JP3487829B2 - Vascular aging evaluation device - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for evaluating aging of blood vessels by utilizing an acceleration pulse wave.

[0002]

2. Description of the Prior Art Pulse pressure is the difference between systolic and diastolic blood pressure, which is a function of stroke volume and arterial compliance. The pulse pressure waveform changes from the aorta to the peripheral arteries. It is considered that this is because the projected wave and the reflected wave are combined at various sites to cause resonance, and the degree of transformation can be regarded as the sum of the effects of the properties or characteristics of the blood vessel. Comparing the intra-arterial pressures in the aorta and the peripheral arteries, the mean arterial pressure in the peripheral arteries is lower than that in the aorta and the diastolic blood pressure in the peripheral arteries is lower than that in the aorta. However, systolic blood pressure
Due to the combination of the projected wave and the reflected wave, the peripheral artery becomes higher, so that the pulse pressure increases. Therefore, there is an advantage that the waveform of the peripheral pulse wave has larger irregularities than the central pulse wave and the waveform can be easily discriminated. Even so, the baseline of the original waveform may not be stable and it may be difficult to recognize the inflection point. Therefore, a secondary differential wave (referred to as “acceleration pulse wave”) obtained by differentiating the original waveform of the peripheral pulse wave twice is used in research and clinical practice as a waveform more suitable for evaluation. Currently, the most widely used sphygmograph is the photoelectric fingertip sphygmograph. The principle of this sphygmograph is based on the method of irradiating the fingertip with light having a wavelength having an absorption specificity to hemoglobin, obtaining the volume change of blood flow in the blood vessel from the absorbed light or the reflected light, and obtaining the waveform. . Although the volume pulse wave and the pressure pulse wave reflect differently, the waveforms have the same meaning.

Although various studies have been conducted so far on what physiological activity of the living body is expressed by the acceleration pulse wave which is a peripheral pulse wave, a clear result has not always been obtained. This is because, since the pulse wave of the living body is unstable, it is difficult to precisely define the correspondence between the component waves of the individual waveforms and the actual physiological activity and blood vessel characteristics.
Many researchers have hypothesized that the waveform of the acceleration pulse wave represents the organic or functional stiffness of the arterial system, and various studies have been conducted. So intuitive,
If a method for objectively evaluating a visually recognized waveform pattern is established, this hypothesis can be proved and clinical application is easy.

The acceleration pulse wave is a waveform of the systole of the heart,
As shown in FIG. 1, there are five component waves of a, b, c, d, and e waves, and these component waves change constantly depending on the condition of the living body and with aging. . The component wave having the apex a corresponds to the rising waveform of the original waveform, and the component wave having the apex corresponds to the notch portion of the original waveform at the end of contraction. The ae interval from apex a to apex corresponds to the left ventricular contraction time. Therefore, at the time of extrasystole or tachycardia, the ae interval is shortened and the component wave is also deformed. When the quadrant above the baseline of the waveform is positive and the quadrant below is the negative quadrant, the a wave is a positive wave that is always located above the baseline, the b wave is a negative wave that is always located below the baseline, and the c wave is The d wave and the e wave are component waves that change to positive or negative depending on the condition of the living body. Therefore, as a parameter for waveform evaluation, the baseline is taken as the x-axis, the distance from the baseline to the vertex of each component wave is taken as the y coordinate, and the distance from the baseline of the a wave is taken as the denominator,
Using b / a, c / a, d / a, and e / a with the distance from the baseline of the b-wave, c-wave, d-wave, and e-wave to the apex as the numerator There are many studies that are trying to clarify what is expressed in.

[0005]

The inventor of the present invention first classifies the waveform of the acceleration pulse wave (APG) into four types, type 1 is a standard waveform (standard pattern) and type 2 is a deep d waveform. Thing (d
eeper-d pattern) Type 3 c deep waveform (deeper-c pattern)
pattern) (in this case, the d waveform is also deep), type 4 was named a shallow-b pattern (in this case, the d waveform is deep), and the age characteristics of the waveform were clarified. As a result, if type 1 of the youth waveform was used as the reference waveform, its shape gradually changed with aging, and in the 40s, the type 2 waveform with deep d-waves increased, and as a result of aging, it became more than 60 years old. For example, it was clarified that the b-wave is shallow and the d-wave is deep. Furthermore, in the examination of the physiological factors that influence the waveform, type 4 is a waveform type that is particularly associated with the progression of aortic hardening, and type 3 in which the c wave deepens with the d wave in the 40 years and older generations. It was shown to be corrugated at the same rate as that of type 4, and was particularly associated with heart rate. It was also shown that waveform changes were associated with changes in functional characteristics of arteries. Therefore, in the previous research, the present inventor has proposed, as a waveform evaluation method, a simple formula based on the relative blood vessel age in which the height is corrected based on these four waveform types. And by analysis using relative vascular age, smoking, low vital capacity, high diastolic blood pressure,
It has been shown that hypercholesterolemia is a risk for aging blood vessels. However, there is a problem that the relative vascular age formula is apt to show an irrational number to the subjects over 60 years old and is an insufficient index for clinical application.

According to the prior art, it is clear that the acceleration pulse wave can represent the degree of aging of blood vessels. In other words, organic
Since the waveform changes due to a change in the compliance of the functional arterial system, if the waveform can be reasonably evaluated, it is possible to diagnose the degree of aging of the blood vessel or the degree of arteriosclerosis based on the waveform. However, the standard waveform of the acceleration pulse wave is the type of instrument, that is, the light source, the filter, the waveform reading method,
Subtly different depending on the conditions such as signal processing. In addition, it is difficult to discriminate between physiological changes and pathological changes because they change with age. In addition, there are gender differences in the waveform. In order to evaluate different waveforms depending on the instrument, measurement environment, age, etc., it is necessary to establish a common waveform evaluation method that can be applied to any condition. That is, if the measurement environment is the same, it is necessary to create a common standard that can be commonly used by any device and any age group, and evaluate based on that standard.

An object of the present invention is to solve the above-mentioned problems of the prior art, which is a sufficient index for clinical application, and is a standard common to all machines and all age groups. An object is to provide a device for evaluating vascular aging based on possible parameters.

[0008]

The present inventor has made diligent efforts to find a common standard for waveform evaluation of acceleration pulse waves, and as a result, found a new waveform parameter having a strong correlation with age, and found the new waveform parameter. A method of creating a database of waveform parameter values and then calculating a common score using the obtained new waveform parameters was devised. As a result, two types of vascular aging scores have been successfully used as an index of organic / functional elasticity or sclerosis of the arterial system, and the present invention has been completed.

The vascular aging evaluation apparatus of the present invention is a vascular aging score obtained from an acceleration pulse wave, and is (d /
a)-(b / a) (In this formula, a represents the distance from the baseline of the waveform of the rising portion of the original waveform to the apex of the acceleration pulse wave component, and b is the original waveform of the acceleration pulse wave component. Represents the distance from the baseline of the 2nd waveform to the apex when counted from the waveform of the rising part of d, and d is from the baseline of the 4th waveform counted from the waveform of the rising part of the original waveform of the acceleration pulse wave component The vascular aging score of 1 derived from the average value and standard deviation of the waveform index I of (representing the distance to the apex), and (c / a)-(b / a) (where a and b are as described above). And c is the third from the waveform of the rising portion of the original waveform in the acceleration pulse wave component.
Represents the distance from the baseline of the th waveform to the apex. 2) is a device for evaluating the aging of blood vessels by using the average value and standard deviation of the waveform index II of 2) and the blood vessel aging score 2.
The vascular aging scores 1 and 2 are derived from the average value and the standard deviation of the waveform indexes I and II for each sex of 5 years, and are common scores that are not affected by age or type of device. Therefore, it is useful for health management and disease management as an index of vascular aging.

According to the present invention, when the vascular aging scores 1 and 2 are 60 or more, it can be evaluated that the blood vessels are aging.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below.

In the present invention, as described in detail below, (d / a)-(b / a) (waveform index I) is used as an index for waveform evaluation.
By using (c / a)-(b / a) (waveform index II), the intended purpose was achieved. The position of the peak of the component b wave and the component d wave of the acceleration pulse wave varies depending on the extensibility of the artery and the change in peripheral vascular resistance, so the parameters b / a and d / a can represent the compliance of the arterial system. Is understood. However, a certain conclusion has not yet been obtained for the component c wave. The present invention does not show a certain tendency for men. It is said that the influence of age on the component c-wave differs depending on the gender, and that it is easily affected by the heart rate. Therefore, the APG index [(-b
+ C + d) / a], when three different parameters are put together, the fluctuation of the component c wave may mask the variability of the component b wave and the component d wave. Therefore, in the present invention, (d / a)-(b / a) (waveform index I) and (c / a)-(b
/ a) (waveform index II).

As shown in the examples below, both waveform indices show a very good correlation with age. However, the waveform indices I and II presented in the present invention are also the same as the conventional AP.
Since it is a quantitative evaluation of the waveform pattern like the G index,
Both arterial physiologic aging changes and pathological changes are included, and it is not clear from these figures whether arterial changes are physiologically included in the majority of changes. It is difficult to determine if you are present. By expressing what kind of rank the waveform obtained by measuring the acceleration pulse wave is located in a certain age group,
If the degree of deviation can be determined, there is a possibility that the organic and functional evaluation of arteries can be easily performed.

Therefore, in the present invention, as described below,
The deviation value method, which is the most classical method of knowing the position in the population, is adopted to derive the desired vascular aging score. That is, a reference group, which is a wide age group of 20-84 years old, is set, and the waveform indices I and II calculated by the waveform measurement of the group are set.
The individual deviation value was calculated from the average value and the standard deviation for each sex and age group of 5 years. The deviation value of the waveform index I is used as the blood vessel aging score 1, and the deviation value of the waveform index II is used as the blood vessel aging score 2.
It is what Both scores are indexes that are unrelated to age and are common to both sexes. If both scores are 60 or more in the numerical value calculated by the formula described in Example 1 below, it is evaluated that the aging of blood vessels is progressing. Can be done.

At present, there are two types of acceleration sphygmographs, a reflection type and a transmission type.
The waveform of each product is slightly different due to the difference in the differential format. In the present invention, the pulse wave meter of the reflection type visible light is used in the following examples, but since a common score can be made by creating a database that employs this method,
It is considered to be useful for future research development and health management.

[0016]

Embodiments of the present invention will be described below with reference to the drawings. (Example 1)

In this embodiment, an acceleration plethysmometer described below is used to measure acceleration plethysmograms for a predetermined number of males and females, and vascular aging scores 1 and 2 are calculated based on these values to calculate vascular aging. Was evaluated.

Acceleration plethysmometer:

The light source of the acceleration sphygmograph used was blue visible light, and the pulse wave was measured by capturing the waveform signal of the reflected light. The filter used both analog and digital
(Sampling time: 126 Hz = about 8 msec). The obtained pulse wave digital original waveform was differentiated twice by a software differentiating circuit. Although the measurement error (error rate) due to communication failure was designed to be within 1%, the actual measurement was within 3%. The diurnal variation of b / a of the waveform parameter based on the obtained waveform within an individual was within 10%.

Measurement target:

A total of 178 men, 1055 men and 729 women
4 persons (aged 20 to 84) were measured at rest sitting position, heart height, and the acceleration pulse wave was measured with the 2-3 fingers of the right hand.
The measurement was recorded for 0 seconds.

Formulation of evaluation method: (1) Table 1 shows descriptive statistics of 1784 measurement subjects.

[0023]

[Table 1]

(2) Waveform parameters b / a, c / a, d
The age regression lines of / a and e / a are shown for men and women, and the relationship with age was examined (Fig. 2 (A) and
(B)). (3) (d / a)-(b / a) (waveform index I) and (c / a)
-For (b / a) (waveform index II), calculate the average value and standard deviation value (SD) for each age group (every 5 years old) (Table 2), and make a line graph of the average value for each age group. Shown by gender (waveform index I is shown in FIG. 3 and waveform index II is shown in FIG. 4). In addition, a line graph of the average value of ae intervals for each male and female age group (every 5 years old) is shown in FIG.

[0025]

[Table 2]

(4) (d / a)-(b / a) (waveform index I)
(c / a)-(b / a) (waveform index II) by age group (every 5 years old)
The deviation value for each age group was calculated from the average value and the standard deviation value of 1 according to the following formula, and the results were set as the blood vessel aging score 1 and the blood vessel aging score 2. The deviation value of X1 = d / a-b / a (waveform index I) is the vascular aging score 1, and X2 = c / a.
The deviation value of −b / a (waveform index II) is the blood vessel aging score 2.

In the above equation, X1 = (d / a)-(b / a) (waveform index I).

In the above equation, X2 = (d / a)-(b / a) (waveform index II).

Properties of vascular aging score: (1) The relationship between each of vascular aging score 1 and vascular aging score 2 and age was examined. (2) The relationship between vascular aging score 1 and systolic blood pressure (SBP) and diastolic blood pressure (DBP) is shown in a scatter diagram by gender.
(Male: FIG. 6 (A) and (B), Female: FIG. 7 (A) and
(B)). (3) The relationship between vascular aging score 2 and systolic blood pressure (SBP) and diastolic blood pressure (DBP) is shown in a scatter diagram by gender.
(Male: FIG. 8 (A) and (B), Female: FIG. 9 (A) and
(B)).

Formulation of the above-mentioned evaluation method and vascular aging score
The result of the term of the property of a is explained below. (1) As shown in Table 1, 1784 subjects (105 males)
5 people, 729 women: 20-84 years old, male
Average age is 47.9 years old, average height is 168.4 cm, flat
Average weight is 65.2 kg, average body fat percentage is 20.2%, average
Blood pressure was 124/77 and average heart rate was 62. Woman
Has an average age of 46.9, an average height of 155.9 cm, and a flat
Average weight is 53.0kg, average body fat percentage is 26.6%, average
Blood pressure was 122/74 and average heart rate was 65. (2) Regression of waveform parameters and age: shown in Fig. 2 (A)
, Male waveform parameters: b / a, c / a, d /
a and e / a are all significantly regressed with age.
It was Age regression of b / a, c / a, d / a, e / a
R in the formula^TwoIs 0.1903, 0.0884, 0.3039,
It was 0.0209. In addition, as shown in FIG.
Even women, each year of b / a, c / a, d / a, e / a
All ages returned significantly, b / a, c / a, d / a, c / a
R of the age regression equation^TwoIs 0.2559, 0.2442, 0.
2976 and 0.0308. (3) Average straightness and standard deviation of waveform index I and II by age group
The difference is shown in Table 2. (4) Age at the mean value of waveform index I and II for each age group
The line is (d / a)-(b / a) as shown in FIGS.
(Waveform index I), (c / a)-(b / a) (waveform index II)
The mean value decreased linearly with age for both men and women. Well
In addition, as shown in FIG.
It shortens as time goes by, especially for women from the 40s onwards
Contracted. In addition, the above-mentioned vascular aging scores 1 and 2 are calculated.
If the numerical value obtained from the formula given is 60 or more, the blood vessels become old.
It can be evaluated that it falls into the category of commodification. To this numerical point
The second embodiment will be described in more detail below. (5) Regarding the blood vessel aging score and age,
Cores 1 and 2 are age-independent scores for both men and women
(Both: R^Two<0.0001, n.s.). (6) Regarding vascular aging score 1 and blood pressure, see FIG.
And (B) and FIGS. 7 (A) and (B),
Vascular aging score 1 for men and women is systolic blood pressure and diastole
Positive correlation with blood pressure (male: systolic blood pressure: R^Two=
0.0289, p <0.01, diastolic blood pressure: R^Two= 0.0
306, p <0.01; female: systolic blood pressure: R ^Two= 0.0
614, p <0.01, diastolic blood pressure: R^Two= 0.068
9, p <0.01). (7) Regarding vascular aging score 2 and blood pressure, FIG. 8 (A)
And (B) and FIGS. 9 (A) and (B),
Vascular aging score of 2 indicates systolic blood pressure and diastole in men
Positive correlation with blood pressure (male: systolic blood pressure: R^Two=
0.0190, p <0.01, diastolic blood pressure: R^Two= 0.0
181, p <0.01). In women, only systolic blood pressure
Positive correlation was shown (female: systolic blood pressure: R^Two= 0.00
79, p <0.05, diastolic blood pressure: R^Two= 0.0058,
n.s.).

As has been clarified in the first embodiment, the waveform change of the acceleration pulse wave occurs in such a manner that the component b wave becomes shallower and the component d wave becomes deeper as the artery ages. . Therefore, at a certain age, that is, after the age of 65 for men and after the age of 55 for women, the reversal of the peak positions of the b-wave and the d-wave, that is, the component d-wave Even the phenomenon of becoming deeper than the b-wave occurs. Therefore, it is understood that b / a and d / a are good indicators of the aging phenomenon. On the other hand, when observing the aging change of the component c wave, its apex is located above the baseline in the youth, but after the age of 30, it is located below the baseline and becomes deeper with aging. I understand. However, only women have a good association of c / a with age. The component e-wave tends to become shallower and closer to the baseline with aging, but the relationship between e / a and age is not so clear.

Comparing the waveforms of men and women, there is not much difference in the position of the component d wave, but the peak of the component b wave tends to be shallower from the baseline in the female, and the peak of the component c wave is opposite. Especially men tend to be shallower. Also, the component e-wave is always shallower for women and is located near the baseline. As described above, the characteristics of the waveforms of men and women are different, and even at the same age, it is easier for women to take an aging waveform classified into the so-called type 3 or type 4 described above, in which the b wave is apparently shallow and the c wave is deep. Although it is not clear where the difference in the waveform of the male and female is caused, it is possible that the fluctuation of the left ventricular contraction time and the difference of the heart rate may influence the waveform. The ae time, which is the time from the a wave to the e wave of the acceleration pulse wave, corresponds to the systolic time of the left ventricle of the heart.
The longer this is, the shallower the component b wave and the deeper the component d wave. On the other hand, as shown in FIG. 5, ae time changes with age. In other words, the ae time is longer in women than in men until around 40 years old, but then sharply shortens and becomes shorter than men. It is considered that this is because of the tendency of tachycardia after menopause, but the component c wave tends to be deeper in tachycardia. Of course, it cannot be denied that physical characteristics such as the length of the upper limb may affect the waveform through the synthesis of reflected waves. This is because it is often reported that the shorter the height, the easier it is for the aging waveform to occur. As described above, the waveform of the acceleration pulse wave shows age-related changes common to both men and women, and at the same time, the difference between men and women is clear. Therefore, the waveforms must be evaluated by gender. (Example 2)

As described below, the relationships between vascular aging scores 1 and 2 and fundus arteriosclerosis findings and hypertension were compared for the subjects shown in Table 1 by χ square test for each gender. The results are shown in Tables 3 and 4 below. However, S
Normal blood pressure when BP is 140 or less and DBP is 90 or less,
Others are called "hypertension."

[0034]

[Table 3]

[0035]

[Table 4]

The following can be seen from Table 3 showing the relationship between the vascular aging score 1 and other indexes.

In males under the age of 60, (1) the incidence of positive fundus arteriosclerosis was 30.9% in the group with a score of less than 60, but was 56.7% in the group with a score of 60 or more. . The odds ratio is 2.927.
(1.918-4.466) was significant. Here, the odds ratio is a measure of the susceptibility of arteriosclerosis of the fundus artery, and the odds ratio 2.927 is 60 or more.
This means that arteriosclerosis of the fundus artery is likely to occur almost 2.9 times as much as when the score is less than 60. (2) The incidence of hypertension was 16.
It was 4%, but it was 32.7% in the group with a score of 60 or higher. Odds ratio is 2.484 (1.568-3.935)
Was significant. When the score is 60 or more, the hypertension is about 2.5 times more likely to occur than when the score is less than 60.

In the males aged 60 or over, (1) the positive expression rate of the fundus arteriosclerosis was 50.4% in the score less than 60 group and 69.6% in the score 60 or more group. The odds ratio was 2.247 (0.861-5.864), which was significant. In the group having a score of 60 or more, the fundus arteriosclerosis was more likely to occur about 2.2 times.

In women under the age of 60, (1) the positive expression rate of fundus arteriosclerosis was 15.7% in the group with a score of less than 60, but 37.
It was 7%. The odds ratio is 3.248 (1.916-
5.507) was significant. The group with a score of 60 or higher is more likely to develop fundus arteriosclerosis about 3.3 times. (2) Hypertension appearance rate is 9.0% in the group with score less than 60
However, it was 26.3% in the group with a score of 60 or higher. Odds ratio is 3.620 (2.002-6.546)
Was significant. The group with a score of 60 or more is almost 3.6 times more likely to develop hypertension.

In women aged 60 and over, (1) the incidence of hypertension was 28.0% in the group with a score less than 60,
The score was 60% in the group of 60 or higher. The odds ratio is 3.
It was significant at 848 (1.231-12.029).
The group with a score of 60 or more is more likely to develop hypertension about 3.8 times.

The following can be seen from Table 4 showing the relationship between the vascular aging score 2 and other indices.

In the men under 60 years old, (1) the positive expression rate of fundus arteriosclerosis was 32.1% in the group less than score 60, but 48.
It was 2%. The odds ratio is 1.968 (1.310-
2.954). The group with a score of 60 or higher is more likely to develop fundus arteriosclerosis approximately 2.0 times. (2) The incidence of hypertension was 17.
Although it was 3%, the appearance rate of the group with a score of 60 or higher was 25.9.
%, And the odds ratio is 1.664 (1.040-2.6).
63). The group with a score of 60 or higher is almost 1.7 times more likely to develop hypertension.

As is clear from the analysis results of Tables 3 and 4 above, in women under the age of 60, vascular aging score 1 was associated with all fundus findings and blood pressure, and those scores of 60 or above were abnormal. The risk of becoming 1.5 times to nearly 4 times. In particular, the fundus and hypertension are strongly associated with each other. If the score is 60 or more, 40% of them may have sclerosis of the fundus artery and 25% of them may have hypertension. . Even in men under the age of 60, there is a strong association with abnormal fundus findings and hypertension, and the risk of abnormal findings is 2.5-3 times.

However, when both men and women are over 60 years old,
The meaning of having a score of 60 or higher is a little weakened. Only a few are associated with hypertension in women and with abnormal fundus findings in men. This is probably because most people over the age of 60 have advanced arteriosclerosis, which makes the difference small. For example, if the score is less than 60, the fundus abnormality is almost 16% in women under the age of 60.
If you are 60 years old or older, it will increase to 40% or more. Almost 30% of men increase to over 50%. In addition, high blood pressure is 9% in women under 60 years old, but increases to 28% in women over 60 years old. Even in men, almost 16%
Increase to almost 32%.

[0045]

According to the present invention, a database of new waveform parameter values having a strong correlation with age is created, a common score is calculated using the obtained new waveform parameters, and two types of blood vessels are calculated. Since aging scores 1 and 2 are used, aging of blood vessels can be significantly evaluated. That is, (d / a)-(b / a) (In this equation, a represents the distance from the baseline of the waveform of the rising part of the original waveform to the apex of the acceleration pulse wave component, and b represents the acceleration pulse wave. The distance from the baseline to the apex of the second waveform, which is counted from the rising waveform of the original waveform of the component,
d represents the distance from the baseline to the apex of the fourth waveform counted from the rising waveform of the original waveform in the acceleration pulse wave component. ), The vascular aging score 1 derived from the average value and the standard deviation of the waveform index I, and (c / a)-(b / a)
(In this formula, a and b are as described above, and c
Represents the distance from the baseline to the apex of the third waveform counted from the waveform of the rising portion of the original waveform of the acceleration pulse wave component. The vascular aging score 2 derived from the average value and standard deviation of the waveform index II of) is used as an index of organic / functional elasticity or sclerosis of the arterial system, which is a sufficient index for clinical application. Also, it becomes a standard common to all machines and all age groups, and aging of blood vessels can be significantly evaluated based on it.

[Brief description of drawings]

1 is a systolic waveform of the heart, a, b, c,
The standard waveform diagram of the acceleration pulse wave which has five component waves of d and e waves.

[FIG. 2] (A) Waveform parameter b / a, c / a, d / a,
And the graph which shows the age regression line of the male of e / a. (B) Waveform parameters b / a, c / a, d / a, and e /
The graph which shows the age regression line of the woman of a.

FIG. 3 is a line graph in which the waveform index I is plotted by age group.

FIG. 4 is a line graph in which the waveform index II is plotted by age group.

FIG. 5 is a line graph in which ae intervals are plotted according to male and female age groups.

FIG. 6 (A) Male vascular aging score 1 and systolic blood pressure (S
Scatter plot showing the relationship with BP). (B) Scatter plot showing the relationship between vascular aging score 1 and diastolic blood pressure (DBP) in men.

FIG. 7 (A) Female vascular aging score 1 and systolic blood pressure (S
Scatter plot showing the relationship with BP). (B) Scatter plot showing the relationship between vascular aging score 1 and diastolic blood pressure (DBP) in women.

FIG. 8 (A) Male vascular aging score 2 and systolic blood pressure (S
Scatter plot showing the relationship with BP). (B) Scatter plot showing the relationship between vascular aging score 2 and diastolic blood pressure (DBP) in men.

FIG. 9 (A) Female vascular aging score 2 and systolic blood pressure (S
Scatter plot showing the relationship with BP). (B) Scatter plot showing the relationship between vascular aging score 2 and diastolic blood pressure (DBP) in women.

─────────────────────────────────────────────────── ─── Continuation of the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61B 5/02-5/03 JISST file (JOIS)

Claims (2)

(57) [Claims] 1. A vascular aging score obtained from an acceleration pulse wave, wherein (d / a)-(b / a) (wherein a is the waveform of the rising portion of the original waveform in the acceleration pulse wave component). Represents the distance from the baseline to the apex, b represents the distance from the baseline to the apex of the second waveform counted from the rising waveform of the original waveform of the acceleration pulse wave component, and d represents the acceleration pulse wave. The aging score of 1 derived from the average value and standard deviation of the waveform index I of the component representing the distance from the baseline to the apex of the fourth waveform counted from the rising waveform of the original waveform, and (c / A)-(b / a) (where a and b are as described above, and c is the baseline of the third waveform counted from the rising waveform of the original waveform in the acceleration pulse wave component) Represents the distance from the to Evaluation device vascular aging and evaluating the aging vessel using the vascular aging score 2 derived from II mean and standard deviation of. 2. The blood vessel aging evaluation device according to claim 1, wherein the blood vessel aging scores 1 and 2 are evaluated to be aging blood vessels when they are 60 or more, respectively.