JP4474565B2 - Non-invasive blood pressure monitor - Google Patents

Description

The present invention relates to a non-invasive sphygmomanometer that measures blood pressure in order to cope with rapid blood pressure fluctuations during a patient's operation or the like. to prevent the measurement erroneous based on the noise component generated, it can be removed easily the noise component included in the measurement of the blood pressure, yet it is possible to achieve even less always proper blood pressure measurement burden on the patient non The present invention relates to a blood pressure monitor .

  Conventionally, as a non-invasive sphygmomanometer, for example, as a device for measuring a subject's systolic blood pressure (maximum blood pressure), the cuff is wound around the subject's arm or wrist and the artery is increased by pressurizing the cuff to a pressure value equal to or higher than the systolic blood pressure. Oscillometric that measures the systolic blood pressure from the change in amplitude of the vibration by observing the pressure fluctuation inside the compression cuff and blocking the blood flow and detecting the vibration due to the pulsation of the artery The law is known.

  However, when measuring blood pressure using such a cuff, the area of the cuff wearing portion changes depending on the age, physique, etc. of the subject, and thus erroneous detection occurs if the cuff is inappropriately attached to the subject. there is a possibility. From such a viewpoint, a sphygmomanometer has been proposed that can determine whether or not the cuff is worn or wound properly (see Patent Document 1).

  The sphygmomanometer in Patent Document 1 is an electronic sphygmomanometer that has a compression cuff that compresses a blood pressure measurement site and measures blood pressure based on a change in vibration of an arterial wall accompanying a change in cuff pressure, A measurement cuff is provided as a vibration detection means for measuring the vibration of the artery wall at an arbitrary position of the compression cuff, a peak detection means for detecting a peak from the vibration signal measured by the measurement cuff is provided, and the peak detection The structure which provided the winding state determination means which determines the winding state of a cuff using the signal detected by the means is disclosed.

  Moreover, in a sphygmomanometer that measures only blood pressure fluctuations as a sphygmomanometer that can continuously measure blood pressure using a cuff, the blood pressure is calculated based on the amount of change in the pulse wave. If a disturbance is placed on the wave waveform, there is a problem that accurate blood pressure measurement cannot be performed. From this point of view, a non-invasive blood pressure monitor has been proposed that separates noise due to body motion from a pulsating component synchronized with a heartbeat, and enables accurate and continuous blood pressure measurement even under free action (patent) Reference 2).

  The non-invasive sphygmomanometer in Patent Document 2 includes (1) at least two sensors that are held on the body surface of a subject and detect a pulsation component obtained in synchronization with a heartbeat and output as an analog signal; 2) A / D conversion means for inputting an analog signal from the sensor and converting the analog signal into a digital signal, and (3) disturbance due to body motion is included in the pulsation component detected by the sensor, The frequency and phase change linearly until a pulsation component including disturbance is detected by the sensor, and it is assumed that the disturbance due to body movement and the pulsation component synchronized with the heartbeat not including disturbance are mixed. Separation that calculates a plurality of separation matrices for separating disturbance from the pulsation component including the disturbance by using the statistical independence of the pulsation component not including the disturbance and the disturbance when being deceived Matrix meter And (4) a body motion indicating a disturbance and a pulsation component synchronized with a heartbeat not including a disturbance by causing the plurality of separation matrices to act on the digital signal converted by the A / D conversion means. A signal separation calculation means that separates into components, and (5) a blood pressure value calculation means that continuously calculates a blood pressure value based on a pulsation component synchronized with a heartbeat that does not include a disturbance taken in from this signal separation calculation means. The thing which consists of a structure which has is disclosed.

JP 2001-245859 A JP 2001-204695 A

  However, in the electronic sphygmomanometer disclosed in Patent Document 1, a measurement cuff for measuring the vibration of the arterial wall at an arbitrary position is provided to the compression cuff that compresses the blood pressure measurement site, and the cuff used for measurement is provided. It is possible to determine whether or not the winding state is appropriate, and no measures are taken into account for the noise component included in the blood pressure measurement value due to the body movement of the subject.

  On the other hand, in the non-invasive blood pressure monitor disclosed in Patent Document 2, two or more sensors that detect the pulsation component obtained in synchronization with the heartbeat by being held on the body surface of the subject are provided. The signal obtained by the sensor is separated from the pulsation component including disturbance due to body movement, etc. by the separation matrix calculation means, and also separated into the pulsation component synchronized with the heartbeat not including the disturbance and the body movement component indicating the disturbance. By performing the arithmetic processing, it is possible to remove the noise component described above. However, in this case, if there is one noise (disturbance) source, the noise (disturbance) component can be removed by the above-described separation matrix calculation means. However, for example, noise components detected by a plurality of sensors at different ratios. Removal is difficult. That is, since the plurality of sensors described above are provided on one common cuff, the cuff pressure waveforms detected by the sensors interfere with each other, so that the pulsation component and the body motion component indicating disturbance are described above. It is difficult to properly separate them from each other.

  Thus, as a result of various examinations and trial manufactures, the present inventors have provided two or more sensors for detecting a pulsation component that is held on the subject's body surface and obtained in synchronization with the heartbeat, The cuff attached to the body measurement site is provided with two or more independent air bladders that are set to have the same pressure condition, and each of the sensors is independent. A non-invasive sphygmomanometer that can be attached to an air bladder, detect cuff pressure waveform signals with each sensor, and appropriately remove noise components by applying a separation matrix method to the detected cuff pressure waveform signals. I found out.

That is, for example, in the case where a cuff pressure signal obtained in synchronization with a heartbeat including a noise component is detected using two air bladders and two sensors for a cuff worn on the body surface of the subject, the first The first cuff pressure signal CC1 detected by the second pressure sensor and the second cuff pressure signal CC2 detected by the second pressure sensor can be expressed by the following equations.
CC1 = OSC1 + BM1 (1)
CC2 = OSC2 + BM2 (2)
BM1 / BM2 = k (3)
However, OSC1 and OSC2 indicate oscillation waveforms, BM1 and BM2 indicate noise components, and k is an optimum value obtained from an actual measurement value.
The noise component is eliminated based on the equations (1), (2), and (3). Therefore, the following formula CC1-k.CC2 = OSC1-k.OSC2 (4)
From this relationship, it was found that noise components (BM1, BM2) can be removed.

  Further, the first cuff pressure signal s1 detected by the first pressure sensor is observed contaminated with the noise component n1, and the second cuff pressure signal s2 detected by the second pressure sensor is the noise component n2. Assuming that the signal is contaminated and observed, only the noise component n ′ is obtained from each observed signal, and the noise component n ′ is a noise component correlated with the noise component n1. By setting the coefficient vector h of the adaptive filter so as to minimize the noise, it was found that the output signal of the adaptive filter converges to a cuff pressure signal that is not contaminated by noise components, and as a result, the noise components can be removed.

Accordingly, an object of the present invention is to prevent a noise component included in a blood pressure measurement value in order to prevent erroneous measurement based on a noise component generated by an operator or the like in contact with a measurement unit of a sphygmomanometer or by a patient 's body movement. An object of the present invention is to provide a non-invasive sphygmomanometer that can be easily removed and can always achieve an appropriate blood pressure measurement with less burden on the patient.

  In order to achieve the above object, the non-invasive blood pressure monitor according to claim 1 of the present invention is the same for each cuff that detects a pulsating component that is held on the body surface of a subject and obtained in synchronization with a heartbeat. An air bladder having two or more independent configurations set to satisfy the pressure conditions is provided, and two or more pressure sensors for detecting a cuff pressure waveform signal corresponding to each air bladder are connected and arranged. Then, based on the cuff pressure waveform signal detected by each pressure sensor, the separation matrix method and / or adaptive filter is applied alone or in combination to perform arithmetic processing, and the blood pressure signal from which noise components due to body movement and the like are removed An arithmetic processing means is provided.

  A non-invasive blood pressure monitor according to claim 2 of the present invention provides an air pump for supplying air to each air bladder, and an air pump for supplying each air bladder to a cuff provided with two or more independent air bladders. An air supply / exhaust control valve for controlling air supply and exhaust is integrally provided, and pressure sensors for detecting the cuff pressure waveform signals of the respective air bladders are provided in the apparatus main body separated from the cuff, and are mutually connected by an air hose. In addition to the connection configuration, the air pump and the supply / exhaust control valve are controlled by control means provided in the apparatus main body.

  The non-invasive blood pressure monitor according to claim 3 of the present invention is integrated with an exhaust control valve for controlling the exhaust from each air bladder to a cuff provided with two or more independent air bladders. A pressure sensor for detecting a cuff pressure waveform signal of each air bladder is provided in the apparatus main body separated from the cuff and connected to each other by an air hose, and supplied to each air bladder via the air hose. An air pump for supplying air and an air supply control valve for controlling air supply to each air bladder are provided in the apparatus main body, and the air pump, the air supply control valve, and the exhaust control valve are controlled by control means provided in the apparatus main body. It is configured as described above.

  The non-invasive blood pressure monitor according to claim 4 of the present invention is configured to provide a pressure sensor for detecting a cuff pressure waveform signal of each air bladder with respect to a cuff provided with an air bladder having two or more independent configurations. Provided in the apparatus main body separated from the cuff and connected to each other by an air hose, and an air pump for supplying air to each air bladder via the air hose and a supply for controlling supply and exhaust of each air bladder An exhaust control valve is provided in the apparatus main body, and the air pump and the supply / exhaust control valve are controlled by control means provided in the apparatus main body.

  The non-invasive blood pressure monitor according to claim 5 of the present invention is configured such that a pressure sensor that detects a cuff pressure waveform signal of each air bladder is provided for a cuff provided with an air bladder having two or more independent configurations. Provided in the device body that is constructed and arranged integrally with the cuff and connected to each other by an air hose, and controls the air pump for supplying air to each air bladder via the air hose and the air supply and exhaust to each air bladder An air supply / exhaust control valve is provided in the apparatus main body, and the air pump and the air supply / exhaust control valve are controlled by control means provided in the apparatus main body.

The non-invasive sphygmomanometer according to claim 6 of the present invention is the non-invasive sphygmomanometer according to claim 1, wherein the arithmetic processing means for obtaining a blood pressure signal from which a noise component due to body movement or the like has been removed ,
The first cuff pressure signal CC1 detected by the first pressure sensor and the second cuff pressure signal CC2 detected by the second pressure sensor are respectively related to the oscillation waveform component OSC and the noise component BM. Is expressed by the following equation:
CC1 = OSC1 + BM1 (1)
CC2 = OSC2 + BM2 (2)
BM1 / BM2 = k (3)
Based on the above formulas (1), (2), (3) (k is the optimum value obtained from the actual measurement value),
CC1-k.CC2 = OSC1-k.OSC2 (4)
The noise component removal arithmetic processing by the separation matrix method that removes the noise component BM from the relationship is performed.

The non-invasive sphygmomanometer according to claim 7 of the present invention is the non-invasive sphygmomanometer according to claim 1, wherein the arithmetic processing means for obtaining a blood pressure signal from which a noise component due to body movement or the like has been removed ,
The first cuff signal s1 detected by the first pressure sensor is observed contaminated with the noise component n1, and the second cuff signal s2 detected by the second pressure sensor is observed contaminated with the noise component n2. Assuming that
Only the noise component n ′ is obtained based on the observed signals, and the coefficient vector h is set such that the noise component n ′ is a noise component correlated with the noise component n1 and the power of the error output is minimized. By using an adaptive filter that sets, the output signal of the adaptive filter is converged to an uncontaminated cuff pressure waveform signal,
The present invention is characterized in that a calculation process of noise component removal by the adaptive filter for removing the noise component is performed.

  According to the noninvasive sphygmomanometer according to the first to fifth aspects of the present invention, the influence of noise due to body movement or the like in the noninvasive blood pressure measurement is reduced, and more accurate noninvasive blood pressure measurement is easily performed. be able to. In particular, in the non-invasive blood pressure monitor of the present invention, two or more air bladders are provided, but the appearance of the conventional air bladder is the same as one cuff, and the burden on the person being measured and the person to be measured increases. Absent. In addition, according to the noninvasive blood pressure monitor of the present invention, even the measurement subject who cannot restrain movement, such as an ICU, a child, or a newborn, can reduce the influence of body movement and appropriately perform noninvasive blood pressure measurement. be able to.

Further , according to the non-invasive blood pressure monitor according to claim 6 of the present invention, the ratio of the detection signal components obtained by the respective air bladders is obtained. Thus, non-invasive blood pressure can be obtained. On the other hand, when this ratio is no longer 1, it is indicated that noise due to body movement or the like is mixed, and the separation of the pulse wave component and the noise component is performed smoothly, so that the pulse wave component can be properly extracted. Can be easily achieved.

Therefore, according to the non-invasive sphygmomanometer according to claim 6 of the present invention, it is possible to obtain a non-invasive sphygmomanometer that can perform appropriate and simple noise component removal with a relatively simple configuration. .

Furthermore , according to the non-invasive blood pressure monitor according to claim 7 of the present invention, by using the adaptive filter, it is possible to easily achieve appropriate extraction of the pulse wave component from which the noise component has been removed by relatively simple arithmetic processing. be able to.

Therefore, according to the non-invasive sphygmomanometer according to the seventh aspect of the present invention, it is possible to obtain a non-invasive sphygmomanometer capable of appropriately and simply removing noise components with a simpler configuration.

Next, embodiments of the non-invasive blood pressure monitor according to the present invention will be described in detail below with reference to the accompanying drawings.

[ Configuration example 1 of non-invasive blood pressure monitor ]
1 to 3 show a configuration example of a noninvasive blood pressure monitor according to the present invention, FIG. 1 is a schematic block diagram of the noninvasive blood pressure monitor, and FIG. FIG. 3 is a schematic block connection diagram showing a control system of the non-invasive blood pressure monitor. Reference numeral 10 indicates a cuff of the non-invasive blood pressure monitor, and reference numeral 20 indicates a non-invasive blood pressure monitor. The apparatus main body of a sphygmomanometer is shown.

  In the non-invasive sphygmomanometer of this configuration example, the cuff 10 includes a first air bladder 12A and a second air bladder 12B which are configured independently of each other, and simultaneously from the air pump 12 to the air bladders 12A and 12B. And a supply / exhaust control valve 16 for controlling the supply and exhaust to the outside. On the other hand, in the apparatus main body 20, a first pressure sensor is connected to the air bladders 12A, 12B and the air hoses 13A, 13B, and detects pressure fluctuations generated in the air bladders 12A, 12B. 22A and a second pressure sensor 22B are provided (see FIGS. 1 and 2).

  However, in the non-invasive blood pressure monitor of this configuration example, the apparatus main body 20 converts the pressure waveform signals detected by the first pressure sensor 22A and the second pressure sensor 22B into A / D converters 24A and 24B, respectively. Is converted into a digital signal and input to the CPU 26. The air pump 14 and the air supply / exhaust control valve 16 output control signals for controlling blood pressure measurement from the CPU 26 and convert these control signals into analog signals by the D / A converter 28. Then, they are transmitted to the air pump 14 and the air supply / exhaust control valve 16 via the control lines 29a and 29b, respectively, and are configured to perform control for blood pressure measurement (see FIG. 3).

  In this case, as a control signal for controlling the blood pressure measurement by the CPU 26 to the air pump 14 and the air supply / exhaust control valve 16 by the CPU 26, at the time of non-measurement and measurement (at the time of pressurization and decompression) The operating conditions are set as shown in FIG. That is, the opening and closing of the control valve is controlled by “Open” in all three directions, or “Close” in both directions, and when “Control”, the pressure between the air bladders 12A and 12B is equalized by feedback control or the like. Control.

  In the CPU 26, a noise component to be described later is based on the pressure waveform signals detected by the first pressure sensor 22A and the second pressure sensor 22B input via the A / D converters 24A and 24B. It is comprised so that the arithmetic control for removing may be performed. The CPU 26 is provided with a display means 30 for displaying a pressure waveform signal and the like accompanying a noise component removing operation and a switch means 32 for performing a control operation.

[ Configuration example 2 of non-invasive blood pressure monitor ]
4 to 6 show another configuration example of the noninvasive blood pressure monitor according to the present invention. FIG. 4 is a schematic block diagram of the noninvasive blood pressure monitor, and FIG. 5 is a noninvasive blood pressure monitor. FIG. 6 is a schematic block connection diagram showing a control system of the non-invasive blood pressure monitor. For convenience of explanation, the same reference numerals are given to the same components as those in the above-described configuration example, and detailed description thereof will be omitted.

  That is, in the non-invasive blood pressure monitor of the present configuration example, the cuff 10 includes the first air bladder 12A and the second air bladder 12B that are configured independently of each other, and exhausts the air bladders 12A and 12B simultaneously. The exhaust control valve 15B for performing control is provided. On the other hand, in the apparatus main body 20, a first pressure sensor is connected to the air bladders 12A, 12B and the air hoses 13A, 13B, and detects pressure fluctuations generated in the air bladders 12A, 12B. 22A and a second pressure sensor 22B are provided, and an air supply control valve 15A that controls air supply from the air pump 14 to the air bladders 12A and 12B simultaneously through the air hoses 13A and 13B is provided ( FIG. 4 and FIG. 5).

  However, in the non-invasive blood pressure monitor of this configuration example, the apparatus main body 20 converts the pressure waveform signals detected by the first pressure sensor 22A and the second pressure sensor 22B into A / D converters 24A and 24B, respectively. Is converted into a digital signal and input to the CPU 26. In addition, control signals for controlling blood pressure measurement are output from the CPU 26 to the air pump 14, the air supply control valve 15A, and the exhaust control valve 15B, and these control signals are output to the D / A converter 28. Is converted to an analog signal and transmitted to the air pump 14, the air supply control valve 25A, and the exhaust control valve 15B via the control lines 29a, 29b, and 29c, and each is configured to perform control for blood pressure measurement ( (See FIG. 6). In this case, the control signal for controlling the blood pressure measurement by the CPU 26 to the air pump 14 and the air supply control valve 15A and the exhaust control valve 15B by the CPU 26 is not measured and measured (at the time of pressurization and The operation conditions at the time of depressurization are set as shown in FIG. 13B, and the details of the operation are as described above. The other configuration is the same as the configuration example shown in FIGS.

[ Configuration example 3 of non-invasive blood pressure monitor ]
7 to 9 show still another configuration example of the noninvasive blood pressure monitor according to the present invention. FIG. 7 is a schematic block diagram of the noninvasive blood pressure monitor, and FIG. 8 is the noninvasive blood pressure monitor. FIG. 9 is a schematic block connection diagram showing a control system of a non-invasive blood pressure monitor. For convenience of explanation, the same components as those in the configuration example described above are denoted by the same reference numerals, and detailed description thereof is omitted.

  That is, in the non-invasive blood pressure monitor of the present configuration example, the cuff 10 has a configuration including a first air bladder 12A and a second air bladder 12B that are configured independently of each other. On the other hand, in the apparatus main body 20, a first pressure sensor is connected to the air bladders 12A, 12B and the air hoses 13A, 13B, and detects pressure fluctuations generated in the air bladders 12A, 12B. 22A and a second pressure sensor 22B, and a structure including a supply / exhaust control valve 17 for supplying and exhausting air from the air pump 14 to the air bladders 12A and 12B simultaneously via the air hoses 13A and 13B. (See FIGS. 7 and 8).

  However, in the non-invasive blood pressure monitor of this configuration example, the apparatus main body 20 converts the pressure waveform signals detected by the first pressure sensor 22A and the second pressure sensor 22B into A / D converters 24A and 24B, respectively. Is converted into a digital signal and input to the CPU 26. The air pump 14 and the air supply / exhaust control valve 17 output control signals for controlling blood pressure measurement from the CPU 26 and convert these control signals into analog signals by the D / A converter 28. Then, it is transmitted to the air pump 14 and the air supply / exhaust control valve 17 via the control lines 29a and 29b, and is configured to perform control for blood pressure measurement (see FIG. 9). In this case, as a control signal for controlling the blood pressure measurement by the CPU 26 to the air pump 14 and the air supply / exhaust control valve 17 by the CPU 26, at the time of non-measurement and measurement (at the time of pressurization and decompression) The operation conditions are set as shown in FIG. 13C, and the details of the operation are as described above. The other configuration is the same as the configuration example shown in FIGS.

[ Configuration example 4 of non-invasive blood pressure monitor ]
10 to 12 show another configuration example of the noninvasive blood pressure monitor according to the present invention. FIG. 10 is a schematic block diagram of the noninvasive blood pressure monitor, and FIG. 11 is a noninvasive blood pressure monitor. FIG. 12 is a schematic block connection diagram showing a control system of the non-invasive blood pressure monitor. For convenience of explanation, the same components as those in the configuration example described above are denoted by the same reference numerals, and detailed description thereof is omitted.

  That is, in the non-invasive blood pressure monitor of the present configuration example, the cuff 10 has a configuration including a first air bladder 12A and a second air bladder 12B that are configured independently of each other. On the other hand, the apparatus main body 20 is configured to be integrated with the cuff 10. Therefore, in the apparatus main body 20, the first pressure sensor 22A for detecting pressure fluctuations that are connected to the air bladders 12A and 12B via the air hoses 13A and 13B and that are generated in the air bladders 12A and 12B. The second pressure sensor 22B is provided, and the air bladder 12A, 12B is provided with a supply / exhaust control valve 18 that simultaneously supplies and exhausts air from the air pump 14 via the air hoses 13A, 13B. FIG. 10 and FIG. 11).

  However, in the non-invasive blood pressure monitor of this configuration example, the apparatus main body 20 converts the pressure waveform signals detected by the first pressure sensor 22A and the second pressure sensor 22B into A / D converters 24A and 24B, respectively. Is converted into a digital signal and input to the CPU 26. Further, for the air pump 14 and the air supply / exhaust control valve 18, control signals for controlling blood pressure measurement are output from the CPU 26, and these control signals are converted into analog signals by the D / A converter 28. Then, it is transmitted to the air pump 14 and the air supply / exhaust control valve 18 via the control lines 29a and 29b, and is configured to perform control for blood pressure measurement (see FIG. 12). In this case, as a control signal for controlling the blood pressure measurement by the CPU 26 to the air pump 14 and the air supply / exhaust control valve 18 by the CPU 26, at the time of non-measurement and measurement (at the time of pressurization and decompression) The operation conditions are set as shown in FIG. 13D, and the details of the operation are as described above. The other configuration is the same as the configuration example shown in FIGS.

  Next, a control method by the CPU 26 when the non-invasive blood pressure monitor having the above-described configuration is used to remove noise components due to body movement or the like during blood pressure measurement will be described.

[ Noise component removal method 1 ]
For example, for the cuff 10 to be worn on the body surface of a subject, two air bladders 12A and 12B and two pressure sensors 22A and 22B corresponding to these air bladders 12A and 12B are used to generate a heartbeat including noise components. When detecting the cuff pressure waveform signal obtained in synchronization, the first cuff pressure waveform signal CC1 detected by the first pressure sensor 22A and the second cuff pressure detected by the second pressure sensor 22B. The waveform signal CC2 can be expressed by the following equation.

CC1 = OSC1 + BM1 (1)
CC2 = OSC2 + BM2 (2)
BM1 / BM2 = k (3)
However, OSC1 and OSC2 indicate oscillation waveforms, BM1 and BM2 indicate noise sources, k is a noise coefficient, and is an optimum value obtained from an actual measurement value.

  In order to eliminate the noise components (BM1, BM2) from the air bladder condition setting set in the cuff based on the equations (1), (2), (3), the relationship CC1-k · CC2 is obtained. Therefore, the noise components (BM1, BM2) can be removed by determining the optimum value of the noise coefficient k from the relationship of the following equation (4).

  CC1-k.CC2 = OSC1-k.OSC2 (4)

  Therefore, when the cuff pressure waveform and the oscillation waveform in the case of using the noise component removal method 1 were observed with the noninvasive blood pressure monitor of the present invention having the above-described configuration example, (a) in FIG. Results as shown in (b) and (c) were obtained. 14A shows a signal waveform diagram before noise component removal processing, and shows the waveforms of the pressure signals P1 and P2 acting on the first air bladder 12A and the second air bladder 12B, respectively. FIG. 14 (b) shows the first noise component detected by the first pressure sensor 22A and the second pressure sensor 22B corresponding to the pressure signals P1 and P2 before the noise component removal processing. The waveforms of the first oscillation signal CC1 and the second oscillation signal CC2 are shown. FIG. 14 (c) shows a signal waveform diagram after the noise component removal processing. The noise component signal BM and the oscillation signal component OSC respectively separated from the oscillation signals CC1 and CC2 are shown in FIG. Waveform is shown. Therefore, according to (c) of FIG. 14, it is confirmed that the oscillation signal component OSC from which the noise component signal BM is appropriately removed is obtained.

[ Noise component removal method 2 ]
Further, the first oscillation signal s1 detected by the first pressure sensor 22A is contaminated with the noise component n1, and the second oscillation signal s2 detected by the second pressure sensor 22B is contaminated with the noise component n2. Assuming that each of the components is observed, an arithmetic circuit using the separation matrix calculator 42 and the adaptive filter adjustable coefficient calculator 40 shown in FIG. 15 is used to perform noise component removal processing. .

  First, the observed first cuff pressure signal s1 + n1 and second cuff pressure signal s2 + n2 are input to the separation matrix calculator 42 to obtain only the noise component n ′. Therefore, the noise component n ′ is output from the adaptive filter output computing unit 44 via the adaptive filter adjustable coefficient computing unit 40 in which the filter coefficient is set by the required coefficient vector h, thereby removing the noise component. An oscillation signal component can be obtained. That is, in the adaptive filter adjustable coefficient calculator 40, the coefficient vector h is set so that the power of the error e between the desired signal and the output signal is minimized, whereby noise having a strong correlation with the noise component n ′ is set. The component can be removed to obtain the desired oscillation signal component (see FIG. 16).

  Accordingly, when the cuff pressure waveform was observed when the noise component removal method 2 was used, as shown in FIGS. 16A to 16C, FIGS. 17A and 17B, and FIG. Results were obtained. That is, (a) to (c) in FIG. 16 and (a) and (b) in FIG. 17 show signal waveform diagrams before noise component removal processing, and (a) in FIG. Pseudo biological signal s [= sin (2π × k × 0.002)], (b) is a pseudo noise component n1 [= sin (2π × k × 0.004)], (c) Indicates each waveform of the pseudo-noise component n2 [= sin (2π × k × 0.008)] (where k = 0, 1, 2,... 1000). 17A shows the cuff pressure waveform signal x1 [= s + an1 + bn2] detected by the first pressure sensor 22A, and FIG. 17B shows the cuff pressure waveform signal x2 [=] detected by the second pressure sensor 22B. s + cn1 + dn2] are shown respectively (provided that a = 0.7c, b = 0.5d).

  FIG. 18 shows a signal waveform diagram after the noise component removal processing. The adaptive filter adjustable coefficient calculator 40 is applied to the cuff pressure waveform signal x1 detected by the first pressure sensor 22A. Thus, it can be confirmed that the blood pressure signal component s ′ from which the noise component has been removed gradually converges to the pseudo biological signal s, and the noise component n1 is removed.

  The preferred embodiment of the present invention has been described above. However, the present invention is not limited to the above-described configuration example of the non-invasive blood pressure monitor. For example, two or more air bladders to be set in the cuff are provided. It is possible to provide two or more corresponding pressure sensors, and to change the design of the air pump and its supply / exhaust control valve and the control means accordingly, and to the extent that does not depart from the spirit of the present invention. Many design changes can be made.

It is a schematic block block diagram which shows the example of 1 structure of the noninvasive blood pressure meter which concerns on this invention. It is a schematic structure explanatory drawing which shows the mounting state with respect to the test subject of the noninvasive blood pressure meter shown in FIG. FIG. 2 is a schematic block connection diagram showing a control system of the noninvasive blood pressure monitor shown in FIG. 1. It is a schematic block block diagram which shows another structural example of the noninvasive blood pressure meter which concerns on this invention. It is a schematic structure explanatory drawing which shows the mounting state with respect to the test subject of the noninvasive blood pressure meter shown in FIG. FIG. 5 is a schematic block connection diagram showing a control system of the noninvasive blood pressure monitor shown in FIG. 4. It is a schematic block block diagram which shows another structural example of the noninvasive blood pressure meter which concerns on this invention. It is a schematic structure explanatory drawing which shows the mounting state with respect to the test subject of the noninvasive blood pressure meter shown in FIG. FIG. 8 is a schematic block connection diagram showing a control system of the noninvasive blood pressure monitor shown in FIG. 7. It is a schematic block block diagram which shows the other structural example of the noninvasive blood pressure meter which concerns on this invention. It is schematic structure explanatory drawing which shows the mounting state with respect to the test subject of the noninvasive blood pressure meter shown in FIG. It is a schematic block connection diagram which shows the control system of the noninvasive blood pressure monitor shown in FIG. It is a process table | surface which shows the control operation state of the control valve which performs the pump in the blood pressure measurement by the noninvasive blood pressure meter which concerns on this invention, and its air supply and discharge | emission, (a) is the noninvasive blood pressure meter shown in FIG. (B) is a process table of the non-invasive blood pressure monitor shown in FIG. 4, (c) is a process table of the non-invasive blood pressure monitor shown in FIG. 7, and (d) is a non-invasive blood pressure shown in FIG. It is a total process chart. It is a wave form diagram which shows the processing state of the noise component removal by one Example of the noise component removal method in the blood pressure measurement by the noninvasive blood pressure meter which concerns on this invention, Comprising: (a) And (b) is before noise component removal processing A measurement signal waveform diagram, (c) is a signal waveform diagram after the noise component removal processing. It is a signal processing system diagram which shows the processing state of the noise component removal by another Example of the noise component removal method in the blood pressure measurement by the noninvasive blood pressure meter which concerns on this invention. FIG. 16 is a waveform diagram showing an input signal in noise component removal processing by the signal processing system shown in FIG. 15, where (a) is a waveform diagram of a pseudo biological signal s, (b) is a waveform diagram of a pseudo noise component n1, and (c) ) Is a waveform diagram of the pseudo noise component n2, FIG. 16A is a waveform diagram showing an input signal in noise component removal processing by the signal processing system shown in FIG. 15, wherein FIG. 15A is a waveform diagram of the observation signal x1, and FIG. 15B is a waveform diagram of the observation signal x2. FIG. 18 is a waveform diagram showing an output signal after noise component removal processing based on the input signal shown in FIGS. 16 and 17 by the signal processing system shown in FIG. 15.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Non-invasive blood pressure cuff 12A, 12B Air bladder 13A, 13B Air hose 14 Air pump 15A Air supply control valve 15B Exhaust control valve 16 Supply / exhaust control valve 17 Supply / exhaust control valve 18 Supply / exhaust control valve 20 Non-invasive blood pressure monitor device Body 22A, 22B Pressure sensor 24A, 24B A / D converter 26 CPU
28 D / A converters 29a, 29b, 29c Control line 30 Display means 32 Switch means 40 Adaptive filter adjustable coefficient calculator 42 Separation matrix calculator 44 Adaptive filter output calculator

Claims (7)

  For the cuff that is held on the body surface of the subject and detects the pulsating component obtained in synchronization with the heartbeat, an air bladder having two or more independent configurations each set to have the same pressure condition is provided, Two or more pressure sensors for detecting a cuff pressure waveform signal corresponding to each air bladder are connected and arranged, and based on the cuff pressure waveform signal detected by each pressure sensor, a separation matrix method and / or A non-invasive sphygmomanometer comprising arithmetic processing means for applying a adaptive filter alone or in combination to perform arithmetic processing to obtain a blood pressure signal from which a noise component due to body movement or the like is removed.   An air pump for supplying air to each air bladder and a supply / exhaust control valve for controlling supply and exhaust to each air bladder are integrated with a cuff provided with two or more independent air bladders. A pressure sensor for detecting a cuff pressure waveform signal of each air bladder is provided in the apparatus main body separated from the cuff, and connected to each other by an air hose, and the air pump and the supply / exhaust control valve are provided in the apparatus main body. The non-invasive blood pressure monitor according to claim 1, wherein the non-invasive blood pressure monitor is configured to be controlled by a provided control means.   An exhaust control valve for controlling the exhaust from each air bladder is integrally provided for a cuff provided with two or more independent air bladders, and the cuff pressure waveform signal of each air bladder is detected. A pressure sensor is provided in the apparatus main body separated from the cuff and is connected to each other by an air hose. In addition, an air pump for supplying air to the air bladders via the air hose and air supply to the air bladders are controlled. The air supply control valve is provided in the apparatus main body, and the air pump, the air supply control valve, and the exhaust control valve are controlled by control means provided in the apparatus main body. Blood sphygmomanometer.   For cuffs equipped with two or more independent air bladders, a pressure sensor that detects the cuff pressure waveform signal of each air bladder is provided on the device body separated from the cuff and connected to each other by an air hose. An air pump for supplying air to the air bladders via the air hose and an air supply / exhaust control valve for controlling supply and exhaust of air to the air bladders are provided in the apparatus main body, and the air pump and air supply / exhaust control are provided. The non-invasive blood pressure monitor according to claim 1, wherein the valve is controlled by a control means provided in the apparatus main body.   For a cuff provided with an air bladder having two or more independent configurations, a pressure sensor for detecting a cuff pressure waveform signal of each of the air bladders is provided in an apparatus main body configured integrally with the cuff, and an air hose And an air pump for supplying air to each air bladder via the air hose and a supply / exhaust control valve for controlling supply and exhaust of each air bladder are provided in the apparatus body, and the air pump The non-invasive blood pressure monitor according to claim 1, wherein the supply / exhaust control valve is controlled by a control means provided in the apparatus main body. The non-invasive blood pressure monitor according to claim 1, wherein the arithmetic processing means for obtaining a blood pressure signal from which a noise component due to body movement or the like is removed ,
The first cuff pressure signal CC1 detected by the first pressure sensor and the second cuff pressure signal CC2 detected by the second pressure sensor are respectively related to the oscillation waveform component OSC and the noise component BM. Is expressed by the following equation:
CC1 = OSC1 + BM1 (1)
CC2 = OSC2 + BM2 (2)
BM1 / BM2 = k (3)
Based on the above formulas (1), (2), and (3) (k is the optimum value obtained from the measured value),
CC1-k.CC2 = OSC1-k.OSC2 (4)
A non-invasive sphygmomanometer configured to perform a calculation process of noise component removal by the separation matrix method that removes the noise component BM from the above relationship . The non-invasive blood pressure monitor according to claim 1, wherein the arithmetic processing means for obtaining a blood pressure signal from which a noise component due to body movement or the like is removed ,
The first cuff signal s1 detected by the first pressure sensor is observed contaminated with the noise component n1, and the second cuff signal s2 detected by the second pressure sensor is observed contaminated with the noise component n2. Assuming that
Only the noise component n ′ is obtained based on the observed signals, and the coefficient vector h is set such that the noise component n ′ is a noise component correlated with the noise component n1 and the power of the error output is minimized. By using an adaptive filter that sets, the output signal of the adaptive filter is converged to an uncontaminated cuff pressure waveform signal,
A non-invasive sphygmomanometer configured to perform calculation processing of noise component removal by the adaptive filter that removes a noise component .

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