JP3645920B2 - Water-soluble pesticide granules - Google Patents
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Description
【０００１】
【産業上の利用分野】
本発明は、ニテンピラムなどの水溶性農薬活性成分を含有する安定化された水溶性顆粒剤に関する。本発明の製剤は、農業の分野で病害虫防除の目的で使用される。
【０００２】
【従来の技術】
ニテンピラム（nitenpyram, (E)-N-（６-クロロ-３-ピリジルメチル）-N-エチル-N'-メチル-２-ニトロビニリデンジアミン）は、優れた害虫防除能力を有する農業用殺虫剤であり、他の殺虫剤、あるいは殺菌剤などと混合することができ、鉱物性粉末、水溶性の担体、増量剤などと混合して、粉剤、粒剤、水和剤、水溶剤、顆粒剤などの種々の固形製剤として用いることができる（特開平２−１７１号公報）。
その中で、水溶性農薬顆粒剤は、水に完全にかつ容易に溶解する粒剤であり、取り扱いの容易さ、計量の容易さ、粉塵防止、施用の簡便さの点で優れた製剤である。例えば、乳糖を増量剤として配合されている優れたテンピラム含有水溶性顆粒剤が提案されている（特開平６−９２８０３号公報）。
さらに、水溶性顆粒剤におけるニテムピラムの分解がより抑制され、より安定化された水溶性顆粒剤の開発が望まれていた。
【０００３】
【発明が解決しようとする課題】
本発明は、ニテムピラムなどの水溶性農薬活性成分の分解を抑制することができる新規な水溶性農薬顆粒剤を提供することを目的とする。特に、水溶性顆粒剤の特徴である水への易溶性を損なうことなく、水溶性活性成分の保存安定性を向上させた顆粒剤を提供することを目的とする。
【０００４】
【課題を解決するための手段】
本発明者らは、上記の課題を解決するために鋭意検討した結果、ニテンピラムに水溶性弱塩基性物質を配合し、湿式造粒することによって、予想外にも、ニテンピラムの安定な水溶性農薬顆粒剤が得られることを見いだした。さらに、本発明者らは、ニテムピラムに限らず他の水溶性農薬活性成分に適用しても安定な水溶性農薬顆粒剤が得られることを見いだし、さらに検討を重ねた結果、本発明を完成するに至った。すなわち、本発明は、
（１）水溶性農薬活性成分および水溶性弱塩基性物質を含有することを特徴とする水溶性顆粒剤、
（２）水溶性農薬活性成分が２０℃における水に対する溶解度が０．０１ｇ／ｍｌ以上の水溶性農薬活性成分である第（１）項記載の水溶性顆粒剤、
（３）水溶性農薬活性成分がニテムピラムである第（１）項記載の水溶性顆粒剤、
（４）水溶性弱塩基性物質が２０℃における水に対する溶解度が０．０５ｇ／ｍｌ以上であり且つ２５℃における水溶液のｐＨが約７．０〜９．０の水溶性弱塩基性物質である第（１）項〜第（３）項記載の水溶性顆粒剤、
（５）２０℃における水に対する溶解度が０．０５ｇ／ｍｌ以上であり且つ２５℃における水溶液のｐＨが約７．０〜９．０の水溶性弱塩基性物質が、チオ硫酸ナトリウム、リン酸水素２ナトリウム、酢酸ナトリウム、炭酸ナトリウムおよび重曹から成る群から選ばれる１種または２種以上である第（４）項記載の水溶性顆粒剤、および
（６）水溶性顆粒剤全量に対して、水溶性農薬活性成分を約５〜９５重量％、水溶性弱塩基性物質を約１５〜９４重量％含有することを特徴とする第（１）項記載の水溶性顆粒剤を提供する。
【０００５】
さらに具体的には、
（６）水溶性農薬活性成分がアルカリ性条件下において安定な水溶性農薬活性成分である第（１）項または第（２）項記載の水溶性顆粒剤、
（７）水溶性農薬活性成分がニテンピラム、アレスリン、アセフェ−ト、ＥＳＰ（オキシデプロポス）、バミドチオン、ＤＥＰ（トリクロルホン）、バリダマイシンＡ、ジクワットおよびビアラホスから成る群から選ばれる１種または２種以上の水溶性農薬活性成分である第（１）項記載の水溶性顆粒剤、
（８）さらに界面活性剤を含有する第（１）項〜第（７）項記載の水溶性顆粒剤、
（９）界面活性剤が、ＨＬＢ値が約９〜１２の非イオン性界面活性剤である第（８）項記載の水溶性顆粒剤、
（１０）ＨＬＢ値が約９〜１２の非イオン性界面活性剤が、ポリオキシエチレンノニルフェニルエーテル、または酸化エチレンと酸化プロピレンのブロック共重合物である第（９）項記載の水溶性顆粒剤、および
（１１）水溶性顆粒剤全量に対して、界面活性剤を約０．０５〜５重量％含有することを特徴とする第（８）項記載の水溶性顆粒剤を提供する。
【０００６】
本発明の水溶性顆粒剤に用いられる水溶性農薬活性成分としては、例えば２０℃における水に対する溶解度が約０．０１ｇ／ｍｌ以上、好ましくは約０．１ｇ／ｍｌ以上の農薬活性成分などが用いられ、該農薬活性成分としては、例えば殺虫剤、殺菌剤、除草剤などのあらゆる農薬活性成分が用いられる。これらの水溶性農薬活性成分のなかでも、アルカリ性条件下において不安定なものは適当ではなく、アルカリ性条件下において安定な水溶性農薬活性成分が好適である。本発明の水溶性顆粒剤においては、これら水溶性農薬活性成分を１種または２種以上用いることができる。本発明の水溶性顆粒剤に用いられる水溶性農薬活性成分としては、具体的には、例えば、以下のものなどが挙げられる。
【０００７】
本発明の水溶性顆粒剤に用いられる水溶性弱塩基性物質は、特に限定されるものではないが、例えば２０℃における水に対する溶解度が０．０５ｇ／ｍｌ以上で且つ２５℃における水溶液のｐＨが約７．０〜９．０であるものなどが好適である。具体的には、例えばチオ硫酸ナトリウム、リン酸水素２ナトリウム、酢酸ナトリウム、炭酸ナトリウムおよび重曹などから成る群から選ばれる１種または２種以上のものが用いられる。該水溶性弱塩基性物質のグレードは、局方、工業用、食品添加物など何れのものでも用いることができ、さらに結合水の有無にもこだわらず用いることができる。
本発明の水溶性顆粒剤に用いられる水溶性農薬活性成分の含有量は、顆粒剤全量に対して通常約５〜９５重量％、好ましくは約５〜８０重量％である。
本発明の水溶性顆粒剤に用いられる水溶性弱塩基性物質の含有量は、顆粒剤全量に対して通常約１５〜９４重量％、好ましくは約３０〜９０重量％である。
本発明の水溶性顆粒剤は、さらに界面活性剤、色素、結合剤、紫外線吸収剤などの水溶性補助剤を含有してもよい。
【０００８】
該界面活性剤としては、特に限定されるものではないが、非イオン性界面活性剤が比較的好ましく用いられる。特に、ＨＬＢ値が約９〜１２の範囲のものは、水に対する溶解度や湿潤作用の点からみて好ましい。具体的には、例えば、ポリオキシエチレンノニルフェニルエーテル（例：ＮＰ−８５（商品名）、竹本油脂（株）社製等）や酸化エチレンと酸化プロピレンのブロック共重合物（例：ニューポールＰＥ−６４（商品名）、三洋化成（株）社製等）などが用いられる。
該色素としては、具体的にはシアニングリーンＧ（商品名）（住友化学工業（株）社製）などが用いられる。
該結合剤としては、具体的にはデキストリン、ポリビニルアルコール、アラビアガム、アルギン酸ナトリウム、ポリビニルピロリドン、グルコース、ショ糖、マンニトール、ソルビトールなどが用いられる。
これらの他の水溶性補助剤の水溶性顆粒剤中の含有量は、水溶性顆粒剤全量に対して界面活性剤は通常約０．０５〜５重量％、好ましくは１．０〜３．０重量％の範囲であり、色素は通常約０．０１〜０．５重量％、好ましくは約０．０１〜０．１重量％の範囲であり、結合剤は通常約０．５〜１０．０重量％、好ましくは約２．０〜７．０重量％の範囲で選択される。
【０００９】
本発明の水溶性顆粒剤は、通常の水溶性顆粒剤の製造法に従って製造することができる。例えば、噴霧乾燥法または湿式押し出し造法を用いて製造することができる。
噴霧乾燥法の場合、１００重量部の製剤固形分に対して通常約５０〜１０００重量部の水を加えて溶解し、その水溶液を噴霧乾燥で粉末顆粒化し、水溶性顆粒剤を得る。具体的には、水溶性農薬活性成分、水溶性弱塩基性物質、必要であれば界面活性剤等その他の水溶性補助剤を十分に溶解する程度の量の水に溶解し、この水溶液を噴霧乾燥して水溶性顆粒剤を得る。あるいは、水溶性農薬活性成分、水溶性弱塩基性物質を適量の水に溶解し、噴霧乾燥後に界面活性剤等その他の水溶性補助剤を加えて混合してもよい。また、この噴霧乾燥品を後述する湿式押し出し造粒に用いてもよい。得られた顆粒は、その粒子径が約０．０５〜１．０ｍｍ、好ましくは約０．１〜０．５ｍｍの範囲のものが好適である。
湿式押し出し造粒の場合は、１００重量部の製剤固形分に対して通常約１〜１０重量部、好ましくは約２〜５重量部の水を使用して製造する。具体的には、水溶性農薬活性成分、水溶性弱塩基性物質、必要であれば界面活性剤等その他の水溶性補助剤を混合機等によって均一に混合する。この際、固形成分の粒子径が大きく均一に混合できない場合は粗粉砕等により１００μｍ以下程度の適度な粉末にし、混合操作を容易にしておくことが望ましい。この混合物に適量の水を加え、後工程の押し出し造粒に適する程度にまで更に混合機で練る。この混練物を通常の押し出し造粒機で顆粒化後乾燥する。必要により造粒物を整粒し、所望の水溶性顆粒剤を得る。整粒は、目開き３００μｍの篩を通過せず、１，７００μｍの篩を通過する範囲で行われる。得られた顆粒は、その長径が約０．５〜１０．０ｍｍ、好ましくは約０．５〜５．０ｍｍの範囲のものが好適である。
【００１０】
また、この顆粒の嵩密度は通常約０．１〜１．２ｇ／ｍｌの範囲が好ましく、さらには約０．５〜１．０ｇ／ｍｌの範囲が好ましい。
このようにして得られる本発明の水溶性顆粒剤は、植物に対して薬害が実質的に無く、また人や動物に対しても施用時または施用後に害はなく安全に使用できる。そして、本発明の水溶性顆粒剤は、水溶性顆粒剤の特徴である水への易溶性を損なうことなく、水溶性農薬活性成分の保存安定性が向上させられている。
本発明の水溶性顆粒剤は、通常、水に用時溶解希釈して使用する。その希釈は、特に限定する必要はないが、通常約１００〜２，０００倍程度（約１ｇ／１００ｍｌ〜１ｇ／２，０００ｍｌ）が好ましい。そして、この希釈液の散布量は、水溶性農薬活性成分、対象害虫、対象農地、季節などによって異なるが、通常、水田、お茶畑や野菜畑などの畑、果樹園など１ヘクタール当たり約５００〜１５０００ｍｌ、好ましくは１０００〜１００００ｍｌ程度散布する。
【００１１】
【実施例】
以下に、実施例、参考例、試験例を記載して、本発明をより詳細に説明するが、本発明がこれらの例に限定されるものではない。なお、ここにおいて用いられる％および部は、特に記載がない限り全て重量％および重量部を示す。
【実施例】
以下に実施例、比較例、実験例を記載し本発明を更に詳細に説明するが本発明がこれらの例に限定されるものではない。なお、ここにおいて用いられる％および部は特に記載がない限り全て重量％および重量部を示す。
【実施例１】
ニテンピラム１０部、チオ硫酸ナトリウム９０部を４００部の水に溶解し、この水溶液を噴霧乾燥装置（大川原化工機、Ｌ-８）にて固形顆粒化し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【実施例２】
実施例１のチオ硫酸ナトリウム９０部の代わりにリン酸水素２ナトリウム９０部とし、実施例１と同様の手順で噴霧乾燥し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【実施例３】
実施例１のチオ硫酸ナトリウム９０部の代わりに酢酸ナトリウム９０部とし、実施例１と同様の手順で噴霧乾燥し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【実施例４】
実施例１のチオ硫酸ナトリウム９０部の代わりに炭酸ナトリウム９０部とし、実施例１と同様の手順で噴霧乾燥し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【００１２】
【実施例５】
実施例１のチオ硫酸ナトリウム９０部の代わりに重曹９０部とし、実施例１と同様の手順で噴霧乾燥し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【実施例６】
ニテンピラム１０部、界面活性剤ニューポールＰＥ-６４ 1.０部、色素シアニングリーンＧ ０.１５部、結合剤ショ糖 ５.０部、重曹 ８３.８５部を十分混合した後、４部の水を加え練合機（菊水製作所、ＫＭ-１.５）で練合した。この練合物を０.８mm径のスクリーンを用い、押し出し造粒機（菊水製作所、ＲＧ-５Ｍ）にて円柱状の顆粒に造粒した。得られた顆粒を６０℃で１時間乾燥してニテンピラム１０％を含有する水溶性顆粒剤を得た。
【実施例７】
実施例６の重曹８３.８５部の変わりに酢酸ナトリウム１０部及び重曹７３.８５部とし、実施例６と同様の手順で押し出し造粒し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【参考例１】
実施例１のチオ硫酸ナトリウム９０部の代わりに乳糖９０部とし、実施例１と同様の手順で噴霧乾燥し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【参考例２】
実施例６の重曹 ８３.８５部の代わりに乳糖８３.８５部とし、実施例６と同様の手順で押し出し造粒し、ニテンピラム１０％を含有する水溶性顆粒剤を得た。
【００１３】
【試験例】
上記に示した実施例１〜７および比較例１〜２によって製造された水溶性顆粒剤を４０℃の恒温槽中に３カ月間放置し、ニテンピラムの含量を高速液体クロマトグラフィーにより測定し、残存率を次式により算出した。
ニテンピラムの残存率（％）＝（含量／初期含量）×１００
結果を〔表１〕に示した。
【００１４】
【表１】
【００１５】
【発明の効果】
本発明の水溶性顆粒剤は、水への易溶性を損なうことなく、水溶性農薬活性成分の保存安定性を向上させることができる。[0001]
[Industrial application fields]
The present invention relates to a stabilized water-soluble granule containing a water-soluble pesticidal active ingredient such as nitenpyram. The preparation of the present invention is used for the purpose of controlling pests in the field of agriculture.
[0002]
[Prior art]
Nitenpyram, (E) -N- (6-chloro-3-pyridylmethyl) -N-ethyl-N'-methyl-2-nitrovinylidenediamine) is an agricultural insecticide with excellent pest control ability Yes, can be mixed with other insecticides or fungicides, etc., mixed with mineral powder, water-soluble carrier, extender, etc., powder, granule, wettable powder, water solvent, granule etc. Can be used as various solid preparations (JP-A-2-171).
Among them, water-soluble pesticide granules are granules that dissolve completely and easily in water, and are excellent in terms of ease of handling, ease of weighing, dust prevention, and ease of application. . For example, an excellent tempilim-containing water-soluble granule formulated with lactose as a bulking agent has been proposed (JP-A-6-92803).
Furthermore, it has been desired to develop a more stable water-soluble granule in which the decomposition of nitempyram in the water-soluble granule is further suppressed.
[0003]
[Problems to be solved by the invention]
An object of the present invention is to provide a novel water-soluble pesticidal granule capable of suppressing the decomposition of water-soluble pesticidal active ingredients such as Nitempyram. In particular, an object of the present invention is to provide a granule having improved storage stability of a water-soluble active ingredient without impairing the water-solubility that is characteristic of a water-soluble granule.
[0004]
[Means for Solving the Problems]
As a result of diligent investigations to solve the above problems, the present inventors have unexpectedly realized a stable water-soluble pesticide of nitenpyram by blending a water-soluble weak basic substance with nitenpyram and performing wet granulation. It was found that a granule was obtained. Furthermore, the present inventors have found that a stable water-soluble pesticidal granule can be obtained even when applied to other water-soluble pesticidal active ingredients, not limited to nitempyram, and as a result of further studies, the present invention is completed. It came to. That is, the present invention
(1) a water-soluble granule comprising a water-soluble agrochemical active ingredient and a water-soluble weakly basic substance,
(2) The water-soluble granule according to (1), wherein the water-soluble agrochemical active ingredient is a water-soluble agrochemical active ingredient having a solubility in water at 20 ° C. of 0.01 g / ml or more,
(3) The water-soluble granule according to item (1), wherein the water-soluble agrochemical active ingredient is nitempyram;
(4) The water-soluble weakly basic substance is a water-soluble weakly basic substance having a solubility in water at 20 ° C. of 0.05 g / ml or more and a pH of the aqueous solution at 25 ° C. of about 7.0 to 9.0. The water-soluble granule according to item (1) to (3),
(5) A water-soluble weakly basic substance having a solubility in water at 20 ° C. of 0.05 g / ml or more and a pH of an aqueous solution at 25 ° C. of about 7.0 to 9.0 is sodium thiosulfate, hydrogen phosphate The water-soluble granule according to (4), which is one or more selected from the group consisting of disodium, sodium acetate, sodium carbonate and sodium bicarbonate, and (6) water-soluble with respect to the total amount of the water-soluble granule A water-soluble granule according to item (1), comprising about 5 to 95% by weight of an active agrochemical active ingredient and about 15 to 94% by weight of a water-soluble weakly basic substance.
[0005]
More specifically,
(6) The water-soluble granule according to (1) or (2), wherein the water-soluble agrochemical active ingredient is a water-soluble agrochemical active ingredient that is stable under alkaline conditions.
(7) One or more water-soluble pesticide active ingredients selected from the group consisting of nitenpyram, allethrin, acephate, ESP (oxydepropos), bamidthione, DEP (trichlorphone), validamycin A, diquat and bialaphos The water-soluble granule according to item (1), which is a water-soluble agrochemical active ingredient,
(8) The water-soluble granule according to any one of (1) to (7), further containing a surfactant,
(9) The water-soluble granule according to (8), wherein the surfactant is a nonionic surfactant having an HLB value of about 9 to 12,
(10) The water-soluble granule according to (9), wherein the nonionic surfactant having an HLB value of about 9 to 12 is polyoxyethylene nonylphenyl ether or a block copolymer of ethylene oxide and propylene oxide. And (11) The water-soluble granule according to item (8), comprising about 0.05 to 5% by weight of a surfactant based on the total amount of the water-soluble granule.
[0006]
As the water-soluble pesticidal active ingredient used in the water-soluble granule of the present invention, for example, a pesticidal active ingredient having a solubility in water at 20 ° C. of about 0.01 g / ml or more, preferably about 0.1 g / ml or more is used. Examples of the pesticidal active ingredient include all pesticidal active ingredients such as insecticides, fungicides, and herbicides. Among these water-soluble pesticidal active ingredients, those that are unstable under alkaline conditions are not suitable, and water-soluble pesticidal active ingredients that are stable under alkaline conditions are preferred. In the water-soluble granule of the present invention, one or more of these water-soluble pesticidal active ingredients can be used. Specific examples of the water-soluble pesticidal active ingredient used in the water-soluble granule of the present invention include the following.
[0007]
The water-soluble weakly basic substance used in the water-soluble granule of the present invention is not particularly limited. For example, the solubility in water at 20 ° C. is 0.05 g / ml or more and the pH of the aqueous solution at 25 ° C. What is about 7.0-9.0 is suitable. Specifically, for example, one or more selected from the group consisting of sodium thiosulfate, disodium hydrogen phosphate, sodium acetate, sodium carbonate, sodium bicarbonate and the like are used. As the grade of the water-soluble weakly basic substance, any grade such as pharmacopoeia, industrial use, food additive and the like can be used, and further, it can be used regardless of the presence or absence of bound water.
The content of the water-soluble pesticidal active ingredient used in the water-soluble granule of the present invention is usually about 5 to 95% by weight, preferably about 5 to 80% by weight, based on the total amount of the granule.
The content of the water-soluble weakly basic substance used in the water-soluble granule of the present invention is usually about 15 to 94% by weight, preferably about 30 to 90% by weight, based on the total amount of the granule.
The water-soluble granule of the present invention may further contain a water-soluble auxiliary agent such as a surfactant, a dye, a binder, and an ultraviolet absorber.
[0008]
The surfactant is not particularly limited, but a nonionic surfactant is relatively preferably used. In particular, those having an HLB value in the range of about 9 to 12 are preferable from the viewpoint of water solubility and wetting action. Specifically, for example, polyoxyethylene nonylphenyl ether (eg, NP-85 (trade name), manufactured by Takemoto Yushi Co., Ltd.) or a block copolymer of ethylene oxide and propylene oxide (eg, New Pole PE). -64 (trade name), Sanyo Kasei Co., Ltd., etc.) are used.
Specific examples of the dye include cyanine green G (trade name) (manufactured by Sumitomo Chemical Co., Ltd.).
Specific examples of the binder include dextrin, polyvinyl alcohol, gum arabic, sodium alginate, polyvinyl pyrrolidone, glucose, sucrose, mannitol, sorbitol and the like.
The content of these other water-soluble adjuvants in the water-soluble granules is generally about 0.05 to 5% by weight, preferably 1.0 to 3.0% by weight of the surfactant with respect to the total amount of the water-soluble granules. The weight ranges from about 0.01 to 0.5% by weight, preferably from about 0.01 to 0.1% by weight, and the binder is usually from about 0.5 to 10.0. % By weight, preferably in the range of about 2.0 to 7.0% by weight.
[0009]
The water-soluble granule of the present invention can be produced according to a usual method for producing a water-soluble granule. For example, it can be produced using a spray drying method or a wet extrusion method.
In the case of the spray-drying method, about 50 to 1000 parts by weight of water is usually added to 100 parts by weight of the preparation solids and dissolved, and the aqueous solution is granulated by spray drying to obtain water-soluble granules. Specifically, water-soluble agrochemical active ingredients, water-soluble weakly basic substances, and if necessary, other water-soluble adjuvants such as surfactants are dissolved in water in an amount sufficient to dissolve, and this aqueous solution is sprayed. Dry to obtain water-soluble granules. Alternatively, a water-soluble pesticidal active ingredient and a water-soluble weakly basic substance may be dissolved in an appropriate amount of water, and after spray drying, other water-soluble auxiliary agents such as a surfactant may be added and mixed. Moreover, you may use this spray-dried product for the wet extrusion granulation mentioned later. The obtained granule has a particle size of about 0.05 to 1.0 mm, preferably about 0.1 to 0.5 mm.
In the case of wet extrusion granulation, it is usually produced using about 1 to 10 parts by weight, preferably about 2 to 5 parts by weight of water with respect to 100 parts by weight of the preparation solid content. Specifically, a water-soluble agricultural chemical active ingredient, a water-soluble weakly basic substance, and, if necessary, other water-soluble auxiliary agents such as a surfactant are uniformly mixed with a mixer or the like. At this time, if the particle size of the solid component is large and cannot be mixed uniformly, it is desirable that the powder is made into an appropriate powder of about 100 μm or less by coarse pulverization or the like to facilitate the mixing operation. An appropriate amount of water is added to this mixture, and the mixture is further kneaded with a mixer to such an extent that it is suitable for extrusion granulation in the subsequent step. The kneaded product is granulated with a normal extrusion granulator and then dried. If necessary, the granulated product is sized to obtain the desired water-soluble granules. The sizing is performed in a range that does not pass through a sieve having an opening of 300 μm but passes through a sieve having a diameter of 1,700 μm. The obtained granule has a major axis of about 0.5 to 10.0 mm, preferably about 0.5 to 5.0 mm.
[0010]
The bulk density of the granules is usually preferably in the range of about 0.1 to 1.2 g / ml, more preferably in the range of about 0.5 to 1.0 g / ml.
The water-soluble granule of the present invention thus obtained has substantially no phytotoxicity to plants and can be used safely without any harm to humans and animals during or after application. And the water-soluble granule of this invention is improving the storage stability of a water-soluble agrochemical active ingredient, without impairing the water solubility which is the characteristics of a water-soluble granule.
The water-soluble granules of the present invention are usually used after being dissolved and diluted in water. The dilution is not particularly limited, but is usually preferably about 100 to 2,000 times (about 1 g / 100 ml to 1 g / 2,000 ml). The amount of the diluting solution varies depending on the water-soluble pesticide active ingredient, the target pest, the target farmland, the season, and the like. Spray about 15000 ml, preferably about 1000 to 10000 ml.
[0011]
【Example】
Hereinafter, the present invention will be described in more detail by describing examples, reference examples, and test examples, but the present invention is not limited to these examples. In addition, unless otherwise indicated,% and part used here show weight% and a weight part altogether.
【Example】
Hereinafter, the present invention will be described in more detail by describing examples, comparative examples, and experimental examples, but the present invention is not limited to these examples. In addition, unless otherwise indicated,% and a part used here show weight% and a weight part altogether.
[Example 1]
10 parts of nitenpyram and 90 parts of sodium thiosulfate are dissolved in 400 parts of water, and this aqueous solution is solid granulated with a spray-drying device (Okawahara Koki, L-8). Obtained.
[Example 2]
Instead of 90 parts of sodium thiosulfate in Example 1, 90 parts of disodium hydrogen phosphate was used and spray-dried in the same procedure as in Example 1 to obtain water-soluble granules containing 10% nitenpyram.
[Example 3]
Instead of 90 parts of sodium thiosulfate in Example 1, 90 parts of sodium acetate was used and spray-dried in the same procedure as in Example 1 to obtain water-soluble granules containing 10% nitenpyram.
[Example 4]
Instead of 90 parts of sodium thiosulfate in Example 1, 90 parts of sodium carbonate was used and spray-dried in the same procedure as in Example 1 to obtain water-soluble granules containing 10% nitenpyram.
[0012]
[Example 5]
Instead of 90 parts of sodium thiosulfate in Example 1, 90 parts of sodium bicarbonate was used and spray-dried in the same procedure as in Example 1 to obtain water-soluble granules containing 10% nitenpyram.
[Example 6]
After thoroughly mixing 10 parts of Nitenpyram, 1.0 part of the surfactant Newpol PE-64, 0.15 part of the dye cyanine green G, 5.0 parts of the binder sucrose, 83.85 parts of baking soda, 4 parts of water And kneaded with a kneading machine (Kikusui Seisakusho, KM-1.5). This kneaded product was granulated into cylindrical granules using an extrusion granulator (Kikusui Seisakusho, RG-5M) using a 0.8 mm diameter screen. The obtained granule was dried at 60 ° C. for 1 hour to obtain a water-soluble granule containing 10% nitenpyram.
[Example 7]
Instead of 83.85 parts of sodium bicarbonate of Example 6, 10 parts of sodium acetate and 73.85 parts of sodium bicarbonate were used and extruded and granulated in the same manner as in Example 6 to obtain water-soluble granules containing 10% nitenpyram. .
[Reference Example 1]
Instead of 90 parts of sodium thiosulfate in Example 1, 90 parts of lactose was used and spray-dried in the same procedure as in Example 1 to obtain water-soluble granules containing 10% nitenpyram.
[Reference Example 2]
Instead of 83.85 parts of baking soda in Example 6, 83.85 parts of lactose was used, and extrusion granulation was performed in the same manner as in Example 6 to obtain water-soluble granules containing 10% nitenpyram.
[0013]
[Test example]
The water-soluble granules produced in Examples 1 to 7 and Comparative Examples 1 and 2 shown above were left in a constant temperature bath at 40 ° C. for 3 months, and the content of nitenpyram was measured by high performance liquid chromatography. The rate was calculated by the following formula.
Nitenpyram residual rate (%) = (content / initial content) × 100
The results are shown in [Table 1].
[0014]
[Table 1]
[0015]
【The invention's effect】
The water-soluble granule of the present invention can improve the storage stability of the water-soluble agrochemical active ingredient without impairing the water-solubility.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP08884694A JP3645920B2 (en) | 1994-04-26 | 1994-04-26 | Water-soluble pesticide granules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP08884694A JP3645920B2 (en) | 1994-04-26 | 1994-04-26 | Water-soluble pesticide granules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07291804A JPH07291804A (en) | 1995-11-07 |
| JP3645920B2 true JP3645920B2 (en) | 2005-05-11 |
Family
ID=13954346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP08884694A Expired - Fee Related JP3645920B2 (en) | 1994-04-26 | 1994-04-26 | Water-soluble pesticide granules |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3645920B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69836479T2 (en) | 1997-02-10 | 2007-09-20 | Sumitomo Chemical Takeda Agro Co., Ltd. | Wettable or water-soluble granulated agrochemical composition |
| US6090399A (en) * | 1997-12-11 | 2000-07-18 | Rohm And Haas Company | Controlled release composition incorporating metal oxide glass comprising biologically active compound |
| US7157094B2 (en) | 2001-03-09 | 2007-01-02 | Arysta Lifescience North America Group | Granulated active ingredients |
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1994
- 1994-04-26 JP JP08884694A patent/JP3645920B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07291804A (en) | 1995-11-07 |
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