JP4406287B2 - 応答曲線の質の制御を包含する、分子結合相互作用の検出のための方法、システムおよびコンピュータプログラム - Google Patents
応答曲線の質の制御を包含する、分子結合相互作用の検出のための方法、システムおよびコンピュータプログラム Download PDFInfo
- Publication number
- JP4406287B2 JP4406287B2 JP2003578928A JP2003578928A JP4406287B2 JP 4406287 B2 JP4406287 B2 JP 4406287B2 JP 2003578928 A JP2003578928 A JP 2003578928A JP 2003578928 A JP2003578928 A JP 2003578928A JP 4406287 B2 JP4406287 B2 JP 4406287B2
- Authority
- JP
- Japan
- Prior art keywords
- quality
- descriptor
- sensorgram
- sensorgrams
- response curve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims description 61
- 230000004044 response Effects 0.000 title claims description 35
- 230000003993 interaction Effects 0.000 title claims description 14
- 238000001514 detection method Methods 0.000 title claims description 9
- 238000004590 computer program Methods 0.000 title claims description 8
- 230000009149 molecular binding Effects 0.000 title claims description 3
- 239000013598 vector Substances 0.000 claims description 31
- 239000011159 matrix material Substances 0.000 claims description 23
- 238000010494 dissociation reaction Methods 0.000 claims description 12
- 230000005593 dissociations Effects 0.000 claims description 12
- 238000010200 validation analysis Methods 0.000 claims description 12
- 230000027455 binding Effects 0.000 claims description 9
- 230000004001 molecular interaction Effects 0.000 claims description 8
- 238000005259 measurement Methods 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 238000001303 quality assessment method Methods 0.000 claims description 5
- 238000012482 interaction analysis Methods 0.000 claims description 4
- 238000013528 artificial neural network Methods 0.000 claims description 2
- 238000013441 quality evaluation Methods 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000011179 visual inspection Methods 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 15
- 239000012491 analyte Substances 0.000 description 10
- 238000004422 calculation algorithm Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 7
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
- 239000010931 gold Substances 0.000 description 6
- 229910052737 gold Inorganic materials 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 238000010606 normalization Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 238000013442 quality metrics Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000009191 jumping Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000004611 spectroscopical analysis Methods 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920002307 Dextran Polymers 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000000572 ellipsometry Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000010897 surface acoustic wave method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000010291 electrical method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000105 evaporative light scattering detection Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000004186 food analysis Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000013450 outlier detection Methods 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000001028 reflection method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Data Mining & Analysis (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Immunology (AREA)
- Evolutionary Biology (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36780602P | 2002-03-27 | 2002-03-27 | |
| SE0200949A SE0200949D0 (sv) | 2002-03-27 | 2002-03-27 | Method and system for curve quality control |
| PCT/SE2003/000500 WO2003081245A1 (en) | 2002-03-27 | 2003-03-26 | Method, system and computer program for detecting molecular binding interactions comprising response curve quality control |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005521054A JP2005521054A (ja) | 2005-07-14 |
| JP2005521054A5 JP2005521054A5 (enExample) | 2009-08-06 |
| JP4406287B2 true JP4406287B2 (ja) | 2010-01-27 |
Family
ID=28456464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578928A Expired - Fee Related JP4406287B2 (ja) | 2002-03-27 | 2003-03-26 | 応答曲線の質の制御を包含する、分子結合相互作用の検出のための方法、システムおよびコンピュータプログラム |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1488237B1 (enExample) |
| JP (1) | JP4406287B2 (enExample) |
| AU (1) | AU2003217123B2 (enExample) |
| WO (1) | WO2003081245A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7230714B2 (en) * | 2004-10-22 | 2007-06-12 | Agilent Technologies, Inc. | Nonlinear filtering for events in SPR sensing |
| GB0509833D0 (en) * | 2005-05-16 | 2005-06-22 | Isis Innovation | Cell analysis |
| EP1893978A4 (en) * | 2005-06-13 | 2020-06-17 | GE Healthcare Bio-Sciences AB | AFFINITY ANALYSIS METHOD AND SYSTEM |
| DE602005017148D1 (de) * | 2005-08-30 | 2009-11-26 | Perkinelmer Cellular Technolog | Verfahren zum Nachweis einer biochemischen Interaktion |
| JP5017678B2 (ja) * | 2005-08-31 | 2012-09-05 | 鵬 陳山 | 信号検査方法および信号検査モジュール |
| US8045173B2 (en) * | 2009-08-04 | 2011-10-25 | General Electric Company | Adaptive linear filter for real time noise reduction in surface plasmon resonance systems |
| JP2013524210A (ja) | 2010-03-29 | 2013-06-17 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 表面プラズモン共鳴センサグラムのリアルタイムノイズ低減のための適応線形フィルタ |
| US20130331292A1 (en) * | 2011-02-28 | 2013-12-12 | Ge Healthcare Bio-Sciences Ab | Screening method |
| FR3091346B1 (fr) * | 2018-12-31 | 2020-12-25 | Aryballe Tech | Procede de caracterisation de composes cibles |
| GB201914063D0 (en) * | 2019-09-30 | 2019-11-13 | Ge Healthcare Bio Sciences Ab | Method for classifying monitoring results from an analytical sensor system arranged to monitor molecular interactions |
| GB202009910D0 (en) * | 2020-06-29 | 2020-08-12 | Cytiva Sweden Ab | Method and system for classifying monitored molecular interactions |
| CN112884057B (zh) * | 2021-03-04 | 2022-03-18 | 晶仁光电科技(苏州)有限公司 | 基于点云数据的三维曲面质量分类方法、系统及存储介质 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE462454B (sv) * | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| JP3323512B2 (ja) | 1995-08-07 | 2002-09-09 | ロシュ ダイアグノスティックス コーポレーション | ディスタンス・アウトライア検知を使用した生物学的流体分析 |
| SE9503028D0 (sv) * | 1995-09-01 | 1995-09-01 | Pharmacia Biosensor Ab | Method of analysing chemical and physical interactions at a sensor surface |
| GB9518429D0 (en) * | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
| JP4095189B2 (ja) * | 1998-12-16 | 2008-06-04 | 株式会社東芝 | 自動分析装置および自動分析装置の検量線判定処理方法 |
| DE10005301A1 (de) * | 2000-02-07 | 2001-08-09 | Trutnau Hans Heinrich | Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren |
-
2003
- 2003-03-26 EP EP03713156A patent/EP1488237B1/en not_active Expired - Lifetime
- 2003-03-26 WO PCT/SE2003/000500 patent/WO2003081245A1/en not_active Ceased
- 2003-03-26 JP JP2003578928A patent/JP4406287B2/ja not_active Expired - Fee Related
- 2003-03-26 AU AU2003217123A patent/AU2003217123B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003081245A1 (en) | 2003-10-02 |
| AU2003217123A1 (en) | 2003-10-08 |
| AU2003217123B2 (en) | 2011-02-24 |
| EP1488237B1 (en) | 2011-05-11 |
| EP1488237A1 (en) | 2004-12-22 |
| JP2005521054A (ja) | 2005-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20120173156A1 (en) | Method and system for curve quality control | |
| JP4406287B2 (ja) | 応答曲線の質の制御を包含する、分子結合相互作用の検出のための方法、システムおよびコンピュータプログラム | |
| US20050131650A1 (en) | Method and system for interaction analysis | |
| US20250347691A1 (en) | Method and system for interaction analysis | |
| JP2025109716A (ja) | 分子間相互作用をモニターするように配置された分析センサーシステムからのモニタリング結果を分類するための方法 | |
| JP7772722B2 (ja) | 観測された分子間相互作用を分類するための方法とシステム | |
| US20130331292A1 (en) | Screening method | |
| US11093583B2 (en) | Method and system for improving the evaluation of an interaction between an analyte and a ligand using a biosensor | |
| WO2006135309A9 (en) | Method and system for affinity analysis | |
| US10151694B2 (en) | Method and system for sensor response curve evaluation | |
| US20070016378A1 (en) | Method and system for affinity analysis | |
| JP2007506967A (ja) | 分子相互作用分析の方法及びシステム |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060224 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20080610 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090317 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20090617 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090714 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090909 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20091013 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20091106 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121113 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121113 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131113 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |