JP4177868B2 - Food / beverage product additive or food / beverage product auxiliary agent for adsorbing phosphate ions in food / beverage products and method for producing the same - Google Patents

Description

The present invention relates to a food / beverage product additive or a food / beverage product auxiliary agent capable of adsorbing phosphate ions that cause excessive intake as a problem with high efficiency. More specifically, the present invention relates to a food and beverage additive or a food and beverage aid for preventing various diseases caused by phosphorus, which can solve the problem of excessive intake of phosphorus from food and beverage.

  Phosphorus is an essential substance for living bodies. Here, humans break down and absorb food into phosphate ions in the digestive tract (especially the small intestine). Incidentally, the daily average phosphorus intake of a Japanese adult is about 1000 mg. For normal people, about 80 percent of this is absorbed, and about 80 percent of the absorbed phosphorus is said to be excreted from the kidneys. However, when renal function is impaired (renal failure), the amount of phosphorus excreted decreases, resulting in an increase in serum phosphorus concentration (hyperphosphatemia). Here, the serum phosphorus concentration of a healthy person is maintained at 0.25 to 4.5 mg / dl, and 4.5 mg / dl or more is defined as hyperphosphatemia.

  This hyperphosphatemia causes abnormal calcium metabolism and increased parathyroid function, changes in the bones of the whole body (renal osteodystrophy), calcium deposition in various organs, especially the heart valve・ Causes deposition in the aorta and lungs (ectopic calcification). These not only impair the quality of life (QOL) of patients with renal failure, but also cause fatal complications such as myocardial infarction and worsen the prognosis. Furthermore, hyperphosphatemia itself is said to be a factor that promotes kidney damage. Thus, how to maintain the normal blood concentration of phosphorus in patients with renal failure is an important issue.

  Here, as described above, in renal failure, the absolute amount of phosphorus that can be excreted by the kidney decreases. Thus, in renal failure, phosphorus is accumulated in the body when the amount of phosphorus absorbed from the gastrointestinal tract exceeds the capacity of the kidney. Thus, until now, renal failure has been treated such that the total amount of phosphorus absorbed from the digestive tract does not exceed the capacity of the kidney. Specifically, in addition to dietary diets with a phosphorus-restricted diet, a phosphorus adsorbent (adsorbs phosphate ions generated from food in the digestive tract, especially in the small intestine, and excretes it as it is to reduce the amount of phosphorus absorbed. (For example, Patent Documents 1 to 4).

  However, the phosphorus adsorbents that have been actually used and have been studied for clinical application have the following problems.

  First of all, aluminum preparation (aluminum hydroxide gel) has a strong adsorption power of phosphate ions in the digestive tract and lowers serum phosphorus concentration. However, once aluminum is absorbed from the digestive tract, it is not excreted from the body. Aluminum poisoning became a problem (aluminum encephalopathy, aluminum osteopathy, anemia). Therefore, in Japan, the administration of aluminum preparations to dialysis patients has been contraindicated since June 1992.

  Next, calcium preparations (calcium carbonate, calcium acetate, etc.) are still widely used in Japan in place of aluminum preparations. However, in order to improve hyperphosphatemia, it is necessary to take a large amount and taste. There is a problem that it is bad and difficult to drink, and conversely, calcium is absorbed from the gastrointestinal tract and causes hypercalcemia, resulting in further deterioration such as ectopic calcification.

In addition, new substances have recently emerged as phosphorus adsorbents and their use is currently under consideration. One of them is a hydrochloride salt of a polymer of prop-2-en-1-amine and 1-chloro-2,3-epoxypropane, which is a phosphorus-binding polymer developed in the United States {Sevelamer ™ hydrochloride} It has already been approved and used in Japan in January 2003. However, this drug often requires a large dose to improve hyperphosphatemia, and there are a number of problems with gastrointestinal complications such as constipation that must be resolved. . The use of another lanthanum carbonate is being studied in the United States and Europe, but the effects of lanthanum on the living body have not been fully elucidated and may have the same problems as aluminum preparations. Therefore, there is a question whether it will be put to practical use.
JP-A-2-77266 Japanese Patent Laid-Open No. 3-182259 Japanese Patent Laid-Open No. 7-2903 WO01 / 66607

When a large amount of phosphorus-containing food or drink is ingested, a large amount of phosphate ions appears in the digestive tract. And when a large amount of phosphoric acid produced in the gastrointestinal tract is absorbed in a large amount from the mucosa of the gastrointestinal tract and exceeds the excretion capacity of the kidney, phosphorus may accumulate in the body, resulting in the above-mentioned phosphorus disorder . Therefore, the present invention is a phosphate ion effective for preventing various diseases in which the phosphate ion is directly or indirectly involved by adsorbing phosphate ion generated by digestion and decomposition of food and drink. It aims at providing the food-drinks additive or the food-drinks auxiliary agent which was excellent in the biological safety which uses the iron compound with high adsorbability as an active ingredient.

In the present invention (1), ferric hydroxide is added with an oxidizing agent in a ferrous aqueous solution in an amount less than the equivalent amount of ferrous iron, and then an alkali is added to adjust the pH at the end of the reaction to 1.5 to 5. A food or beverage additive or food or beverage containing ferric hydroxide produced by adjusting to 5 (preferably 1.5 to 4.0, more preferably 2.0 to 3.5) It is an adjuvant .

In the present invention (2), ferric hydroxide is added to an aqueous ferrous solution so that an oxidizing agent is added to a redox potential of +400 to 770 mV (preferably +500 to 730 mV, more preferably +600 to 700 mV). Then, alkali is added to adjust the pH at the end of the reaction to 1.5 to 5.5 (preferably 1.5 to 4.0, more preferably 2.0 to 3.5). It is the food-drinks additive or food-drinks adjuvant containing ferric hydroxide made.

According to the present invention (3), ferric hydroxide is added to an aqueous ferrous iron solution with an oxidizing agent in an amount less than the equivalent of ferrous iron, and the redox potential is +400 to 770 mV (preferably +500 to 730 mV, more preferably Is adjusted to +600 to 700 mV), and an alkali is added so that the pH at the end of the reaction is 1.5 to 5.5 (preferably 1.5 to 4.0, more preferably 2.0 to 3.5). It is the food-drinks additive or the food-drinks auxiliary agent containing the ferric hydroxide produced | generated by adjusting so that it may become.

This invention (4) is the food / beverage product additive or food / beverage product auxiliary agent of any one of the said invention (1)-(3) whose said oxidizing agent is a hypochlorite.

This invention (5) is the food-drinks additive or food-drinks adjuvant of any one of said invention (1)-(4) whose said ferric hydroxide is amorphous.

This invention (6) is the food-drinks additive or the food-drinks adjuvant of any one of said invention (1)-(5) which further contains glycerol.

In the present invention ( 7 ), an oxidizing agent is added to a ferrous aqueous solution in an amount less than the equivalent of ferrous iron, and then an alkali is added to adjust the pH to 1.5 to 5.5 (preferably 1.5 to 4.0, It is a manufacturing method of the food-drinks additive or the food-drinks adjuvant containing ferric hydroxide characterized by including the process adjusted so that it may become 2.0-3.5) more suitably.

In the present invention ( 8 ), an oxidizing agent is added to a ferrous aqueous solution so that the redox potential is +400 to 770 mV (preferably +500 to 730 mV, more preferably +600 to 700 mV), and then an alkali is added to adjust the pH to 1. The ferric hydroxide is characterized by including a step of adjusting to become 5.5 to 5.5 (preferably 1.5 to 4.0, more preferably 2.0 to 3.5). It is a manufacturing method of the food-drinks additive or the food-drinks auxiliary agent to contain .

In the present invention ( 9 ), an oxidizing agent is added to a ferrous aqueous solution in an amount less than the equivalent of ferrous iron, and the redox potential is +400 to 770 mV (preferably +500 to 730 mV, more preferably +600 to 700 mV). And then adding an alkali to adjust the pH to 1.5 to 5.5 (preferably 1.5 to 4.0, more preferably 2.0 to 3.5). It is a manufacturing method of the food-drinks additive or the food-drinks auxiliary agent containing ferric hydroxide .

The present invention ( 10 ) is the process according to any one of the inventions ( 7 ) to ( 9 ), wherein the oxidizing agent is hypochlorite.

The present invention ( 11 ) is the production method according to any one of the inventions ( 7 ) to ( 10 ), wherein the ferric hydroxide is amorphous.

This invention ( 12 ) is any one manufacturing method of said invention ( 7 )-( 11 ) which further includes the process of adding glycerol.

The present invention ( 13 ) is the production method according to any one of the inventions ( 7 ) to ( 12 ), further comprising a step of dehydration, freeze drying or spray drying.

This invention ( 14 ) is a manufacturing method of the said invention ( 13 ) which implements the addition process of glycerol after the said pH adjustment process, before the process of spin-drying | dehydration, freeze-drying, or spray-drying at the time of the said process. is there.

  Here, each term in this specification is explained. “Ferrous species” refers to substances in which iron is present in a divalent state, such as ferrous ions and ferrous compounds (eg, ferrous hydroxide). The “ferrous iron aqueous solution” is not particularly limited as long as it is an aqueous solution containing ferrous ions, and may contain other substances. The “oxidant” is not particularly limited, and examples thereof include hypochlorite, hydrogen peroxide, and calcium hydroperoxide, and hypochlorite is preferable. “Phosphorus disorder” refers to the fact that excessive accumulation of phosphorus in the body caused by chronic renal failure in many cases causes damage to various organs. The main diseases or symptoms include, for example, bone Examples include disorders, calcium deposition in organs such as the heart, arteries and lungs, anemia, and secondary hyperparathyroidism. The “prevention improving drug” refers to a drug used for at least one of prevention, improvement and treatment. The “oral preparation” is not particularly limited as long as it is orally administered. For example, when it is added to a food or drink (food additive), when it is taken separately from a food or drink (such as a supplement) All of food and beverage aids are included.

  The best mode of the present invention will be described below. First, the phosphorus adsorbent will be described, and then each application will be described in detail.

The present phosphorus adsorbent includes amorphous ferric hydroxide produced under conditions where ferrous species (eg, ferrous hydroxide) are present. Here, the active ingredient exhibiting high phosphorus adsorption capacity is amorphous ferric hydroxide, but if ferric hydroxide is used, the effect is not achieved. For example, ferric hydroxide produced by adding caustic soda to a ferric solution or commercially available ferric hydroxide does not show such a high phosphorus adsorption capacity (see Examples). This ferric hydroxide is based on the Eh (redox potential) -pH diagram in the Fe ²⁺ -Fe (OH) ₃ system, and it remains in ferrous iron when iron ions exist as stable chemical species. Is produced under extremely unstable conditions such as existing as ferric iron while being under Eh-pH conditions. And is in an unstable and extremely high amorphous state. Therefore, the -Fe-O-Fe-O-Fe- bond is unstable and easy to break, and this ferric hydroxide breaks the bond while newly forming Fe-OH group and phosphate ion. It is presumed that a very high adsorptive power is exhibited.

  Here, the chemical structure of ferric hydroxide is not clear, but based on experimental results and the like, it is presumed that it is the following structure (however, the ferric hydroxide of the present invention is in the estimated form) It is not limited at all). In other words, the ferric hydroxide essentially contains ferric iron, and the oxygen atom or hydroxyl group is six-coordinated to the iron atom, and the six-coordinate iron is linked through the oxygen atom. It is estimated that Then, it is presumed that a certain type of water molecule present around the iron atom destabilizes the bond as a result of affecting the bond between the iron atom and the oxygen atom. And it is thought that an iron atom couple | bonds with an anion (phosphate ion) as a result of the exchange of the hydroxyl group or the destabilized oxygen atom coordinated to the iron atom, and an anion (for example, phosphate ion). Under the assumption, a preferred form is that in which -Fe-O-Fe-O-Fe- (cluster) has an appropriate size due to the presence of an appropriate hydroxyl group.

Here, in one production process of the present phosphorus adsorbent, as described below, ferrous hydroxide is changed to ferric hydroxide by reacting ferrous iron with an oxidizing agent (for example, sodium hypochlorite). ing. Here, the oxidation-reduction reaction formula is shown below. In the following formula, for easy understanding, ferric hydroxide is simplified and described as “Fe (OH) ₃ ”.

Formula 1

  Thus, 1 mol of hypochlorous acid reacts with 2 mol of ferrous iron (that is, 1 mol of hypochlorous acid is equivalent to 2 mol of ferrous iron). And, as explained below, in the production process, the amount of the oxidizing agent used is less than the equivalent of ferrous iron (for example, less than 1 mole of hypochlorous acid in the case of 2 moles of ferrous iron). By doing so, the state where ferrous iron is not completely oxidized to ferric iron is constructed.

  Here, “amorphous” or “extremely amorphous” means at least 1 in the range of 5 ° to 80 ° in terms of 2θ value in powder X-ray diffraction using Cu Kα ray as an X-ray source. It has two amorphous halo shapes, meaning that there are no obvious crystalline peaks. Note that a slight crystalline peak may be observed in the amorphous halo figure depending on the starting material at the time of production. In such a case, in powder X-ray diffraction using Cu Kα ray as an X-ray source. The crystallinity peak intensity observed in the range of 5 ° to 80 ° as a 2θ value may be 5% or less in terms of the ratio of the corresponding crystalline reference material to the crystallinity peak (% X-ray diffraction intensity / reference material). . As specific% X-ray diffraction intensity / reference substance, those given by the following formula based on ASTM (American Society for Testing and Materials) D3906 can be used. The number of crystalline peaks used for calculating the integrated reflection intensity is not particularly limited, but a range of 1 to 8 is preferable.

Formula 2

  Thus, although the active ingredient is ferric hydroxide, it is generated under the condition that ferrous species (for example, ferrous hydroxide) exist as described above. Containing. The content of the ferrous species (for example, ferrous hydroxide) is not particularly limited, but is usually 5% by weight or less with respect to the dry weight (furnace dry, 105 ° C., 2 hours), and preferably 0. It is 01 to 4 weight%, More preferably, it is 0.1 to 2 weight%. In addition, at the time of manufacture, ferrous species are inevitably contained as described above, but the components may be removed by washing.

  Further, the present phosphorus adsorbent may contain crystalline ferric hydroxide as long as amorphous ferric hydroxide as an active ingredient is present. In this case, the amorphous component is preferably 30% or more, more preferably 50% or more, and further preferably 75% or more.

  It is preferable that the present phosphorus adsorbent further contains glycerin. Ferric hydroxide can be dried or aging (long-term storage), depending on whether -Fe-O-Fe-O-Fe- OH groups bound to iron are dehydrated and clusters are enlarged. It may change to a stable state and the adsorption power may be reduced. Therefore, for example, by mixing glycerin with ferric hydroxide in a wet state, dehydration of OH groups is unlikely to occur even when dried, so that a reduction in adsorption power can be remarkably suppressed. Here, the content of glycerin is preferably 20% by weight or less based on the dry weight (furnace dry, 105 ° C., 2 h).

  Next, the manufacturing method of the phosphorus adsorbent according to the best mode will be described. In the present phosphorus adsorbent (Step 1A), an oxidizing agent (for example, a hypochlorite aqueous solution) is added to an aqueous ferrous solution less than the equivalent of ferrous iron (preferably 0.3 to 0.95, more preferably 0). .4 to 0.8) or (step 1B) an oxidizing agent (for example, a hypochlorite aqueous solution) is added to the ferrous aqueous solution with a redox potential of +400 to 770 mV (preferably +500 to (Step 2) After adding alkali (preferably caustic alkali), pH 1.5 to 5.5 (preferably 1.5 to 4.0) is added. , More preferably 2.0 to 3.5). Here, the order of (Step 1A) or (Step 1B) and (Step 2) is important. If the order is reversed, a phosphorus adsorbent having a high adsorption capacity cannot be obtained. Hereinafter, each condition will be described.

  First, the ferrous salt that can be used in the ferrous aqueous solution is not particularly limited as long as it is a water-soluble salt, and examples thereof include ferrous sulfate, ferrous chloride, and ferrous nitrate. Ferrous sulfate is preferred because of the simple filtration of the precipitate. Further, the ferrous ion concentration in the ferrous aqueous solution is preferably 0.05 to 2M.

  Next, the usable oxidizing agent is not particularly limited, but is preferably hypochlorite. Here, examples of hypochlorite include sodium hypochlorite and calcium hypochlorite, and sodium hypochlorite is particularly preferable. In addition, although the hypochlorite density | concentration in hypochlorite aqueous solution is not specifically limited, The thing of 5-10% marketed can be used.

  Here, in the case of adopting Step 1A, the amount of the oxidizing agent to be used is an amount that is less than the equivalent of ferrous iron in the ferrous aqueous solution. Here, the amount of the oxidizing agent is preferably 0.3 to 0.95 in terms of equivalent ratio with respect to the amount of ferrous iron, and more preferably 0.4 to 0.8.

  In the case of adopting Step 1B, an oxidizing agent (for example, hypochlorite aqueous solution) is added to the ferrous aqueous solution, and the oxidation-reduction potential is +400 to 770 mV (preferably +500 to 730 mV, more preferably +600 to 700 mV). At this time, it is preferable to drop an oxidizing agent solution (for example, a hypochlorite aqueous solution) while stirring.

  In addition, the process 1A and the process 1B are not necessarily mutually independent processes, and when the process 1A is performed, the case where the process 1B is performed as a result and vice versa are included.

  Next, after adding a predetermined amount of oxidizing agent in Step 1A or after confirming that the oxidation-reduction potential is within the above range in Step 1B, Step 2 of adding alkali is performed. Here, the alkali is not particularly limited, but is preferably a caustic alkali. Examples of the caustic alkali include caustic soda and caustic potassium, and caustic soda is preferable. In addition, the alkali concentration (preferably caustic concentration) is, for example, 0.5 to 5N. Then, an alkaline aqueous solution (preferably a caustic aqueous solution) is added to a solution to which a predetermined amount of an oxidizing agent has been added (step 1A) or a solution in which the oxidation-reduction potential is within the above range (step 1B), and pH 1 It adjusts so that it may become 0.5-5.5 (preferably 1.5-4.0, more preferably 2.0-3.5). By performing this operation, amorphous ferric hydroxide precipitates, and the present phosphorus adsorbent can be obtained.

  The phosphorus adsorbent is preferably in a dry form for handling. Here, the drying method is preferably dehydration, freeze drying, or spray drying, and according to these methods, the dehydration from the Fe—OH bond at the time of drying is small, so that the phosphate adsorption power is kept high.

  Furthermore, when glycerin is mixed before drying, at the time of drying, or after that, the decrease in phosphate adsorption power can be suppressed to a small extent. Here, the addition amount of glycerin is 20% or less (preferably 3 to 7%) with respect to the dry weight (furnace dry, 105 ° C., 2 hours). The timing of mixing glycerin is not particularly limited, but is preferably after pH adjustment and before drying.

  Next, the use and usage of the present phosphorus adsorbent will be described. The present phosphorus adsorbent is useful as a prophylactic agent for various diseases in which excessive phosphorus and biological safety are problematic, for example, various diseases caused by excessive phosphorus intake. This will be specifically described below.

  From the viewpoint of preventing various diseases caused by excessive intake of phosphorus, the present phosphorus adsorbent may be used as an “oral preparation”. That is, when this agent is taken orally with foods and drinks containing phosphorus, the substance adsorbs phosphoric acid generated in the intestine. Thus, this drug is extremely effective for the prevention of phosphorus disorders caused by a large intake of phosphate. The dose is, for example, 1 to 5 g per day, although it depends on the age and weight of the human being ingested and the type and amount of food and beverage to be ingested. Moreover, the form (for example, additive) added to what is taken into the body orally, such as food-drinks, may be a physically separate form (for example, supplement) from these.

Production of phosphorus adsorbent (oral preparation) 6% sodium hypochlorite (5% active chlorine) was added dropwise to 800 ml of 0.1M ferrous sulfate aqueous solution with stirring so that the oxidation-reduction potential was 650 mV. 29.8 g; equivalent ratio = 0.588) and left for 3 minutes with stirring. 1N sodium hydroxide was added to the solution until the pH was stabilized at 2.7 to obtain a phosphorus adsorbent according to this example. The pH at the end of the reaction was 2.7, and the oxidation-reduction potential was +584 mV.

Component analysis (1) Quantitative analysis by Fe type The above phosphorus adsorbent was quantitatively analyzed with respect to T-Fe, M-Fe, Fe ²⁺ and Fe ³⁺ (where "T" means total, "M "Means metal). For T-Fe, stannous chloride reduction-potassium dichromate titration method, for M-Fe, mercuric chloride dissolution-potassium dichromate titration method, and for Fe2 ⁺ , an inert gas-filled acid. It measured by the dissolution-potassium dichromate titration method, and calculated about Fe3 ⁺ by the calculation method [Fe3 ⁺ = T-Fe- (M-Fe + Fe2 ⁺ )]. Table 1 shows the results. No. No. 1 is a paste-like phosphorus adsorbent. 2 is a lyophilized phosphorus adsorbent.

(2) Component phase identification apparatus by X-ray diffraction (XRD): RINT-2200 type tube manufactured by Rigaku Corporation: Cu
Voltage-current: 40kV-40mA
Scanning speed: 4 ° / min
Scanning range: 5 ° -80 ° (2θ)
An X-ray diffraction test was performed under the above measurement conditions. The X-ray diffraction measurement charts are shown in FIGS.

  From the analysis results, sample no. 1 and no. In both cases, repidocrocite (γ-FeOOH) was detected very weakly. Moreover, both samples were broad except for the diffraction peak obtained in the X-ray diffraction chart, and it was found that the degree of amorphousness was extremely high.

Phosphorus adsorption ability test Phosphorus absorption ability is measured by taking 0.5 g of the phosphorus adsorbent according to this example in a dry weight, adding 20 ml of an ammonium phosphate solution (5.9 gP / l), and allowing to stand for 24 hours with occasional shaking. did. And this was filtered and the phosphorus concentration of the filtrate was measured and computed. For comparison, ferric hydroxide produced by rapidly stirring 1N NaOH in a 1M FeCl ₃ aqueous solution so as to have a pH of 7.5 to 8.0, or ferric hydroxide was produced by dehydration. With respect to hydrous iron oxide (commercially available product), the adsorption ability was tested in the same manner. The results are shown in Table 3.

Addition example of glycerin, etc. Glycerin, ethanol and skim milk were added to a phosphorous adsorbent with a water content of 70% produced according to the above method, and 5% by weight of the phosphorous adsorbent was added and freeze-dried. Table 4 shows the phosphorus adsorption capacity of the dried product.

Test Example 1 (Confirmation test of blood phosphorus concentration lowering effect using rats)
A group of 3 SD male rats (8 weeks old) were bred for 1 week by administration of a diet containing the present phosphorus adsorbent (oral) added to the feed. Blood phosphorus concentration before administration (Day 1), blood was collected 2 days later (Day 3), 4 days later (Day 5), and 7 days later (Day 8), and blood phosphorus concentration was measured. The group that does not contain this phosphorus adsorbent is called Control, and the groups that ingest the feed containing 1%, 3%, and 5% of this phosphorus adsorbent are 1% of this phosphorus adsorbent, 3% of this phosphorus adsorbent, and this phosphorus adsorption, respectively. It was shown in the figure (FIG. 5) as an agent 5%. Moreover, the significant difference with the phosphorus concentration in each time of Control was shown by ** (P <0.01).

Test Example 2 (Phosphorus adsorption test under the same system as small intestinal fluid)
In order to approximate the composition of the test solution to that of the intestinal solution, 187 g / 700 ml of enteral nutrient-elental (Ajinomoto Pharma Co., Ltd.) aqueous solution and 1 l of Ringer's solution adjusted to pH 7.2, which is a small intestinal fluid model, are mixed. The test solution was used. And after adding 0.178 g (dry weight conversion) of the phosphorus adsorbent (oral preparation) according to this example to 100 ml of the test solution, the water-soluble P concentration in the system was measured. For comparison, the same measurement was performed when no phosphorus adsorbent was added (Tests 1 and 2). Furthermore, the same measurement was performed when water-soluble phosphoric acid (the amount assuming that the total amount of organic P in the enteral nutrient was digested in the intestine) was added to the test solution (test). 3 and 4). The results are shown in the table. As can be seen from the table, water-soluble P was removed by the present phosphorus adsorbent (oral), and when a large amount of water-soluble phosphorus was further added, the amount of phosphorus removed by this phosphorus adsorbent (oral) increased. That is, when the water-soluble phosphorus concentration was low, the amount of adsorption was small, and when it was high, the amount of adsorption was large. In the table, “total P” is the total value of water-soluble and water-insoluble phosphorus. In addition, “water-insoluble phosphorus” refers to phosphorus that is not water-soluble, such as phosphorus in proteins.

FIG. 1 is an X-ray diffraction measurement chart of FIG. FIG. 1 is an X-ray diffraction measurement chart of FIG. FIG. 2 is an X-ray diffraction measurement chart of FIG. FIG. 2 is an X-ray diffraction measurement chart of FIG. FIG. 5 shows the results of Test Example 1 (the effect of reducing the phosphorus concentration in blood of a phosphorus adsorbent using rats).

Claims (14)

After adding an oxidizing agent to an aqueous solution of ferrous salt in an amount less than 0.3 equivalents to less than equivalents of ferrous ions, an alkali is added to adjust the pH at the end of the reaction to 1.5 to 5.5. The food-drinks additive or food-drinks auxiliary agent containing the ferric hydroxide produced | generated in this way . It is produced by adding an oxidizing agent to a water-soluble ferrous salt aqueous solution so that the oxidation-reduction potential becomes +400 to 770 mV, and then adding alkali to adjust the pH to 1.5 to 5.5 at the end of the reaction. The food-drinks additive or food-drinks auxiliary agent containing ferric hydroxide . An oxidizing agent is added to a water-soluble ferrous salt aqueous solution in an amount less than 0.3 equivalents to less than equivalents of ferrous ions to make the oxidation-reduction potential +400 to 770 mV, and then an alkali is added so that the pH at the end of the reaction is 1. The food-drinks additive or food-drinks auxiliary agent containing the ferric hydroxide produced | generated by adjusting so that it might be set to 5-5.5 . The food-drinks additive or food-drinks adjuvant as described in any one of Claims 1-3 whose said oxidizing agent is a hypochlorite . The food-drinks additive or food-drinks adjuvant as described in any one of Claims 1-4 whose said ferric hydroxide is amorphous . The food-drinks additive or food-drinks adjuvant as described in any one of Claims 1-5 which further contains glycerin . Adding an oxidant to the water-soluble ferrous salt aqueous solution in an amount less than 0.3 equivalents to less than equivalents of ferrous ions, and then adding an alkali to adjust the pH to 1.5 to 5.5. The manufacturing method of the food-drinks additive or the food-drinks adjuvant containing the ferric hydroxide characterized by the above-mentioned. It includes a step of adding an oxidizing agent to a water-soluble ferrous salt aqueous solution so that the redox potential is +400 to 770 mV, and then adding an alkali to adjust the pH to 1.5 to 5.5. The manufacturing method of the food-drinks additive or the food-drinks auxiliary agent containing ferric hydroxide. An oxidizing agent is added to a water-soluble ferrous salt aqueous solution in an amount less than 0.3 equivalents to less than equivalents of ferrous ions to make the oxidation-reduction potential +400 to 770 mV, and then an alkali is added to adjust the pH to 1.5 to 5.5. The manufacturing method of the food-drinks additive or the food-drinks auxiliary agent containing the ferric hydroxide characterized by including the process adjusted so that it may become. The manufacturing method as described in any one of Claims 7-9 whose said oxidizing agent is a hypochlorite. The manufacturing method according to any one of claims 7 to 10 , wherein the ferric hydroxide is amorphous. The manufacturing method as described in any one of Claims 7-11 which further includes the process of adding glycerol. The production method according to any one of claims 7 to 12 , further comprising a step of dehydration, freeze drying or spray drying. The manufacturing method of Claim 13 which implements the addition process of glycerol before the process of spin-drying | dehydration, freeze-drying, or spray-drying at the time of the said process after the said pH adjustment process.

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