JP4210542B2 - Timed chemical solution dispensing device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a timed chemical liquid metering apparatus.
[0002]
[Prior art]
[Patent Document 1]
  5-82879
[Patent Document 2]
  JP-A-6-255688
[Patent Document 3]
  JP 2001-114360 A
[0003]
In general aerosol products, the contents are jetted almost simultaneously when the jetting operation is performed, and the contents are jetted continuously when the jetting operation is continued. For this reason, there are large variations in usage methods such as the amount used and the number of times used by users, and if the appropriate amount is not used, the effect of the drug as designed cannot be obtained, or if it is used excessively, it may have an adverse effect There is.
[0004]
On the other hand, the present applicant has proposed a fixed-quantity aerosol device (product) in which a fixed amount of contents is injected by a single injection operation (see Patent Document 1, Patent Document 2, and Patent Document 3). In the case of these fixed-injection aerosol devices, when the injection member is operated, the fixed-quantity chamber and the internal space of the container main body are shut off. Not jetted. Therefore, a certain amount of contents are always ejected even if there is a variation in operation time. Therefore, a desired effect can be obtained by the chemical liquid provided by one injection set by the producer.
[0005]
[Problems to be solved by the invention]
However, depending on the user, there are variations in the number of uses and frequency of use, and even if it is the above-mentioned quantitative type aerosol device, and even if the usage / dose such as the number of uses and intervals is described in the product, May be used once or in a short time. In that case, the daily permissible amount of the active ingredient may be exceeded.
[0006]
The present invention has been made in view of such a problem, and is a timed chemical liquid quantitative supply device capable of limiting the amount of chemical liquid that can be injected within a predetermined time and limiting the number of times of use and the time interval of use. The technical challenge is to provide Furthermore, the present invention provides a timed chemical solution quantitative supply device capable of injecting the limited use amount by a plurality of injection operations, and making the injection amount per injection quantitative. It is said.
[0007]
[Means for Solving the Problems]
  Timed chemical liquid supply device of the present inventionIsA container for holding a chemical under pressure,Attached to the opening of the containerValve for communicating / blocking inside / outside of container and its valveIs provided in communication with the valve below,Temporarily store a certain amount of chemical before sprayingA mounting cup that is fixed to the upper opening of the container, a cylindrical housing that is held in the center of the mounting cup, and an axial direction of the housing that slides up and down in the housing. The fixed quantity is composed of a stem that is provided so as to be movable, a spring that constantly biases the stem upward, and a stem rubber that is provided on the upper part of the housing so as to sandwich the mounting cup and closes the stem hole of the stem. The chamber has a double cylinder shape sharing the shaft with the housing, and an outer cylinder provided with an inner cylinder communicating the inside of the container and the valve, and an urging means for urging in a direction in which the volume is variable and the volume is increased. The inner cylinder is provided with a communication hole communicating with the outer cylinder formed in the upper part, an annular seal member provided below the communication hole, and a lower part of the seal member. A tubular flow rate adjusting member and a filter provided below the flow rate adjusting member, and by lowering the stem, the lower end of the stem comes into contact with the seal member, and the center hole of the seal member is formed. Close and close the container and the valveIt is characterized by that.
In such a timed chemical liquid supply device, it is preferable that the flow rate adjusting member is airtightly attached by a gasket. Further, it is preferable that a dip tube is attached to the lower end of the inner cylinder, and a filter is provided at the lower end of the dip tube.
An annular piston is slidably accommodated in the gap between the inner cylinder and the outer cylinder, and a spring for biasing the piston downward is provided on the upper surface of the piston and the metering chamber. Also good. The outer cylinder may be a bottomed cylindrical diaphragm attached to surround the inner cylinder.
[0008]
The second aspect of the timed chemical liquid metering device of the present invention is a container for holding a chemical liquid in a pressurized state, a mounting cup fixed to the upper opening of the container, and held at the center of the mounting cup. A cylindrical housing, a stem provided in the housing so as to be slidable in the axial direction of the housing, a spring that constantly biases the stem upward, and a mounting cup sandwiched between the upper part of the housing A valve having a stem rubber that closes the stem hole of the stem, and a cylindrical portion that communicates the inside of the container and the valve with the lower end of the valve and shares the shaft with the housing. A seal member is provided, a tubular flow rate adjusting member is provided below the seal member, and a filter is provided below the flow rate adjusting member. Provided, by lowering the stem, the lower end of the stem contacts said seal member, closing the central hole of the seal member is characterized by closing the vessel and the valve.
In the timed chemical liquid metering supply device of the second aspect, it is preferable that a dip tube is attached to the lower end of the cylindrical portion and a filter is provided at the lower end of the dip tube.
[0009]
According to a third aspect of the timed liquid medicine fixed amount supply device of the present invention, there is provided a container for holding a chemical liquid in a pressurized state, a valve for communicating / blocking the inside / outside of the container, and a passage communicating the valve and the inside of the container. A liquid reservoir chamber for temporarily storing a predetermined amount of chemical liquid before jetting, and a flow rate adjusting unit for suppressing the flow rate of the chemical liquid supplied to the liquid reservoir chamber, and adjusting the liquid reservoir chamber and the flow rate A seal portion is interposed between the liquid reservoir chamber and the flow chamber when the valve is operated to allow the liquid reservoir chamber to communicate with the flow rate adjusting section. And a storage chamber having a larger volume than the liquid storage chamber is interposed between the liquid storage chamber and the flow rate adjusting unit.
In such a timed chemical liquid supply device of the third aspect, it is preferable that the volume ratio of the storage chamber to the liquid storage chamber is an integer value. Further, it is preferable that the liquid storage chamber and / or the storage chamber have a variable volume and include a biasing means for biasing in a direction in which the volume of the liquid storage chamber and / or the storage chamber increases. Further, the liquid storage chamber and / or the storage chamber has a piston slidably provided therein, and the piston separates the interior of the container from the liquid storage chamber, and the piston is connected to the liquid storage chamber. What is provided with the spring urged | biased in the direction which enlarges the volume of a chamber is preferable.
[0010]
[Operation and effect of the invention]
In the timed chemical liquid metering device of the present invention (Claim 1), when the valve is opened, the chemical liquid contained in the liquid reservoir is injected. Even if the operation of opening the valve is continued in a state where the liquid reservoir is empty, the chemical liquid entering the valve is hardly injected outside because the flow rate is suppressed by the flow rate adjusting unit. Next, when the valve is closed, the inside of the valve housing and the reservoir chamber are at atmospheric pressure, so the chemical solution is supplied into the reservoir chamber due to the pressure difference from the inside of the container body. The flow rate (inflow amount per hour) of the chemical solution flowing in is limited and slowly flows in over time. Therefore, even if the valve is operated many times before filling, only the amount accumulated until then can be ejected.
[0011]
That is, once a predetermined amount of chemical liquid has been injected, a predetermined time is required until the liquid reservoir is filled again with the chemical liquid so that the next injection can be performed. Therefore, it is possible to prevent erroneous and repeated use. As described above, the timed chemical liquid metering device of the present invention can limit the amount of use per fixed time as well as the amount of use per time as in the prior art. Therefore, the variation by the user is reduced, and the effect as set can be given. Moreover, it can prevent accidental repeated use in a short time, and can prevent use exceeding the allowable amount. Furthermore, when such a device is used for a medicine, a quasi-drug, a medical device, or the like, the quantitative supply and the frequency of the quantitative supply can be realized with a simple device.Further, since the above-described seal portion is interposed between the liquid reservoir and the flow rate adjusting portion, the liquid reservoir chamber is a fixed-quantity chamber, so that it is possible to prevent extra chemical from flowing out during injection. be able to. Therefore, it becomes an apparatus with higher quantitative injection accuracy.
[0012]
The third aspect of the timed chemical liquid quantification device of the present invention is:Since a predetermined storage chamber is provided between the liquid storage chamber and the flow rate adjusting unit, a necessary injection amount can be stored in the storage chamber in advance. That is, it is possible to inject the amount necessary for use in a plurality of times. Especially when the volume ratio of the storage chamber to the liquid storage chamber is an integral multipleMessengerIt is possible to inject the required amount at the time of use by dividing it by a predetermined amount.
[0013]
In the timed chemical liquid metering device of the present invention,The liquid storage chamber and / or the storage chamber are variable in volume, and are provided with an urging means for urging the liquid storage chamber and / or the storage chamber in an increasing direction.ThingsWhen the valve is opened and the volume of the liquid storage chamber and / or the storage chamber is reduced, the urging means adjusts (weakens) the jetting force, and an appropriate feeling of use can be obtained according to the application. For example, when used in places sensitive to stimuli such as mucous membranes and affected areas such as eyes, nasal cavity, throat, and mouth, the urging means can be strengthened to softly apply the drug solution. When the valve is closed, the volume of the liquid reservoir chamber tends to be expanded by the urging means, so that the pressure difference between the liquid reservoir chamber and the reservoir chamber and the internal pressure in the container body is further increased. Furthermore, even if the pressure in the container fluctuates, the liquid storage chamber and the storage chamber are returned to their original volumes by the biasing means. As a result, the chemical solution is more reliably supplied into the liquid storage chamber or the storage chamber through the flow rate control unit.
[0014]
  In the timed chemical liquid supply device of the present invention, the liquid storage chamber and / or the storage chamber has a piston.thingWhen the valve is opened and the reservoir and the storage chamber communicate with the atmosphere, the piston slides due to the pressure difference with the atmosphere, and all the chemicals in the reservoir and the reservoir can be injected. . On the other hand, when communication with the atmosphere is interrupted after injection, the liquid is filled into the liquid storage chamber or the storage chamber over a predetermined time from the flow rate adjusting unit, and the piston is pushed back until the chemical reaches a predetermined amount. It is. At this time, since the piston is urged by the spring in the direction in which the volume of the liquid storage chamber or the storage chamber is increased, it is possible to assist in filling the liquid storage chamber or the storage chamber with the chemical solution.
[0015]
DETAILED DESCRIPTION OF THE INVENTION
Next, an embodiment of a timed chemical liquid metering device of the present invention will be described with reference to the drawings. 1a and 1b are side cross-sectional views showing an embodiment of the metering device of the present invention, and FIGS. 2a, 2b and 2c are oblique views showing different embodiments of the flow control member according to the present invention, FIG. 3 is a side sectional view showing another embodiment of the quantitative supply device of the present invention, FIG. 4 is a side sectional view showing still another embodiment of the quantitative supply device of the present invention, and FIG. Fig. 6 is a side sectional view showing still another embodiment of the quantitative supply device of the present invention, Fig. 6 is a process diagram showing a usage state of the quantitative supply device of the present invention, and Figs. 7a and 7b are further diagrams of the quantitative supply device of the present invention. It is a principal part cross-sectional side view which shows other embodiment.
[0016]
1a includes a container body 11 having pressure resistance, a valve 12 attached to an opening of the container body, a metering chamber 20 provided integrally below the valve, and a stem of the valve. 16 and an injection member 13 attached to the upper end. The container body 11 is filled with a chemical liquid W in a pressurized state with a propellant such as a compressed gas V or a liquefied gas.
[0017]
The said container main body 11 is a conventionally well-known thing, and has the bottomed cylindrical trunk | drum 1 and the shoulder part 2 and neck part 3 which are formed in the upper end of the trunk | drum 1 by necking etc., and the neck part 3 A bead 4 is formed by curling on the upper end of the substrate. As such a container main body 11, metal containers, such as aluminum and tinplate generally used for aerosol products, resin containers, such as a polyethylene terephthalate, and glass containers, such as a pressure-resistant glass, can be used. In addition, as will be described later, a double-structure aerosol apparatus can be provided by providing a shrinkable inner bag or a slidable piston inside the container body 11 (see FIG. 4).
[0018]
The valve 12 includes a mounting cup 14 that is fixed to the upper opening of the container body 11, a housing 15 that is held by the mounting cup 14, and a stem 16 that is provided so as to be slidable up and down in the housing. It comprises a spring 17 that constantly biases the stem 16 upward, and a stem rubber 19 that closes the stem hole 18 of the stem. The mounting cup 14 is a conventionally known one that is crimped to the inner periphery of the bead 4. Such a mounting cup 14 is manufactured by processing a metal plate such as aluminum or tinplate. In addition, when using the container which does not have the bead 4, the bottomed cylindrical mounting cup opened downward is used, and the lower end opening part is clinched from the outside and fixed (refer FIG. 7a).
[0019]
The housing 15 is substantially the same as a conventionally known push-down valve housing except that the housing 21 of the metering chamber 20 is integrally formed. A tilt type valve can also be used. The stem 16 is a known one having a stem hole 18 and an in-stem passage 18 a communicating with the stem hole 18. The lower end of the stem is aligned with the rod-like portion 35 so as to closely fit a seal member 23 described later.
It is. A conventionally known spring 17 is used, and the spring 17 is held between a step 16 a provided on the stem 16 and a step 15 a provided on the lower portion of the housing 15. The housing 15 and the stem 16 are made of synthetic resin or the like. Moreover, metal things, such as aluminum and stainless steel, can also be used.
[0020]
The housing 21 of the fixed amount chamber 20 is composed of an inner cylinder 21a and a bottomed cylindrical outer cylinder 21b, and has a double cylinder shape in which the upper end of the gap between the two is closed. In the middle of the inner cylinder 21a, a partition wall 21d having a communication hole 21c at the center is provided, and an annular seal member 23 is provided at the upper part thereof. Below the partition wall 21d, a flow rate adjusting member 24 communicating with the communication hole 21c is airtightly attached by a gasket 24a. The lower end side of the inner cylinder 21 a is a dip tube mounting portion 25 for attaching the dip tube 26. The upper end of a conventionally known dip tube 26 is fitted and fixed to the dip tube mounting portion 25. The partition wall 21d having the communication hole 21c and the flow rate adjusting member 24 constitute a flow rate adjusting unit in the present invention.
[0021]
In the vicinity of the upper end of the inner cylinder 21a, a communication hole 30 is formed which communicates the inside and outside of the inner cylinder 21a. An annular piston 33 is accommodated in the gap between the inner cylinder 21a and the outer cylinder 21b so as to be slidable in the axial direction. A ring 21e for retaining the piston 33 is secured to the lower end of the outer cylinder 21b. A space surrounded by the inner cylinder 21a, the outer cylinder 21b, and the piston 33 is an original quantitative chamber. The volume of the metering chamber 20 changes as the piston 33 slides. An opening 34 is provided on the bottom surface of the quantification chamber 20 and communicates with the inside of the container. A spring 36 is disposed between the piston 33 and the upper surface of the metering chamber, and urges the piston 33 downward.
[0022]
The flow rate adjusting member 24 can be formed of, for example, a hollow tube main body 27 as shown in FIG. 2A and a suppressing member 28 provided therein. The suppressing member 28 is formed, for example, by twisting seven core members 32 and inserted into a tube body 27 having an inner diameter substantially the same as the outer diameter of the suppressing member 28. The flow rate adjusting member 24 can be adjusted to a desired flow rate by selecting the number and thickness of the cores, with the gap between the suppressing member 28 and the tube body 27 serving as a chemical liquid passage 29. As a result, when the stem hole 18 is opened and the chemical solution W in the container body 11 passes, passage resistance is applied to suppress the flow rate of the chemical solution W, and a sufficient time is required until the fixed amount chamber 20 is filled with the chemical solution W. I try to take it. Thereby, even if the injection member 13 is operated in the middle until it is full, only the amount accumulated so far can be injected. Moreover, once it fills, it is not filled any more and only the capacity | capacitance of the fixed_quantity | quantitative_assay chamber 20 can be injected at maximum. Thereby, excessive supply of the chemical | medical solution W can be prevented.
[0023]
As such a restraining member, for example, a capillary tube having a complicated cross-sectional shape as shown in FIG. 2b can be used. Since this has a longer contour length than the cross-sectional area of the passage 29, the frictional resistance is large. The cross-sectional shape is not particularly limited to this, and a plurality of pores may be provided. The flow rate of the chemical liquid W can be adjusted by the cross-sectional area of the pores and the length of the suppressing member 28. The suppression member 28a formed of the capillary tube in FIG. 2b can be used as the flow rate adjusting member 24b as it is without using the tube body.
[0024]
Further, as shown in FIG. 2c, a restraining member 28b in which the coil 31 is tightly wound around the outer periphery of the core member 32 is formed, and the restraining member 28b is inserted into a tube body 27 having an inner diameter substantially the same as its outer diameter. It is also possible to use the flow rate adjusting member 24c. In the flow rate adjusting member 24b, the gap between the coil and the tube main body 27 becomes a passage 29 for the chemical solution W, and the flow rate can be adjusted to a desired flow rate by selecting the number of turns and the thickness of the coil.
[0025]
Further, in addition to the suppressing member 28, a resin sintered body (polyethylene, polypropylene, ethylene vinyl acetate, methyl methacrylate, polytetrafluoroethylene, polysulfone, etc., after being pressed and shaped in the mold) Alternatively, a synthetic resin porous body having a network structure formed by heating at a temperature lower than the melting point or at a temperature at which it partially dissolves may be used. These flow rate adjusting members 24, 24a, 24b are preferably provided with filters so that the passages 29 are not blocked by insoluble materials such as dust and dust. The filter is provided on the upstream side (lower side in the figure) such as the lower end of the tube body 27 such that the chemical liquid W that has passed through the filter is supplied to the flow rate suppressing member. In the quantitative supply device 10 of FIG. 1 a, a filter 37 is attached to the lower end of the dip tube 26.
[0026]
Returning to FIG. 1 a, when the valve 12 is not in operation (the stem 16 is not pushed down), the stem hole 18 is sealed by the stem rubber 19. Is not sprayed. At this time, the inside of the fixed quantity chamber 20 is filled with the chemical solution A because the inside of the housing 21 and the inside of the container body 11 communicate with each other from the dip tube 26 and the flow rate suppressing member 24 through the communication hole 30.
[0027]
When the injection member 13 mounted on the stem 16 is operated in the valve 12 to change from the non-actuated state (FIG. 1a) to the normal injection state (FIG. 1b), the stem hole 18 is opened and the inside and outside of the container communicate with each other. At the same time, a rod-like portion 35 below the stem 16 is disposed on the upper surface of the seal member 23 to block communication between the flow rate adjusting member 24 and the inside of the housing. Next, the piston 33 in the metering chamber 20 slides upward due to a pressure difference with the atmosphere, pushes out the chemical liquid A filled in the metering chamber 20, and is ejected from the ejection member 13.
[0028]
When the finger is released from the ejection member 13, the stem 16 is raised by the urging force of the spring 17, and the stem hole 18 is again blocked by the stem rubber 19. At this time, the rod-shaped portion 35 is separated from the seal member 23, and the inside of the container body 11 and the metering chamber 20 communicate with each other again through the communication hole 30. Thereby, as described above, the chemical liquid W is slowly supplied to the metering chamber 20 by the flow rate adjusting member 24. At this time, the piston 33 moves in the direction of increasing the volume of the metering chamber 20 by the urging of the spring 36 to assist the supply of the chemical solution W to the metering chamber 20.
[0029]
Moreover, in this fixed amount supply apparatus 10, when the stem 16 is pushed down, the rod-shaped part 35 arrange | positioned at the stem lower part has interrupted | blocked the communicating hole 21c. If it carries out like this, the chemical | medical solution A will be injected by the volume of the fixed_quantity | quantitative_assay chamber 20, and fixed_quantity | quantitative_assay is good. On the other hand, even if the rod-shaped portion 35 does not block the communication hole 21c, the chemical liquid W inside the container is difficult to pass through the communication hole 21c due to the resistance of the flow rate adjusting member 24 attached to the communication hole 21c. Therefore, the seal member 23 and the rod-shaped part 35 can be eliminated when the accuracy of quantitative determination is not required. In this case, the chemical liquid W flows out from the flow rate adjusting member 24 during the injection. If the flow rate adjusting member is not cut off at the time of injection in this way, the fixed quantity chamber 20 is no longer sufficiently equipped with a function for stabilizing the fixed quantity accuracy, and is simply referred to as a liquid reservoir.
[0030]
Further, the time (supply time) from the time when the liquid medicine A is injected until the metering chamber 20 is filled can be arbitrarily set according to the kind of the liquid medicine, the usage / dose of the liquid medicine, and the like. For example, in the case of a product that injects 3 ml once a day, the supply time of 3 ml is set to one day or more, and the upper limit of the amount used per day is set to 3 ml. In addition, in the case of products that are sprayed 1 ml 3 times a day, the supply time of 1 ml is 8 hours or more, the upper limit of the amount used per time is 1 ml, and the upper limit of the amount used per day is 3 ml And
[0031]
As the chemical solution W filled in such a container main body 11, for example, a stock solution in which an active ingredient is dissolved in a solvent is used. Anti-inflammatory analgesics such as methyl salicylate, camphor, diphenhydramine, indomethacin, piroxicam, felbinac, ketoprofen, crotamiton, epsilon-aminocaproic acid, allantoin, berberine chloride, berberine sulfate, sodium azulenesulfonate, dipotassium glycyrrhizinate Antiseptics such as zinc sulfate, zinc lactate, lysozyme chloride, antipruritic agents such as crotamiton, l-menthol, d-camphor, urea, bactericidal disinfectants such as benzalkonium chloride, benzethonium chloride, alkylpolyaminoethylglycine, boric acid , Allantoin, glycyrrhetinic acid, dipotassium glycyrrhizinate, azulene, ufenamate and other anti-inflammatory agents, diphenhydramine hydrochloride, diphenhydramine, chlorf maleate Antihistamines such as niramine, local anesthetics such as dibucaine hydrochloride, tetracaine hydrochloride, lidocaine hydrochloride, antibacterial agents such as sulfamethoxazole, sodium sulfamethoxazole, sulfisoxazole, sulfisomidine sodium, epinephrine , Epinephrine hydrochloride, Ephedrine hydrochloride, Tetrahydrozoline hydrochloride, Naphazoline hydrochloride, Naphazoline nitrate, Phenylephrine hydrochloride, dl-Methylephedrine hydrochloride and other ocular muscle regulatory components such as methyl sulfate neostigmine, flavin adenine dinucleotide sodium, cyanocobalamin, acetic acid Vitamins such as retinol, retinol palmitate, panthenol, calcium pantothenate, sodium pantothenate, tocopherol acetate, potassium L-aspartate Amino acids such as L-magnesium aspartate, L-magnesium and potassium (equal mixture), aminoethylsulfonic acid, chondroitin sulfate sodium, assembly extract, chili pepper tincture, placenta extract, pantothenic acid, salicylic acid, capronium chloride, etc. Examples include hair restorers, asthma drugs such as peclomethasone dipropionate and salbutamol.
[0032]
Examples of the solvent include water (purified water, physiological saline and the like), alcohol (lower alcohol such as ethanol and isopropanol), and a mixture of water and alcohol.
[0033]
In addition to the above active ingredients, solubilizers, buffers, isotonic agents, preservatives (preservatives), stabilizers, pH adjusters, antioxidants, cooling agents, inorganic salts, thickeners, wearing Adjuvants such as fragrances can be blended.
[0034]
Examples of the solubilizer include glycerin fatty acid esters, polyglycerin fatty acid esters such as (di, tri, tetra, hexa, deca), polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin. Fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene castor oil / hardened castor oil, polyoxyethylene fatty acid amides, fatty acid alkylolamides, alkyl polyglucosides, etc. Examples thereof include ionic surfactants.
Examples of the buffer include a phosphate buffer, a borate buffer, a carbonate buffer, a citrate buffer, and a tartaric acid buffer.
[0035]
Examples of the isotonic agent include sugars such as sorbitol, glucose and mannitol, polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycol, and inorganic salts.
[0036]
Examples of the preservative (preservative) include benzalkonium chloride, benzethonium chloride, paraoxybenzoate (methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, etc.), phenoxyethanol, benzyl alcohol Phenethyl alcohol, chlorhexidine and the like.
[0037]
Examples of the stabilizer include sodium edetate and ethylenediaminetetraacetate.
[0038]
Examples of the pH adjusting agent include sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, acetic acid, citric acid, hydrochloric acid, phosphoric acid, borax and the like.
[0039]
Examples of the refreshing agent include l-menthol, d-camphor, geraniol, eucalyptus oil, peppermint oil, rose oil, peppermint oil and the like.
[0040]
Examples of the inorganic salts include sodium chloride, potassium chloride, calcium chloride, sodium carbonate, sodium hydrogen carbonate, dry sodium carbonate, magnesium sulfate, sodium hydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate. .
[0041]
Examples of the thickener include polyvinyl alcohol, polyvinyl pyrrolidone, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, glucose, methyl cellulose and the like.
[0042]
The said chemical | medical solution (stock solution) is prepared by dissolving the said active ingredient and adjuvant in a solvent. Further, as the propellant for pressurizing the chemical solution, a compressed gas such as nitrogen gas, carbon dioxide gas or compressed air, a liquefied gas such as liquefied petroleum gas, chlorofluorocarbons such as dimethyl ether or tetrafluoroethane, or a mixture thereof may be used. Can do.
[0043]
The timed chemical liquid metering device of the present invention can be manufactured by filling the container body with the chemical liquid, fixing the valve, and filling the propellant. The resulting device can be used for anti-inflammatory analgesics, antipruritics, eyewashes, eye drops, nasal rinses, nasal drops, athlete's foot drugs, wounds, hair restorers, asthma drugs, etc., quasi drugs, medical devices, etc. Can be used. Moreover, you may use for cosmetics, such as a lotion.
[0044]
FIG. 3 shows another embodiment of the quantitative supply device. This fixed amount supply device 40 is substantially the same as the above-described fixed amount supply device 10 except that a diaphragm type liquid reservoir chamber is adopted instead of the piston / cylinder type fixed amount chamber and the seal member 23 is omitted. Are denoted by the same reference numerals and description thereof is omitted. This quantitative supply device 40 is characterized by a liquid storage chamber 41. The liquid reservoir chamber 41 has a shallow cup-shaped flange 42 integrally provided at the lower portion of the housing of the valve 12, an inner cylinder 21a extending downward from the lower portion of the housing, and a bottomed cylindrical shape attached so as to surround the inner cylinder 21a. It consists of a diaphragm 43. The upper end of the outer peripheral wall 43a of the diaphragm 43 is fitted and fixed to the inner surface of the outer wall 42a of the flange 42 in an airtight manner, an opening is formed in the center of the bottom wall 43b, and the inner peripheral edge of the opening is airtight to the outer periphery of the inner cylinder 21a. The fitting is fixed. The connecting corner between the outer peripheral wall 43a and the bottom wall 43b is curved so as to be easily deformed.
[0045]
The diaphragm 43 is formed of a material having elasticity such as rubber. When the external pressure (pressure in the container body) becomes larger than the pressure in the liquid reservoir chamber due to the elasticity, the diaphragm 43 is deformed inwardly. When the pressure is equalized, it returns to its original natural state. Therefore, it is urged toward the outside in which the internal volume increases. Therefore, an elastic tank or bag made of silicone rubber or synthetic rubber can be used for the liquid storage chamber 41.
[0046]
When actually using such a fixed amount supply apparatus 40, first, when the stem 16 is pushed down, the stem hole 18 is opened, and the liquid storage chamber 41 and the outside of the container communicate with each other. Thereby, due to the pressure difference between the inside and outside of the diaphragm 43, the elastic diaphragm 43 is deformed inward (two-dot chain line in the figure). As a result, the volume of the liquid reservoir 41 is reduced, and the chemical liquid A filled therein is pushed out and injected from the injection hole of the injection member through the passage in the stem, as in the case of FIG. 1b. When the valve 12 is closed, communication between the liquid reservoir 41 and the outside of the container is blocked. In this state, since the inside of the liquid reservoir 41 is still at atmospheric pressure, the chemical liquid W flowing in from the flow rate adjusting unit flows in, and returns to the original state again over a predetermined time. At that time, the urging force that elastically restores the diaphragm 43 acts, so that the inflow of the chemical solution W is assisted.
[0047]
The fixed-quantity supply apparatus 44 shown in FIG. 4 has shown the Example at the time of using a double container. This is substantially the same as the quantitative supply device 10 of FIG. 1a except that a flexible inner container 45 is accommodated inside the container body 11. Therefore, the same parts are denoted by the same reference numerals and description thereof is omitted. The inner container 45 is conventionally known and can be formed from a synthetic resin, a laminate material of a metal foil and a synthetic resin, a metal thin plate, or the like. When the mounting cap 14 of the valve 12 is crimped to the container main body 11, the peripheral edge of the upper end opening of the inner container 45 is sandwiched and fixed therebetween. The inside of the inner container 45 is filled with the aforementioned chemical liquid W, and a pressurized agent (propellant V) such as compressed gas is filled between the container body 11 and the inner container, so that the chemical liquid can be held in a pressurized state.
[0048]
Also in the case of this quantitative supply device 44, the piston 33 of the quantitative chamber 20 can slide due to the pressure difference between the inside and outside of the container even if the stem 16 is pushed down to inject the chemical liquid A. In this case as well, the fixed-quantity chamber 20 can be used as the liquid storage chamber 41.
[0049]
FIG. 5 shows another embodiment of the quantitative supply device. The fixed amount supply device 46 shown in FIG. 5 has a storage chamber 47 between the fixed amount chamber 20 and the flow rate adjusting member 24. In this embodiment, it has a cylindrical shape, and its upper end is thinned so as to be fixed in the dip tube mounting portion 25 of the metering chamber 20. The lower end is narrowed to secure to the somewhat hard tube 48 to hold the flow rate adjustment member 24. The storage chamber 47 is made of a flexible material such as silicone rubber, synthetic rubber, or synthetic resin.
[0050]
When the stem 16 of the metering supply device 44 is pushed down, the storage chamber 47 and the metering chamber 20 are blocked by the rod-shaped portion 35 and the chemical solution A inside the metering chamber 20 is injected. Next, when the stem 16 is stopped from being pushed down, the blocking by the rod-like portion 35 is released. Then, the piston 33 arranged inside the fixed quantity chamber 20 is pushed back by the spring 36, the chemical solution A inside the storage chamber 47 flows in, and it becomes possible to inject again. When this operation is repeated several times and the chemical solution A in the storage chamber 47 is exhausted, the chemical solution W is supplied again through the flow rate adjusting member 24 over a predetermined time.
[0051]
As the storage chamber, in addition to the above-described one, the metering chamber 20 of FIG. 1 in which a piston is disposed can be used as the storage chamber. An embodiment in this case is shown in FIG.
[0052]
A fixed quantity supply device 50 shown in FIG. 6 uses a conventionally known quantitative injection valve 51 as a valve provided on the upper part of the container body 11 (see Patent Document 2). That is, an elastically deformable tank 53 is provided on the outer periphery of the inner housing 52, and an outer housing 54 for restricting the maximum enormous shape of the tank 53 is provided on the outer side thereof. The internal housing 52 regulates the minimum contraction shape of the tank 53, and the gap between the internal housing 52 and the tank 53 constitutes a substantial quantitative chamber. The inner housing 52 and the outer housing 54 are formed with holes 52a and 54a communicating with the inside and the outside, respectively.
[0053]
A seal portion 55 having the same action as that of the seal member 23 described above is provided at the lower portion of the fixed quantity injection valve 51, and the upstream portion is shut off from the seal portion 55 when the rod-like portion 35 moves downward. To do. The seal portion 55 can be formed integrally with the lower end of the tank 53. A storage chamber 47 a having the same configuration as that of the metering chamber 20 of FIG. 1 is provided at the lower end of the metering injection valve 51. The operation of the quantitative supply device 50 is substantially the same as that of the quantitative supply device 46 of FIG. However, the accuracy of the volume change of the storage chamber 47a is higher than that in the case of FIG.
[0054]
When such a fixed amount supply device is used in several places such as the nasal cavity or when it is used in different parts such as hands and legs, and when it is assumed to be sprayed a plurality of times, a predetermined amount of liquid medicine A Can be cut and used by a certain amount (capacity of the quantitative chamber 20). In other words, when the injection member 13 is pushed down in a state where the fixed amount chamber 20 and the storage chamber 47a are filled with the chemical solution A (first step S1), the chemical solution A in the fixed amount chamber 20 is injected (second step S2). Next, when the finger is released from the ejection member, the chemical solution A is immediately supplied from the storage chamber 47a to the metering chamber 20 (third step S3). Therefore, even if the injection member 13 is pushed down immediately, the second injection can be performed. And if the chemical | medical solution A of the storage chamber 47a runs out, it cannot be made to inject until the chemical | medical solution is filled in the fixed_quantity | quantitative_assay chamber 20 and the storage chamber 47a next (4th process S4).
[0055]
It is preferable to set the volume of the storage chamber 47a to be an integral multiple of the volume of the liquid storage chamber (quantitative chamber), that is, the volume of the number of times of use, because no chemical solution remains in the storage chamber 47a. In addition, in the case of the fixed quantity supply apparatus provided with such a storage chamber, there is a possibility that a single injection is mistakenly performed a plurality of times. Therefore, in the case of a chemical solution in which the amount to be dispensed per time is strictly limited, it is preferable to employ a fixed amount supply device that does not have a storage chamber as shown in FIG. In the case of the quantitative supply device 50 of FIG. 6, a liquid storage chamber having a large capacity can be provided below the quantitative chamber 51. Further, when the communication hole 21c is closed at the lower end of the rod-like portion 35 of the stem 16, it can be seen that a storage chamber 47a provided with a second fixed amount chamber is provided at the lower portion of the fixed amount chamber.
[0056]
When the propellant V is a liquefied gas, the fixed volume chamber 20, the liquid reservoir chamber 41, and the storage chamber 47 described so far do not use the piston 33 or an elastic material so that the internal volume thereof is variable. In both cases, when the liquefied gas is vaporized, an internal pressure is generated in the metering chamber, the liquid reservoir, and the storage chamber, and can be injected outside the container. That is, it is possible to use a fixed amount chamber, a liquid storage chamber, or a storage chamber whose volume does not change before and after injection. In this case, the valve housing 57 whose volume does not change can be used as it is as the metering chamber, for example, like the metering device 56 shown in FIGS. 7a and 7b. That is, the fixed amount supply device 56 can be configured by providing an annular seal portion 55 that can be sealed by the rod-like portion 35 below the stem 16 at the lower portion of the housing 57 and providing the flow rate adjusting member 24 at the lower portion. it can.
[0057]
7a and 7b is used for a so-called outer clinching type aerosol product, and the mounting cap 14 is made of a thin metal plate and has a bottomed cylindrical shape opening downward. The valve housing 57 is fitted into the upper end opening of the container body, and the mounting cap 14 is put on the outer periphery of the mouth of the container body. Then, the outer periphery near the lower end of the mounting cap 14 is clinched and fixed to an engagement groove or the like of the container mouth.
[Brief description of the drawings]
FIG. 1a and FIG. 1b are side cross-sectional views showing an embodiment of a quantitative supply device of the present invention.
2a, 2b, and 2c are a perspective view, a cross-sectional view, and a side view, respectively, showing a flow rate adjusting member.
FIG. 3 is a side cross-sectional view showing another embodiment of the quantitative supply device of the present invention.
FIG. 4 is a cross-sectional view showing a side cross-sectional view showing still another embodiment of the quantitative supply device of the present invention.
FIG. 5 is a side cross-sectional view showing still another embodiment of the quantitative supply device of the present invention.
FIG. 6 is a cross-sectional side view showing a usage state of still another embodiment of the quantitative supply device of the present invention.
7a and 7b are cross-sectional side views showing still another embodiment of the metering supply device of the present invention together with a use state.
[Explanation of symbols]
A chemical solution (reservoir chamber, quantitative chamber, storage chamber)
V propellant
W chemical
1 trunk
2 shoulder
3 neck
4 beads
10 Metering device
11 Container body
12 Valve
13 Injection member
14 Mounting cap
15 Housing
15a Step
16 stem
16a Step
17 Spring
18 Stem hole
18a Stem hole passage
19 Stem rubber
20 Determination chamber
21 Housing
21a Inner cylinder
21b outer cylinder
21c Communication hole
21d partition wall
21e ring
23 Seal member
24 Flow rate adjusting member
24a gasket
24b Flow rate adjusting member
24c Flow rate adjusting member
25 Dip tube mounting part
26 Dip tube
27 Tube body
28 Suppression member
28a Suppression member
28b Suppression member
29 Passage
30 communication hole
31 coils
32 Core
33 piston
34 opening
35 Bar
36 Spring
37 Filter
40 Fixed amount supply device
41 Reservoir chamber
42 Flange
43 Diaphragm
43a outer wall
43b Bottom wall
44 Metering device
45 Inner container
46 Metering device
47, 47a Reservoir
48 tubes
50 Metering device
51 Valve for metering injection
52 Internal housing
52a hole
53 tanks
54 External housing
54a hole
55 Sealing part
56 Metering device
57 housing

Claims (11)

A container for holding a chemical under pressure,
A valve attached to the opening of the container for communicating / blocking the inside and outside of the container;
A metering chamber is provided below the valve in communication with the valve, and temporarily stores a predetermined amount of chemical before spraying ,
The valve is provided with a mounting cup that is fixed to the upper opening of the container, a cylindrical housing that is held in the center of the mounting cup, and an axial direction of the housing that can slide up and down within the housing. And a stem rubber that is provided so as to sandwich the mounting cup at the top of the housing and closes the stem hole of the stem,
The fixed-quantity chamber has a double cylindrical shape sharing the shaft with the housing, and includes an inner cylinder that communicates the inside of the container and the valve, and a biasing means that biases in a direction in which the volume is variable and the volume is increased. The outer cylinder,
The inner cylinder includes a communication hole communicating with an outer cylinder formed in an upper portion, an annular seal member provided below the communication hole, and a tube-like flow rate adjusting member provided below the seal member; And a filter provided below the flow rate adjusting member,
By lowering the stem, the lower end of the stem comes into contact with the seal member, closes the central hole of the seal member, and closes the inside of the container and the valve.
Timed chemical solution metering device. The timed chemical liquid metering device according to claim 1, wherein the flow rate adjusting member is airtightly attached by a gasket. A dip tube is attached to the lower end of the inner cylinder,
The timed type liquid medicine fixed quantity supply device according to claim 1, wherein a filter is provided at a lower end of the dip tube . An annular piston is accommodated in the gap between the inner cylinder and the outer cylinder so as to be slidable in the axial direction,
The timed liquid medicine fixed quantity supply device according to claim 1, wherein a spring for urging the piston downward is provided on the upper surface of the piston and the fixed quantity chamber. The timed liquid medicine fixed quantity supply device according to claim 1, wherein the outer cylinder is a bottomed cylindrical diaphragm attached so as to surround the inner cylinder. A container for holding a chemical under pressure,
A mounting cup fixed to the upper opening of the container, a cylindrical housing held in the center of the mounting cup, and a stem provided to be slidable in the axial direction of the housing within the housing; A valve having a spring that constantly biases the stem upward, and a stem rubber that is provided at the top of the housing so as to sandwich the mounting cup and closes the stem hole of the stem;
The lower end of the valve communicates with the inside of the container and the valve, and consists of a cylindrical part that shares the shaft with the housing.
An annular seal member is provided at the lower end of the housing,
A tubular flow rate adjusting member is provided below the seal member,
A filter is provided below the flow rate adjusting member,
By lowering the stem, the lower end of the stem comes into contact with the seal member, closes the central hole of the seal member, and closes the inside of the container and the valve.
Timed chemical solution metering device. A dip tube is attached to the lower end of the cylindrical portion,
The timed type liquid medicine fixed quantity supply device according to claim 6, wherein a filter is provided at a lower end of the dip tube. A container for holding a chemical under pressure,
A valve for communicating / blocking the inside and outside of the container;
A liquid reservoir chamber that temporarily stores a predetermined amount of a chemical before spraying on a passage that communicates the valve and the inside of the container;
A flow rate adjustment unit that suppresses the flow rate of the chemical solution supplied to the liquid storage chamber;
Between the liquid reservoir chamber and the flow rate adjustment unit, there is interposed a seal portion that shuts off the communication between the liquid reservoir chamber and the flow rate adjustment unit when the valve is operated and kneaded inside and outside the container,
As a result, the liquid storage chamber constitutes the quantitative chamber,
A timed chemical liquid quantitative supply device in which a storage chamber having a larger volume than the liquid storage chamber is interposed between the liquid storage chamber and the flow rate adjusting unit. The timed chemical liquid quantification device according to claim 8, wherein a volume ratio of the storage chamber to the liquid storage chamber is an integer value. The timed chemical liquid metering supply according to claim 8, further comprising biasing means for biasing the liquid storage chamber and / or the storage chamber in a direction in which the volume is variable and the volume of the liquid storage chamber and / or the storage chamber increases. apparatus. The liquid storage chamber and / or the storage chamber has a piston slidably provided therein, and the piston partitions the interior of the container from the liquid storage chamber, and the piston is connected to the liquid storage chamber. The timed chemical liquid metering device according to claim 8, further comprising a spring that biases in a direction to increase the volume of the timed chemical liquid.

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