JP3488374B2 - External anti-infective aid - Google Patents

Description

Description: TECHNICAL FIELD [0001] The present invention relates to a topical anti-infective aid. 2. Description of the Related Art Conventionally, the use of a gougon extract in cosmetics for skin and hair such as rough skin, acne and kayumi has been performed. For example, Japanese Patent Publication No. 2-37883 proposes to use the product as a hair-protecting cosmetic product, and Japanese Patent Publication No. 2-58245 discloses a cosmetic containing baicalin or baicalein as an extract of pentagon. A cosmetic composition has been proposed, and it has been shown to be used as a cosmetic for the skin and hair as having solubilizing and improving stability. Other external preparations for skin
Japanese Patent Application Publication No.-111710 proposes a cosmetic composition which has a function to improve rough skin, acne and kayumi, and to suppress the increase in POV, in which Japanese gourd is improved. Japanese Patent Application Laid-Open No. 2-36125 discloses that testosterone 5α-reductase inhibitor derived from Japanese gourd is used as a therapeutic agent for acne, seborrheic dermatosis injury and alopecia in pharmaceuticals, cosmetics, and testosterone 5α-reductase inhibitor. It has been proposed as having. Others have been proposed as various external preparations and cosmetics because they have an antipruritic effect, sunburn, and anti-inflammatory effects. [0003] In addition, oubaku has been put to practical use as an anti-inflammatory and analgesic agent for muscle pain, bruises and sprains, and as a patch or ointment. Rhizotium chloride is an enzyme made from chicken egg white, and is widely used in chronic sinusitis, respiratory diseases, face-wash creams, after-shave creams and the like. [0004] However, it is apparent that each of the pentagon, oak, and lysodium chloride is used independently for each application as described above. However, when each is used alone, its effects are limited. For example, lysotium chloride is an enzyme that catalyzes the hydrolysis of polysaccharides, which are constituents of bacterial cell membranes, and it is known that lysotium exhibits lytic development. However, it was not used with so-called crude drugs. In addition, Ogon and Obak also use baicalin, baicalein, or berberine, which each has, for their own purposes. [0005] However, the present inventor has previously proposed a crude drug containing licorice as a main ingredient and an extract of ogon and oak as an effective drug for atopic dermatitis and the like (Patent No. 2).
No. 609564). However, it is true that they are effective for atopic dermatitis and the like, but there have been cases in which an infection develops during or after the treatment. [0006] Considering these facts, it seems that the recent rough hand is not only caused by allergies but also often accompanied by infectious diseases. In particular, the antibacterial effect on Staphylococcus aureus may be adversely affected because the cream for allergic dermatitis is completed as a medium for Staphylococcus aureus. Therefore, the present inventor has reported that oak has a high antibacterial activity against Staphylococcus aureus and a high lysolytic effect of lysotium chloride. The present invention has been achieved by focusing on the fact that it can be further enhanced and the ability to modify the stratum corneum increases. [0008] The results of the measurement of the minimum growth inhibitory concentration (MIC) for various bacteria by single or various combinations of gougan, oak, and lysodium chloride are shown below. Sensitivity test result (1) Sample No. 1: 20% ogon 2: 20% oak 3: 1% lysodium chloride 4: 20% oak 5: 20% oak 5%: 20% oak + 1% lysotium chloride 6: 20% ogon + 1% lysotium chloride 7: 20% ogon + 20% oak + 1% lysodium chloride [Table 1] Test bacteria: Staphylococcous aureus (Staphylococcus aureus) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution Rate ━━━━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 １ 1---+ + + + + + + 2----+ + + + + + 3---+ + + + + + + + 4---+ + + + + + + + 5-----+ + + + + 6-+ + + + + ++++++ 7------+++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Mueller Hinton Broth [Table 2] Test bacteria: Candida albicans ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution rate ━━━━━━━━ ━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 @ 1 + + + + + + + + + + 2 ++++++++++++++ 3 ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++ 7 ++++++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Sabouraud agar [Table 3] Test bacteria: Trichophyton mentagrophytes (tinea pedis) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution rate ━━━ ━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 １ 1--+ + + + + + + + 2 ++++++++++++++ 3 ++++++++++++++ ---- ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++ 7 −−−−− ++++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Sabouraud agar medium Sensitivity test result (2) Sample No. 1: 20% ogon 2: 20% oak 3: 1% lysodium chloride 4: 20% oak 5: 20% oak 5%: 20% oak + 1% lysotium chloride 6: 20% ogon + 1% lysotium chloride 7: 20% ogon + 20% oak + 1% lysodium chloride [Table 4] Test bacteria: Staphylococcous aureus (Staphylococcus aureus) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution Rate ━━━━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 １ 1---+ + + + + + + 2----+ + + + + + 3---+ + + + + + + + 4---+ + + + + + + + 5-----+ + + + + 6-+ + + + + ++++++ 7------+++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Mueller Hinton Broth [Table 5] Test bacteria: Candida albicans ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution rate ━━━━━━━━ ━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 @ 1 + + + + + + + + + + 2 ++++++++++++++ 3 ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++ 7 ++++++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Sabouraud agar [Table 6] Test bacteria: Trichophyton mentagrophytes (tinea pedis) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution rate ━━━ ━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 １ 1--+ + + + + + + + 2 ++++++++++++++ 3 ++++++++++++++ ---- ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++ 7 −−−−− ++++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Sabouraud agar medium [Table 7] Test bacteria: Pseudomonas aeruginosa (Pseudomonas aeruginosa) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution rate ━━━ ━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 @ 1 + + + + + + + + + + 2 ++++++++++++++ 3 ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++ 7 ++++++++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Mueller Hinton agar Medium [Table 8] Test bacteria: Propionnidacterium acnes (acne bacteria) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution rate ━━━ ━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 １ 1----+ + + + + + 2------+ + + + + 3------+ + + + + + 4------+ + + + + 5------+ + + + + 6----+ ++++++ 7--------+++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Mueller Hinton agar Medium sensitivity test results (3) Sample No. 1: 20% ogon 2: 20% oak 3: 1% lysodium chloride 4: 20% oak 5: 20% oak 5%: 20% oak + 1% lysotium chloride 6: 20% ogon + 1% lysotium chloride 7: 20% ogon + 20% oak + 1% lysodium chloride [Table 9] Test bacteria: Staphylococcous aureus (Staphylococcus aureus) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Dilution Rate ━━━━━━━━━━━━━━━━━━━━━━━ Sample No. 2 4 8 16 32 64 128 256 512 1024 １ 1--+ + + + + + + + 2------+ + + + + 3--+ + + + + + + + + + 4-------+ + + + 5--------+ + + 6-+ + + + ++++++ 7-------+++++ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Medium: Mueller Hinton Broth Next, the present invention will be described based on embodiments. First, pure water is charged into a tank, heated to 40 ° C., and 1.3% of butylene glycol is used as a solvent for paraben, and 0.16% of methyl paraben is used as a preservative. 80% ethylene paraben 0.08% propyl paraben 0.005%
Into a tank after heating. Next, 0.02% of l-menthol in 1.3 butylene glycol, d
Heating and dissolving 0.04% of camphor as a detergent at 50 to 60 ° C., and put into a tank. [0010] Then, the pentagon extract 0.01-10
%, And 0.01 to 10% of the oak extract are premixed and put into a tank. Ougon is an extract of Euglena's ethanol, and baicalin 0.15-0.25 w /
v%. Obaku is Japan's 1.3
A butylene glycol extract containing berberine as berberine chloride in an amount of 0.15 to 0.25 w / v% is used. Next, lithodium chloride 0.001 to 2.0
% Is dissolved in hot water and put into a tank. Finally, 0.15 Allantoin is melted with hot water and put into a tank to complete. [Example 1] [Weight%] Japanese gourd 0.5 Obak 0.5 Licorice 0.2 Clove 0.02 Rhizotium chloride 0.05 1.3 3-butylene glycol 2 Preservative methylene paraben 0 .16 Ethylene paraben 0.08 Propyl paraben 0.02 Butylene paraben 0.005 Purified water residue [Example 2] (% by weight) Ogon 0.5 Oubak 0.5 Lithotium chloride 0.2 Alanitone 0.1 1 0.3-butylene glycol 4 preservative methylene paraben 0.16 ethylene paraben 0.08 propyl paraben 0.02 butylene paraben 0.005 purified water residue [Example 3] (% by weight) Ohgon 0.5 Obak 0. 1 Lithotium chloride 0.1 Alanitone 0.1 1.3 Butylene glycol Preservative Methylene paraben 0.16 Ethylene paraben 0.08 Propyl paraben 0.02 Butylene paraben 0.005 Purified water Residue [Example 4] (% by weight) Ogon 10 Oubak 10 Rhizotium chloride 1 1.3-butylene glycol 1 Phenoxyethanol 0.3 Remaining purified water [Example 5] (% by weight) Ogon 5 Oubaku 5 Lithotium chloride 0.5 1.3-butylene glycol 1 Phenoxyethanol 0.7 Purified water remaining As an example, a large number of beauticians with daily skin irritation who are engaged in hair shampooing, rinsing, etc., were used daily. Of course, the results differ depending on the degree of inflammation, but most of the pruritused persons have pruritus, and the effect is remarkable. The earliest people have a few days, and the late ones have itchy within a few weeks and the inflammation has healed in many cases. Regarding the difference between the practical examples of each embodiment, there are few cases, and it takes time to find out. It is also noted that in practical examples, treatment with various drugs for tinea pedis was not improved, and remarkable improvement was observed in 15 cases. In this practical example, tissue paper is wrapped around the affected part. The tissue paper is impregnated with the lotion of Example 5, re-impregnated with the lotion every few minutes, and repeated several times. Even the most severely affected person completed the above operation continuously for 25 days. In this case, the same operation was continued for two months thereafter. After three years, ringworm has not appeared. [Table 10] [Table 11] [Table 12] [Table 13] As described above, according to the present invention, 0.01% to 10% of red ogre, 0.01% to 10% of red oak, 0.001% to 20% of lysodium chloride. %, So that the lytic action of lysotium chloride has the anti-allergic and anti-inflammatory effects of baicalin and vancarene of Ougon, and the bactericidal effects of berberine of oubak, especially the growth inhibitory and anti-inflammatory effects of staphylococci. In addition, the wound healing effect is enhanced in cooperation with the bacteriolysis effect, and the penetration effect of the gourd and oak is enhanced. As a result, it was found that the anti-inflammatory effect on hand dermatitis and the healing effect on ringworm were great. For this reason, the use of this product in other external preparations is highly effective.

──────────────────────────────────────────────────の Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61P 31/00 A61K 37/54 (56) References JP-A-8-198738 (JP, A) Journal of Japanese Society of Periodontology, 1997 39, no. 1, pp. 72-76 Journal of Japanese Society of Pharmaceutical Sciences, 1997, Vol. 14, No. 4, pp. 432-433 Journal of Japanese Society of Pharmaceutical Sciences, 1989, Vol. 3, pp. 512-513 Journal of Japanese Society of Pharmaceutical Sciences, 1987, Vol. 3, pp. 303-305 Hiroshima University Dental Journal, 1988, Vol. 1, PP. 158-161 (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K 35/78 A61K 38/46

Claims (1)

(57) [Claims] [Claim 1] 0.01-10% of pentagon and 0.1% of pentagon.
01 to 10%, lithodium chloride 0.001 to 20. % Of an external anti-infective aid.