JP3521517B2 - External preparation for skin - Google Patents

External preparation for skin

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Publication number
JP3521517B2
JP3521517B2 JP33944894A JP33944894A JP3521517B2 JP 3521517 B2 JP3521517 B2 JP 3521517B2 JP 33944894 A JP33944894 A JP 33944894A JP 33944894 A JP33944894 A JP 33944894A JP 3521517 B2 JP3521517 B2 JP 3521517B2
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JP
Japan
Prior art keywords
skin
liposome
weight
phospholipid
hydrogenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP33944894A
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Japanese (ja)
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JPH08183726A (en
Inventor
久美 亀山
昇 内藤
真理子 浅井
Original Assignee
株式会社コーセー
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Publication date
Application filed by 株式会社コーセー filed Critical 株式会社コーセー
Priority to JP33944894A priority Critical patent/JP3521517B2/en
Publication of JPH08183726A publication Critical patent/JPH08183726A/en
Application granted granted Critical
Publication of JP3521517B2 publication Critical patent/JP3521517B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION This invention relates to skin external agents, More particularly, the antioxidant you characterized by containing a liposome-containing aqueous dispersion is composed of specific components and an antioxidant
The present invention relates to an external preparation for skin which has a remarkably good effect .

[0002]

2. Description of the Related Art Liposomes, which are closed vesicles composed of bilayer membranes of phospholipids, which are the main constituents of biological membranes, have been used for research as a model of biological membranes, and have long been used as microcapsules for pharmaceuticals and cosmetics. Was being attempted. In the cosmetics field, in particular, it has attracted attention because it has a valuable form as a microcapsule and the phospholipid itself, which is a constituent component of the liposome, is a highly safe amphipathic substance derived from biological membranes. Was there.

[0003]

There has been an urgent need to develop not only the application of these liposomes to cosmetics but also the function of the liposomes, and the cosmetics and external preparations for skin having remarkable effects which have never been obtained. .

[0004]

Means for Solving the Problems As a result of intensive studies by the present inventors, an aqueous dispersion containing liposomes composed of specific components was obtained.
It was found that a topical skin preparation with dramatically improved anti-oxidant effect can be obtained by containing the compound and a specific antioxidant, and the present invention has been completed. That is, the present invention is
(A) Phospholipid 0.1 to 5% by weight, (b) Cholesterol and / or its derivative 0.1 to 5% by weight, (c) Glycerin and / or 1,3-butylene glycol 5 to 40
% By weight, and (a) :( b) is 1: 0.1.
1: 1 liposome-containing aqueous dispersion and malt root extraction
And an anti-oxidant selected from mocha extracts .

Examples of the phospholipid of the component (a) used in the present invention include natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin and soybean lecithin; Synthetic phospholipids such as oleoylphosphatidylcholine, or hydrogenated phospholipids obtained by saturating unsaturated carbon chains of naturally-derived phospholipids with hydrogen, and other phospholipids extracted from microorganisms such as Escherichia coli.
These can be used alone or in combination of two or more.

Among these, one or more selected from hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, hydrogenated phosphatidylcholine and hydrogenated phosphatidylserine are preferable, and the compounding amount is 0.1 to 5% by weight (hereinafter , Simply indicated by "%"). If it is less than 0.1%, the liposome production rate will be low, and if it exceeds 5%, gelation will occur, which is not preferable.

Examples of the cholesterol and / or its derivative as the component (b) include cholesterol, cholesteryl stearate, cholesteryl palmitate and the like, and these can be used alone or in combination of two or more kinds. The blending amount is preferably 0.1 to 5%,
If it is less than 0.1%, the stability of the liposome will be poor, and if it is more than 5%, the component (b) will precipitate over time.

Component (c) glycerin and / or 1,3
The amount of butylene glycol is 5-40%. 5
If it is less than 40%, the dispersibility and stability of the liposome will be poor, and if it exceeds 40%, stickiness will occur, which is not preferable in terms of sensory properties.

Further, it is essential that the weight ratio of the component (a) to the component (b) is (a) :( b) = 1: 0.1 to 1: 1. Within this range, a liposome-containing aqueous dispersion having good stability can be obtained.

In the present invention, the liposome-containing aqueous dispersion containing the above components can be prepared by a generally known method, for example, the vortex swing method (AD Bangham, J. Mol. Biol., 1).
3,238 (1965)), sonication method (C.Huang, Biochem.,
8,344 (1969)), pre-vesicle method (H.Trauble, Neurosci.
Res.Prog.Bull., 9,273 (1971)), ethanol injection method (S.
Batzri, Biochem.Biophys.Acta., 298,1015 (1973)), French press extrusion method (Y.Barenholz, FEBS Lett., 99,210
(1979)), cholic acid removal method (Y.Kagawa, J. Biol. Chem., 24
6,5477 (1971)), Triton X-100 batch method (WJGe
rritsen, Eur. J. Biochem., 85, 255 (1978)), Ca2 + fusion method (D. Papahadojopoulos, Biochem. Biophys. Acta., 394, 4).
83 (1975)), ether injection method (D.Deazer, Biochem. Bioph
ys.Acta., 443,629 (1976)), annealing method (R.Lawacz
eck, Biochem. Biophys. Acta., 443, 313 (1976)), freeze-thaw fusion method (M. Kasahara, J. Biol. Chem., 252, 7384 (197).
7)), W / O / W emulsion method (S. Matsumoto, J. Coll
oid Interface Sci., 62,149 (1977)), reverse phase evaporation method (FS
zoka, Proc. Natl. Acad. Sci. USA, 75, 4194 (1978)), the polyhydric alcohol method (JP-A-60-7932) and the like.

The amount of the above liposome-containing aqueous dispersion compounded in the external preparation for skin of the present invention is not particularly limited, but is preferably 1.0 to 90%. Furthermore, the external preparation for skin of the present invention can be obtained by using an antioxidant together.

[0015] As the antioxidant, wheat Mene extract can be formulated by appropriately selecting one or more selected from currently extract. The blending amount of the antioxidant is not particularly limited,
The dry solid content is preferably 0.0001 to 5%. When used in this range, the antioxidant effect of the product of the present invention becomes more remarkable.

[0017] The present invention product of skin external preparation is obtained by mixing the liposome-containing aqueous dispersion of the antioxidant described above described above, but methods of preparation, and admixed with the liposome-containing aqueous dispersion prepared Alternatively, it may be added in advance when the liposome-containing aqueous solution is prepared.

The external preparation for skin of the present invention comprises, in addition to the above-mentioned essential components, components to be added to the external preparation for skin and cosmetics, for example,
Oil agent, surfactant, powder, pigment, dye, water-soluble polymer,
An ultraviolet absorber, an antiseptic, a fragrance and the like can be added within a range that does not impair the effects of the present invention.

[0019]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

Production Examples 1 to 3 and Comparative Production Examples 4 to 6 Liposome-containing aqueous dispersions A liposome-containing aqueous dispersion having the composition shown in Table 1 below was produced.

[0021]

[Table 1]

(Production Method) A: Components 1 to 3 are hydrated with a part of the component 6, and then dispersed in the rest of the component 6. B: A is processed with a microfluidizer. C: Components 4 and 5 are added to B to obtain a liposome-containing aqueous dispersion.

When the aqueous dispersion containing liposomes obtained as described above was observed with a transmission electron microscope, Production Examples 1 to 3 according to the present invention showed better liposome morphology than Comparative Production Examples 4 to 6. And stability was also good.

Examples 1 and 2 and Comparative Examples 1 to 4 Creams Creams having the compositions shown in Table 2 below were produced, the lipid peroxide concentration was measured, and the skin beautifying effect and the skin aging preventing effect were evaluated.

[0042]

[Table 2]

(Manufacturing Method) A: Components 1 to 7 are mixed by heating to 70 ° C. B: Components 8 to 11 and 14 are mixed by heating to 70 ° C. C: B is added to A, emulsified and mixed, and after cooling, components 12 and 1
3 was added and mixed uniformly to obtain a cream.

1. Measurement of Lipid Peroxide Concentration The cream obtained above was placed in a constant temperature bath at 40 ° C for 4
After being stored for a week, it was diluted to 1% with purified water to obtain a sample solution. As a reagent, use trichloroacetic acid 15 g, thiobarbituric acid 0.375 g, 1N hydrochloric acid 25 ml and ethanol solution 3 ml containing 2% of butylhydroxyanisole to make 100 ml by adding purified water (hereinafter referred to as TBA reagent). I was there. 1 ml of the sample solution was taken in a test tube, 2 ml of the above-mentioned TBA reagent was added to and mixed with the test tube, the test tube was sealed, heated at 95 ° C. for 15 minutes, and then rapidly cooled to room temperature. Then, after centrifuging at 2500 rpm for 10 minutes, the supernatant liquid is collected and 535 nm
The absorbance of was measured. As a standard solution, 1, 1, 3, 3
-Using tetraethoxypropane solution, the same operation was performed to prepare a calibration curve, and the lipid peroxide concentration was determined from this calibration curve.

2. Beautiful skin and skin aging prevention effect 15 female evaluation panels aged 28 to 58, 2 products each, 2 times each day, twice a day, morning and noon, for 6 weeks, after applying a proper amount of the test cream to the face after applying face wash. Was observed. The following criteria evaluated the beautiful skin and the skin aging prevention effect by application.

<Beautiful skin effect> (Evaluation) (Content) Effective: The dullness of the skin is less noticeable. Somewhat effective: The dullness of the skin became less noticeable. Invalid: No change from before use. <Skin aging prevention effect> (Evaluation) (Content) Effective: The skin's elasticity and gloss were improved. Slightly effective: The skin's elasticity and gloss were slightly improved. Invalid: No change from before use. Table 3 shows the evaluation results.

[0047]

[Table 3]

As is clear from the above evaluation results, the cream according to the present invention has antioxidative ability and is excellent in the skin beautifying effect and the skin aging preventing effect.

[0049]

As described above, according to the present invention, the external preparation for skin of the present invention, identified as liposome-containing aqueous dispersion consisting of particular configuration
The by blending the antioxidant, the effect possessed by the antioxidants is remarkably improved, is extremely useful in the cosmetic and medical.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. 7 Identification code FI A61K 7/00 A61K 7/00 X (56) References JP-A-3-193714 (JP, A) JP-A-1-197419 ( JP, A) JP 4-29915 (JP, A) JP 6-9330 (JP, A) JP 63-275506 (JP, A) JP 63-51311 (JP, A) Sugibayashi Ken Next, Mutsuo Okumura, Current status and future of transdermal absorption enhancer, Fragrance Journal, November 25, 1987, No. 87, 40-47 (58) Fields investigated (Int.Cl. 7 , DB name) A61K 7/ 00-7/50

Claims (3)

(57) [Claims]
1. The following components (a), (b) and (c): (a) 0.1 to 5% by weight of phospholipid (b) Cholesterol and / or its derivative 0.1 to 5
% By weight (c) 5-40% by weight of glycerin and / or 1,3-butylene glycol, and (a) :( b) is 1: 0.1-1: 1.
And liposome-containing aqueous dispersion is, wheat Mene extracts, skin external agent characterized by containing the one or more antioxidants selected from the currently extract.
2. A phospholipid, hydrogenated egg yolk phospholipid, hydrogenated soybean phospholipid, hydrogenated phosphatidylcholine, skin according to claim 1, characterized in that one or more selected from hydrogenated phosphatidyl serine Topical agent.
3. 0 content of antioxidants as dry solids.
The external preparation for skin according to claim 1 or 2, which is 0001 to 5% by weight.
JP33944894A 1994-12-28 1994-12-28 External preparation for skin Expired - Lifetime JP3521517B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP33944894A JP3521517B2 (en) 1994-12-28 1994-12-28 External preparation for skin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33944894A JP3521517B2 (en) 1994-12-28 1994-12-28 External preparation for skin

Publications (2)

Publication Number Publication Date
JPH08183726A JPH08183726A (en) 1996-07-16
JP3521517B2 true JP3521517B2 (en) 2004-04-19

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Family Applications (1)

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JP33944894A Expired - Lifetime JP3521517B2 (en) 1994-12-28 1994-12-28 External preparation for skin

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009110205A1 (en) 2008-03-04 2009-09-11 ナガセケムテックス株式会社 Agent for increasing the quantity of hyaluronic acid

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416771B1 (en) 1995-03-23 2002-07-09 The Nisshin Oil Mills Ltd. Moisturizing composition, base containing the same, and cosmetic or external preparation containing the moisturizing composition
WO1998013436A1 (en) * 1995-03-23 1998-04-02 The Nisshin Oil Mills, Ltd. Humectant composition, base containing the same, and cosmetic material or external preparation containing said humectant composition
FR2799645B1 (en) * 1999-10-13 2004-04-30 Oreal Use of dhea or its precursors or metabolic derivatives as depigmentant
JP5642924B2 (en) * 2008-07-18 2014-12-17 御木本製薬株式会社 Oil-in-water emulsified composition for promoting skin barrier function recovery
JP2010196048A (en) * 2009-01-30 2010-09-09 Kose Corp Novel water-soluble polymer, and cosmetic material or skin preparation for external use containing the same
JP2010254974A (en) * 2009-03-31 2010-11-11 Kose Corp Water-soluble copolymer and cosmetic or external preparation for skin obtained by blending the same
JP5695308B2 (en) * 2009-10-02 2015-04-01 株式会社フェース Cosmetic base comprising collagen-modified liposome and skin cosmetic containing the same
CN107405265A (en) 2015-03-27 2017-11-28 株式会社高丝 Liposome composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杉林堅次、奥村睦男,経皮吸収促進剤の現状と将来,フレグランス ジャーナル,1987年11月25日,No.87,40−47

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009110205A1 (en) 2008-03-04 2009-09-11 ナガセケムテックス株式会社 Agent for increasing the quantity of hyaluronic acid

Also Published As

Publication number Publication date
JPH08183726A (en) 1996-07-16

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