JP3534869B2 - Lid for sealing the opening - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a lid for sealing an opening of a bottomed cylindrical container such as a blood dispensing tube so that a specimen such as blood for analysis, which is the content, can be collected. Regarding

[0002]

2. Description of the Related Art Blood tests are widely performed in hospitals, test centers and the like. This is because it is possible to understand the human body condition such as the blood type, white blood cell amount, cholesterol amount, blood glucose level, etc. by the blood test, and it is possible to judge the human health condition from these values. is there.
In addition, it is possible to know whether or not the person is infected with a pathogenic bacterium or virus that causes diseases such as hepatitis and AIDS by a blood test.

When performing such a blood test, the collected blood is divided into aliquots by a predetermined amount corresponding to the test item, and different tests are performed on the blood aliquoted in the aliquot tubes. It is common.

Dispensing pipes used in such inspections are made of glass or plastic, and in recent years, plastic pipes are often used. The dispensing pipes have a diameter of about 10 mm and a deep depth. There are various sizes and shapes, including a test tube-like container with a length of about 80 mm.

Generally, blood collected from a patient is collected in the above-mentioned dispensing tube. Next, cover the opening of the dispensing tube where the blood was dispensed with a resin lid of a size that can be fitted into the opening of the dispensing tube molded by a method such as injection molding, and after transferring to the inspection department. The lid is removed, and a hollow needle-shaped sample collecting device called a chip is inserted into the blood in the dispensing tube to suck up a required amount of blood for testing. Humans may perform the entire inspection process,
Recently, many analyzers that automatically perform the process of sucking blood by a chip and subsequent processes have been used.

[0006]

Even when such an analyzer is used, since the lid of the dispensing tube is manually removed, it is inefficient and labor costs increase. It had drawbacks. Further, in most cases, the conventional lid has a cylindrical shape without a bottom surface on one side, and has a drawback that the content easily leaks due to tipping of the dispensing tube during transfer, etc. It was Further, the conventional lid is an injection-molded product, and since such an injection-molded lid is disposable, it has a drawback of high cost.

The present invention has been made in view of the above circumstances, and is a lid used for a specimen collecting container such as a blood dispensing tube, which needs to be removed when the contents are sorted. It is an object of the present invention to provide a lid for closing an opening, which is free from the above problems, has a good sealing property, does not leak contents, and is inexpensive.

[0008]

In order to achieve the above object, an opening-sealing lid of the present invention comprises a resin film capable of piercing and penetrating a hollow needle-shaped body, and a resin film formed on one surface of the resin film. Ri Na <br/> from the laminated easily peelable heat seal layer, and is adapted for use in a container for specimen collection.

As a preferred structure, the resin film is selected from the group consisting of uniaxially stretched polypropylene film, uniaxially stretched high density polyethylene film, biaxially stretched polypropylene film, biaxially stretched polyethylene terephthalate film, cyclic olefin resin and polyphenylene sulfone. It was configured to use the resin film of choice.

On the other hand, as another preferable configuration, the tip diameter is 0.
The lid for opening opening of the present invention is configured so that it can be pierced and penetrated with a tip of 5 to 5 mm with a force of 10 kgf or less, and a tip with a tip diameter of 0.5 to 5 mm is 10 kgf or less. When the opening of a bottomed tube having an inner diameter of 5 to 15 mm is sealed, the tip having a tip diameter of 0.5 to 5 mm is centered on the lid that covers the opening. Deformation width when piercing a finger is 5 mm
The opening sealing lid of the present invention was constructed as follows. In addition, the easy peel heat seal layer is
-Based polyolefin heat-seal adhesive, acrylic
Heat seal adhesive, polyester heat seal
Adhesives, modified polyester heat seal adhesives, E
VA heat seal adhesive, PVA heat seal adhesive
Agent, vinyl acetate heat-seal adhesive, hydrochloric acid / vinyl acetate
Nyl copolymer type heat seal adhesive, vinyl chloride type
Seal adhesive or polyether heat seal
And / or adhesive
As described above, the opening sealing lid of the present invention was constructed.

[0011]

The opening-sealing lid of the present invention is formed of a resin film capable of piercing and penetrating a hollow needle-shaped body (chip) for collecting a sample such as blood. Further, since the heat-sealant capable of easy peeling is laminated on the resin film, the lid can be adhered to the upper opening of the sample collecting container by heating and pressure bonding for a short time.

According to the lid of the present invention, the lid is securely heat-sealed to the edge portion of the upper end of the specimen collecting container by the heat-sealable agent capable of peeling easily. Even if shaken, the contents such as blood samples will not leak out.

Further, by piercing the lid with the chip, the specimen in the container can be taken out without removing the lid, and the labor cost can be reduced. Further, since the heat-sealing layer forming the lid has an easy peel property, when the entire amount of the specimen in the container is taken out, the adhered lid can be easily removed to take out the specimen. Moreover, since a cheap resin film can be used as the base material of the lid, the cost of the lid can be reduced.

[0014]

EXAMPLES Next, the lid of the present invention will be specifically described with reference to examples. The opening sealing lid 1 of the present invention is shown in FIG.
As shown in, the resin film 2 and the resin film 2
And an easy peel heat seal layer 3 laminated on one surface.

As shown in FIG. 2, the opening-sealing lid 1 of the present invention is heat-sealed to the periphery of the sample-collecting container 5 in order to seal the opening. In such a state, the chip 4 for sorting the sample in the sample collecting container 5 is pressed against the lid body 1 and pierces the lid body 1 to penetrate it. The lid 1 is preferably one that can be penetrated by the tip 4 as easily as possible. For example, when a tip having a tip diameter of 0.5 to 5 mm is used, it is usually 10 kgf.
Hereafter, those having a puncture resistance strength of preferably 7 kgf or less are used. In addition, as the lid 1 is less likely to extend, it becomes easier to pierce and penetrate. For example, as shown in FIG. 2, the lid 1 is heat-sealed to the opening of the sample collecting container having an inner diameter D of 5 to 15 mm, and a tip having a tip diameter of 0.5 to 5 mm is provided at the center of the lid 1 covering the opening. When pressing 4 to pierce and pierce, the piercing resistance strength is usually 10 kg as described above.
f or less, preferably 7 kgf or less, and the tip 4
It is preferable that the deformation width H of the cover 1 before the cover breaks through the cover 1 is 5 mm or less.

The characteristics of the lid 1 can be adjusted by the kind of resin forming the resin film 2, the film thickness, the method of molding or processing the film, and the like.
Examples of the resin forming the lid of the present invention include polyethylene, high density polyethylene, polypropylene, polyalkylene terephthalate, cyclic olefin resin, polyphenylene sulfone, polyethylene naphthalate, nylon and the like.

The film formed from such a resin may be an unstretched film, a uniaxially stretched film or a biaxially stretched film. Particularly, polyethylene, high-density polyethylene, polypropylene, polyethylene naphthalate, and nylon are preferably used after being uniaxially stretched or biaxially stretched. When these resins are stretched and used, the stretching ratio is usually 1.5 to 6 times,
It is preferably 2 to 5 times. Further, it is preferable to stretch and use a polyalkylene terephthalate film, specifically, a polyethylene terephthalate film, as in the case of the polyolefin resin film as described above. When a polyethylene terephthalate film is used, the stretching ratio is usually 1.5 to 6 times, preferably 2 to 5 times.

The cyclic olefin resin and polyphenylene sulfone are usually used without stretching,
Stretching is preferred for thinning. Particularly in the present invention, the resin film is formed of any one of uniaxially stretched polypropylene film, uniaxially stretched high density polyethylene film, biaxially stretched polypropylene film, biaxially stretched polyethylene terephthalate film, cyclic olefin resin and polyphenylene sulfone. It is preferable.

The resin film 2 formed of the above materials is usually 1 to 40 μm, preferably 10 to 35 μm.
It has a thickness of μm. Resin film thickness is 1 μm
If the thickness is thinner, the opening of the specimen collection container may not be reliably sealed during heat sealing, and if it is thicker than 40 μm, the chip does not pierce the lid body in normal operation regardless of the type of resin. Sometimes.

An easy peel heat seal layer 3 is formed on one surface of the resin film 2. This easy-peel heat-sealing layer 3 surely seals the opening of the specimen collecting container with the lid 1 of the present invention, and when the lid 1 is removed, it can be easily peeled off. The lid 1 and the specimen collecting container 5 are bonded together.

The heat-sealable adhesive used to form the easy-peel heat-seal layer used here is as follows:
Various types can be used. For example, according to the classification based on the composition, 1. Modified polyolefins such as maleic acid modified polyethylene and chlorinated polypropylene, 2. Acrylics such as PMA, MMA, EMA or EAA, 3. Polyesters, 4. Modified polyesters , 5. EVA, 6. PVA, 7. Vinyl acetate-based, 8. Hydrochloric acid / vinyl acetate copolymer-based, 9. Vinyl chloride-based, 10. Polyether-based heat-sealable adhesives. In addition, for example, water-based 2. solvent-based 3. hot-melt type 4. emulsion-type heat-sealable adhesives can be given as examples according to the classification according to the form.

Such an easy-peel heat-sealing agent usually has a softening temperature of 80 ° C. or higher and an adhesive strength of 50 to 50.
The composition is adjusted so that it will be 300 gf / 15 mm. Further, a tackifier such as petroleum resin may be blended in order to adjust the heat sealability.

The easy-peel heat sealing agent used is usually selected in accordance with the material constituting the resin film 2 to which it is applied. For example, when an α-olefin (co) polymer such as polyethylene or polypropylene is used as the resin film as the base material, the easy peel heat sealant is M
It is preferable to use an olefin-based easy peel heat sealant such as C-3800 (manufactured by Mitsubishi Petrochemical Co., Ltd.) or AD-345 (Toyo Morton Co., Ltd.), and polyethylene terephthalate is used as a base material. When a resin having a polar group is used, for example, PES-330S
It is preferable to use a polyester type easy peel heat sealant such as K (Toagosei Kagaku Kogyo Co., Ltd.).

The coating amount of the easy-peel heat-sealing layer is usually 1 to 15 g / m ² , preferably ^{2 to} 10 g / m ^2.
Is within the range of. The easy peel heat seal layer 3 is formed by applying the above easy peel heat seal agent to one surface of the resin film 2 by a known application method such as a gravure reverse coater or a gravure coater. be able to.

The lid of the present invention is, for example, an actual fair 4-36.
It can be used as a sealing film used in a test tube opening sealing device as described in Japanese Patent No. 25. Referring to FIG. 3, the opening-sealing lid 1 of the present invention is usually wound into a roll in the form of a film. Then, first, the film pull-out device 19 of the film tensioning mechanism 15 is operated to pick up the end portion of the film-shaped lid 1 from the film feeder 18 and pull it out. At this time, the sample collecting container 5 specified as the dispensing tube in FIG. 3 is being conveyed along the conveying path 12, and
Has stopped at the position. The pulled-out film-like lid 1 of the present invention is horizontally stretched in the opening 5a of the stopped sample collecting container 5.

Next, with the pressing plate 21 and the receiving plate 22,
The film-shaped lid 1 of the present invention is clamped from both upper and lower surfaces.
At this time, the film-shaped lid 1 of the present invention is provided with the pressing plate 21.
By the cutting blade 25 attached to the film, the film is horizontally cut near the supply port of the film supply device 18. The film-shaped lid body 1 cut in this way has a film contact mechanism 20.
As a result, the peripheral portion is held.

Next, the film contact mechanism 20 descends while holding the peripheral portion of the cut lid 1. When the film contact mechanism 20 descends to a predetermined level, the central part of the lid 1 contacts the opening 5a of the sample collecting container. After the lid 1 comes into contact with the opening 5 a in this manner, the lid 1 is released from the pressing plate 21 and the receiving plate 22. At the same time, the piston shaft 3 is attached to the cylinder 32 of the film coating mechanism 30.
The cylindrical body 34 interlocking via 3 descends and fits into the upper end portion of the specimen collecting container 5. The peripheral portion of the lid body 1 is narrowed down by the cylindrical body 34, and the lid body 1 is placed along the outer peripheral surface of the specimen collecting container 5. With the opening 5a covered with the film piece that is the lid 1 of the present invention as described above, the specimen collecting container 5 advances along the transport path and is provided with a film welding mechanism (not shown). Stop at stop position 2. The film welding mechanism descends from above the sample collection container 5 stopped at the second position, and the lid 1 is heated and pressure-bonded to the peripheral portion of the opening 5a of the sample collection container.

The sample-collecting container having the lid of the present invention welded to the opening in this way is sent to an analyzer equipped with a chip, and the chip is pierced into the cover to sample and analyze the sample in the container. It

Next, an experimental example will be shown. Example 1 A uniaxially stretched polypropylene film having a thickness of 25 μm was used as a resin film for a substrate, and an olefin-based easy peel heat sealing agent (main component: PVA) was applied to one surface of this resin film by a gravure reverse method. Then, the lid of the present invention was manufactured. The coating amount was 4 g / m ² .

Next, the lid is placed on the opening of a polypropylene dispensing tube (diameter 10 mm, depth 80 mm) containing 1 ml of blood, and the sealing temperature is 140 ° C. and the sealing time is 0.5 seconds.
Heat sealing was performed under the condition of a sealing pressure of 3 kgf / cm ² .

After sealing, the dispensing tube was laid down sideways for 10 seconds, but no blood leaked. Further, the tip with a diameter of 1 mm at the tip was pushed against the lid with a force of 1.5 kgf, so that the lid could be pierced and the blood in the dispensing tube could be sucked up. Table 1 shows the material of the resin film,
The thickness, blood leakage and piercing properties when lying sideways are summarized. Example 2 A lid was manufactured in the same manner as in Example 1 except that a uniaxially stretched high density polyethylene (HDPE) film having a thickness of 25 μm was used instead of the uniaxially stretched polypropylene film. When the dispensing tube was sealed using this lid in the same manner as in Example 1, one chip with a tip diameter of 1 mm was
By pushing with a force of kgf, the lid could be pierced and the blood in the dispensing tube could be sucked up.
Table 1 shows a summary of the lid material, thickness, blood leakage and piercing properties when it is laid down on its side. Example 3 A lid was produced in the same manner as in Example 1 except that a biaxially oriented polypropylene film having a thickness of 15 μm was used instead of the uniaxially oriented polypropylene film. When the dispensing tube was sealed using this lid in the same manner as in Example 1, the lid could be pierced by pushing a tip with a tip diameter of 1 mm with a force of 2 kgf. I was able to suck up blood. Table 1 shows the material of the lid,
The thickness, blood leakage and piercing properties when lying sideways are summarized. Example 4 In Example 1, a biaxially stretched polyethylene terephthalate (PET) film having a thickness of 9 μm was used instead of the uniaxially stretched polypropylene film, and a polyester-based easy peel heat was used instead of the olefin easy peel heat seal agent. A lid was manufactured in the same manner except that a sealant (main component: copolyester) was used. When the dispensing tube was sealed using this lid in the same manner as in Example 1, 1.8 kg of a tip having a tip diameter of 1 mm was sealed.
By pushing with the force of f, the lid could be pierced and the blood in the dispensing tube could be sucked up. Table 1 shows a summary of the lid material, thickness, blood leakage and piercing properties when it is laid down on its side. Example 5 A lid was manufactured in the same manner as in Example 1 except that a 25 μm thick cyclic olefin resin film (main component: tetracyclododecene) was used instead of the uniaxially stretched polypropylene film. Example 1 using this lid
When the dispensing tube was sealed in the same manner as above, the tip diameter was 1
The lid body could be pierced by pushing the mm tip with a force of 1.5 kgf, and the blood in the dispensing tube could be sucked up. Table 1 shows a summary of the lid material, thickness, blood leakage and piercing properties when it is laid down on its side. Example 6 In Example 1, instead of the uniaxially stretched polypropylene film, polyphenylene sulfone (P
A lid was manufactured in the same manner except that a PS) film was used. When the dispensing tube was sealed using this lid in the same manner as in Example 1, 2.2 kg of a tip having a diameter of 1 mm was used.
By pushing with the force of f, the lid could be pierced and the blood in the dispensing tube could be sucked up. Table 1 shows a summary of the lid material, thickness, blood leakage and piercing properties when it is laid down on its side. Comparative Example 1 A lid was produced in the same manner as in Example 1 except that an unstretched polypropylene film having a thickness of 15 μm was used instead of the uniaxially stretched polypropylene film. When the dispensing tube was sealed using this lid in the same manner as in Example 1, a chip having a tip diameter of 1 mm was struck with a force of 1 kgf, but the lid was too extended (deformation width 8 mm). The tip was hard to pierce. Table 1 shows a summary of the lid material, thickness, blood leakage and piercing properties when it is laid down on its side. Comparative Example 2 A lid was manufactured in the same manner as in Example 1 except that a 50 μm thick biaxially oriented polyethylene terephthalate (PET) film was used instead of the uniaxially oriented polypropylene film. When the dispensing tube was sealed using this lid in the same manner as in Example 1, a tip having a tip diameter of 1 mm was pierced, but a force of 10 kgf or more was required to pierce the lid with the tip. Needed and the tip was hard to pierce. Table 1 shows a summary of the lid material, thickness, blood leakage and piercing properties when it is laid down on its side.

[0032]

[Table 1]

[0033]

As described above, according to the lid body of the present invention, the lid body is securely welded to the edge portion of the upper end of the specimen collecting container by the heat-sealant capable of easy peeling, so that the container is in transit during transfer. Even if it falls or is shaken, the sample such as blood, which is the content, does not leak out.

Further, by piercing the lid with the chip, the blood in the specimen collecting container can be taken out without removing the lid, and the labor cost can be reduced. Furthermore, since the heat-sealing layer that constitutes the lid has an easy peeling property, when removing the entire amount of the sample in the sample collection container, the adhered lid should be easily removed to take out blood. You can

Since an inexpensive resin film can be used as the base material of the lid, the cost of the lid can be reduced. Furthermore, even after the tip is pierced into this lid to analyze the blood, the holes formed by the puncture of the tip are small, so there is no evaporation of water etc. even when the test is carried out again at a later date, and the reproducibility is high. An inspection can be done.

[Brief description of drawings]

FIG. 1 is a cross-sectional view schematically showing a lid of the present invention.

FIG. 2 is a diagram showing the chip piercing properties of the lid of the present invention.

FIG. 3 is a diagram showing an example of an apparatus for sealing the opening of the specimen collecting container using the lid of the present invention.

[Explanation of symbols]

1 ... Lid 2 ... Resin film 3 ... Easy peel heat seal layer 4 ... Chip 5 ... Sample collection container 12 ... Transport path 18 ... Film supply device 20 ... Film contact mechanism 21 ... Pressing plate 22 ... Support plate 25 ... Cutting blade 34 ... Cylindrical body

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI B32B 27/36 B32B 27/36 B65D 41/18 B65D 41/18 C08J 7/04 CES C08J 7/04 CESR G01N 35/02 G01N 35 / 02 B // G01N 33/49 33/49 Z (58) Fields investigated (Int.Cl. ⁷ , DB name) B32B 1/00-35/00 A61F 1/00 B65D 35/00 B65D 39/00- 55/00

Claims (5)

(57) [Claims] 1. A hollow needle-like body piercing pierceable resin film, Ri Do from the one easily peelable heat seal layer laminated on the surface of the resin film, containers for specimen collection
A lid body for sealing an opening, which is used in a container . 2. The resin film selected from the group consisting of uniaxially stretched polypropylene film, uniaxially stretched high density polyethylene film, biaxially stretched polypropylene film, biaxially stretched polyethylene terephthalate film, cyclic olefin resin and polyphenylene sulfone. The lid for sealing an opening according to claim 1. 3. The opening sealing lid according to claim 1, wherein a tip having a tip diameter of 0.5 to 5 mm can be pierced and penetrated with a force of 10 kgf or less. 4. When the opening of a bottomed tube having an inner diameter of 5 to 15 mm is sealed, the deformation width when the tip having a tip diameter of 0.5 to 5 mm is pierced at the center of the lid covering the opening is 5.
The lid body for sealing an opening according to claim 3, which has a size of not more than mm. 5. The easy peel heat seal layer
Is a modified polyolefin heat-seal adhesive,
Lil heat seal adhesive, polyester heat seal
Adhesive, modified polyester heat seal adhesive
Agent, EVA heat seal adhesive, PVA heat seal
Adhesive, vinyl acetate heat seal adhesive, hydrochloric acid
Vinyl acetate copolymer heat seal adhesive, vinyl chloride
Heat-seal adhesive or polyether-based heat
Formed with at least one of
The opening according to any one of claims 1 to 4.
Sealing lid.