JP3521517B2 - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JP3521517B2 JP3521517B2 JP33944894A JP33944894A JP3521517B2 JP 3521517 B2 JP3521517 B2 JP 3521517B2 JP 33944894 A JP33944894 A JP 33944894A JP 33944894 A JP33944894 A JP 33944894A JP 3521517 B2 JP3521517 B2 JP 3521517B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- liposome
- phospholipid
- weight
- hydrogenated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Cosmetics (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、皮膚外用剤に関し、更
に詳細には、特定成分より構成されたリポソーム含有水
分散液と抗酸化剤とを含有することを特徴とする抗酸化
効果が顕著に良好な皮膚外用剤に関する。BACKGROUND OF THE INVENTION This invention relates to skin external agents, More particularly, the antioxidant you characterized by containing a liposome-containing aqueous dispersion is composed of specific components and an antioxidant
The present invention relates to an external preparation for skin which has a remarkably good effect .
【０００２】[0002]
【従来の技術】生体膜の主要構成成分であるリン脂質の
二分子膜からなる閉鎖小胞であるリポソームは、生体膜
モデルとして研究に用いられるとともに、古くから薬剤
のマイクロカプセルとして医薬品や化粧品への利用が試
みられていた。特に、化粧料分野においては、マイクロ
カプセルとして価値のある形態であること、リポソーム
の構成成分であるリン脂質そのものが生体膜由来の安全
性の高い両親媒性物質であること等から、注目を集めて
いた。2. Description of the Related Art Liposomes, which are closed vesicles composed of bilayer membranes of phospholipids, which are the main constituents of biological membranes, have been used for research as a model of biological membranes, and have long been used as microcapsules for pharmaceuticals and cosmetics. Was being attempted. In the cosmetics field, in particular, it has attracted attention because it has a valuable form as a microcapsule and the phospholipid itself, which is a constituent component of the liposome, is a highly safe amphipathic substance derived from biological membranes. Was there.
【０００３】[0003]
【発明が解決しようとする課題】このリポソームを化粧
料に応用することのみならず、更にその機能を高め、従
来にない顕著な効果を有する化粧料及び皮膚外用剤の開
発が急務とされていた。There has been an urgent need to develop not only the application of these liposomes to cosmetics but also the function of the liposomes, and the cosmetics and external preparations for skin having remarkable effects which have never been obtained. .
【０００４】[0004]
【課題を解決するための手段】本発明者らは鋭意研究の
結果、特定成分から構成されるリポソーム含有水分散液
と特定の抗酸化剤とを含有することにより、抗酸化効果
が飛躍的に向上する皮膚外用剤が得られることを見いだ
し、本発明を完成するに至った。すなわち、本発明は、
（ａ）リン脂質０．１〜５重量％、（ｂ）コレステロー
ル及び／又はその誘導体０．１〜５重量％、（ｃ）グリ
セリン及び／又は１，３−ブチレングリコール５〜４０
重量％を含有し、かつ、（ａ）：（ｂ）が１：０．１〜
１：１であるリポソーム含有水分散液と、麦芽根抽出
物、モッカ抽出物から選ばれる１種以上の抗酸化剤とを
含有することを特徴とする皮膚外用剤である。Means for Solving the Problems As a result of intensive studies by the present inventors, an aqueous dispersion containing liposomes composed of specific components was obtained.
It was found that a topical skin preparation with dramatically improved anti-oxidant effect can be obtained by containing the compound and a specific antioxidant, and the present invention has been completed. That is, the present invention is
(A) Phospholipid 0.1 to 5% by weight, (b) Cholesterol and / or its derivative 0.1 to 5% by weight, (c) Glycerin and / or 1,3-butylene glycol 5 to 40
% By weight, and (a) :( b) is 1: 0.1.
1: 1 liposome-containing aqueous dispersion and malt root extraction
And an anti-oxidant selected from mocha extracts .
【０００５】本発明で用いられる（ａ）成分のリン脂質
としては、例えば、ホスファチジルコリン、ホスファチ
ジルエタノールアミン、ホスファチジルセリン、ホスフ
ァチジルイノシトール、リゾホスファチジルコリン、ス
フィンゴミエリン、卵黄レシチン、大豆レシチン等の天
然リン脂質、ジオレオイルホスファチジルコリンなどの
合成リン脂質、または天然由来のリン脂質の不飽和炭素
鎖を水素により飽和とした水素添加リン脂質、その他大
腸菌等の微生物から抽出されるリン脂質等が挙げられ、
これらを一種又は二種以上組み合わせて使用することが
できる。Examples of the phospholipid of the component (a) used in the present invention include natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin and soybean lecithin; Synthetic phospholipids such as oleoylphosphatidylcholine, or hydrogenated phospholipids obtained by saturating unsaturated carbon chains of naturally-derived phospholipids with hydrogen, and other phospholipids extracted from microorganisms such as Escherichia coli.
These can be used alone or in combination of two or more.
【０００６】この中で、水素添加大豆リン脂質、水素添
加卵黄リン脂質、水素添加ホスファチジルコリン、水素
添加ホスファチジルセリンから選ばれる一種又は二種以
上が好ましく、配合量は０．１〜５重量％（以下、単に
「％」で示す）である。０．１％よりも少ないとリポソ
ームの生成率が低くなり、また、５％を超えて配合する
とゲル化してしまい好ましくない。Among these, one or more selected from hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, hydrogenated phosphatidylcholine and hydrogenated phosphatidylserine are preferable, and the compounding amount is 0.1 to 5% by weight (hereinafter , Simply indicated by "%"). If it is less than 0.1%, the liposome production rate will be low, and if it exceeds 5%, gelation will occur, which is not preferable.
【０００７】（ｂ）成分のコレステロール及び／又はそ
の誘導体としては、例えば、コレステロール、コレステ
リルステアレート、コレステリルパルミテート等が挙げ
られ、これらを一種又は二種以上組み合わせて使用する
ことができる。配合量は、０．１〜５％が好ましく、
０．１％よりも少ないとリポソームの安定性が悪くな
り、また、５％を超えて配合すると経時的に（ｂ）成分
の沈澱が析出してしまう。Examples of the cholesterol and / or its derivative as the component (b) include cholesterol, cholesteryl stearate, cholesteryl palmitate and the like, and these can be used alone or in combination of two or more kinds. The blending amount is preferably 0.1 to 5%,
If it is less than 0.1%, the stability of the liposome will be poor, and if it is more than 5%, the component (b) will precipitate over time.
【０００９】（ｃ）成分のグリセリン及び／又は１，３
−ブチレングリコールの配合量は５〜４０％である。５
％よりも少ないとリポソームの分散性や安定性が悪くな
り、また、４０％を超えて配合するとべたつきを生じる
ため、官能特性上好ましくない。Component (c) glycerin and / or 1,3
The amount of butylene glycol is 5-40%. 5
If it is less than 40%, the dispersibility and stability of the liposome will be poor, and if it exceeds 40%, stickiness will occur, which is not preferable in terms of sensory properties.
【００１０】さらに、上記（ａ）成分と（ｂ）成分の重
量比が、（ａ）：（ｂ）＝１：０．１〜１：１であるこ
とを必須とする。この範囲内であると安定性の良好なリ
ポソーム含有水分散液を得ることができる。Further, it is essential that the weight ratio of the component (a) to the component (b) is (a) :( b) = 1: 0.1 to 1: 1. Within this range, a liposome-containing aqueous dispersion having good stability can be obtained.
【００１１】本発明において、上記成分を含有するリポ
ソーム含有水分散液は、通常知られている方法、例え
ば、ボルテクスイング法（A.D.Bangham、J.Mol.Biol.,1
3,238(1965)）、ソニケーション法（C.Huang,Biochem.,
8,344(1969)）、プレベシクル法（H.Trauble,Neurosci.
Res.Prog.Bull.,9,273(1971)）、エタノール注入法（S.
Batzri,Biochem.Biophys.Acta.,298,1015(1973)）、フ
レンチプレス押出法（Y.Barenholz,FEBS Lett.,99,210
(1979)）、コール酸除去法（Y.Kagawa,J.Biol.Chem.,24
6,5477(1971)）、トリトンＸ−１００バッチ法（W.J.Ge
rritsen,Eur.J.Biochem.,85,255(1978)）、Ｃａ2+融合
法（D.Papahadojopoulos,Biochem.Biophys.Acta.,394,4
83(1975)）、エーテル注入法（D.Deazer,Biochem.Bioph
ys.Acta.,443,629(1976)）、アニーリング法（R.Lawacz
eck,Biochem.Biophys.Acta.,443,313(1976)）、凍結融
解融合法（M.Kasahara,J.Biol.Chem.,252,7384(197
7)）、Ｗ／Ｏ／Ｗエマルジョン法（S.Matsumoto,J.Coll
oid Interface Sci.,62,149(1977)）、逆相蒸発法（F.S
zoka,Proc.Natl.Acad.Sci.USA,75,4194(1978)）、多価
アルコール法（特開昭６０−７９３２号）等により調製
することができる。In the present invention, the liposome-containing aqueous dispersion containing the above components can be prepared by a generally known method, for example, the vortex swing method (AD Bangham, J. Mol. Biol., 1).
3,238 (1965)), sonication method (C.Huang, Biochem.,
8,344 (1969)), pre-vesicle method (H.Trauble, Neurosci.
Res.Prog.Bull., 9,273 (1971)), ethanol injection method (S.
Batzri, Biochem.Biophys.Acta., 298,1015 (1973)), French press extrusion method (Y.Barenholz, FEBS Lett., 99,210
(1979)), cholic acid removal method (Y.Kagawa, J. Biol. Chem., 24
6,5477 (1971)), Triton X-100 batch method (WJGe
rritsen, Eur. J. Biochem., 85, 255 (1978)), Ca2 + fusion method (D. Papahadojopoulos, Biochem. Biophys. Acta., 394, 4).
83 (1975)), ether injection method (D.Deazer, Biochem. Bioph
ys.Acta., 443,629 (1976)), annealing method (R.Lawacz
eck, Biochem. Biophys. Acta., 443, 313 (1976)), freeze-thaw fusion method (M. Kasahara, J. Biol. Chem., 252, 7384 (197).
7)), W / O / W emulsion method (S. Matsumoto, J. Coll
oid Interface Sci., 62,149 (1977)), reverse phase evaporation method (FS
zoka, Proc. Natl. Acad. Sci. USA, 75, 4194 (1978)), the polyhydric alcohol method (JP-A-60-7932) and the like.
【００１２】本発明品の皮膚外用剤に対する上記リポソ
ーム含有水分散液の配合量は特に限定されないが、好ま
しくは、１．０〜９０％である。さらに、抗酸化剤を併
用することにより、本発明品の皮膚外用剤を得ることが
できる。The amount of the above liposome-containing aqueous dispersion compounded in the external preparation for skin of the present invention is not particularly limited, but is preferably 1.0 to 90%. Furthermore, the external preparation for skin of the present invention can be obtained by using an antioxidant together.
【００１５】抗酸化剤としては、麦芽根抽出物、モッカ
抽出物から選ばれる一種以上を適宜選択して配合するこ
とができる。抗酸化剤の配合量は特に限定されないが、
好ましくは乾燥固形分として０．０００１〜５％であ
る。この範囲で用いれば、本発明品の抗酸化効果がより
顕著なものとなる。[0015] As the antioxidant, wheat Mene extract can be formulated by appropriately selecting one or more selected from currently extract. The blending amount of the antioxidant is not particularly limited,
The dry solid content is preferably 0.0001 to 5%. When used in this range, the antioxidant effect of the product of the present invention becomes more remarkable.
【００１７】本発明品の皮膚外用剤は、上記の抗酸化剤
を前述したリポソーム含有水分散液に配合することによ
って得られるが、調製方法としては、調製したリポソー
ム含有水分散液に添加混合しても、また、リポソーム含
有水溶液調製時に予め添加しても良い。[0017] The present invention product of skin external preparation is obtained by mixing the liposome-containing aqueous dispersion of the antioxidant described above described above, but methods of preparation, and admixed with the liposome-containing aqueous dispersion prepared Alternatively, it may be added in advance when the liposome-containing aqueous solution is prepared.
【００１８】本発明品の皮膚外用剤は、上記必須成分の
他に、皮膚外用剤や化粧料に配合される成分、例えば、
油剤、界面活性剤、粉体、顔料、染料、水溶性高分子、
紫外線吸収剤、防腐剤、香料等を本発明の効果を損なわ
ない範囲で配合することができる。The external preparation for skin of the present invention comprises, in addition to the above-mentioned essential components, components to be added to the external preparation for skin and cosmetics, for example,
Oil agent, surfactant, powder, pigment, dye, water-soluble polymer,
An ultraviolet absorber, an antiseptic, a fragrance and the like can be added within a range that does not impair the effects of the present invention.
【００１９】[0019]
【実施例】次に、実施例を挙げて本発明をさらに詳細に
説明するが、本発明はこれら実施例に限定されるもので
はない。EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.
【００２０】製造例１〜３及び比較製造例４〜６ リポ
ソーム含有水分散液
下記表１に示す組成のリポソーム含有水分散液を製造し
た。Production Examples 1 to 3 and Comparative Production Examples 4 to 6 Liposome-containing aqueous dispersions A liposome-containing aqueous dispersion having the composition shown in Table 1 below was produced.
【００２１】[0021]
【表１】 [Table 1]
【００２２】（製造方法）
Ａ：成分１〜３を成分６の一部で水和した後、成分６の
残部に分散する。
Ｂ：Ａをマイクロフルイダイザーにて処理する。
Ｃ：Ｂに成分４、５を添加し、リポソーム含有水分散液
を得る。(Production Method) A: Components 1 to 3 are hydrated with a part of the component 6, and then dispersed in the rest of the component 6. B: A is processed with a microfluidizer. C: Components 4 and 5 are added to B to obtain a liposome-containing aqueous dispersion.
【００２３】上記のように得られたリポソーム含有水分
散液を透過型電子顕微鏡にて観察したところ、本発明に
係わる製造例１〜３は、比較製造例４〜６に比べて良好
なリポソーム形態を有し、安定性も良好であった。When the aqueous dispersion containing liposomes obtained as described above was observed with a transmission electron microscope, Production Examples 1 to 3 according to the present invention showed better liposome morphology than Comparative Production Examples 4 to 6. And stability was also good.
【００４１】実施例１〜２及び比較例１〜４ クリーム
下記表２に示す組成のクリームを製造して、過酸化脂質
濃度を測定し、さらに美肌効果及び皮膚老化防止効果に
ついて評価した。Examples 1 and 2 and Comparative Examples 1 to 4 Creams Creams having the compositions shown in Table 2 below were produced, the lipid peroxide concentration was measured, and the skin beautifying effect and the skin aging preventing effect were evaluated.
【００４２】[0042]
【表２】 [Table 2]
【００４３】（製造方法）
Ａ：成分１〜７を加熱混合し、７０℃とする。
Ｂ：成分８〜１１及び１４を加熱混合し、７０℃とす
る。
Ｃ：ＡにＢを加えて乳化混合し、冷却後、成分１２、１
３を加えて均一に混合してクリームを得た。(Manufacturing Method) A: Components 1 to 7 are mixed by heating to 70 ° C. B: Components 8 to 11 and 14 are mixed by heating to 70 ° C. C: B is added to A, emulsified and mixed, and after cooling, components 12 and 1
3 was added and mixed uniformly to obtain a cream.
【００４４】１．過酸化脂質濃度の測定
上記のように得られたクリームを４０℃の恒温槽にて４
週間保存した後、精製水で１％に希釈したものを試料溶
液とした。試薬として、トリクロロ酢酸１５ｇ、チオバ
ルビツール酸０．３７５ｇ、１Ｎ塩酸２５ｍｌ及びブチ
ルヒドロキシアニソールを２％含有するエタノール溶液
３ｍｌに、精製水を加えて１００ｍｌとしたもの（以
下、ＴＢＡ試薬という）を用いた。試料溶液１ｍｌを試
験管に取り、これに上述のＴＢＡ試薬２ｍｌを加えて混
合し、試験管を密閉して９５℃にて１５分間加熱後、速
やかに室温まで冷却した。そして、２５００ｒｐｍにて
１０分間遠心分離した後、上澄み液を取り、５３５ｎｍ
の吸光度を測定した。標準溶液として、１，１，３，３
−テトラエトキシプロパン溶液を用い、同様の操作を行
い検量線を作成して、この検量線より過酸化脂質濃度を
求めた。1. Measurement of Lipid Peroxide Concentration The cream obtained above was placed in a constant temperature bath at 40 ° C for 4
After being stored for a week, it was diluted to 1% with purified water to obtain a sample solution. As a reagent, use trichloroacetic acid 15 g, thiobarbituric acid 0.375 g, 1N hydrochloric acid 25 ml and ethanol solution 3 ml containing 2% of butylhydroxyanisole to make 100 ml by adding purified water (hereinafter referred to as TBA reagent). I was there. 1 ml of the sample solution was taken in a test tube, 2 ml of the above-mentioned TBA reagent was added to and mixed with the test tube, the test tube was sealed, heated at 95 ° C. for 15 minutes, and then rapidly cooled to room temperature. Then, after centrifuging at 2500 rpm for 10 minutes, the supernatant liquid is collected and 535 nm
The absorbance of was measured. As a standard solution, 1, 1, 3, 3
-Using tetraethoxypropane solution, the same operation was performed to prepare a calibration curve, and the lipid peroxide concentration was determined from this calibration curve.
【００４５】２．美肌及び皮膚老化防止効果
２８〜５８才の女性評価パネル１５名により、各人２品
づつ毎日、朝と昼の２回、６週間にわたって洗顔後に被
験クリームの適量を顔面に塗布した際の肌状態を観察し
た。塗布による美肌及び皮膚老化防止効果を以下の基準
によって評価した。2. Beautiful skin and skin aging prevention effect 15 female evaluation panels aged 28 to 58, 2 products each, 2 times each day, twice a day, morning and noon, for 6 weeks, after applying a proper amount of the test cream to the face after applying face wash. Was observed. The following criteria evaluated the beautiful skin and the skin aging prevention effect by application.
【００４６】〈美肌効果〉 （評価） （内容） 有効 ：肌のくすみが目立たなくなった。 やや有効 ：肌のくすみがあまり目立たなくなった。 無効 ：使用前と変化なし。 〈皮膚老化防止効果〉 （評価） （内容） 有効 ：肌のはり、つやが改善された。 やや有効 ：肌のはり、つやがやや改善された。 無効 ：使用前と変化なし。 上記各評価結果を表３に示す。<Beautiful skin effect> (Evaluation) (Content) Effective: The dullness of the skin is less noticeable. Somewhat effective: The dullness of the skin became less noticeable. Invalid: No change from before use. <Skin aging prevention effect> (Evaluation) (Content) Effective: The skin's elasticity and gloss were improved. Slightly effective: The skin's elasticity and gloss were slightly improved. Invalid: No change from before use. Table 3 shows the evaluation results.
【００４７】[0047]
【表３】 [Table 3]
【００４８】上記評価結果から明らかなように、本発明
に係わるクリームは、抗酸化能を有し、美肌効果及び皮
膚老化防止効果に優れたものであった。As is clear from the above evaluation results, the cream according to the present invention has antioxidative ability and is excellent in the skin beautifying effect and the skin aging preventing effect.
【００４９】[0049]
【発明の効果】以上述べたように、本発明の皮膚外用剤
は、特定の構成より成るリポソーム含有水分散液と特定
の抗酸化剤とを配合することにより、抗酸化剤の持つ効
果を著しく向上させ、美容及び医療において極めて有用
なものである。As described above, according to the present invention, the external preparation for skin of the present invention, identified as liposome-containing aqueous dispersion consisting of particular configuration
The by blending the antioxidant, the effect possessed by the antioxidants is remarkably improved, is extremely useful in the cosmetic and medical.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ Ａ６１Ｋ 7/00 Ａ６１Ｋ 7/00 Ｘ (56)参考文献 特開 平３−193714（ＪＰ，Ａ) 特開 平１−197419（ＪＰ，Ａ) 特開 平４−29915（ＪＰ，Ａ) 特開 平６−9330（ＪＰ，Ａ) 特開 昭63−275506（ＪＰ，Ａ) 特開 昭63−51311（ＪＰ，Ａ) 杉林堅次、奥村睦男，経皮吸収促進剤 の現状と将来，フレグランス ジャーナ ル，1987年11月25日，Ｎｏ．87，40−47 (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/50 ─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. 7 Identification code FI A61K 7/00 A61K 7/00 X (56) References JP-A-3-193714 (JP, A) JP-A-1-197419 ( JP, A) JP 4-29915 (JP, A) JP 6-9330 (JP, A) JP 63-275506 (JP, A) JP 63-51311 (JP, A) Sugibayashi Ken Next, Mutsuo Okumura, Current status and future of transdermal absorption enhancer, Fragrance Journal, November 25, 1987, No. 87, 40-47 (58) Fields investigated (Int.Cl. 7 , DB name) A61K 7/ 00-7/50
Claims (3)
重量％ （ｃ）グリセリン及び／又は１，３−ブチレングリコー
ル５〜４０重量％ を含有し、かつ、（ａ）：（ｂ）が１：０．１〜１：１
であるリポソーム含有水分散液と、麦芽根抽出物、モッ
カ抽出物から選ばれる１種以上の抗酸化剤とを含有する
ことを特徴とする皮膚外用剤。1. The following components (a), (b) and (c): (a) 0.1 to 5% by weight of phospholipid (b) Cholesterol and / or its derivative 0.1 to 5
% By weight (c) 5-40% by weight of glycerin and / or 1,3-butylene glycol, and (a) :( b) is 1: 0.1-1: 1.
And liposome-containing aqueous dispersion is, wheat Mene extracts, skin external agent characterized by containing the one or more antioxidants selected from the currently extract.
添加大豆リン脂質、水素添加ホスファチジルコリン、水
素添加ホスファチジルセリンから選ばれる一種又は二種
以上であることを特徴とする請求項１記載の皮膚外用
剤。2. A phospholipid, hydrogenated egg yolk phospholipid, hydrogenated soybean phospholipid, hydrogenated phosphatidylcholine, skin according to claim 1, characterized in that one or more selected from hydrogenated phosphatidyl serine Topical agent.
０００１〜５重量％であることを特徴とする請求項１又
は２記載の皮膚外用剤。3. 0 content of antioxidants as dry solids.
The external preparation for skin according to claim 1 or 2, which is 0001 to 5% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33944894A JP3521517B2 (en) | 1994-12-28 | 1994-12-28 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33944894A JP3521517B2 (en) | 1994-12-28 | 1994-12-28 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08183726A JPH08183726A (en) | 1996-07-16 |
| JP3521517B2 true JP3521517B2 (en) | 2004-04-19 |
Family
ID=18327565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP33944894A Expired - Lifetime JP3521517B2 (en) | 1994-12-28 | 1994-12-28 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3521517B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009110205A1 (en) | 2008-03-04 | 2009-09-11 | ナガセケムテックス株式会社 | Agent for increasing the quantity of hyaluronic acid |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998013436A1 (en) * | 1995-03-23 | 1998-04-02 | The Nisshin Oil Mills, Ltd. | Humectant composition, base containing the same, and cosmetic material or external preparation containing said humectant composition |
| US6416771B1 (en) | 1995-03-23 | 2002-07-09 | The Nisshin Oil Mills Ltd. | Moisturizing composition, base containing the same, and cosmetic or external preparation containing the moisturizing composition |
| FR2799645B1 (en) * | 1999-10-13 | 2004-04-30 | Oreal | USE OF DHEA OR ITS PRECURSORS OR METABOLIC DERIVATIVES AS DEPIGMENTANT |
| JP5642924B2 (en) * | 2008-07-18 | 2014-12-17 | 御木本製薬株式会社 | Oil-in-water emulsified composition for promoting skin barrier function recovery |
| JP2010196048A (en) * | 2009-01-30 | 2010-09-09 | Kose Corp | Novel water-soluble polymer, and cosmetic material or skin preparation for external use containing the same |
| JP2010254974A (en) * | 2009-03-31 | 2010-11-11 | Kose Corp | Water-soluble copolymer and cosmetic or external preparation for skin obtained by blending the same |
| JP5695308B2 (en) * | 2009-10-02 | 2015-04-01 | 株式会社フェース | Cosmetic base comprising collagen-modified liposome and skin cosmetic containing the same |
| CN107405265A (en) | 2015-03-27 | 2017-11-28 | 株式会社高丝 | Liposome composition |
| CN113115833A (en) * | 2019-12-31 | 2021-07-16 | 丰益(上海)生物技术研发中心有限公司 | Thick soup and preparation process thereof |
-
1994
- 1994-12-28 JP JP33944894A patent/JP3521517B2/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 杉林堅次、奥村睦男，経皮吸収促進剤の現状と将来，フレグランス ジャーナル，１９８７年１１月２５日，Ｎｏ．８７，４０−４７ |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009110205A1 (en) | 2008-03-04 | 2009-09-11 | ナガセケムテックス株式会社 | Agent for increasing the quantity of hyaluronic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08183726A (en) | 1996-07-16 |
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