JP4014811B2 - Oral hygiene food - Google Patents

Description

【００４３】
＜参考例６、比較例３＞
次に、表２に示す組成にて、下記のようにしてタブレットを調製した。
【００４４】
（タブレットの調製）
各原料を混合し、打錠して、１辺９ｍｍ×３辺、厚み４ｍｍ大の三角形状で重量０．３４ｇ／個となるように成形し、タブレットを調製した。
【００４５】
このようにして得られた参考例品、比較例品のタブレットについて、専門パネラー２０名がその２粒を口中にて５分間舐め、風味、食感につき官能評価を行うと共に、口腔衛生評価について下記のようにして行った。その結果を表２に示す。
【００４６】
（タブレットの口腔衛生評価）
▲１▼溶出性
上記タブレット２粒を、２０℃の冷水１００ｃｃ中で１５分間スターラーで撹拌し、溶液中のガロタンニン溶出量及び重合リン酸塩溶出量を、タブレット中への配合量を１としたときの重量比で示した。
▲２▼ｐＨ安定性
上記溶液のｐＨを測定し、０．０１％濃度のＨＣｌ、１ｃｃを添加した時のｐＨ変動を比較した。
【００４７】
【表２】

【００４８】
表１の結果から明らかなように、実施例４及び参考例１〜３、５のチューインガムは、重量比でガロタンニン１に対して重合リン酸塩が特定比率含有されているので、チューインガムの変色が防止され、口中のｐＨ安定性が良好であった。また、ガロタンニンの溶出が効率的に行われ、口腔衛生効果に優れていた。特に、実施例４のチューインガムは、グルコマンナンが含有されていたので、義歯等への付着防止効果に優れていると共に、風味及びその持続性と食感に優れたチューインガムが得られており、かつ、ガロタンニン及びリン酸カルシウムの溶出効率に優れていた。
これに対し、比較例１のチューインガムは、ガロタンニンに対する重合リン酸塩の含有量が少なすぎたため、ガロタンニンの不溶化を充分に防止することができず、チューインガムが変色し、外観が悪かった。また、口中のｐＨ安定性が悪かった。また、比較例２のチューインガムは、ガロタンニンに対する重合リン酸塩の含有量が多かったため、風味が劣り、ガロタンニンの溶出効率が悪く、口腔衛生効果が劣っていた。
【００４９】
また、表２の結果から明らかなように、参考例６のタブレットは、ガロタンニン及び重合リン酸塩の重量比率が特定範囲内であるので、タブレットの変色が防止され、口中のｐＨ安定性が良好であった。また、ガロタンニンの溶出が効率的に行われ、口腔衛生効果に優れていた。
これに対し、比較例３のタブレットは、ガロタンニンに対する重合リン酸塩の重量比率が不適当であったため、口中のｐＨ安定性及びガロタンニンの溶出効率が悪く、口腔衛生効果が劣っていた。また、タブレットが変色し、外観が悪かった。[0001]
BACKGROUND OF THE INVENTION
The present invention, dental caries, and oral diseases periodontal disease and the like, to the mouth腔衛raw foods that suitably used in the postprandial oral hygiene.
[0002]
[Prior art]
In general, oral hygiene is maintained by brushing teeth to clean the mouth, but even if you brush your teeth, you can still eat candy in your mouth, have less saliva, periodontal tissue Oral hygiene will deteriorate if plaque remains on the surface, bacteria in the periodontal tissue grow, or suffers from oral disease.
[0003]
Therefore, for oral hygiene, toothpastes and mouthwashes containing various medicinal ingredients are on the market, but these are used for periodontitis, gingivitis, caries, bad breath prevention, etc. It has been developed separately for each application, and does not necessarily improve oral hygiene widely. Even if these are used, the way of brushing teeth is bad, or there are no effects depending on the type of bacteria in the oral cavity and the state of oral disease.
[0004]
Also, for the purpose of oral hygiene, viscoelastic foods (for example, chewing gum) are widely used. However, viscoelastic foods have specific viscoelasticity, and thus easily adhere to teeth due to the interfacial force with the tooth surface. . This adhesion is particularly remarkable in the case of dentures such as dentures, and therefore, a person who uses dentures is a great obstacle to enjoying viscoelastic foods.
[0005]
Even if an active ingredient for oral hygiene is added to a viscoelastic food, the active ingredient is adsorbed in the food base and is not easily eluted even if it is chewed.
[0006]
In addition, when a saccharide sweetener is included in a viscoelastic food, acid is likely to be generated by mutans bacteria that parasitize in the oral cavity, and even if a saccharide sweetener is not included, visceral diseases or added Since the saliva secretion amount decreases with age, the pH in the mouth tends to be acidic, and this state causes various oral diseases such as dissolution of tooth enamel.
[0007]
By the way, as an example of a conventional active ingredient for oral cavity, for example, a collagenase activity inhibitor described in Japanese Patent Publication No. 7-91196 is known. This inhibitor uses the gallotannin as an effective component for the prevention and improvement of periodontal disease, thereby inhibiting the collagenase activity of periodontal pathogenesis present in the periodontal tissue.
[0008]
However, gallotannin becomes an insoluble tannic acid compound in which gallotannin and metal react with each other in the presence of a trace amount of metal originally contained in the inhibitor or food, and the effect of inhibiting collagenase activity is reduced. Cause discoloration.
[0009]
[Problems to be solved by the invention]
The present invention was made in view of such circumstances, it is an object of caries, dental and oral diseases such as periodontal disease, mouth腔衛raw foods that suitably used for an after-meal oral hygiene a is the active ingredient of the oral hygiene, Warazu effectively acts contracture in the formulation of the other components, also to suppress the fluctuation of the pH in the mouth that cause oral diseases, further added to the viscoelastic food also, to provide a superior mouth腔衛raw food effect of preventing adhesion to teeth and dentures.
[0010]
[Means for Solving the Problems]
The above object is an oral hygiene food containing gallotannin, polymerized phosphate, and glucomannan , and contains 0.01 to 0.5% by weight of polymerized phosphate in the total weight of the oral hygiene food. Achieved by the featured oral hygiene food .
[0011]
Preferably, the oral hygiene food is a viscoelastic food.
[0012]
That is, the inventors firstly made gallotannin insoluble in the presence of a metal, and discolored a composition (hereinafter simply referred to as “composition”) such as a dentifrice, mouthwash, and food containing the component. We examined how to prevent it. As a result, when the weight ratio of the polymer phosphate to gallotannin 1 is set to a specific ratio, the polymer phosphate sequesters free metal ions and efficiently dissolves gallotannin into the oral cavity and effectively acts on the periodontal tissue. In addition, it has been found that discoloration of the composition can be prevented.
It has also been found that by containing a polymerized phosphate, the polymerized phosphate can act as a buffer in the oral cavity and prevent the pH in the oral cavity from fluctuating.
Furthermore, when gallotannin and polymerized phosphate are used in foods (particularly viscoelastic foods), when glucomannan is used in combination, the whole food becomes difficult to adhere to teeth, especially dentures, and gallotannin and polymerized phosphoric acid. The present inventors have found that salt is not easily adsorbed in food tissues and that an effective amount is surely eluted to effectively act in the oral cavity.
[0013]
DETAILED DESCRIPTION OF THE INVENTION
Next, the present invention will be described in detail.
Mouth腔衛raw food of the present invention contains a gallotannin polymerization phosphate and glucomannan.
[0014]
First, gallotannins are galloyl glucoses widely distributed in the plant kingdom, such as pentose and gallic, as well as a variety of herbal medicines such as glaze and peony skin, and from 1 to 12 per glucose molecule. It is a combination of molecular gallic acid. For example, in pentaploid tannin, an average of 8.3 molecules of gallic acid is bound to 1 molecule of glucose, and the average molecular weight is 1434.
Conventionally, gallotannins are known to be used as deproteinizers, astringents, antiseptics, crusts, and the like.
[0015]
The method for producing gallotannin used in the present invention is not particularly limited, and may be produced by a commonly used method.
For example, as a method of manufacturing from a Chinese quintuplet or a Turkish quintuplet, leaching is performed by water leaching method, alcohol leaching method, or alcohol / ether leaching method, etc. A method is mentioned. In general, gallotannins are obtained in a yield of about 50-60% from a quintuplet and about 70% from a quintuplet of Turkey.
Specifically, for example, “Tannin AL” (manufactured by Fuji Chemical Co., Ltd.) and the like can be mentioned.
[0016]
Next, the polymerized phosphate used in the present invention is an alkali metal or alkaline earth metal salt of phosphoric acid.
Specific examples include sodium pyrophosphate, sodium polyphosphate, sodium metaphosphate and the like, and these may be used alone or in combination. Among these, sodium metaphosphate is preferable in terms of suitably preventing insolubilization and discoloration of gallotannin and suppressing pH variation in the mouth.
Also, combined use of polymerized calcium phosphate is preferable in terms of reinforcing the tooth tissue.
[0017]
In the composition for oral hygiene contained in the oral food of the present invention, the polymerized phosphate is set to 0.1 to 50, more preferably 1 to 10, with respect to gallotannin 1 by weight ratio. It is desirable to do.
That is, when the weight ratio of the polymerized phosphate with respect to gallotannin 1 is less than 0.1, the effect of preventing insolubilization and discoloration of gallotannin and suppressing the fluctuation of pH in the mouth cannot be obtained. On the other hand, when the polymerized phosphate exceeds 50, the solubility of the polymerized phosphate is lowered, and it is difficult to obtain an effective amount with respect to the content. In addition, it has a bitter taste.
[0018]
In addition, there are no particular limitations on the excipient or adjuvant used when formulating the composition for oral hygiene, but examples include sugar sweeteners such as lactose, sorbit, mannitol, aspartame, and acesulfur. High-sensitivity sweeteners such as farm K, sucralose, saccharin, thickening polysaccharides such as gum arabic and carrageenan, coloring agents, fragrances, emulsifiers, fungicides such as chlorhexidine, antibiotics such as ampicillin, magnesium stearate, celluloses, Examples include surfactants such as sodium lauryl sulfate and sodium lauroyl sarcosine, alcohols such as glycerin, polyethylene glycol, polyvinyl alcohol, and ethanol, fatty acids, silicic acid, organic acids, and hydroxyapatite.
[0019]
The composition for oral hygiene is suitably used for dentifrices, mouthwashes, troches, coating solutions, foods and the like.
[0020]
Examples of food forms when the above oral hygiene composition is added to foods to obtain oral hygiene foods include, for example, viscoelastic foods (chewing gum, gummy jelly, soft candy, nougat, marshmallow, etc.), hard candy, beverage, chocolate , Tablets, powdered foods and the like.
Among these, viscoelastic foods are preferably used in terms of a long residence time in the mouth and a large contact area with teeth, periodontal tissue, and tongue by chewing, and among them, chewing gum is particularly a sanitary state in the mouth. It is suitable at the point which raises.
[0021]
Further, when gallotannin and polymerized phosphate are used for oral hygiene food, the content of gallotannin is preferably 0.001 to 2.0% by weight, more preferably 0.01 to 2.0% in the total weight of the oral hygiene food. It is desirable to set it to 1.0% by weight.
That is, when the gallotannin content is less than 0.001% by weight, the oral hygiene effect tends to be inferior, and conversely, when it exceeds 2.0% by weight, the flavor tends to be inferior.
[0022]
The content of the polymerization phosphate, mouth腔衛raw food total weight of 0.01 to 0.5 wt%, more preferably it is desirable to set 0.1 to 0.3 wt%.
That is, when the content of the polymerizable phosphate is less than 0.01 wt%, to prevent the insolubilization and discoloration of gallotannins, that a hardly effect of suppressing the variation in the mouth pH is obtained. Conversely, when the polymerization phosphate exceeds 0.5 wt%, a decrease and uneven distribution of solubility, or expression is decreased effect, that Teisu bitterness in terms of flavor.
[0023]
When viscoelastic food is used as the oral hygiene food of the present invention, when glucomannan is contained together with gallotannin and polymerized phosphate, the viscoelastic food itself has physical properties that are difficult to adhere to teeth, particularly dentures, and It is preferable that gallotannin and polymerized phosphate are difficult to be adsorbed in the food tissue, and the effective amount is surely eluted to effectively act in the oral cavity.
[0024]
The glucomannan used in the present invention is a linear polysaccharide in which D-glucose and D-mannose are linked by β-1,4 at a ratio of 1: 1.6, and is a water-soluble high molecular weight polysaccharide having a molecular weight of 670,000 to 1,900,000. It is a polysaccharide having the largest molecular weight among the polysaccharides. The origin is konjac potato, hardwood, Iris rhizome, aloe leaf.
Specifically, “SOAMANNA GM-210” manufactured by MRC Polysaccharides may be used.
[0025]
Examples of the form of glucomannan include powder.
The particle size of the glucomannan powder is preferably 60 mesh pass, more preferably a particle size finer than 100 mesh pass, from the viewpoint that it hardly affects the texture of the viscoelastic food.
[0026]
In addition, the content of the glucomannan is preferably 0.01 to 3.0% by weight, more preferably 0.05 to 3.0% by weight in the total weight of the viscoelastic food in terms of suitably obtaining the physical properties of the non-adhesive viscoelastic food. It is desirable to set it as 1.0 weight%. That is, when glucomannan exceeds 3.0% by weight, the effect of preventing adhesion to teeth and dentures tends to be obtained, but the texture of viscoelastic foods tends to be hard. On the other hand, when glucomannan is less than 0.01% by weight, the effect of preventing adhesion to teeth and dentures tends to be difficult to obtain.
[0027]
Next, the case of chewing gum is shown below as an example of a viscoelastic food.
Chewing gum consists of a gum base and auxiliary materials.
First, as a gum base, it is a normal gum base, for example, an elastic body, a wax, an inorganic substance etc. are selected suitably, and are used.
Examples of the elastic body include natural rubber, polyisobutylene, polyisoprene, vinyl acetate resin, and the like, which may be appropriately selected from these and used alone or in combination. Among these, vinyl acetate resin is particularly preferable in terms of non-adhesiveness.
Next, examples of the wax include rice wax, carnauba wax, and microcrystalline wax. These may be used alone or in combination.
Next, examples of the inorganic material include calcium carbonate and talc. These may be used alone or in combination.
[0028]
The gum base may be appropriately designed and used, such as a bubble gum type mainly composed of vinyl acetate resin and a regular gum type mainly composed of natural chicle. In particular, it is desirable that the vinyl acetate resin and the inorganic substance are contained in that the adhesion preventing effect is suitably obtained.
[0029]
In addition to the gum base, saccharides, pigments, emulsifiers, stabilizers, acidulants, softeners, and the like may be used in appropriate combinations as auxiliary materials. For example, as an emulsifier, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester and the like may be mentioned, and these may be used alone or in combination.
[0030]
And an oral hygiene chewing gum is manufactured as follows using the said gum base, an auxiliary material, a gallotannin, a polymeric phosphate, and glucomannan, for example. First, a gum base, gallotannin, polymerized phosphate, glucomannan, auxiliary materials and the like are kneaded together and usually shaped to form an oral hygiene chewing gum.
[0031]
In addition, when adding gallotannin and polymerized phosphate, if it is added to other raw materials after making it into a solution, the polymerized phosphate preferably prevents the reaction between gallotannin and other free metals. It is desirable from the viewpoint of preventing the chewing gum from being discolored.
[0032]
In addition, as a method of adding glucomannan to chewing gum, it may be added to chewing gum as it is in powder form, but after being dispersed in glycerin or starch syrup, it is added to chewing gum in a shorter time. Glucomannan is preferred because it is uniformly dispersed and has an excellent anti-adhesion effect on teeth and dentures. Moreover, when glucomannan is added to chewing gum in an unheated state, it is preferable in that the effect of preventing adhesion to teeth and dentures is excellent.
[0033]
【The invention's effect】
As described above, oral hygiene food of the present invention, by containing Polymerization phosphate, polymerization phosphate acts as a buffer in the oral cavity, pH in the mouth can be prevented from fluctuating.
Furthermore, when gallotannin and polymerized phosphate are used in viscoelastic foods, the combined use of glucomannan makes the food itself difficult to adhere to teeth, especially dentures, and gallotannin and polymerized phosphate are foods. Since it becomes a physical property that is difficult to be absorbed in the tissue, the effective amount is surely eluted and acts effectively in the oral cavity.
[0034]
【Example】
Next, the present invention will be specifically described with reference to examples.
[0035]
<Example 4 , Reference Examples 1-3, Comparative Examples 1-2>
With the composition shown in Table 1, chewing gum was prepared as follows.
[0036]
(Preparation of chewing gum)
The chewing gum composition and the oral hygiene composition were put into a chewing gum mixer and homogeneously mixed for 15 minutes to obtain a chewing gum.
[0037]
Next, oral hygiene evaluation, sensory evaluation, and physical property test were performed as follows using the obtained chewing gum.
[0038]
(Oral hygiene evaluation of chewing gum)
(1) Dissolution The 3 g of the above chewing gum is cut into 1 cm square × 2 mm thick pieces, stirred with a stirrer for 15 minutes in 100 cc of cold water at 20 ° C., and the gallotannin elution amount and polymerized phosphate elution amount in the solution are determined. the amount into the gum showed a weight ratio when the 1 00.
(2) pH stability The pH of the above solution was measured, and the pH variation when 0.01% concentration of HCl and 1 cc were added was compared.
[0039]
(Color tone)
The color tone of chewing gum stored at 40 ° C. and 80% humidity for 10 days was evaluated by comparing it with a blank without added polymerized phosphate.
[0040]
(sensory evaluation)
Twenty professional panelists using dentures (methacrylate resin, crown, teeth), chewing one chewing gum (3.0 g) of each example and comparative example, adhering to denture, chewing comfort, flavor Evaluated.
[0041]
(Physical property test)
Chewing gum 3.0 of each example , reference example and comparative example at a constant speed by a specialized panelist
The bite after g was chewed for 3 minutes was used as a sample, and the adhesion to the denture material was measured with a rheometer. Denture material made of methacrylate resin is attached to a dedicated rheometer column, inserted 3 mm under the conditions of 1 kg compression load and 80 mm / min of the sample stage, and then pulled 20 mm under the same conditions. ) Was measured. That is, the smaller the stress value, the less the gum feels to the denture.
[0042]
[Table 1]

[0043]
< Reference Example 6, Comparative Example 3>
Next, tablets having the composition shown in Table 2 were prepared as follows.
[0044]
(Preparation of tablet)
Each raw material was mixed, tableted, and molded into a triangular shape having a side of 9 mm × 3 sides and a thickness of 4 mm and a weight of 0.34 g / piece to prepare a tablet.
[0045]
About the tablet of the reference example product obtained in this way and the comparative example product, 20 professional panelists licked two of them in the mouth for 5 minutes, and while performing sensory evaluation on flavor and texture, I went as follows. The results are shown in Table 2.
[0046]
(Tablet oral hygiene evaluation)
(1) Dissolution The above 2 tablets were stirred in 100 cc of cold water at 20 ° C. for 15 minutes with a stirrer, and the amount of gallotannin and polymerized phosphate dissolved in the solution was set to 1. The weight ratio is shown.
{Circle around (2)} pH stability The pH of the above solutions was measured, and pH fluctuations when 0.01% HCl and 1 cc were added were compared.
[0047]
[Table 2]

[0048]
As is clear from the results in Table 1, the chewing gums of Example 4 and Reference Examples 1 to 3 and 5 contain a specific ratio of polymerized phosphate with respect to gallotannin 1 in a weight ratio. And pH stability in the mouth was good. Moreover, the elution of gallotannin was performed efficiently and the oral hygiene effect was excellent. In particular, since the chewing gum of Example 4 contained glucomannan, the chewing gum was excellent in the effect of preventing adhesion to dentures, etc., and the flavor and its durability and texture were obtained, and The elution efficiency of gallotannin and calcium phosphate was excellent.
On the other hand, since the chewing gum of Comparative Example 1 contained too little polymer phosphate with respect to gallotannin, insolubilization of gallotannin could not be sufficiently prevented, and the chewing gum was discolored and the appearance was poor. In addition, the pH stability in the mouth was poor. Moreover, since the chewing gum of Comparative Example 2 had a high content of polymerized phosphate with respect to gallotannin, the flavor was poor, the elution efficiency of gallotannin was poor, and the oral hygiene effect was poor.
[0049]
Further, as apparent from the results in Table 2, since the tablet of Reference Example 6 has a weight ratio of gallotannin and polymerized phosphate within a specific range, discoloration of the tablet is prevented and pH stability in the mouth is good. Met. Moreover, the elution of gallotannin was performed efficiently and the oral hygiene effect was excellent.
On the other hand, since the weight ratio of the polymerized phosphate to gallotannin was inappropriate in the tablet of Comparative Example 3, the pH stability in the mouth and the elution efficiency of gallotannin were poor, and the oral hygiene effect was poor. Moreover, the tablet discolored and the external appearance was bad.

Claims (2)

An oral hygiene food containing gallotannin, polymerized phosphate, and glucomannan, characterized by containing 0.01 to 0.5% by weight of polymerized phosphate in the total weight of the oral hygiene food Food. Oral hygiene food according to claim 1, wherein the oral hygiene food is viscoelastic food.