JP4324287B2 - Transfer needle - Google Patents

Description

【００１５】
（比較例１〜４）
比較のため、流体通路の中空部にまったく加工しないトランスファーニードルを作成し、これを実施例と同様に液の戻り状況を測定した。結果を表２に示す。
【００１６】
【表２】

【００１７】
【発明の効果】
本発明のトランスファーニードルは、製造も容易でありコストもかからず、また流体通路中空部に凸条または溝を設ける簡単な加工により、溶解液入り容器から薬剤入り容器へ及び薬剤入り容器から溶解液入り容器への薬液等の注入が確実にかつ薬剤入り容器への薬液の残留の心配なしに行われ、輸液等の調製が容易となるものである。またトランスファーニードルを冠着した薬剤入り容器は、その衛生性、使用の容易、確実性から薬剤の溶解を無菌的に短時間でかつ薬剤の損失をもたらすことなく行えるなど極めて有効な効果を奏するものである。
【図面の簡単な説明】
【図１】本発明のトランスファーニードルの１例の外観図。
【図２】本発明の中空針に使用できる中空部断面形状の例。
【図３】本発明の流体通路に凸条または溝を設けた中空部断面図。
【図４】本発明のトランスファーニードルが冠着されている薬剤入り容器の断面図。
【図５】溶解液入り容器と薬剤入り容器をトランスファーニードルを用いて接続した状態を示した外観図。
【符号の説明】
１ 両頭中空針
２ 流体通路
３ 溶解液入り容器用栓
４ 薬剤入り容器用栓
５ 中空針保持具
６ 中空部凸条
７ 中空部溝
１０ トランスファーニードル
１１ 薬剤入り容器
１２ 中空針保持具
１３ 中空針
１４ プロテクターキャップ
１５ ゴムキャップ
１６ 溶解液入り容器[0001]
BACKGROUND OF THE INVENTION
In the preparation of an infusion solution or the like, the present invention enables the solution to be easily transferred from the solution-containing container to the drug-containing container when dissolving and mixing the drug and the drug such as a solution or other drug solution. The present invention relates to a transfer needle that can reliably return the liquid to the container containing the dissolved liquid.
[0002]
[Prior art]
In medical institutions such as hospitals, anticancer drugs, antibiotics, powdered drugs such as blood products or lyophilized drugs contained in containers such as vials can be easily altered or stored as liquid drugs. Drugs whose medicinal effects decrease when stored as such are dissolved immediately before use, and are used for infusion treatment as, for example, infusions.
For mixing or diluting the drug for dissolving the drug, a dilute solution or drug solution (hereinafter referred to as “dissolved solution”) is used from a diluent container or drug solution container (hereinafter referred to as “dissolved solution container”) with a syringe or the like. A method of extracting and injecting into a drug container such as a vial (hereinafter referred to as “drug-containing container”), dissolving the drug, and extracting the same with a syringe or the like and re-injecting it into a solution-containing container has been employed.
[0003]
This method is not only complicated, but also has a sanitary problem. To improve this, the hollow part is smooth. In some cases, metal is used at the tip for reinforcement, or both heads are provided with reinforcing ribs. A method was adopted in which a hollow needle was used to directly connect a solution-containing container and a drug-containing container, the solution was fed into the drug-containing container and mixed, and then the solution in which the drug was dissolved was returned as it was. In addition, a solution-containing container-double-ended hollow needle integrated product (hereinafter referred to as a “kit product”) that has further improved hygiene and sterility by this method is also on the market.
The mixing method using a double-ended hollow needle is to connect the container containing the drug and the container containing the solution, place the drug container side down, inject the solution into the container containing the drug, dissolve the drug, and then reverse the drug. A method is used in which a solution obtained by dissolving the medicine on the container side is returned to the container containing the solution.
[0004]
Therefore, in order to allow this operation to be easily performed, air or a solution or a solution in which a drug is dissolved is allowed to pass, so that the cross-sectional shapes of the hollow portions of the double-ended hollow needle are asymmetrical or hollow. Proposals have been made such as making the length (height) of the part non-uniform, and making the cross-sectional shapes of the solution-containing container and the drug-containing container side non-uniform (different shapes at both ends in the same hollow part). It was. Furthermore, in order to improve water repellency and slipperiness, measures such as applying silicone have been taken.
However, the selective passage between air and drug solution does not always occur, and the dissolved solution remains in the drug container or, in extreme cases, a high concentration solution injected into the drug container. In some cases, the container does not return to the solution-containing container. For this reason, the container containing the drug may be pressed, the movement of the liquid may be promoted by hitting, or the drug solution itself must be discarded.
[0005]
[Problems to be solved by the invention]
In order to solve the above problems, the present invention provides a hygienic and aseptic method for easily and surely transferring a dissolved solution or a dissolved solution of a drug when the container containing the dissolved solution and the container containing the drug are connected. An object of the present invention is to develop a transfer needle that is easy to manufacture and inexpensive.
[0006]
[Means for Solving the Problems]
The present invention
[1] A transfer needle comprising a double-ended hollow needle body in which a plurality of fluid passages are arranged in parallel, wherein one or a plurality of ridges or grooves are provided in at least a part of the hollow portion of the fluid passage. [2] In a transfer needle comprising a hollow needle body in which a plurality of fluid passages are arranged in parallel at the mouth portion of a vial containing a medicine, at least a part of the hollow portion of the fluid passage is 1 Or a container containing a medicine, wherein a transfer needle provided with a plurality of ridges or grooves is crowned,
The above objective was achieved by developing
[0007]
DETAILED DESCRIPTION OF THE INVENTION
The present invention will be specifically described below with reference to the drawings.
The double-ended hollow needle 1 of the transfer needle 10 according to the present invention may be similar in shape and size to a conventional double-ended hollow needle as shown in FIG. The material may be a hard synthetic resin or a metal as in the case of the conventional transfer needle. A characteristic portion of the transfer needle 10 of the present invention is in the shape of a fluid passage 2 (hollow portion inside the needle) of the needle 1, and at least a part of the needle 1, preferably a cutting edge, more preferably one over the entire length of both ends. Alternatively, a large number, preferably several to several dozen ridges 6 or grooves 7 are provided in the hollow portion. The size of the ridge 6 or the groove 7 can be freely selected within a range that does not adversely affect the passage of fluid.
[0008]
Normally, two fluid passages 2 are provided in the needle 1, but three fluid passages 2 can be used. Providing four or more only complicates the operation and does not improve the efficiency of fluid flow (air passage in the direction opposite to the liquid passage). The cutting edge of the needle 1 has a sharp shape so as to penetrate the solution-containing container and the rubber stopper of the drug-containing container.
The transfer needle 10 serves as a holder when the double-headed hollow needle 1 is set in the container and the container-filled container stopper 3, the drug-containing container stopper 4 provided so as to penetrate the double-headed hollow needle 1. It consists of a hollow needle holder 5. A rubber stopper is usually used as the stopper 3 for the container containing the solution or the stopper 4 for the medicine container. Further, when the hollow needle is made of resin, the hollow needle holder 5 may be integrally formed of the same resin as the double-ended hollow needle.
[0009]
In addition, the transfer needle of the present invention may use a material in which the surface of a molded product is subjected to surface treatment or a material in which additives such as various water repellents and hydrophilic agents are blended.
As a method for forming a ridge or groove in the hollow portion of the fluid passage, a method in which a ridge or groove is put in advance in a material for forming a double-ended hollow needle, a shape (projection or groove) in a mold is transferred. And a method of polishing with a polishing material or other processing machine in polishing of the edge of a hollow needle of a double-ended hollow needle by a conventional method.
[0010]
On the other hand, as shown in FIG. 4, the needle 13 used on the side of the drug-containing container 11 having the transfer needle attached thereto does not need to penetrate the rubber stopper of the drug-containing container. However, it is only necessary that the fluid passage 2 without a sharp blade edge is opened on the medicine container 11 side. Even in this case, one or a plurality of protrusions penetrate through a part of the hollow portion of the fluid passage 2, preferably the blade edge (dissolved liquid container side) portion or the container side end portion, more preferably from the blade edge to the other end. It is necessary to provide the strip 6 or the groove 7. Also in this case, it is preferable to provide several to ten or several ridges or grooves like the transfer needle. After putting the medicine in the medicine-containing container 11, the transfer needle 10 is crowned, and in order to protect the edge of the sharp needle, ensure the safety of the operator, and prevent bacterial contamination of the edge, etc. It is preferable to cover the rubber cap 15 and to cover the rubber cap with a plastic protector cap 14.
[0011]
In use, the protector cap 14 and the rubber cap 15 are removed, and the transfer needle 13 is inserted into the rubber stopper of the container 16 containing the solution with the hollow needle holder 12 and penetrated. To the bottom of the container 16 containing the solution, and the solution is moved to the container 11 containing the drug.
The drug-containing container 11 into which the dissolution liquid has been injected is stirred to dissolve the drug, the positions of the dissolution liquid-containing container 11 and the drug-containing container 16 are reversed, and the high-concentration solution in which the drug is dissolved is returned to the dissolution liquid-containing container 16. Thus, an infusion solution can be prepared. If necessary, the drug recovery rate can be increased by repeating this multiple times.
The container with the medicine to which the transfer needle of the present invention is attached can be used aseptically sealed in the hospital or the like at the side of the medicine container, there is no risk of contamination with bacteria, etc. The transfer needle that is pierced into the container containing the liquid is also aseptically protected by a rubber cap or the like until use, so that the hygienic safety in the preparation of the infusion is maintained extremely high.
[0012]
The transfer needle of the present invention could not be completely clarified until that reason, but the liquid can be smoothly moved by allowing the hollow portion of the fluid passage to penetrate the ridge or groove from the blade tip to the other end. As a result, it was confirmed that the solution could be reliably and easily moved between the solution-containing container and the drug-containing container.
Probably, in the present invention, the fine ridges or grooves on the tip of the hollow portion of the fluid passage of the transfer needle break the liquid tension due to the surface tension of the liquid, break up the liquid agglomeration and prevent the inflow of air. In order to eliminate the interference, it is assumed that air easily passes through one hollow part, thereby facilitating the flow of the liquid.
[0013]
【Example】
(Examples 1 to 11)
A physiological saline solution [TN: 100 ml] manufactured by Otsuka Pharmaceutical Co., Ltd. was used as the solution-containing container, and an empty container and Shionogi Pharmaceutical Co., Ltd. [vancomycin: 1 g] were used as the drug-containing containers.
Transfer needles using the raw materials shown in Table 1 and having a hollow portion and a hollow double-ended hollow needle whose inner surface shape is shown in Table 1 (two hollow portions having a major axis of 2.9 mm and a minor axis of 1.7 mm arranged in parallel) After moving the solution from the solution-containing container to the drug-containing container until it is fully filled, reverse the solution in about 0.5 seconds, and return the liquid when standing with the drug-containing container up. It was measured. This measurement was repeated 100 times, and the number of times the liquid returned was expressed in%. The results are shown in Table 1.
[0014]
[Table 1]

[0015]
(Comparative Examples 1-4)
For comparison, a transfer needle that was not processed at all in the hollow portion of the fluid passage was prepared, and the return state of the liquid was measured in the same manner as in the example. The results are shown in Table 2.
[0016]
[Table 2]

[0017]
【The invention's effect】
The transfer needle of the present invention is easy to manufacture and does not cost, and can be dissolved from a solution-containing container to a drug-containing container and from a drug-containing container by a simple process of providing a protrusion or groove in the fluid passage hollow portion. The injection of the chemical solution or the like into the liquid container is reliably performed without worrying about the remaining of the chemical solution in the drug container, and the preparation of the infusion solution or the like is facilitated. In addition, a drug-filled container with a transfer needle has extremely effective effects such as the ability to dissolve the drug aseptically in a short time without causing loss of the drug due to its hygiene, ease of use, and certainty. It is.
[Brief description of the drawings]
FIG. 1 is an external view of an example of a transfer needle of the present invention.
FIG. 2 shows an example of a cross-sectional shape of a hollow part that can be used in the hollow needle of the present invention.
FIG. 3 is a cross-sectional view of a hollow portion in which ridges or grooves are provided in the fluid passage of the present invention.
FIG. 4 is a cross-sectional view of a medicine container in which the transfer needle of the present invention is attached.
FIG. 5 is an external view showing a state in which a solution-containing container and a drug-containing container are connected using a transfer needle.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Double-headed hollow needle 2 Fluid path 3 Dissolving solution container stopper 4 Drug-containing container stopper 5 Hollow needle holder 6 Hollow part protrusion 7 Hollow part groove | channel 10 Transfer needle 11 Drug containing container 12 Hollow needle holder 13 Hollow needle 14 Protector cap 15 Rubber cap 16 Container with solution

Claims (2)

In a transfer needle comprising a double-ended hollow needle body in which a plurality of fluid passages are arranged in parallel, a plurality of ridges or grooves are provided on the entire inner surface of the hollow portion of the fluid passage in a direction parallel to the fluid passage. Transfer needle. In a transfer needle comprising a hollow needle body in which a plurality of fluid passages are arranged in parallel at the mouth portion of a vial containing a medicine, the entire inner surface of the hollow portion of the fluid passage is arranged in a number parallel to the fluid passage . A drug-containing container in which a transfer needle provided with ridges or grooves is crowned.

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