., and the vinyl acetate content is 28%. If it does, melting | fusing point can be about 58 degreeC. As the ethylene-vinyl acetate copolymer, one having a vinyl acetate content of 5 to 35% is typically used.

  The ethylene ionomer is a metal salt of a copolymer of ethylene and an unsaturated carboxylic acid, and the melting point can be set in the range of 80 to 100 ° C. by selecting the kind of metal salt and the ratio of monomers. Examples of the metal salt include Zn and Na.

  The resin film for opening formation of the present invention has a transmittance of 10% with respect to light of a specific wavelength, for example, light in the range of visible light to near infrared light, from the viewpoint of reducing the amount of light energy to be applied to the resin film. It is preferable to form the following. Further, when the film thickness is unreasonably small, the transmittance increases. Therefore, in this respect, the film thickness is preferably set to 5 μm or more. On the other hand, if the film thickness is unreasonably large, heat energy diffuses from the light-irradiated region, and the temperature of the target site cannot be increased efficiently. In this respect, the film thickness is set to 100 μm or less. preferable.

  Hereinafter, first and second embodiments of the present invention will be described with reference to the drawings.

  First, a first embodiment of the present invention will be described with reference to FIGS.

  The analysis tool 1 shown in FIGS. 1 to 3 is provided with a flow path 10 for moving a sample using capillary force. The analysis tool 1 includes a substrate 2 in which a recess 20 is formed and a cover 3 in which two through holes 30 and 31 are formed, and the flow path 10 is defined by these elements 2 and 3. Yes.

  The concave portion 20 of the substrate 2 includes a sample introduction unit 21, a sample moving unit 22, a reaction unit 23, and a discharge unit 24. In the reaction part 23, a reagent part 4 for reacting with a sample is formed.

  The through holes 30 and 31 of the cover 3 are for communicating the inside of the flow path 10 to the outside, and are formed at portions corresponding to the sample introduction part 21 and the discharge part 24, respectively. The through holes 30 and 31 are sealed with resin films 50 and 51. Thereby, the sealed state inside the flow path 10 is maintained, and the reagent part 4 is suppressed from being exposed to moisture or the like. The resin films 50 and 51 are fixed to the cover 3 using, for example, an adhesive or by fusion. The resin films 50 and 51 are preferably fixed to the cover 3 in a state where the resin films 50 and 51 are slightly stretched from the natural state. If it does so, opening will be able to be formed more reliably by the effect | action of tension | tensile_strength.

  In the resin films 50 and 51, when light is irradiated, the light irradiation region is melted to form an opening, and the inside of the flow path 10 is in communication with the outside through the formation of the opening. The resin films 50 and 51 are configured such that, for example, an opening is formed when a laser beam having a spot diameter of 50 to 300 μm and an output of 15 to 50 mW is irradiated for 0.5 to 10 seconds. More specifically, the resin films 50 and 51 are made of, for example, a thermoplastic resin containing light-absorbing particles and a heat storage filler, and have a thickness of 5 to 100 μm.

  As the thermoplastic resin, it is preferable to use a resin having a melting point of 100 ° C. or lower, for example, an ethylene-vinyl acetate copolymer. As the light absorbing particles, those having an average particle diameter of 0.1 to 30 μm are used. The type of the light absorbing particles is selected according to the wavelength of light applied to the resin films 50 and 51. For example, nickel powder is used as the heat storage filler. The heat storage filler may be omitted, and instead of the heat storage filler or in addition to the heat storage filler, a mesh may be used to ensure heat storage and strength.

  As shown in FIG. 2, the analysis tool 1 irradiates the resin film 50 with light of a specific wavelength and forms an opening in the resin film 50, thereby allowing the sample to flow into the flow path 10 through the through hole 30. Will be able to supply. On the other hand, although not shown in the drawing, the gas inside the flow path 10 can be discharged to the outside through the through hole 31. As a result, a capillary force is generated inside the flow path 10, and the sample introduced through the through hole 30 can be moved toward the through hole 31.

  In the analysis tool 1, the through hole 30 for introducing the sample and the through hole 31 for discharging the gas are closed by the resin films 50 and 51, the internal airtightness is maintained, and the reagent part 4 is exposed. It is suppressed. The resin films 50 and 51 can be changed from a closed state to an open state by a simple method of irradiating light. For this reason, when the opening is formed in the analysis tool 1, the configuration of the analyzer using the analysis tool is not so complicated, and therefore the opening can be formed in the analysis tool 1 while suppressing an increase in manufacturing cost. . Further, when the analysis tool 1 is configured to analyze the sample based on an optical method, an opening is formed in the analysis tool 1 using a light source for irradiating the analysis tool 1 with light. You can also Furthermore, the resin films 50 and 51 are advantageous in terms of running cost because an opening can be formed with less power consumption if a laser diode is used as a light source.

  Next, a second embodiment of the present invention will be described with reference to FIG.

  The container 6 shown in FIG. 4 includes a plurality of accommodating portions 60. In the illustrated container 6, the liquid reagent is held in the storage unit 60. The opening 61 of each housing portion 60 is closed by a resin film 62, and the airtightness of the housing portion 60 is ensured. The resin film 62 has the same configuration as the resin films 50 and 51 (see FIGS. 1 to 3) of the analysis tool 1 described above. Therefore, in the container 6, the liquid reagent can be taken out from the storage unit 60 by irradiating the resin film 62 with light to form an opening in the resin film 62.

  In the container 6, it is not always necessary to provide a plurality of storage units 60, and the number of storage units 60 may be determined according to the purpose. Moreover, when providing the some accommodating part 60, you may close the opening part 61 with a resin film for every each accommodating part 60 separately.

  In the first and second embodiments, the case where a resin film is applied to an analysis tool or a container has been described as an example. However, the resin film according to the present invention is not limited to an analysis tool or a container, but a specific film. This can be applied when it is necessary to selectively form a fine opening with respect to a region.

  In this example, as shown in Table 1, a plurality of sheets 1 to 7 having different compositions were prepared, the light transmittance of each sheet 1 to 7 was measured, and each sheet 1 to 7 was measured. It was examined whether or not holes were formed in the sheets 1 to 7 when the laser beam was irradiated.

  In Table 1, EVA1 has a vinyl acetate ratio of 28% and a melting point of 62 ° C, a vinyl acetate copolymer (Mitsui / DuPont Chemical), and EVA2 has a vinyl acetate ratio of 25% and a melting point of 66 ° C. Vinyl acetate copolymer (Mitsui / DuPont Chemical). Colorant 1 is a phthalocyanine blue pigment having an average particle size of 1 μm (manufactured by Dainichi Seika), Colorant 2 is a carbon black pigment having an average particle size of 1 μm (manufactured by Dainichi Seika), and Colorant 3 is an average particle. Ansoraquinone blue-green pigment having a diameter of 1 μm (manufactured by Bayer) and Colorant 4 are ansoraquinone red pigment having an average particle diameter of 1 μm (manufactured by Bayer). The average particle diameter of the Ni powder is 10 μm.

(Create a sheet)
In forming the sheets 1 to 7, first, the base resin was dissolved in toluene to prepare a resin solution having a solid content concentration of 20%. Next, while agitating the resin solution with a stirrer, light-absorbing particles were added so as to achieve a target weight ratio, and a heat storage filler was added as necessary to prepare a material solution. Furthermore, the material liquid was apply | coated on the polyester separator by which the peeling process was given to both surfaces using the coating device. Then, the sheets 1-7 whose film thickness is 30 micrometers were obtained by volatilizing toluene from a material liquid in a drying tower.

(Measurement of light transmittance)
The light transmittance of the sheets 1 to 7 was measured using a spectrophotometer (“SCANING SPECTROPHOTOMETER UV-3101PC”; manufactured by Shimadzu Corporation) at a measurement wavelength of 660 nm. The measurement results of the light transmittance are shown in Table 2.

(Examination of hole formation)
The presence / absence of opening formation was confirmed by visual observation of whether holes were formed in the sheets 1 to 7 when the sheets 1 to 7 were irradiated with laser light. At the same time, the time required until the opening was formed was measured. Table 2 shows the presence / absence of opening formation and the time required for forming the opening.

  The sheets 1 to 7 were irradiated with laser light using a laser diode unit (manufactured by Sakai Glass Engineering Co., Ltd.). This laser diode unit is equipped with a laser diode (HL6501MG; Hitachi, Ltd.) capable of emitting red light having a center wavelength of 660 nm as a light source, with a focal length of 3 mm and a spot diameter at the focal point of 100 μm. It is comprised so that it may become. The light output from the laser diode was 27.5 mW.

As can be seen from Table 2, no aperture could be formed in the sheets 6 and 7 whose light transmittance was 20% or more. On the other hand, in the sheets 1 to 5 having a light transmittance of 5% or less, the openings were formed in a short time (1.5 seconds or less). Therefore, considering light transmittance as a reference, in order to form an opening in a sheet in 1.5 seconds or less, the light transmittance may be set to 5% or less, and an opening is formed in about 5 to 10 seconds. If so, the possibility that an aperture can be formed even if the light transmittance is set to about 10% can be fully understood.

  In addition, when focusing on the light-absorbing particles, blue, blue-green, and black colorants are added to 100 parts by weight of the thermoplastic resin in order to form holes in the sheet using laser light having a wavelength of 660 nm. On the other hand, it is understood that 5 parts by weight or more should be added.

  Further, as can be seen from a comparison between the resin sheet 3 and the resin sheet 5, it can be seen that the time required to form the opening is shortened by adding the Ni powder. From this point, it can be seen that the opening is easily formed by adding a material having a specific heat smaller than that of the thermoplastic resin.

1 is an overall perspective view of an analysis tool according to a first embodiment of the present invention. It is sectional drawing which follows the II-II line of FIG. It is a disassembled perspective view of the analytical tool shown in FIG. It is sectional drawing of the container which concerns on the 2nd Embodiment of this invention. (a) is a top view which shows an example of the conventional analytical tool, (b) is sectional drawing which follows the Vb-Vb line | wire of (a).

Explanation of symbols

1 Analysis tool 30, 31 Through hole (opening)
50, 51 Resin film (for analysis tool) 6 Container 61 Opening (for container) 62 Resin film (seal part)

Claims (9)

It includes a thermoplastic resin and light-absorbing particles for actively absorbing light in the range of visible light to near-infrared light, and an opening can be formed in the light-irradiated portion by irradiating light An opening forming resin film,
The thermoplastic resin is selected from a nylon polyamide resin having a melting point of 100 ° C. or lower, and an ethylene copolymer having a melting point of 100 ° C. or lower,
The light absorbing particles are phthalocyanine pigments, carbon pigments, anthraquinone pigments, perylene oil-soluble pigments, iron-chromium black, copper-iron black, iron black, cobalt green, and titanium / cobalt green. At least one of them,
The average particle diameter of the light absorbing particles Ri 0.1~30μm der, and
A resin film for forming an opening, wherein the light transmittance is 10% or less .   The resin film for forming an opening according to claim 1, wherein the content of the light absorbing particles is 1 to 30 parts by weight with respect to 100 parts by weight of the thermoplastic resin. Gold, silver, copper, nickel, aluminum, and of the glass that further include a heat storage filler comprising at least one opening forming resin film according to claim 1 or 2. The heat storage filler has an average particle size of Ru 5~30μm der, aperture-forming resin film of claim 3. 5. The opening-forming resin film according to claim 3 , wherein a content of the heat storage filler is 5 to 30 parts by weight with respect to 100 parts by weight of the thermoplastic resin. The opening forming resin film according to claim 1 , wherein the thermoplastic resin has a melting point of 70 ° C. or less . The ethylene-based copolymer, ethylene - vinyl acetate copolymer, according to claim 1 to the opening forming resin film according to any one of 6. The said ethylene-vinyl acetate copolymer is a resin film for opening formation of Claim 7 whose ratio of vinyl acetate is 5-35% on the basis of a weight . The resin film for opening formation according to any one of claims 1 to 8 , wherein the thickness is 5 to 100 µm .

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