JP3691891B2 - A container capable of repeatedly delivering a predetermined amount of powder and an inhalation or injection administration kit capable of repeatedly administering a predetermined amount of powder medicine - Google Patents

Description

[0001]
[Technical field]
The present invention is a container capable of repeating the operation of compressing and separating powder to a predetermined amount and transferring it to a delivery unit, and as an application thereof, a predetermined amount of powder medicine is repeatedly administered into the oral cavity without going through a liquid medium. The present invention relates to an inhalation kit to be obtained or another injection administration kit that can be repeatedly administered into a body cavity, for example, into the nasal cavity, or an injection administration kit that can be repeatedly administered to the following site requiring treatment other than in the body cavity.
[0002]
Specifically, in addition to the above-described ability, the present invention is not limited in the direction of the kit at the time of use, and there is little possibility of causing a blockage or the like in the gas flow path due to the agglomeration of the powder containing the powder drug, Powder delivery container that can be used repeatedly many times, or an inhalation kit for oral administration in which a predetermined amount of powdered medicine can be repeatedly administered, or a kit for injection into other body cavities, especially the nasal cavity, or eczema, burns, chemical damage The present invention relates to a jet administration kit that can be repeatedly administered to a site requiring treatment such as an injured site.
[0003]
[Prior art]
Kits for injecting the powder medicine into the oral cavity in a liquid form such as a solution obtained by dissolving a powder medicine in a liquid medium or a suspended suspension are already commercially available. However, these kits still had various limitations, such as:
・ There was always a large variation in the supply volume at each injection.
・ There was a restriction that the inhaler should use it in a certain posture.
・ It was inconvenient to carry because the kit was not designed to inject powder medicine directly, but inhaled as a solution.
[0004]
[Problems to be solved by the invention]
The present invention eliminates the limitations associated with the above-described conventional kits, and can be used to repeatedly deliver a predetermined amount of powder that exhibits the following various characteristics, and to the oral cavity capable of repeatedly administering a predetermined amount of powdered medicine. It is an object of the present invention to provide an inhalation kit, an injection kit for injection into another body cavity, for example, the nasal cavity, and an injection administration kit for a site requiring treatment. Features of a container capable of repeatedly delivering a predetermined amount of powder of the present invention, and an inhalation kit and a jet administration kit of a predetermined amount of powdered drug:
◆ Powder can be repeatedly supplied to the delivery part with a predetermined amount with high accuracy.
◆ In addition to being able to supply powder medicine directly into the oral cavity by inhalation, and injecting into a body cavity other than the oral cavity, for example, into the nasal cavity, sites that require treatment other than within the body cavity, such as eczema, burns, drug damage or injury Can be administered repeatedly, etc.
◆ PowderConditionThere is almost no variation in the delivery amount and dose (inhalation amount and injection dose) of each substance,
◆ There are no restrictions on the posture of use when delivering powder from the container or when inhaling or injecting powdered medicine from the kit.
[0005]
[Means for Solving the Problems]
The present invention solves the above-mentioned problems, and a container capable of repeatedly delivering a predetermined amount of powder having the various features described above, an inhalation kit capable of repeatedly administering a predetermined amount of powdered medicine into the oral cavity, and other body cavities For example, in order to provide a kit that can be repeatedly injected into the nasal cavity and a kit that can be injected into a site that requires treatment other than inside the body cavity, the following `` Basic configuration of a quantitative delivery container '', `` Improved configuration of fixed-rate delivery container 1 ”to“ Improved configuration of fixed-rate delivery container ”4”And the following“ Basic configuration of the inhalation or injection administration kit ”and“ Improved configuration 1 of the inhalation or injection administration kit ”to“ Improved configuration 8 of the inhalation or injection administration kit ”: It is necessary to have it as a suitable requirement.
[0006]
    [Basic configuration of the quantitative delivery container]
  By moving linearlyCompression member that compresses powder contained in a cylindrical member to a predetermined densityWhen,
  It is arranged to be able to reciprocate between a powder metering section configured at the end of the moving area of the compression member and a powder delivery section configured at the end side of the moving area of the compression member, and opposed to the compression member So that the measuring hole functioning as the powder measuring part was formedWeighing memberAnd comprising
  Part of the powder contained in the cylindrical member is introduced into the measuring hole of the measuring member, and a predetermined amount of powder compressed in the measuring hole by the movement of the compression member is moved to the measuring member. Along with this, the powder is transferred from the powder metering unit to the powder sending unit, and after emptying a predetermined amount of powder transferred to the powder sending unit, the measuring member is returned to the original position to enable repeated operation. A container capable of repeatedly delivering a predetermined amount of powder.
[0007]
    [Improved configuration of fixed-volume delivery container 1]
  SaidThe compression member is a piston or a plunger;The compression member isIn the direction of approaching the measuring memberonlyIt can be movedIt is characterized byA container capable of repeatedly delivering a predetermined amount of the powder described in [Basic configuration of a quantitative delivery container].
[0008]
    [Improved configuration of fixed-volume delivery container 2]
  The weighing member is substantially the same as the moving distance per time of the compression member.Has a plate thickness and compresses the powderCooperation with pressure receiving member that receives pressureA predetermined amount of powder is dispensed byA container capable of repeatedly delivering a predetermined amount of the powder described in [Basic configuration of a quantitative delivery container] and [Improved configuration 1 of a quantitative delivery container].
[0009]
    [Improved configuration 3 of the quantitative delivery container]
  The cylindrical member isTo the tubular memberProvided with a display means for indicating the number of delivered powders or the remaining amount of powder.It is characterized byA container capable of repeatedly delivering a predetermined amount of powder as described in [Basic configuration of quantitative delivery container] and [Improved configuration 1 of quantitative delivery container] and [Improved configuration 2 of quantitative delivery container].
[0010]
    [Improved configuration of fixed-volume delivery container 4]
  A gas introduction hole is formed in the powder delivery part.While connecting the pressurized gas supply means to the gas introduction hole,ConcernedIn the powder delivery sectionThe injection part is formed in a nozzle shapeA container capable of repeatedly delivering a predetermined amount of the powder according to [Basic configuration of quantitative delivery container] and [Improved configuration 1 of quantitative delivery container] to "Improved configuration 3 of quantitative delivery container".
[0011]
    [Basic configuration of inhalation or injection kit]
  The outer body is constituted by the upper main body (11) formed in a substantially cylindrical shape and the bottomed cylindrical lower main body (12) rotatably attached to the upper main body (11). A mouthpiece (11m) having a powder delivery port is attached to the upper end of the upper body (11),
The upper body (11) includes a transparent window hole that runs in the vertical direction on the side wall thereof,
The mouthpiece (11m) includes a barrier (11mb) that closes a part of the opening area in the middle of the inner wall, and a barrier (11mc) that substantially blocks the remaining opening area at the lower end region thereof,
Inside the outer shell,
Powder compression means A for compressing the contained powder medicine to a predetermined density,
Weighing means B for dispensing a predetermined amount of powder medicine from the powder medicine compressed by the powder compression means A;
Force transmitting means C for transmitting external force applied to compress the powder to the powder compressing means A;
A powder delivery means D for delivering a predetermined amount of the powder medicine compressed by the powder compression means A to the outside with the introduction of gas;
The powder compressing means A includes an inner cylinder (11i) accommodated in the inclusion cylinder (11g), a compression member (12p) inserted from the lower end side of the inner cylinder (11i), and a lower end of the inner cylinder (11i). A push-up shaft (12s) inserted from the side to push up the compression member (12p),
The metering means B is disposed on the upper end side of the inner cylinder (11i), and a metering hole functioning as a powder metering portion is formed at an equiangular interval with respect to the center. Having a powder transfer function of transferring the measured powder medicine to a powder take-out section configured on the side of the powder measurement section after releasing the force applied to compress the powder medicine;
The force transmission means C is
The lower body (12);
A post (12 ps) integrally standing upward from the bottom surface of the lower body (12);
A push-up nut (12n) with a hollow quadrant missing in the cross-sectional shape and an internal cavity with a shape substantially complementary to the outer shape of the post (12ps) in the remaining part;
A rotating cylinder (12r) disposed concentrically outside the push-up nut (12n);
A sawtooth gear (12g) disposed in a portion where a part of the hollow quadrant push-up nut (12n) is missing;
It is inserted into a central through hole formed in the saw-tooth gear (12g), and a male left screw is formed on the entire outer wall of the saw tooth gear (12g). ) A push-up shaft (12s) engaged with a female left-hand thread formed on the inner wall;
A ratchet mechanism configured between the sawtooth gear (12g) and a sawtooth vertical groove (12a) formed on the inner wall of the rotating cylinder (12r),
The powder delivery means D includes
A gas inlet (11h) formed in the side wall of the upper body (11);
The gas introduced into the inclusion cylinder (11g) having the gas inlet (11ah) on the side wall and introduced through the gas inlet (11h) and the gas inlet (11ah) into the mouthpiece (11m). A screw housing cylinder (11a) that can be delivered;
A diffusion member (11s) mounted in the screw housing cylinder (11a) and swirling the gas introduced into the screw housing cylinder (11a);
When the lower body (12) is rotated in the right direction when viewed from above with respect to the upper body (11),
A rightward rotational force applied to the lower body (12) is transferred via the lower body (12). The post (12 ps) is rotated in the right direction integrally with the lower body (12), and further the rotational force from the post (12 ps) to the push-up nut (12n). As a result, the push-up nut (12n) is rotated rightward together with the lower body (12) and the post (12ps), and the push-up nut (12n) is turned rightward together. When rotated, the connection body of the sawtooth gear (12g) and the push-up shaft (12s) is revolved rightward around the central axis of the outer shell,
And at the time of the right turn of this connected body,
The lower main body (12), the post (12ps), the push-up nut (12n), the sawtooth gear (12g), the inclusion cylinder (11g), and the members constituting the measuring means B are integrated in the right direction. Rotated to
Furthermore, at the time of the right turn of the connected body,
The connecting body composed of the sawtooth gear (12g) and the push-up shaft (12s) is connected to the left side of the connecting body by engagement of the sawtooth gear (12g) and the vertical groove (12a) of the rotating cylinder (12r). The push-up shaft (12s) rises in a direction protruding with respect to the push-up nut (12n) by allowing the rotation to the left, and the raised push-up shaft (12s). Gives a compressive force to the powder medicine in the inner cylinder (11i), and the powder medicine is compressed to a predetermined density in the measuring hole,
By releasing the rotational force in the right direction applied to the lower main body (12) from this state, and then performing the operation of applying the rotational force in the left direction to the lower main body (12), By the powder transfer function of the measuring means B, a predetermined amount of the powder medicine measured in the measurement hole is transferred to a powder take-out unit arranged on the side of the powder measurement unit,
Further, along with the swirl flow generated by the gas introduced from the gas introduction hole (11h) in the powder delivery means D passing through the screw containing cylinder (11a) on which the diffusion member (11s) is mounted. An inhalation or injection administration kit characterized in that a predetermined amount of powder medicine is delivered from the powder delivery port of the mouthpiece (11m) to the outside.
[0012]
    [Improved Configuration of Inhalation or Injection Kit 1]
  SaidCompression member(12p)Is a piston or plungerIt is characterized byThe inhalation or injection administration kit according to [Basic configuration of inhalation or injection administration kit].
[0013]
    [Improved configuration 2 of inhalation or injection administration kit]
  SaidMeasurementMean BConfigureOne of the components is rotated integrally with the inclusion cylinder (11g),Compression member(12p)The weighing plate holder that receives the compression pressure when compressing the powdered medicine to a predetermined density(11b)IsIt is characterized byThe inhalation or injection administration kit according to [Basic configuration of inhalation or injection administration kit] and [Improved configuration 1 of inhalation or injection administration kit].
[0014]
    [Improved Configuration 3 of Inhalation or Injection Kit]
  SaidMeasurementOne of the elements constituting the means B isDefine the volume of the compressed powder drugHas a metering hole (11 vh)With a measuring plate (11v)There is a counterclockwise ratchet (11vr) formed on the outer peripheral edge of the measuring plate (11v), and it rotates in the right direction when the comprehensive cylinder (11g) is viewed from above with respect to the upper body (11). When this is done, the left-rotation prohibited ratchet (11vr) engages with the left-rotation prohibited ratchet (11ger) provided on the inner wall of the enlarged diameter portion (11ge) of the inclusion cylinder (11g). The cylinder (11g) and the measuring plate (11v) are integrally rotated and rotate rightward.The inhalation or injection administration kit according to [Basic configuration of inhalation or injection administration kit] and [Improved configuration 1 of inhalation or injection administration kit] and [Improved configuration 2 of inhalation or injection administration kit].
[0015]
    [Improved Configuration 4 of Inhalation or Injection Kit]
  SaidMeasurementOne of the elements constituting the means B isWith the measuring plate ratchet (11r)Yes,
A cylindrical projection (11rp) having a recess (11rpc) is provided at the center of the lower surface of the measurement plate ratchet (11r), and the recess (11rpc) rises from the center of the top surface of the measurement plate (11v). The large-diameter portion (11vxb) of the divergent shaft (11vx) is fitted, whereby the measurement plate ratchet (11r) and the measurement plate (11v) are integrally rotated to the right, and
A left-rotation prohibited ratchet (11rb) is formed on the outer peripheral edge of the measuring plate ratchet (11r), and the left-rotation prohibited ratchet (11rb) is provided on the inner wall surface near the upper end region of the upper body (11). In addition, the counterclockwise engagement with the left rotation prohibiting ratchet (11x) prevents rotation to the left as viewed from above the measuring plate ratchet (11r).The inhalation or injection administration kit according to [Basic configuration of inhalation or injection administration kit] and [Improved configuration 1 of inhalation or injection administration kit] to [Improved configuration 3 of inhalation or injection administration kit].
[0016]
    [Improved Configuration 5 of Inhalation or Injection Kit]
  SaidRotating cylinder(12r)A part of the inner wall of the busSaidSawtooth gear(12g)Mesh withSaidSawtooth flutes(12a)Is engravedIt is characterized byThe inhalation or ejection administration kit according to [Basic configuration of inhalation or ejection administration kit] and [Improved configuration 1 of inhalation or ejection administration kit] to [Improved configuration 4 of inhalation or ejection administration kit].
[0017]
    [Improved Configuration 6 of Inhalation or Injection Kit]
  SaidSawtooth gear(12g) and the push-up shaft (12s)Rotation in the upward directionThe male left-hand thread formed on the outer periphery of the push-up shaft (12s) and the female left-hand thread formed on the inner wall of the through-hole (12nh) of the push-up nut (12n) are permitted.The rotation in the downward direction isThe right rotation prohibiting ratchet (12gs) extending from the push-up nut (12n)prohibitedIt is characterized byThe inhalation or jet administration kit according to [Basic configuration of inhalation or jet administration kit] and [Improved configuration 1 of inhalation or jet administration kit] to [Improved configuration 5 of inhalation or jet administration kit].
[0018]
    [Improved Configuration 7 of Inhalation or Injection Kit]
  SaidInner cylinder(11i)But,Number of times the kit is used orSaidInner cylinder(11i)Provided with a display means for indicating the remaining amount of the powder medicine contained thereinIt is characterized byThe inhalation or jet administration kit described in [Basic configuration of inhalation or jet administration kit] and [Improved configuration 1 of inhalation or jet administration kit] to [Improved configuration 6 of inhalation or jet administration kit].
[0019]
    [Improved configuration of inhalation or injection administration kit 8]
  SaidGas introduction hole(11h)The pressure gas supply means was connected toIt is characterized byThe inhalation or ejection administration kit according to [Basic configuration of inhalation or ejection administration kit] and [Improved configuration 1 of inhalation or ejection administration kit] to [Improved configuration 7 of inhalation or ejection administration kit].
[0020]
DETAILED DESCRIPTION OF THE INVENTION
The means for fractionating the powder substance of the present invention is shown in the simplest form in FIG. In the drawings of the present invention, “up, down, left and right” are expressions for convenience of explanation. Further, in the present specification, the position of the mouthpiece and the side where the injection nozzle is located may be referred to as “upward”.
[0021]
In addition to the example of a container that is the simplest and most basic, and can repeatedly transfer a predetermined amount of powder to the delivery part as a mechanism that is knitted to operate each part or each member in principle without any interlocking relationship, As the most useful examples, an inhalation kit that can repeatedly administer a predetermined amount of powdered medicine into the oral cavity and an injection administration kit that injects into other body cavities such as the nasal cavity and other sites requiring treatment will be described below.
[0022]
FIG. 1 (a) can be used as an inhalation kit for a predetermined amount of powdered medicine into the oral cavity, but is a container capable of repeatedly delivering a predetermined amount of powder organized by the simplest and basic members and parts. Of course, for users who do not have the ability to inhale by themselves, as shown in FIG.PumpingIt is also possible to change the “inhalation kit” to the “injection administration kit” by attaching the gas containing member (Bb) to the gas introduction hole (Ah). The structure is roughly composed of a suction part (Am) positioned at the upper end part and a trunk part (Ak) extending downward from the lower end thereof, and a cylindrical part is provided on one side of the trunk part (Ak).Material(Ac) is formed, and a downward progression prohibition ratchet portion (Ar) is formed following the lower end of the cylindrical member (Ac).
[0023]
Cylindrical partMaterialA compression member (Ap) is inserted into (Ac) from below, and the cylindrical portionMaterial(Ac) The powder medicine accommodated in is compressed. What receives the compressive force is the lower surface of the partition wall (Amw) protruding from the inner wall of the suction portion (Am). Bottom surface of partition wall (Amw) and cylindrical partMaterialA measuring member (Av) is fitted between the upper end of (Ac), is slidable to the left and right, and is fitted as close to both parts as possible.
[0024]
Cylindrical partMaterial(Ac) or downEtThe inserted compression member (Ap) is pushed upward by a rod-like member (As) that pushes up the compression member (Ap) extending downward from the lower surface thereof, and performs a compression action. However, the rod-shaped member (As) quantitatively moves the compression member (Ap) upward, but must not return downward. In order to secure it, the lower end region of the rod-shaped member (As) is provided with one or more engaging teeth (Asr) for engaging with the downward-progress-prohibited ratchet portion (Ar).
[0025]
In FIG. 1 (a), the inhalation part (Am) is a so-called mouthpiece, and its opening (Ami) is closed about half of the cross-sectional area by a partition wall (Amw). A transport gas circulation hole (Amd) is formed. The shape of the flow hole (Amd) is a cylindrical member (Ac) provided in parallel therewith, which accommodates the powdered drug and also contributes to the compression of the upper end of the cylindrical member (Ac). It is important to agree.
[0026]
In FIG. 1 (a), the measuring member (Av) is an elongated plate-like member, and a through hole (Avh) is perforated at a substantially central portion thereof. The measuring member (Av) slides left and right in the insertion hole formed in the connecting portion between the base of the mouthpiece (Am) and the upper end of the trunk (Ak). The through hole (Avh) drilled in the measuring member (Av) functions as a measuring hole, and the powder medicine accommodated in the cylindrical member (Ac) is put into the measuring hole (Avh) by the compression member (Ap). When pushed in, it becomes a predetermined amount.
[0027]
At this time, when the head (Ave) provided at the end of the measuring member (Av) is pushed to the right side in the drawing and pushed to the base of the head (Ave) into the insertion hole, the measuring hole (Avh) is moved to the right. It is important that the position of the measuring hole (Avh) and the length of the measuring member (Av) are set so as to move in the same direction and coincide with the position of the flow hole (Amd) of the transport gas.
[0028]
As a result, the powder medicine compressed and filled in the measuring hole (Avh) moves into the gas flow hole (Amd). Next, the user uses the mouthpiece (Am: Opening in the suction part) Into the mouth of his / herself and breathe in strongly, the air sucked in from the gas introduction hole (Ah) blows up the powder medicine and transports it through the mouthpiece mouth (Ami).
[0029]
For this purpose, it is important to select the direction of the gas introduction hole (Ah) and the shape of the innermost part of the gas flow hole (Amd) so that the heavy powder drug can be sufficiently blown up. In FIG. 1, the gas introduction hole (Ah) is formed to have a relatively small diameter, is directed to the innermost part of the gas flow hole (Amd), and the innermost part is formed into a concave curved surface.
[0030]
In order to secure the quantitative compression action of the compression member (Ap), the engagement teeth engraved in the lower end region of the rod-like member (As) extending from the lower side to the lower side of the compression member (Ap) and its reversal are prohibited. However, it is necessary to cooperate with a locking means for advancing upward by a predetermined distance, in FIG. 1, a downward movement prohibiting ratchet (Ar).
[0031]
Of course, the locking means for moving upward by a predetermined distance while prohibiting the downward movement is not limited to the combination of the ratchet and the engaging teeth engaged therewith, and may be other locking means. A combination of a small hole drilled at a predetermined interval in the portion and a locking pin planted in the lower end region of the rod-shaped member (As) for insertion through the small hole can be used.
[0032]
The container (B) shown in FIG. 1 (b) has an injection nozzle (Bj) andPumpingThe gas containing member (Bb) is different from the container (A) shown in FIG. The container (B) shown in FIG. 1 (b) can be used as a kit for injecting a powder medicine into a body cavity other than the oral cavity, for example, into the nasal cavity, and most of the reference numerals given to each part are If the first symbol in FIG. 1A is replaced from “A” to “B”, this corresponds to FIG. In that case, it is sufficient to give a different code starting with “B” only to a portion (member) that does not exist in FIG.
[0033]
The container (B) shown in FIG. 1B is intended for a body cavity other than the oral cavity, for example, the “nose” as described above. Therefore, when using it, the injection of powder medicinenozzleInsert (Bj) into the nasal cavity and push the head (Bve) to the right to position the measurement hole (Bvh) on the measurement plate (Bv)The injection nozzleMatch the position of the gas flow path (Bji) in (Bj)PumpingA valve (not shown) provided at the neck of the gas delivery member (Bb) is opened to send pressurized gas from the gas introduction hole (Bh) to the gas flow passage (Bji).
[0034]
When this powder medicine injection kit (B) is used in the form of injection administration from below at the user's position, problems are unlikely to occur. However, when the user uses the device in the lying position, it is desirable to introduce the pressurized gas immediately when the measuring member (Bv) moves. However, this is unexpectedly difficult. In order to eliminate the difficulty, it is preferable to configure the kit so that the movement of the measuring member (Bv) and the opening of the valve are interlocked. As its specific configuration, since the end of the measuring member (Bv) opposite to the head (Bve) protrudes, an interlocking form in which the lever attached to the valve is pushed and moved is sufficient.
[0035]
<< Most practical and highly reliable powder drug administration kit >>
Preferred embodiments of the powder medicine inhalation or injection administration kit (1) of the present invention (sometimes abbreviated as “kit of the present invention”) will be specifically described below with reference to the drawings. FIG. 2 shows the state of the inhalation or injection administration kit of the present invention. FIG. 2 (a) shows the full-scale appearance, and FIG. 2 (b) shows that the overcap (C) of the kit (1) is removed.TheThe full size appearance of the state and (c) of FIG. 2 show a longitudinal section of the kit.
[0036]
The detailed configuration will be described based on the enlarged longitudinal sectional view of FIG. 2 (c) shown in FIG. In FIG. 3, the kit (1) of the present invention has a narrow end directed upwardsoAlthough FIG. 3 is an enlarged longitudinal sectional view of the kit (1) of the present invention, it is not a longitudinal sectional view by a single plane including the major axis, but the right half of FIG. The left half is a vertical cross-sectional view of a different plane that rises 60 degrees with respect to the plane.
[0037]
In addition, when it is difficult to understand the details of the structure only with FIG. 3, the cross-sectional view shown in FIG. 4 may be referred to. That is, each figure [(a)-(d)] of Drawing 4 is a transverse cross section which cut the kit of the present invention in various places (circle cut). The reason why the cutting plane showing the left half sectional view is different from the right half is that the axis of the saw-toothed gear (12g) whose rotation is prohibited is the same as the axis of the push-up shaft (12s). The purpose is to show the surface.
[0038]
<< Overcap (C) >>
Again, in FIG. 3, (C) is an overcap. The upper body (11) of the kit (1) of the present invention is protected and functions to isolate the upper body (11) from contamination and the like. On the inner wall of the lower end area of the overcap (C), there is provided means for engaging with the engaging means of the outer wall of the upper end area of the lower main body (12) of the kit (1) of the present invention. The most common engagement means is a female screw. However, the engaging means is not limited to screws, and other means such as bayonet mount can be used. The following describes the case where the overcap (C) is removed.
[0039]
<< Mouthpiece (11m) >>
The mouthpiece (11m) is located at the uppermost end of the kit of the present invention, and is cylindrical, and its outer wall is usually narrowed upward. The significance of the tapered shape comes from the convenience of inserting the mouthpiece (11m) into the mouth of the inhaler. Its inner wall (11mi) Middle to barrier (11mb) Overhangs to the length of the approximate radius.
[0040]
Barrier (11mbThe function of) is measured inside the kit and the powder medicine waiting to be sprayed collapses before being used in the inverted state with the right side of the kit down, and the powder medicine does not float in the gas at the time of subsequent inhalation The purpose is to prevent a sudden discharge.
[0041]
The lower end region of the mouthpiece (11m) is fitted in the upper end region of the upper body (11) of the kit (1) of the present invention. The means for locking both members is not limited to the illustrated screwing.
<< Upper body (11) >>
The upper main body (11) is a cylinder, and the outer wall of the upper end region is usually tapered, and a gas introduction hole (11h) is provided on the lower right side wall. The function of the gas inlet hole (11h) is to provide an inlet for a transport gas for inhalation. In addition, the left side wall of the upper body (11) is illustrated as being cut out long in parallel to the generatrix, but the function thereof is within the inner cylinder (11i) incorporated in the kit (1) of the present invention. In addition, the number of uses of the kit (1) of the present invention or the remaining amount of the powder medicine accommodated in the inner cylinder (11i) can be seen through from the outside of the kit. The means for making it possible to detect the number of uses of the kit (1) of the present invention or the remaining amount of the stored powder medicine from the outside of the kit is not limited to the above illustrated example, and may be another means. Hereinafter, various members housed in the upper main body (11) will be described.
[0042]
<< Inclusive cylinder (11g) >>
The inclusion cylinder (11g) is a cylinder mounted on the inner side of the upper body (11), and has an enlarged diameter portion (11ge) at the upper end region, and a measuring plate holder (11b) at the upper edge of the enlarged diameter portion (11ge). ) And the enlarged diameter portion (11ge) is usually provided with four notches (11gc) from its upper edge. This notchKi (11gc) is fitted with a hook (11bc) of a measuring plate holder (11b) described later. Furthermore, several left-rotation prohibited ratchets (11ger). The left-rotation prohibition ratchet (11ger) engages with a left-rotation prohibition ratchet (11vr) provided on the periphery of the later-described measuring plate (11v) and prohibits the left rotation.
[0043]
The inclusion cylinder (11g) is provided with notches (11gc) at its lower end (in the example of the present invention, 4 pieces with a width of 45 degrees), thereby projecting from the outer wall of the enlarged diameter portion (12ne) of the push-up nut (12n) described later. It fits into a notch (12nfc) provided on the flange (12nf) and rotates as a unit.
[0044]
<< Measurement plate ratchet (11r), measurement plate holder (11b), measurement plate (11v) >> The measurement plate ratchet (11r) is a circular plate and usually has a plurality of counterclockwise non-rotating ratchets (11rb) on the outer periphery. And two or more through holes (11rh). The number and position of the through holes (11rh) coincide with the number and position of the measurement holes (11vh) provided in the measurement plate (11v) described later. The measuring plate ratchet (11r) is attached to the upper end of the large-diameter portion inside the upper body (11). The function of the weighing plate ratchet (11r) is to rotate it clockwise with the later-described weighing plate (11v) located coaxially therewith. For this purpose, a cylindrical projection (11rp) is provided at the center of the lower surface of the measuring plate ratchet (11r), and for example, a triangular recess (11rpc) is provided therein. The shape of the recess (11 rpc) may be a quadrangular shape, but it is preferable to avoid a pentagonal shape or more in order to inhibit the rotation of the rod-shaped body accommodated in the portion.
[0045]
The measurement plate holder (11b) is provided in contact with the lower surface of the measurement plate ratchet (11r), and is a disc having a left-rotation prohibited ratchet (11bb) at the periphery thereof, and in addition to the outer periphery from the upper surface periphery. It has a large diameter ridge (11bf) that protrudes upward and rises upward.
[0046]
Usually, a plurality of notches having a thickness of about ½ or less from the lower surface of the ridge (11bf) are usually provided, and four in the illustrated embodiment. Further, a small-diameter through hole (11bhs) is formed in the disc region, and a large-diameter circular through-hole (11bhb) is formed on the outer side on the same radius. The diameter and position of the circular through hole (11bhb) are the same as those of the through hole (11rh) drilled in the measuring plate ratchet (11r).
[0047]
The small-diameter through hole (11bhs) and the large-diameter circular through-hole (11bhb) drilled on the same radius as the outside communicate with each other, and the width of the communicating portion is the same as the small-diameter through-hole (11bhs). It is enough. The function of this communicating portion is a divergent extending from the upper surface of the measuring plate (11v) that should be positioned in contact with the lower surface of the measuring plate holder (11b).axis (11vx) has a large-diameter portion (11vxb) penetrated and the small-diameter portion (11vxs) is moved to a small-diameter through hole (11bbhs) to be supported.
[0048]
The measuring plate (11v) is a circular plate, and usually has three measuring holes (11vh) penetrating therethrough and has a divergent shaft (11vx) rising from the center of the top surface. Suehiro rising from the center of the topaxis (The large diameter portion (11vxb) of 11vx has a triangular cross section, for example, and fits into a recess (11rpc) drilled at the center of a cylindrical projection (11rp) extending from the lower surface of the measuring plate ratchet (11r). Accordingly, the measuring plate (11v) is rotated integrally with the above-described measuring plate ratchet (11r) intermittently 120 degrees to the right. The small diameter portion (11vxs) of the divergent shaft (11vx) has a circular cross section and is accommodated in the small diameter through hole (11bhs) of the measuring plate holder (11b).
[0049]
The measuring plate (11v) is provided with a left-rotation prohibition ratchet (11vr) at the periphery thereof, and the left-rotation prohibition ratchet (11vr) is a left-rotation prohibition ratchet (11) provided on the inner wall of the enlarged diameter portion (11ge) of the comprehensive cylinder (11g).ger) And a turning force from the inclusion cylinder (11 g), and it rotates 120 degrees to the right.
[0050]
The function of the measuring plate (11v) is to measure the powder medicine accommodated in the inner cylinder (11i). That is, the piston (12p) fitted in the inner cylinder (11i) compresses and loads the powder medicine into the measuring hole (11vh) of the measuring plate (11v). There are usually three measuring holes (11vh) drilled in the measuring plate (11v) and their mutual positions are shown in FIG.Figure4 (c).
[0051]
Here, (a) of FIG. 4 is a state in which the shape that appears when the kit (1) of the present invention is cut along a cutting line AA that crosses the measuring plate (11v) is looked up in the direction of the arrow. FIG. 4B shows a state in which the shape that appears when the kit (1) of the present invention is cut along the cutting line BB crossing the gas introduction hole (11h) is looked up in the direction of the arrow.
[0052]
However, the measurement of the powder medicine is a joint work with the measuring plate holder (11b) in close contact with the back side (upper surface) of the measuring plate (11v). That is, the measuring plate holder (11b) functions to dam the powdered drug from the back side of the measuring plate (11v) so that the pressing force by the piston (12p) can be effectively exerted on the powdered drug.
[0053]
<< Inner cylinder (11i) >>
The inner cylinder (11i) is a cylindrical member whose inner diameter is the same over its entire length and is the same as the measuring hole (11vh). The inner cylinder (11i) is in close contact with the lower surface of the measuring plate (11v) at the upper edge, is in close contact with the lower surface of the measuring plate (11v), and faces the measuring hole (11vh). Its function is to contain the powder medicine inside.
[0054]
A piston (12p) is inserted from the lower side of the inner cylinder (11i). The function of the piston (12p) is to push up the powder medicine by a predetermined amount (predetermined distance). However, the piston (12p) cannot be raised independently, and is pushed up by a push-up shaft (12s) inserted into the piston (12p) from the downstream side. However, this push-up shaft (12s) is also pushed up by a mechanism described later.
[0055]
<< Screw receiving cylinder (11a) >>
In FIG. 3, a cylinder parallel to the inner cylinder (11i) and a screw accommodating cylinder (11a) can be seen. The function of the screw housing cylinder (11a) is also a gas flow path for transporting the transport gas introduced from the gas introduction hole (11h) to mix with the powdered medicine and to eject it from the mouthpiece (11m). For this purpose, the screw receiving cylinder (11a) is opened at a position corresponding to the gas introduction hole (11h) on the lower right side (11ah).
[0056]
A fixed screw (11s) is mounted in the screw accommodating cylinder (11a). The function of the fixed screw (11s) is to give a swirl to the air flow to float the powder medicine uniformly. Accordingly, the fixed screw (11s) itself does not rotate. The above is a complete exhaustion of the essential members housed in the upper body (11) of the kit (1) of the present invention. Therefore, hereinafter, the lower main body (12) of the kit (1) of the present invention and members mounted therein will be described.
[0057]
<< Lower body (12) >>
According to FIG. 3, the lower main body (12) is a member of the kit (1) of the present invention and is formed in a bottomed cylindrical shape. As described above, a male screw is engraved on the outer wall of the upper end region and is engaged with the female screw of the inner wall of the lower end region of the overcap (C). The function of the lower body (12) is to house a rotating cylinder (12r) and a push-up nut (12n) inside, and to turn the push-up nut (12n) directly by a post (12ps) rising from the inner wall of the bottom plate. It is in. The post (12 ps) is press-fitted into the push-up nut (12n).
[0058]
<< Rotating tube (12r) >>
First, a rotating cylinder (12r) is rotatably mounted in the lower main body (12) close to the inner wall. The rotating cylinder (12r) has an enlarged diameter portion (12re) in the upper end region, and has a flange (12rf) protruding from the middle of the outer wall of the enlarged diameter portion (12re).
[0059]
The function of this ridge (12rf) has several notches (12rfc) in the example of the present invention, and has a notch (12rfc) having a width of 45 degrees and is provided at the corresponding position at the lower end of the upper body (11). It is in close fitting with the notch (11fc) and rotating integrally with the upper body (11).
[0060]
Further, an undercut (12u) is projected from the outer wall closer to the upper end than the flange (12rf). The function of the undercut (12u) may prevent accidental detachment from the upper body (11) by engaging with a groove or a recess (11c) provided in the inner wall of the lower end region of the upper body (11). Is to further reduce.
[0061]
The outer wall other than the enlarged diameter portion (12re) of the rotating cylinder (12r) is provided with several flanges (12rf) so that the peripheral edges of the rotating cylinder (12rf) are in contact with the inner wall of the lower main body (12) and can be easily rotated. Realized. The function of the ridge (12rf) is to reduce friction. That is, the friction resistance that is too large when the entire outer wall of the rotating cylinder (12r) rotates while contacting the inner wall of the lower main body (12) is greatly reduced.
[0062]
<< Push-up shaft (12s) >>
A push-up shaft (12s) is first mounted inside the rotating cylinder (12r). The function of the push-up shaft (12s) is to lift the piston (12p) by moving up counterclockwise. That is, the rotating cylinder (12r) is rotated as shown in FIG. 4 (d), and the rotational force is sawn from the sawtooth vertical groove (12a) (ratchet ridge) provided on the inner wall thereof.ToothTell the car (12g) and rotate it.
[0063]
Due to this contribution, the push-up shaft (12s) engages with a male left screw carved on its outer wall and a female left screw carved on the inner wall of the through hole (12nh) of the push-up nut (12n). Get the driving force to climb. Here, (d) in FIG. 4 above is when the section of the lower body (12) of the kit (1) of the present invention cut along the cutting line DD closest to the bottom plate is viewed upward. It is a section that appears.
[0064]
<< Push-up nut (12n) >>
According to FIG. 4 (c), the upper end region of the push-up nut (12n) is composed of a substantially cylindrical outer shell and a portion protruding from the inner wall of the outer shell. A concentric double circle can be seen in this projecting portion, and the circle at the center shows a trough circle of screws engraved on the outer wall of the push-up shaft (12s) shown in FIG. The outer circle indicates a thread circle engraved on the outer wall of the push-up shaft (12s). FIG. 4 (c) is a cross section that appears when the section of the lower body (12) of the kit (1) of the present invention cut along the cutting line C-C at the middle is viewed upward. Section (c) in FIG. 4 includes a section of the push-up nut (12n).
[0065]
According to FIG. 4 (d), the lower part of the push-up nut (12n) is formed in a complicated shape than the enlarged diameter part (12ne). That is, in the cross-sectional shape, it consists of the combination of the right half of the hollow semicircle and the hollow quadrant. This is actually a tubular body with a sawtooth fluted groove (12a) in which a portion corresponding to a quarter of a cylinder is cut. The push-up shaft (12s) is housed in a state where the sawtooth gear (12g) and the right rotation prohibiting ratchet (12gs) prohibiting the right rotation are engaged with the sawtooth vertical groove (12a).
[0066]
The function of the sawtooth gear (12g) is to lift the inner wall of the rotating cylinder (12r) by rotating counterclockwise while receiving the driving force generated by the right rotation of the rotating cylinder (12r) as described above. is there. That is, a leftward turning force is received from the sawtooth vertical groove (12a) carved in the inner wall of the rotating cylinder (12r). On the other hand, a post (12 ps) rising from the bottom of the inner wall of the lower main body (12) is fitted into the tubular part (12nr) having a hollow semicircular cross section from below. The function of the post (12 ps) is to prevent free rotation of the push-up nut (12n), rotate it integrally with the rotating cylinder (12r), and fix the lower body (12) so that it does not come off. It is in.
[0067]
<< Material to form kit >>
On average, when the members constituting the kit of the present invention are in direct contact with the medicine and when the user operates with fingers, the material is required to be a polyolefin crystalline polymer according to the standards of the Ministry of Health and Welfare. However, in other cases, the necessity of being limited to this standard is lost, and an optimum material can be used in terms of formability, appearance, and the like.
[0068]
Next, the material for forming the multiple cylinder mechanism of the present invention in the case of using a medicine for inhalation will be described. The preferred materials for the polyolefin crystalline polymer, particularly polypropylene crystalline polymer, are as follows:
◆ Overcap (C), mouthpiece (11m), upper body (11), weighing plate holder (11b), weighing plate (11v), diffusion screw, screw-containing cylinder (11a), inclusion cylinder (11g), inner cylinder (11i), in addition to the compression member, in particular the piston (12p) and the lower body (12), exceptionally a rotating cylinder (12r);
Further, members that can be formed of an optimum material in terms of formability, appearance, and the like are as follows:
◆ Weighing plate ratchet (11r), Push-up nut (12n), sawtooth gear (12g) and push-up shaft (12s).
[0069]
[Action]
In the container (A) and the container (B) shown in FIG. 1 of the present invention, since there is almost no interlocking relationship between the respective members or the respective parts, description thereof is omitted here.
[0070]
The relationship between the members when the inhalation or injection administration kit (1) shown in FIG. 3 of the present invention is used will be described as follows. At this point it is assumed that the overcap (C) has been removed:
(1) When the lower main body (12) is rotated 120 degrees to the left, a post (12ps) Rotates the push-up nut (12n) counterclockwise around its central axis. At that time, the sawtooth gear (12g) cannot rotate clockwise. The reason is that it is prevented from rotating right by a right-rotation prohibiting ratchet (12gs) extending from the push-up nut (12n).
[0071]
Therefore, the saw-tooth gear (12g) does not rotate rightward, but tilts the saw-tooth vertical groove (12a) engraved on the inner wall surface of the rotating cylinder (12r) to the left.WhatIt slides and finally reaches the left end of the sawtooth flutes (12a). This is because the sawtooth flutes (12a) are formed of a material rich in elasticity.
[0072]
 (2) When the lower body (12) is rotated 120 degrees to the right, the post (12ps) fitted to the lower stage of the push-up nut (12n) rotates the push-up nut (12n) to the right around its central axis. Return to the original position. At that time, the sawtooth gear (12g) rotates counterclockwise while meshing with the sawtooth vertical groove (12a), and returns to the right end of the sawtooth vertical groove (12a) while ascending the inner wall of the rotating cylinder (12r).
[0073]
At the time of the left rotation, the push-up shaft (12s) is also turned to the left to obtain a rising force while engaging with the female left screw on the inner wall of the through-hole of the push-up nut (12n). As a result, the piston (12p) is pushed up by a predetermined height, and the powder (medicine) contained in the inner cylinder (11i) is caused by the cooperative action of the measuring plate (11v) and the measuring plate presser (11b) on the back side. Compressed.
[0074]
 (3) One or more left-rotation prohibited ratchets provided on the inner wall surface near the upper end region of the upper body (11) are one or more provided on the peripheral surface of the measuring plate ratchet (11r) attached thereto. Engage with the counterclockwise rotation ratchet to prohibit the counterclockwise rotation of the measuring plate ratchet (11r).
[0075]
On the other hand, one or more notches provided in the lower edge of the upper body (11) (four in the example of the present invention and 45 degrees wide) are provided on the outer wall of the enlarged diameter portion of the rotating cylinder (12r). It fits tightly with a notch (11bc) provided at the lower edge corresponding portion of (12rf) and rotates integrally with the rotating cylinder (12r).
[0076]
 (4) One or more notches (4 in the example of the present invention, 45 degrees in width) provided at the upper edge of the enlarged diameter part of the inclusion cylinder (11g) correspond to the lower edge of the flange part of the measuring plate holder (11b) It fits closely with the notch (11bc) provided on the base plate and rotates together with the weighing plate holder (11b). On the other hand, one or more notches (4 in the example of the present invention, 45 degrees in width) provided at the lower edge of the inclusion cylinder (11g) are provided at the corresponding positions of the flange (12nf) of the push-up nut (12n). Further, it closely fits with one or more notches (four in the example of the present invention, 45 degrees in width) and rotates together with the push-up nut (12n).
[0077]
【The invention's effect】
The simplest container of the present invention capable of repeatedly delivering a predetermined amount of powder can be applied to a powder medicine. Therefore, instead of explaining the effect, it will be described below that the powder drug inhalation or injection administration kit of the present invention has the following various effects:
(1) According to the composite mechanism, powder can be separated by compression weighing and a predetermined amount of powder can be transferred to the next process each time.
(2) According to the kit, the powder medicine can be fractionated by compression weighing, and a predetermined amount of powder medicine can be supplied to the inhaler each time.
(3) A predetermined amount of powdered medicine can be supplied to the inhaler each time by a simple operation from a portable kit. The number of times that the kit can be supplied reaches about 60 in the current specification. Furthermore, a large number of times of supply can be easily realized by a slight change in specifications.
(4) In the gas introduction holePumpingIf the supply port of the gas containing member is connected, it can be easily changed to a jet administration kit.
[Brief description of the drawings]
FIG. 1 is a schematic longitudinal sectional view of an inhalation or injection administration kit (A) and an injection supply kit (B) of the present invention, and FIG. 1 (a) is an inhalation or injection administration kit ( It is a typical longitudinal cross-sectional view of A), (b) of FIG. 1 is a schematic longitudinal cross-sectional view of the injection supply kit (B) of this invention.
2 shows the state of the inhalation or injection administration kit (1) of the present invention, FIG. 2 (a) is the full-scale appearance, and FIG. 2 (b) is the removal of the overcap of the kit (1). The full size appearance of the state and (c) of FIG. 2 show a longitudinal section of the kit.
FIG. 3 is a longitudinal sectional view of the kit (1) of the present invention, but is not a longitudinal sectional view by a single plane including an axis, but the right half of FIG. 3 is a longitudinal section by a plane included in the paper surface. The left half of the figure is a vertical cross-sectional view of another plane that rises 60 degrees with respect to the plane.
FIG. 4 is a cross-sectional view of the kit of the present invention cut (rounded) in various places. 4 (a) is a cross-sectional view of the surface of the kit according to the present invention cut along the cutting line AA at the position of the measuring plate, and the surface that appears in the direction of the arrow, and FIG. 4 (b) is the kit according to the present invention. FIG. 4C is a cross-sectional view of the surface that appears by cutting along the cutting line B-B at the expected introduction hole position, and FIG. 4C shows the cutting line C-C at the position of the push-up nut of the kit of the present invention. Sectional drawing which looked up at the surface which cut | disconnects in FIG. FIG. 4 (d) is a cross-sectional view of the surface of the kit of the present invention that is cut off at the position of the bottom surface along the cutting line DD and looking up in the arrow direction.
[Explanation of symbols]
1 Whole powder inhalation or injection administration kit of the present invention
11 Upper body of the powder inhalation or injection administration kit of the present invention
12 Lower body of the powder inhalation or injection administration kit of the present invention
11a Screw-containing cylinder of the powder inhalation or injection administration kit of the present invention
11b Measuring plate holder of powder inhalation or injection administration kit of the present invention
11 g Powder inhalation or jet administration kit inclusive cylinder of the present invention
11h Gas introduction hole on the side wall of the powder inhalation or injection administration kit of the present invention
11i Inner cylinder of the powder inhalation or injection administration kit of the present invention
11m Mouthpiece of the powder inhalation or injection kit of the present invention
11r Measuring plate ratchet of powder inhalation or injection administration kit of the present invention
11s Fixed screw of powder inhalation or injection administration kit of the present invention
11v Measuring plate of powder inhalation or injection administration kit of the present invention
12r Rotating cylinder of powder inhalation or injection administration kit of the present invention
12n Push-up nut of powder inhalation or injection administration kit of the present invention
12s Push-up shaft of powder inhalation or injection administration kit of the present invention
12g sawtooth gear of powder inhalation or injection administration kit of the present invention
12p Piston for compression of the powder inhalation or injection administration kit of the present invention
11ah Gas introduction hole on the side wall of the inclusion cylinder of the powder inhalation or injection administration kit of the present invention
11bb Ratchet that prohibits counterclockwise rotation on the periphery of the weighing plate holder
11bc Measuring plate holder
11bf Large-diameter bowl protruding upward from the periphery of the upper surface of the weighing plate holder
11gc Notch in the upper edge of the expanded part of the comprehensive cylinder
11ge Increasing cylinder diameter
11rb Ratchet of ratcheting plate ratchet
11rh Measuring plate ratchet through-hole
11rp Cylindrical protrusion provided on the bottom surface of the measuring plate ratchet
11vh Measuring hole of measuring plate
11vr Ratchet that prohibits counterclockwise rotation of measuring plate
11vx divergent shaft extending from the top of the measuring plate
12 ps Post of powder inhalation or injection administration kit of the present invention
12re Diameter expansion part of the rotating cylinder
12rf Rotating barrel
12gs Raised ratchet of right-handed sawtooth gear at the bottom of push-up shaft
12nf push nut nut
11bhb Large-diameter through-hole drilled in measuring plate holder
11bhs Small-diameter through-hole drilled in measuring plate holder
11ger Enclosed cylinder expanded part left rotation prohibited ratchet
11rpc Triangular recess in the center of the cylindrical projection on the bottom of the measuring plate ratchet
11vxb Large diameter part of the divergent shaft rising from the top of the measuring plate
11vxs Small diameter part of the divergent shaft rising from the top of the measuring plate
12rfc Notch provided in the punch of the push-up nut
A Powder inhalation kit (A) of the present invention itself
B. Powder injection supply kit (B) of the present invention itself
C Overcap
Ac The cylindrical part of the powder inhalation kit (A) of the present invention
Ak Basic part of the powder inhalation kit (A) of the present invention
Ap Compression member of the powder inhalation kit (A) of the present invention
Am Inhalation part of the powder inhalation kit (A) of the present invention
Ar A ratchet forbidden to move downward engraved in the lower half of the backbone of the powder inhalation kit (A) of the present invention
As A rod-shaped member for pushing up the compression member of the powder inhalation kit (A) of the present invention
Av Metering member of the powder inhalation kit (A) of the present invention
Amd Gas flow path inside the suction part of the powder inhalation kit (A) of the present invention
Ami Opening in the inhalation part of the powder inhalation kit (A) of the present invention
Amw Partition wall inside the suction part of the powder inhalation kit (A) of the present invention
Asr engaging tooth in the lower end region of the rod-shaped member of the powder inhalation kit (A) of the present invention
Ave Head at the end of the measuring member of the powder inhalation kit (A) of the present invention
Avh Measuring hole in measuring member of powder inhalation kit (A) of the present invention
Bj Injection unit in the powder injection supply kit (B) of the present invention
Bb Pressurized gas storage member mounted on the powder injection supply kit (B) of the present invention
Bc The cylindrical part of the powder injection supply kit (B) of the present invention
Bk Core part of the powder injection supply kit (B) of the present invention
Bp Compression member of powder injection supply kit (B) of the present invention
Br Downward movement prohibition ratchet carved in the lower half of the backbone of the powder injection supply kit (B) of the present invention
Bs Bar-shaped member for pushing up the compression member of the powder injection supply kit (B) of the present invention
Bv Metering member of powder injection supply kit (B) of the present invention
Bji Opening of injection part in powder injection supply kit (B) of the present invention
Bjd Gas flow path inside the injection section of the powder injection supply kit (B) of the present invention
Bsr engaging tooth in the lower end region of the rod-like member of the powder injection supply kit (B)
Bve Head at the end of the measuring member of the powder injection supply kit (B) of the present invention
Bvh Metering hole in metering member of powder injection supply kit (B) of the present invention

Claims (14)

A compression member that compresses the powder contained in the cylindrical member to a predetermined density by moving linearly ;
It is arranged to be able to reciprocate between a powder metering section configured at the end of the moving area of the compression member and a powder delivery section configured at the end side of the moving area of the compression member, and opposed to the compression member And a measuring member formed with a measuring hole functioning as the powder measuring unit ,
Part of the powder contained in the cylindrical member is introduced into the measuring hole of the measuring member, and a predetermined amount of powder compressed in the measuring hole by the movement of the compression member is moved to the measuring member. Along with this, the powder is transferred from the powder measuring unit to the powder sending unit, and after emptying a predetermined amount of powder transferred to the powder sending unit, the measuring member is returned to the original position to enable repeated operation. a predetermined amount repeatedly dispensing container capable of powder wherein a. The container according to claim 1, wherein the compression member is a piston or a plunger, and the compression member is movable only in a direction approaching the measuring member. The metering member has a plate thickness that is substantially the same as the moving distance per time of the compression member, and cooperates with a pressure receiving member that receives a pressing force to compress the powder, whereby a predetermined amount of powder is distributed. The container according to claim 1 or 2, wherein a predetermined amount of the powder can be repeatedly delivered. The said cylindrical member is equipped with the display means which shows the frequency | count of sending out of the powder accommodated in the said cylindrical member, or the residual amount of powder, The place of the powder in any one of Claims 1-3 characterized by the above-mentioned. A container that can be sent repeatedly in a fixed quantity. The gas introduction hole is formed in the powder feeding unit, together with the coupling pumping gas supply means to the gas introduction hole, claim 1-4 for, characterized in that the formation of the injection portion of the powder feeding unit to the nozzle shape A container capable of repeatedly delivering a predetermined amount of the powder according to any one of the above. The outer body is constituted by the upper main body (11) formed in a substantially cylindrical shape and the bottomed cylindrical lower main body (12) rotatably attached to the upper main body (11). A mouthpiece (11m) having a powder delivery port is attached to the upper end of the upper body (11),
  The upper body (11) includes a transparent window hole that runs in the vertical direction on the side wall thereof,
  The mouthpiece (11m) includes a barrier (11mb) that closes a part of the opening area in the middle of the inner wall, and a barrier (11mc) that substantially blocks the remaining opening area at the lower end region thereof,
  Inside the outer shell,
  Powder compression means A for compressing the contained powder medicine to a predetermined density,
  Weighing means B for dispensing a predetermined amount of powder medicine from the powder medicine compressed by the powder compression means A;
  Force transmitting means C for transmitting external force applied to compress the powder to the powder compressing means A;
  A powder delivery means D for delivering a predetermined amount of the powder medicine compressed by the powder compression means A to the outside with the introduction of gas;
  The powder compression means A includes an inner cylinder (11i) housed in a comprehensive cylinder (11g), a compression member (12p) inserted from the lower end side of the inner cylinder (11i), and a lower end of the inner cylinder (11i). A push-up shaft (12s) inserted from the side to push up the compression member (12p),
  The measuring means B is disposed on the upper end side of the inner cylinder (11i), and is centered on the center. A metering hole that functions as a powder metering unit is formed at a position that is equiangularly spaced, and after releasing the force applied to compress the powder drug measured in the metering hole, Having a powder transfer function of transferring to a powder take-out unit configured on the side of the powder metering unit;
  The force transmission means C is
  The lower body (12);
  A post (12 ps) integrally standing upward from the bottom surface of the lower body (12);
  A push-up nut (12n) with a hollow quadrant lacking in cross-sectional shape and an internal cavity with a shape substantially complementary to the outer shape of this post (12ps) in the remaining part;
  A rotating cylinder (12r) disposed concentrically outside the push-up nut (12n);
  A sawtooth gear (12g) disposed in a portion where a part of the hollow quadrant push-up nut (12n) is missing;
  It is inserted into a central through hole formed in the sawtooth gear (12g), and a male left screw is formed on the entire outer wall of the sawtooth gear (12g). ) A push-up shaft (12s) engaged with a female left-hand thread formed on the inner wall;
  A ratchet mechanism configured between the sawtooth gear (12g) and a sawtooth vertical groove (12a) formed on the inner wall of the rotating cylinder (12r),
  The powder delivery means D includes
  A gas inlet (11h) formed in the side wall of the upper body (11);
  The gas introduced into the inclusion cylinder (11g) having a gas inlet (11ah) on the side wall and introduced through the gas inlet (11h) and the gas inlet (11ah) into the mouthpiece (11m). A screw housing cylinder (11a) that can be delivered;
  A diffusion member (11s) mounted in the screw housing cylinder (11a) and swirling the gas introduced into the screw housing cylinder (11a);
  When the lower body (12) is rotated in the right direction when viewed from above with respect to the upper body (11),
  The rightward rotational force applied to the lower body (12) is transmitted to the post (12ps) through the lower body (12), whereby the post (12ps) is integrated with the lower body (12). And a rotational force is further transmitted from the post (12 ps) to the push-up nut (12n), whereby the push-up nut (12n) is transferred to the lower body (12) and the post (12ps). ) Together with the sawtooth gear (12g) and the push-up shaft (12s) when the push-up nut (12n) is turned right together with the push-up nut (12n). Revolves rightward around the central axis of the outer shell,
  And at the time of the right turn of this connected body,
  The lower main body (12), the post (12ps), the push-up nut (12n), the sawtooth gear (12g), the inclusion cylinder (11g), and the members constituting the measuring means B are integrated in the right direction. Rotated to
  Furthermore, at the time of the right turn of the connected body,
  The connecting body composed of the sawtooth gear (12g) and the push-up shaft (12s) is connected to the left side of the connecting body by engagement of the sawtooth gear (12g) and the vertical groove (12a) of the rotating cylinder (12r). The push-up shaft (12s) rises in a direction protruding with respect to the push-up nut (12n) by allowing the rotation to the left, and the raised push-up shaft (12s). Gives a compressive force to the powder medicine in the inner cylinder (11i), and the powder medicine is compressed to a predetermined density in the measuring hole,
  By releasing the rotational force in the right direction applied to the lower main body (12) from this state, and then performing the operation of applying the rotational force in the left direction to the lower main body (12), By the powder transfer function of the measuring means B, a predetermined amount of the powder medicine measured in the measurement hole is transferred to a powder take-out unit arranged on the side of the powder measurement unit,
  Furthermore, along with the swirl flow generated by the gas introduced from the gas introduction hole (11h) in the powder delivery means D passing through the screw accommodating cylinder (11a) on which the diffusion member (11s) is mounted. An inhalation or injection administration kit, wherein a predetermined amount of powder medicine is delivered from the powder delivery port of the mouthpiece (11m) to the outside. Inhalation or injection administration kit according to claim 6, wherein the compression member (12p) is a piston or plunger. One of the components constituting the metering means B is rotated together fitted with the comprehensive cylinder (11g), in a position opposite to the compression member (12p), the powder medicament predetermined density The inhalation or injection administration kit according to claim 6 or 7, wherein the inhalation or injection administration kit is a measuring plate presser (11b) for receiving a compression pressing force at the time of compression. One of the elements constituting the metering means B is a measuring hole defining the volume of compressed powder medicine metering plate having a (11vh) (11v), the outer peripheral edge of the metering plate (11v) is A left-rotation prohibited ratchet (11vr) is formed, and when the inclusion cylinder (11g) is rotated to the right when viewed from above with respect to the upper body (11), the left-rotation prohibited ratchet (11vr) , Engaged with the left rotation prohibition ratchet (11ger) provided on the inner wall of the enlarged diameter portion (11ge) of the inclusion cylinder (11g), whereby the inclusion cylinder (11g) and the measuring plate (11v) are integrated. inhalation or injection administration kit according to any one of claims 6-8, characterized in that rotates in the right direction becomes. One of the elements constituting the metering means B is a metering plate ratchet (11r),
A cylindrical projection (11rp) having a recess (11rpc) is provided at the center of the lower surface of the measurement plate ratchet (11r), and the recess (11rpc) rises from the center of the top surface of the measurement plate (11v). The large-diameter portion (11vxb) of the divergent shaft (11vx) is fitted, whereby the measurement plate ratchet (11r) and the measurement plate (11v) are integrally rotated to the right, and
A left-rotation prohibited ratchet (11rb) is formed on the outer peripheral edge of the measuring plate ratchet (11r), and the left-rotation prohibited ratchet (11rb) is provided on the inner wall surface near the upper end region of the upper body (11). 10. The left rotation prohibiting ratchet (11x) is engaged, whereby rotation to the left as viewed from above the measuring plate ratchet (11r) is prohibited. The inhalation or injection administration kit as described. Claims, characterized in that said sawtooth longitudinal groove the over part substantially the whole length of its generatrix length of the inner wall surface of the rotary sleeve (12r) meshing with the serrated wheel (12g) (12a) is carved Item 10. The inhalation or ejection kit according to any one of Items 6 to 10. The sawtooth gear (12g) and the push-up shaft (12s) are rotated in the ascending direction by a male left screw formed on the outer periphery of the push-up shaft (12s) and a through hole (12nh) of the push-up nut (12n). is allowed by the engagement between the female left thread formed on the inner wall, the rotation in the direction of descending, characterized in that it is prohibited by the push-up right rotation inhibiting ratchet extending from the nut (12n) (12gs) The inhalation or ejection administration kit according to any one of claims 6 to 11. The inner tube (11i) is any one of claims 6-12, characterized in that it comprises a display means for indicating the remaining amount of the powdered medicament contained in the number of uses or the inner tube (11i) of the kit An inhalation or ejection administration kit according to 1. Inhalation or ejection administration kit according to any one of claims 6 to 13, characterized in that the concatenation of the pumping gas supply means to the gas introduction hole (11h).

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