JP4106430B2 - Protective agent for biological damage caused by ionizing radiation and protection method using the same - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The invention of this application relates to an agent for protecting biological damage caused by ionizing radiation such as X-rays, γ-rays, and particle beams, and a protection method using the same.
[0002]
[Prior art and problems of the invention]
It is known that biological damage such as genetic damage or lethality appears when exposed to ionizing radiation, and methods for protecting such biological damage action have been studied from various viewpoints.
[0003]
For example, specifically, with respect to the protection of the biohazardous action of ionizing radiation, protection with lead and protection with drugs have been known so far. Thus, since it is considered that indirect action by radical reaction accounts for about 75% of the cytotoxicity of radiation, radical scavengers have been the main protective agents so far. However, many radical scavengers have been studied as radiation protection agents until now, but they are not practical drugs and are considered to be problematic in terms of safety and effectiveness. In recent years, it has become important to protect against radiation that is mainly direct action due to aircraft and space advancements. In fact, there was no way to protect other than trying to reduce external and internal exposure. In other words, there was no safe policy that could be applied directly to people.
[0004]
The invention of this application was made in view of the circumstances as described above, is highly safe and simple, can protect against biological damage of ionizing radiation for a relatively long time, and It is an object to provide new technical means that can be applied to this.
[0005]
[Means for Solving the Problems]
The invention of this application, as to solve the problem as described above, provides a protective agent of biological damage by carbon ions, characterized in that an active ingredient bi Lumpur.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
The invention of this application has the features as described above, and an embodiment thereof will be described below.
[0009]
Above all, what is characteristic in the invention of this application is that biological damage caused by ionizing radiation is extremely effectively protected by a protective agent containing an alcoholic beverage as an active ingredient.
[0010]
The alcoholic beverage as an active ingredient may be any of well-known alcoholic beverages, brewed liquor, distilled liquor, and mixed liquor, and may be various products including commercial products. These alcoholic beverages are, for example, directly as commercial products or diluted with water or physiological saline, and further added with sugar, various flavors, nutrients, and other drugs. A protective agent can be constructed as an addition.
[0011]
Among them, a more effective protective agent in the invention of this application is an alcoholic beverage containing a component saccharified by malt or koji. In particular, one containing beer components is exemplified as an effective one.
[0012]
The content of alcohol (ethanol) in the alcoholic beverage as an active ingredient is preferably about 2 to 15%.
In actual use, it can be administered orally, and the amount used can be adjusted according to the constitution of the subject, the environment exposed to ionizing radiation, the time required for protection, and the like. Of course, the subject of protection may be a person, but the present invention is not limited to this, and the present invention is effectively applied to non-human animals and laboratory animals.
[0013]
Then, an Example is shown below and invention of this application is demonstrated in detail. In the following example, X-ray and carbon ion rays are irradiated to human peripheral blood before and after drinking beer, and the protective effect of beer is examined by measuring the frequency of chromosomal aberrations for genetic damage. Of course, the present invention is not limited by the following examples.
[0014]
【Example】
<Example 1>
Blood collected after drinking 700 ml of beer (Kirin beer) and blood before drinking were irradiated with X-rays (20 mA, 0.5 mm Cu + 0.5 mm Al filter, focus-probe distance 55 cm), or LET 50 keV / μm at 0 to 6 Gy. Biological disorder of beer ionizing radiation by comparing the degree of damage between the group irradiated with X-rays and the group irradiated with carbon ion radiation in blood before and after drinking by measuring the frequency of chromosomal abnormalities (Dicentric). The protective action against was investigated. As shown in the attached FIG. 1 and FIG. 2, the results show that the average chromosomal abnormality appearance frequency per cell is 1.75 for blood before drinking beer (hereinafter abbreviated as (-) group) in X-ray 4Gy. Blood after drinking beer (hereinafter abbreviated as (+) group) is 1.23, carbon ion beam 4Gy is (-) group is 1.85 (+) group is 1.23, and (+ ) The group value was smaller. This indicates that the chromosomal abnormality caused by X-rays or carbon ion rays was cured by drinking beer. From the above results, it was confirmed that beer protects against damage caused by human X-rays or carbon ion rays.
<Example 2>
Blood before drinking and 700 ml of beer (Kirin beer) 30 minutes after drinking, blood collected at 1 hour, 2 hours, 3 hours, 4 hours, 4.5 hours X-ray (20 mA, 0.5 mm Cu + 0.5 mm Al filter, focus 4Gy irradiation was performed at a distance between probes of 55 cm. The degree of damage was measured by measuring the frequency of chromosomal abnormalities (Dicentric; dicentric chromosomes) in blood before and after drinking, and the duration of the protective effect of beer ionizing radiation on biological damage was investigated.
[0015]
The results are shown in FIG.
It was confirmed that the effectiveness of beer bioprotection was sustainable.
[0016]
【The invention's effect】
As described in detail above, the invention of this application makes it possible to protect or reduce biological damage caused by ionizing radiation (including high LET radiation).
[Brief description of the drawings]
FIG. 1 is a diagram showing an example of a failure occurrence result in X-ray irradiation before and after drinking beer.
FIG. 2 is a diagram showing an example of the result of failure in carbon ion irradiation before and after drinking beer.
FIG. 3 is a diagram illustrating the duration of the protective effect against X-rays caused by drinking beer.

Claims (1)

A protective agent for biological damage caused by carbon ion rays , characterized by comprising beer as an active ingredient.

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