JP3612581B2 - Balloon type drug solution syringe for blood vessels - Google Patents
Balloon type drug solution syringe for blood vessels Download PDFInfo
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- JP3612581B2 JP3612581B2 JP2001183171A JP2001183171A JP3612581B2 JP 3612581 B2 JP3612581 B2 JP 3612581B2 JP 2001183171 A JP2001183171 A JP 2001183171A JP 2001183171 A JP2001183171 A JP 2001183171A JP 3612581 B2 JP3612581 B2 JP 3612581B2
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Description
【０００１】
【発明の属する技術分野】
本願発明は、血管における側副血行路の増殖再生その他種々の管状器官の治療のため血管細胞増殖因子その他種々の薬液を注入するために使用されるバルーン型薬液注射器に関する。
【０００２】
【従来の技術】
従来、例えば冠動脈の一部に梗塞が生じた場合に、その近くの血管に血管細胞増殖因子を注入して側副血行路（いわゆるバイパス血管）を再生させる治療法が提案されている。
【０００３】
この場合、血管細胞増殖薬剤は、血管を構成する内膜、中膜及び外膜のうち筋肉質の中膜に注入しなければならないが、従来行われている方法は、収縮したバルーンの表面に血管細胞増殖薬液を塗布し、該バルーンを血管内の所定位置に挿入した後所要時間膨脹させ、それにより血管増殖薬液を内膜を経て中膜に浸透させようとするものであり、それは、血管増殖薬液の１回の使用量がバルーン表面に塗布された少量であるばかりでなく、内膜を経て中膜に達する薬液量がさらに少量にとどまり、しかも長時間バルーンを膨脹させておくことができない条件の下では、結局十分な効果がえられない結果となっていた。
【０００４】
【発明が解決しようとする課題】
本願発明は、１回の施術で必要十分な薬液を血管等の中膜に確実に注入することを課題とする。
【０００５】
【課題を解決するための手段】
上記課題を解決する手段として、本願請求項１の発明は、
血管細胞増殖薬液供給孔を縦通された屈撓性カテーテルの先端部に、本体が円筒状で屈撓性フィルムからなるバルーンを、上記薬液供給孔とバルーン内部を連通させた状態で、設けた構成において、
上記バルーン本体の表面に、硬質薄板からなり矛先状刃先を有する複数枚のブレードを、バルーン膨張時に刃先を放射方向へ向けて突出するように、それぞれ固定し、
上記ブレードの突出高は、上記バルーンが最大限にふくらんだとき該ブレードが血管内膜に切りこんで中膜に至る高さとし、
上記バルーンにおける上記各ブレードの根元位置に上記血管細胞増殖薬液射出小孔をそれぞれ設けた、
血管等用のバルーン型薬液注射器を提案し、
【０００６】
本願請求項２の発明は、
上記請求項１におけるバルーンが、複数本の折り目をつけられ、該バルーン収縮時に上記折り目を介してプリーツ状に折り畳み可能に形成され、上記各ブレードが、バルーン収縮時に上記プリーツ部分の内側に包まれるようにしてある、血管等用のバルーン型薬液注射器を提案する。
以下図面を参照して本発明の実施例について説明する。
【０００７】
【実施例】
まず、請求項２の発明によるバルーン型注射器（Ａ）について説明する。図１において、（１）は、ガイドワイヤ案内孔（２）及び薬液供給孔（３）を縦通された屈撓性カテーテルで、その先端部に、本体が円筒状の屈撓性フィルムからなるバルーン（４）を該カテーテル（１）先端部を包む状態に同心的に取りつけると共に、上記薬液供給孔（３）を通孔（５）を介してバルーン（４）内に連通させている。なお上記薬液供給孔（３）の先端は閉止されている。
【０００８】
上記バルーン（４）の円筒状本体の外周面には、膨脹時のバルーン母線方向へ延長する横断面ほぼ直角三角形の４本の突条（６）…を、互に９０度間隔をあけて、その直角面の一面において、それぞれ突設し、これら突条（６）…の直角面の他面にブレード（７）…を接着により取りつけてある。
【０００９】
上記ブレード（７）…は、特に図２、３に示すように、ステンレス鋼、チタン合金、高結晶性高分子材料等の硬質薄板から、多数のブレード素材が連結板（９）…を介して連続する素材をつくり、その各ブレード素材を横断面山形の樋形に屈曲すると共に先端を矛先状の刃先（８）…に形成したもので、その連結板（９）…を上記突条（６）の直角他面に接着して、各刃先（８）…を膨脹バルーン（４）の放射方向へ突出させ、これら各ブレード（７）…と上記突条（６）との間におけるバルーン（４）フィルムに薬液射出小孔（１０）…を設けてある。
【００１０】
本例では、上記バルーン（４）のフィルムに、図１（ハ）に示すように該バルーン（４）を収縮させたとき内方へ折れこむ内方折り目（１１）及び外方へ突き出る外方折り目（１２）を各ブレード（７）…列の両側に該ブレード列と平行にそれぞれ形成してあり、それにより上記バルーン（４）が収縮したとき、同図（ハ）のように内方折り目（１１）…により上記各ブレード（７）…列の一側に内方へ食いこむ凹み（１３）…を形成して該凹み（１３）…内に各ブレード列を引き入れると共に、外方へ折り目（１２）…により上記各ブレード（７）…列の他側に上記凹み（１３）…の開き口を横切るプリーツ（１４）…を形成し、この凹み（１３）…とプリーツ（１４）…により各ブレード（７）…列を包被するようにしてある。
【００１１】
上例の作用を使用例とともに次に説明する。ガイドワイヤを血管内に挿入し、該ガイドワイヤを図１（ハ）のように収縮したバルーン型注射器（Ａ）のガイドワイヤ案内孔（２）に挿通させ、該ガイドワイヤを案内として上記収縮注射器（Ａ）を血管増殖を行うべき血管（Ｂ）内の所定位置まで挿入する（図６（イ）の状態）。
【００１２】
次に、血管増殖薬液をカテーテル（１）の薬液供給孔（３）内に外部から圧送すると、該薬液が通孔（５）を経てバルーン（４）内に圧送されて該バルーン（４）を膨脹させる。膨脹するバルーン（４）は、各ブレード（７）…を放射方向に起立させつつ円筒状にふくらんでいき、最大径にふくらんだとき各ブレード（７）…が同図（ロ）のように血管（Ｂ）の内膜（Ｂａ）に切りこんで中膜（Ｂｂ）に至り、その状態でバルーン（４）内の血管増殖薬液が射出小孔（１０）…から山形樋状のブレード（７）…を案内溝として中膜（Ｂｂ）へ直接注射される。薬液は連続的に多量に注射される。
【００１３】
注射後、カテーテル（１）の薬液供給孔（３）に外部から負圧を加えてバルーン（４）を同図（イ）のように収縮させ、その状態で注射器（Ａ）を血管内から引き出す。
【００１４】
請求項１の発明の実施例は、上記バルーン（４）に内方折り目（１１）…及び外方折り目（１２）…を設けず、他の構造は図１、２、３、４と実質的に同一である。本例のバルーン型注射器を血管内に挿入する場合は、バルーンを収縮して保護カテーテル内に収納した状態でカテーテルと共に血管内に挿入し、所定位置でバルーン部分を保護カテーテルから押し出して上記と同様に膨脹、薬液注射を行い、注射後バルーンを収縮させて保護カテーテル内に収納して血管内から引き出す。
【００１５】
上記請求項２及び１の発明におけるブレードは、図５に示すように横断面半円弧状のものもえられ、このほか種々の横断面形状を有する樋形のものにすることができる。
【００１６】
【発明の効果】
本願請求項１の発明によれば、収縮したバルーンを血管等の所定位置に挿入した後カテーテルを通じて外部からバルーン内に所要薬液を圧送して該バルーンを膨脹させることにより、各ブレードを起立突出させて血管等の内膜に切りこませて中膜を露出させ、又は中膜近くまで切り開き、それにより射出小孔から射出される薬液を中膜に十分に注入することができると共に、１回の短時間施術で十分な量の薬液を注射することができるようになり、その医学上の使用価値はきわめて高い。
【００１７】
本願請求項２の発明によれば、上記請求項１の発明の効果に加え、バルーンを収縮させたとき、折り目によりバルーンに形成されるプリーツ部分により各ブレードを包みこむことができ、それによりバルーンの血管等内への挿入及び血管等内からの引き出しを安全に行うことができるのである。
【図面の簡単な説明】
【図１】（イ）請求項２の発明のバルーン型薬液注射器の一部省略拡大正面図である。
（ロ）同上側面図である。
（ハ）同上収縮状態の側面図である。
【図２】ブレード列の一部省略拡大正面図である。
【図３】ブレード列の一部省略拡大平面図である。
【図４】図３のＩＶ−ＩＶ線断面図である。
【図５】ブレードの他の例の一部の平面図である。
【図６】（イ）収縮したバルーン型薬液注射器を血管内に挿入した状態の横断面図である。
（ロ）同上バルーンを膨脹させた状態の横断面である。
【符号の説明】
Ａ バルーン型薬液注射器
１ カテーテル
３ 薬液供給孔
４ バルーン
５ 通孔
７、２７ ブレード
８、２８ 刃先
１０、３０ 薬液射出小孔
１１ 内方折り目
１２ 外方折り目
１４ プリーツ部分[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a balloon type drug solution syringe used for injecting vascular cell growth factor and other various drug solutions for the growth and regeneration of collateral blood vessels in blood vessels and other various tubular organs.
[0002]
[Prior art]
Conventionally, for example, when an infarction occurs in a part of a coronary artery, a treatment method has been proposed in which a vascular cell growth factor is injected into a nearby blood vessel to regenerate a collateral circulation (so-called bypass blood vessel).
[0003]
In this case, the vascular cell proliferating drug must be injected into the muscular media among the inner membrane, media and outer membrane that constitute the blood vessel. A cell growth drug solution is applied, the balloon is inserted into a predetermined position in the blood vessel, and then inflated for a required time, thereby trying to infiltrate the blood vessel growth drug solution through the intima into the media. Not only is the amount of the chemical used once on the balloon surface, but also the amount of the chemical that reaches the media through the intima is still smaller, and the balloon cannot be inflated for a long time. In the end, the result was not enough.
[0004]
[Problems to be solved by the invention]
This invention makes it a subject to inject | pour the necessary and sufficient chemical | medical solution reliably in medias, such as a blood vessel, by one treatment.
[0005]
[Means for Solving the Problems]
As means for solving the above problems, the invention of
A balloon made of a flexible film having a cylindrical main body is provided in a state where the drug solution supply hole and the inside of the balloon are in communication with each other at the distal end portion of the flexible catheter that is vertically passed through the vascular cell proliferation drug solution supply hole. In configuration,
On the surface of the balloon body, a plurality of blades made of a hard thin plate and having a cutting edge-like cutting edge are fixed respectively so that the cutting edge protrudes in the radial direction when the balloon is expanded,
The protruding height of the blade is the height at which the blade cuts into the intima and reaches the media when the balloon is swelled to the maximum extent,
The vascular cell proliferation drug solution injection hole is provided at the root position of each blade in the balloon,
Proposed balloon type drug solution syringes for blood vessels, etc.
[0006]
The invention of claim 2 of the present application
The balloon according to
Embodiments of the present invention will be described below with reference to the drawings.
[0007]
【Example】
First, a balloon type injector (A) according to the invention of claim 2 will be described. In FIG. 1, (1) is a bendable catheter vertically passed through a guide wire guide hole (2) and a chemical solution supply hole (3), and the main body is made of a bendable film having a cylindrical shape at the tip thereof. The balloon (4) is concentrically attached so as to wrap the tip of the catheter (1), and communicates with the inside of the balloon (4) through the chemical solution supply hole (3) through the hole (5). The tip of the chemical solution supply hole (3) is closed.
[0008]
On the outer peripheral surface of the cylindrical body of the balloon (4), four ridges (6)... Having a substantially right-angled cross section extending in the direction of the balloon genera at the time of inflation are spaced by 90 degrees from each other. Each of the right-angled surfaces protrudes from each other, and blades (7) are attached to the other surfaces of the right-angled surfaces of the ridges (6) by bonding.
[0009]
As shown in FIGS. 2 and 3, the blade (7) is made up of a large number of blade materials via a connecting plate (9) from a hard thin plate such as stainless steel, a titanium alloy, and a highly crystalline polymer material. A continuous material is made, each blade material is bent into a bowl shape having a cross-sectional angle, and the tip is formed into a spear-shaped blade edge (8), and the connecting plate (9) is connected to the ridge (6 ) Are bonded to the other right-angled surface of each of the blades, and the cutting edges (8) are projected in the radial direction of the inflatable balloon (4), and the balloons (4) between the blades (7) and the protrusions (6) are projected. ) Chemical solution injection holes (10) are provided in the film.
[0010]
In this example, the film of the balloon (4) has an inward fold (11) that folds inward when the balloon (4) is deflated as shown in FIG. A fold line (12) is formed on each side of each blade (7)... In parallel with the blade line. When the balloon (4) is deflated, the inward fold line is formed as shown in FIG. (11)... Each of the blades (7)... Dents (13)... That bite inwardly on one side of the row, and the blade rows are drawn into the recesses (13). (12) ... to form the pleats (14) ... across the opening of the recesses (13) ... on the other side of the blades (7) ... row, and the recesses (13) ... and the pleats (14) ... Each blade (7)... Covers the row.
[0011]
Next, the operation of the above example will be described together with a usage example. A guide wire is inserted into the blood vessel, and the guide wire is inserted into the guide wire guide hole (2) of the balloon type syringe (A) contracted as shown in FIG. (A) is inserted to a predetermined position in the blood vessel (B) where blood vessel growth is to be performed (state shown in FIG. 6 (a)).
[0012]
Next, when the blood vessel proliferating drug solution is pumped from the outside into the drug solution supply hole (3) of the catheter (1), the drug solution is pumped into the balloon (4) through the through hole (5), and the balloon (4) Inflate. The inflating balloon (4) swells in a cylindrical shape with the blades (7) standing in the radial direction, and when swelled to the maximum diameter, each blade (7) is vascularized as shown in FIG. Cut into the intima (Ba) of (B) to reach the intima (Bb), and in this state, the vascular proliferating drug solution in the balloon (4) passes from the injection small hole (10) to the chevron blade (7) Is injected directly into the media (Bb) using the guide groove. The drug solution is continuously injected in large quantities.
[0013]
After injection, negative pressure is applied from the outside to the chemical solution supply hole (3) of the catheter (1) to deflate the balloon (4) as shown in FIG. .
[0014]
In the embodiment of the invention of
[0015]
As shown in FIG. 5, the blades in the inventions of the second and second aspects can have a semicircular cross-sectional shape, and can be of a bowl shape having various cross-sectional shapes.
[0016]
【The invention's effect】
According to the first aspect of the present invention, after inserting the deflated balloon into a predetermined position such as a blood vessel, the required chemical solution is pumped into the balloon from the outside through the catheter to inflate the balloon, thereby causing each blade to stand up and project. In this way, the intima is exposed by cutting into the intima of a blood vessel or the like, or the intima is cut close to the intima, so that the medicinal solution ejected from the injection hole can be sufficiently injected into the intima and It becomes possible to inject a sufficient amount of drug solution in a short time, and its medical use value is extremely high.
[0017]
According to the second aspect of the present invention, in addition to the effect of the first aspect of the present invention, when the balloon is deflated, each blade can be wrapped by the pleat portion formed on the balloon by the folds, whereby the balloon Therefore, it is possible to safely insert into the blood vessel or the like and pull it out from the blood vessel or the like.
[Brief description of the drawings]
FIG. 1 (a) is a partially omitted enlarged front view of a balloon-type drug solution injector according to a second aspect of the present invention.
(B) It is a side view same as the above.
(C) It is a side view of a contracted state same as the above.
FIG. 2 is a partially omitted enlarged front view of a blade row.
FIG. 3 is a partially omitted enlarged plan view of a blade row.
4 is a cross-sectional view taken along the line IV-IV in FIG. 3;
FIG. 5 is a plan view of a part of another example of the blade.
6A is a cross-sectional view of a state in which a deflated balloon-type drug solution injector is inserted into a blood vessel. FIG.
(B) A cross section of the balloon inflated.
[Explanation of symbols]
A Balloon type
Claims (2)
上記バルーン本体の表面に、硬質薄板からなり矛先状刃先を有する複数枚のブレードを、バルーン膨張時に刃先を放射方向へ向けて突出するように、それぞれ固定し、
上記ブレードの突出高は、上記バルーンが最大限にふくらんだとき該ブレードが血管内膜に切りこんで中膜に至る高さとし、
上記バルーンにおける上記ブレードの根元位置に上記血管細胞増殖薬液射出小孔をそれぞれ設けた、
血管等用のバルーン型薬液注射器。 A balloon made of a flexible film with a cylindrical main body is provided at the distal end portion of the flexible catheter that is vertically passed through the vascular cell proliferation drug solution supply hole in a state where the drug solution supply hole and the inside of the balloon are communicated with each other. In configuration,
On the surface of the balloon body, a plurality of blades made of a hard thin plate and having a cutting edge shape are fixed so that the blade edge protrudes in the radial direction when the balloon is inflated.
The protruding height of the blade is the height at which the blade cuts into the intima and reaches the media when the balloon is swelled to the maximum extent,
The vascular cell proliferating drug solution injection hole is provided at the root position of the blade in the balloon,
Balloon type drug solution syringe for blood vessels.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001183171A JP3612581B2 (en) | 2001-06-18 | 2001-06-18 | Balloon type drug solution syringe for blood vessels |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001183171A JP3612581B2 (en) | 2001-06-18 | 2001-06-18 | Balloon type drug solution syringe for blood vessels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003000708A JP2003000708A (en) | 2003-01-07 |
| JP3612581B2 true JP3612581B2 (en) | 2005-01-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001183171A Expired - Fee Related JP3612581B2 (en) | 2001-06-18 | 2001-06-18 | Balloon type drug solution syringe for blood vessels |
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| JP5800801B2 (en) | 2009-04-22 | 2015-10-28 | マーケイター メドシステムズ， インコーポレイテッド | Use of guanethidine to treat hypertension by local vascular delivery |
| CA2887597C (en) | 2011-10-19 | 2018-01-09 | Mercator Medsystems, Inc. | Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation |
| CN117015413A (en) * | 2021-06-22 | 2023-11-07 | 株式会社戈德曼 | Balloon body for catheter and balloon catheter |
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| ES2078936T3 (en) * | 1989-01-31 | 1996-01-01 | Bard Inc C R | CATHETER AND METHOD FOR LOCALLY APPLYING MEDICATION TO THE WALL OF A BLOOD VESSEL OR ANOTHER BODY LUMEN. |
| DE69011784D1 (en) * | 1989-08-25 | 1994-09-29 | Bard Inc C R | Pleated balloon dilatation catheter and method of manufacture. |
| US5320634A (en) * | 1990-07-03 | 1994-06-14 | Interventional Technologies, Inc. | Balloon catheter with seated cutting edges |
| JPH04282146A (en) * | 1991-03-08 | 1992-10-07 | Fujikura Ltd | Endoscope catheter |
| CA2113684A1 (en) * | 1993-01-19 | 1994-07-20 | Robert L. Wilcox | Single-lumen over-the-wire iab catheter |
| US5569198A (en) * | 1995-01-23 | 1996-10-29 | Cortrak Medical Inc. | Microporous catheter |
| EP0768098B1 (en) * | 1995-10-10 | 2000-09-27 | Interventional Technologies Inc | Catheter with fluid medication injectors |
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| US11717670B2 (en) | 2017-06-07 | 2023-08-08 | Shifamed Holdings, LLP | Intravascular fluid movement devices, systems, and methods of use |
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