JP3405342B2 - Method for producing granular material to which flavor and odorant are attached - Google Patents
Method for producing granular material to which flavor and odorant are attachedInfo
- Publication number
- JP3405342B2 JP3405342B2 JP2001275109A JP2001275109A JP3405342B2 JP 3405342 B2 JP3405342 B2 JP 3405342B2 JP 2001275109 A JP2001275109 A JP 2001275109A JP 2001275109 A JP2001275109 A JP 2001275109A JP 3405342 B2 JP3405342 B2 JP 3405342B2
- Authority
- JP
- Japan
- Prior art keywords
- flavoring
- taste
- particles
- substance
- granular material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、不快な風味を呈す
る粒状の医薬品や食品の風味を改善するために、矯味物
質及や矯臭物質を該医薬品や食品類の粒子表面に付着さ
せるための方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for adhering a corrigent or a flavoring substance to the surface of particles of a drug or food in order to improve the taste of a granular drug or food exhibiting an unpleasant taste. Regarding
【０００２】[0002]
【従来の技術】医薬品や食品としての錠剤、顆粒、散
剤、丸剤、トローチ剤等（以下、これらを総称して、
「粒状物」とも称する。）の味、臭いなどの風味の改善
には、従来から種々の矯味物質、矯臭物質が用いられて
いる。代表的な矯味、矯臭物質としてはｌ−メントール
が挙げられる。これらの矯味、矯臭物質は、不快な臭
い、味、風味を呈する粒状の医薬品や栄養食品の臭い、
味、風味等をマスキングして経口摂取し易くするために
種々の状態で粒状物に添加されているが、最も効果的な
マスキング方法は、該粒状物の表面を矯味物質、矯臭物
質で被覆する方法である。2. Description of the Related Art Tablets, granules, powders, pills, troches, etc. for pharmaceuticals and foods (collectively,
Also referred to as "granular material". In order to improve the taste such as taste and smell, various flavoring substances and flavoring substances have been conventionally used. 1-Menthol is mentioned as a typical flavoring and deodorizing substance. These taste-masking and smelling substances are odors of granular medicines and nutritional foods that have an unpleasant odor, taste, and flavor,
It is added to the granules in various states in order to mask the taste, flavor, etc. to facilitate oral ingestion, but the most effective masking method is to coat the surface of the granules with a taste-masking substance or a flavoring substance. Is the way.
【０００３】このように、粒状物の表面を矯味物質、矯
臭物質で被覆する方法としては、通常、矯味物質、矯臭
物質を有機溶媒、例えばエタノールに溶解した後、その
溶解液を粒状物表面に噴霧して表面被覆するのが一般的
であった。溶媒として有機溶媒を用いるのは、これらの
矯味剤が水に難溶なためである。しかし、有機溶媒を使
用する被覆方法の場合、残留溶媒の問題といった製品の
安全性の問題や、その被覆工程において作業者が有機溶
媒を吸引することによる健康面への悪影響の問題、有機
溶媒の価格や環境対策のための使用溶媒の回収費用など
のコスト面の問題等があった。As described above, the method of coating the surface of the granular material with the taste-masking substance and the odor-masking substance is usually to dissolve the taste-masking substance and the odorizing substance in an organic solvent such as ethanol, and then to dissolve the solution on the surface of the granule. It was common to spray and surface coat. The reason why the organic solvent is used as the solvent is that these flavoring agents are hardly soluble in water. However, in the case of a coating method using an organic solvent, there are problems of product safety such as a problem of residual solvent, a problem of adverse health effects caused by an operator inhaling the organic solvent in the coating process, and a problem of organic solvent. There were problems in terms of cost, such as the cost and the cost of collecting the solvent used for environmental protection.
【０００４】特許第３１６６２０２号公報には、粉体に
低融点物質を混合分散し、その混合物を加熱雰囲気中に
噴射した後に冷却させ、コーティング物を製造する方法
が開示されている。この方法では、粉体そのものを噴射
する装置が必要となり、通常の製剤製造工程に導入する
ことは容易ではない。特開平１０−２０３９６５号公報
には、親水性の芯物質を被覆物質の固化温度以下の温度
で混合しながら、加熱溶融した被覆物質を添加しつつ固
化させて被覆物質層を形成させる被覆製剤の製造方法が
開示されている。この方法によれば、被覆前に被覆物質
のみを別装置中で溶融する必要があり、溶融装置、溶融
物の噴射ノズル等に特別な機器を必要とし、噴射装置の
管理、洗浄に多大の労力、費用を要するなどの問題を有
している。Japanese Patent No. 3166202 discloses a method for producing a coating by mixing and dispersing a low melting point substance in powder, spraying the mixture into a heating atmosphere, and then cooling the mixture. This method requires a device for injecting the powder itself, and it is not easy to introduce it into a usual preparation manufacturing process. Japanese Patent Application Laid-Open No. 10-203965 discloses a coating preparation for forming a coating substance layer by mixing a hydrophilic core substance at a temperature equal to or lower than the solidification temperature of the coating substance and solidifying it by adding a coating substance heated and melted. A manufacturing method is disclosed. According to this method, only the coating substance needs to be melted in another device before coating, and special equipment is required for the melting device, the melt injection nozzle, etc., and a great deal of labor is required for the management and cleaning of the injection device. However, it has problems such as cost.
【０００５】以上のように、低融点物質を無溶媒でコー
ティングする従来の方法には、特別な機器、装置を必要
とするなどの問題があり、未だ安価で、かつ効果的な被
覆方法は確立されていないのが現状である。As described above, the conventional method for coating a low-melting point substance with no solvent has problems such as requiring special equipment and equipment, and an inexpensive and effective coating method is still established. The current situation is that it has not been done.
【０００６】[0006]
【発明が解決しようとする課題】本発明の目的は、有機
溶媒を用いず、特別な機器、装置を必要とすることな
く、一般的な加熱機能を備えた流動化装置を使用するこ
とによって、不快な風味を呈する医薬用又は食品用の粒
状物の表面に矯味、矯臭剤を付着させることにより、該
粒状物の不快な味、臭い、風味等をマスキングする方法
を提供することにある。The object of the present invention is to use a fluidizing device having a general heating function without using an organic solvent, without requiring special equipment or device, An object of the present invention is to provide a method for masking the unpleasant taste, odor, flavor and the like of a granular substance for medical or food use, which has an unpleasant taste, by attaching a corrigent or a flavoring agent to the surface of the granular substance.
【０００７】[0007]
【課題を解決するための手段】本発明は、不快な味、臭
いなどの風味を呈する医薬用、食品用の粒状物の表面
に、有機溶媒を用いない方法によって矯味物質、矯臭物
質を融解付着させて、粒状物の不快な味、臭い、風味を
マスキングする方法に関するものであり、以下の各発明
を包含する。Means for Solving the Problems The present invention melts and attaches a taste masking substance and a flavoring substance to a surface of granules for medicinal or food products that have an unpleasant taste, smell or the like by a method without using an organic solvent. The present invention relates to a method for masking the unpleasant taste, smell, and flavor of a granular material, and includes the following inventions.
【０００８】（１）不快風味を呈する粒状物を流動状態
に維持しつつ、低融点の矯味・矯臭物質粒子を添加し、
次いで、給気の加熱によって流動層の温度を該矯味・矯
臭物質粒子の融点以上の温度に上昇させ、該矯味・矯臭
物質粒子の少なくとも一部を融解させて前記粒状物表面
に付着させ、しかる後、該粒状物の温度を該矯味・矯臭
物質の融点未満の温度に冷却することを特徴とする、矯
味・矯臭物質が表面に付着した粒状物の製造方法。[0008] (1) while maintaining the granules exhibit non-free flavor in a fluid state, was added flavoring material particles having a low melting point,
Next, the temperature of the fluidized bed is adjusted by heating the supply air.
The temperature of the odor substance particles is raised to a temperature equal to or higher than the melting point , and at least a part of the taste-masking / flavoring substance particles is melted and adhered to the surface of the granules. A method for producing a granular material having a taste - imparting substance attached to the surface, which comprises cooling to a temperature lower than the temperature.
【０００９】（２）低融点の矯味・矯臭物質の融点が６
０℃以下である（１）項記載の矯味・矯臭物質が表面に
付着した粒状物の製造方法。(2) The melting point of the low-melting flavoring / flavoring substance is 6
The method for producing a granular material, wherein the taste - imparting / flavoring substance according to the item (1) is 0 ° C. or lower and is attached to the surface .
【００１０】（３）低融点の矯味・矯臭物質粒子がｌ−
メントールの粒子又はｄｌ−メントールの粒子である
（１）項又は（２）項に記載の矯味・矯臭物質が表面に
付着した粒状物の製造方法。(3) The low melting point taste and odorant particles are l-
The method for producing a granular material, which is a menthol particle or a dl-menthol particle , having the surface on which the taste - masking / flavoring substance according to (1) or (2) is attached.
【００１１】（４）前記不快風味を呈する粒状物が顆粒
剤、錠剤、散剤、丸剤及びトローチ剤から選ばれる１種
である（１）項〜（３）項のいずれか１項に記載の矯味
・矯臭物質が表面に付着した粒状物の製造方法。(4) The granular material exhibiting an unpleasant taste is one selected from granules, tablets, powders, pills, and troches, and any one of (1) to (3) is described. Taste
A method for producing a granular material having a odorizing substance attached to the surface .
【００１２】（５）不快風味を呈する粒状物が、イソロ
イシン、ロイシン及びバリンの３種の分岐鎖アミノ酸の
みを有効成分として含有する医薬用顆粒剤であり、低融
点の矯味・矯臭物質がｌ−メントール粒子である（１）
項〜（４）項のいずれか１項に記載の矯味・矯臭物質が
表面に付着した粒状物の製造方法。(5) The granular material exhibiting an unpleasant taste is a medicinal granule containing only three kinds of branched chain amino acids of isoleucine, leucine and valine as an active ingredient, and the low-melting flavoring / flavoring substance is 1- Menthol particles (1)
The taste - improving substance according to any one of the items 1 to 4 is
A method for producing particulate matter adhered to the surface .
【００１３】[0013]
【発明の実施の形態】本発明の矯味、矯臭物質を不快風
味を呈する医薬品用又は食品用の粒状物へ付着させてマ
スキングする方法において、マスキング対象とされる粒
状物の形状に特に制限はなく、通常の流動化装置におい
て流動状態を維持できる粒状物であれば、錠剤、顆粒
剤、散剤、丸剤、トローチ剤などの形状のものであるこ
とができる。BEST MODE FOR CARRYING OUT THE INVENTION In the method of masking by attaching the taste masking / flavoring substance of the present invention to pharmaceutical or food-use granules having an unpleasant taste, the shape of the granules to be masked is not particularly limited. As long as it is a granular material that can maintain a fluidized state in an ordinary fluidizing device, it can be in the form of tablets, granules, powders, pills, troches, and the like.
【００１４】また、本発明がマスキング対象とする粒状
物に含まれる不快な味、臭い、風味を呈する成分の種類
にも特に制限はなく、例えばアミノ酸を有効成分として
含有する顆粒剤を示すことができる。アミノ酸の中で
も、分岐鎖アミノ酸であるイソロイシン、ロイシン及び
バリンを有効成分とする医薬用顆粒剤は、特にイソロイ
シンとロイシンに由来する苦味、特有の臭いのためにそ
の服用性に問題があることから、本発明の方法の対象粒
状物としては、該３種の分岐鎖アミノ酸を含有する医薬
用顆粒剤などが特に適している。Further, there is no particular limitation on the kind of the component exhibiting an unpleasant taste, odor or flavor contained in the granular material to be masked by the present invention, and for example, a granule containing an amino acid as an active ingredient may be shown. it can. Among the amino acids, isoleucine, which is a branched chain amino acid, a pharmaceutical granule containing leucine and valine as an active ingredient, bitterness derived from isoleucine and leucine, because of its peculiar odor, there is a problem in its ingestibility, As the target granules of the method of the present invention, pharmaceutical granules containing the three types of branched chain amino acids are particularly suitable.
【００１５】本発明の方法の対象粒状物の粒度は、通常
の流動化層値において容易に流動状態を維持できる限
り、特に制限はなく、一般的には１００〜２０００μｍ
であり、特に２００〜１７００μｍ程度の粒度が好まし
い。The particle size of the target particles of the method of the present invention is not particularly limited as long as the fluidized state can be easily maintained at a normal fluidized bed value, and generally 100 to 2000 μm.
And a particle size of about 200 to 1700 μm is particularly preferable.
【００１６】本発明の方法において使用することができ
る矯味物質、矯臭物質は、低融点であることが必要であ
り、特に６０℃を越えない融点を有する矯味物質、矯臭
物質を使用することが有利である。矯味物質、矯臭物質
の融点が高くなると、流動層全体にわたって均一な高温
状態を維持しつつ、矯味物質、矯臭物質粒子の少なくと
も一部分を融解させた状態で芯物質表面に均一に速やか
に付着させることが困難となるし、粘性の強い矯味物
質、矯臭物質の融解物を介して粒状物同士が付着して大
粒子化するという弊害もでてくる。The taste masking substance and odorizing substance that can be used in the method of the present invention must have a low melting point, and it is particularly advantageous to use the taste masking substance and odorizing substance having a melting point not exceeding 60 ° C. Is. When the melting point of the taste-masking substance and the odor-masking substance becomes high, a uniform high-temperature state is maintained throughout the fluidized bed, while at least a part of the particles of the taste-masking substance and the odorizing substance are melted and uniformly attached to the surface of the core substance quickly. It becomes difficult to do so, and there is also an adverse effect that the granular substances adhere to each other through the melt of the highly viscous taste-masking substance and the odor-eliminating substance and become large particles.
【００１７】粒状物表面に付着させて粒状物の不快な風
味をマスキングするための矯味・矯臭物質としては、粒
状物が前記のイソロイシン、ロイシン及びバリンからな
る３種の分岐鎖アミノ酸を含有する顆粒剤である場合を
例にとると、ｌ−メントールやｄｌ−メントールが使用
できる。l‐メントール（融点：４２．５℃）やｄｌ−
メントール（融点：２７〜３２℃）は常温固体で、通常
の流動化装置において、流動化層全体を均一な温度に容
易にコントロールできる温度で融解し、個々の粒子の一
部又は全部が融解した低粘性の融解物として徐々に粒状
物の表面に付着することから、特に好適な矯味物質、矯
臭物質である。As a taste-masking / flavoring substance for adhering to the surface of the granular material to mask the unpleasant taste of the granular material, the granular material contains the above-mentioned three types of branched chain amino acids consisting of isoleucine, leucine and valine. Taking the case of an agent as an example, 1-menthol and dl-menthol can be used. l-menthol (melting point: 42.5 ° C) and dl-
Menthol (melting point: 27-32 ° C) is a solid at room temperature, and melted in a normal fluidizer at a temperature at which the entire fluidized bed could be easily controlled to a uniform temperature, and some or all of the individual particles melted. Since it gradually adheres to the surface of the granular material as a low-viscosity melt, it is a particularly suitable flavoring substance and flavoring substance.
【００１８】矯味物質、矯臭物質粒子の粒度について
も、通常の流動化装置において容易に流動状態を維持で
きる限り、特に制限はないが、一般的には１００〜２０
００μｍであり、２００〜１７００μｍ程度の粒度がよ
り好ましく、さらには、マスキング対象である粒状物と
同程度の粒度であることが特に好ましい。There are no particular restrictions on the particle size of the corrigent or odorant particles, as long as the fluidized state can be easily maintained in a conventional fluidizing device, but generally 100 to 20.
The particle size is about 00 μm, more preferably about 200 to 1700 μm, and further preferably about the same as the particle size of the granular material to be masked.
【００１９】本発明の矯味物質、矯臭物質による粒状物
の不快風味のマスキングに使用される流動化装置は、本
発明の目的が達成できるものである限り特に制限はな
い。通常の乾燥、造粒、コーティングなどの目的に使用
される流動装置の中から加熱能力のある流動装置が適宜
採用される。例えば、フロイント産業（株）製の流動乾
燥装置「フロードライヤー」、フロイント産業（株）製
の流動層造粒コーティング装置「フローコーター」、
（株）パウレック製の「グラッドＧＰＣＧ」、（株）ダ
ルトン製「マルメライザー」、（株）菊水製作所製「マ
ルチプロセッサー」などが使用できる流動化装置として
挙げられる。The fluidizing device used for masking the unpleasant flavor of the granular substance by the taste masking substance and the flavoring substance of the present invention is not particularly limited as long as the object of the present invention can be achieved. A fluidizing device having a heating capacity is appropriately adopted from fluidizing devices used for usual purposes such as drying, granulation and coating. For example, a fluid drying device “Flow Dryer” manufactured by Freund Sangyo Co., Ltd., a fluidized bed granulation coating device “Flow Coater” manufactured by Freund Sangyo Co., Ltd.,
Examples of fluidizers that can be used include "Glad GPCG" manufactured by Paulec Co., Ltd., "Marmelizer" manufactured by Dalton Co., Ltd., and "Multiprocessor" manufactured by Kikusui Manufacturing Co., Ltd.
【００２０】[0020]
【実施例】以下、実施例にしたがって本発明を具体的に
説明するが、本発明はこれらの実施例によって限定され
るものではない。The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.
【００２１】実施例１
流動乾燥装置〔フロードライヤーＮＦＯＤ−１２０型
フロイント産業（株）社製〕にイソロイシン、ロイシン
及びバリンに結合剤としてヒドロキシプロピルセルロー
スを加えて、押出し造粒法によって造粒した顆粒１２０
ｋｇ（粒度３００〜１４００μｍ）を入れて、温度８０
℃の流動化用空気を吹き込みながら流動層を形成して顆
粒の乾燥を行った。この乾燥顆粒を整粒して粒度５００
〜１０００μｍに調整した後、流動造粒コーティング装
置〔グラッドＧＰＣＧ−１２０型、（株）パウレック社
製〕に入れ、白糖の水溶液のスプレーコーティングを実
施した。コーティング終了後、加熱を止め、流動状態を
維持しながら、流動層の温度をｌ−メントールの融点未
満である４０℃以下となるまで冷却した。Example 1 Flow dryer [Flow dryer NFOD-120 type]
Granules 120 prepared by extrusion granulation by adding isoleucine, leucine and valine with hydroxypropyl cellulose as a binder to Freund Industrial Co., Ltd.].
Kg (particle size 300 to 1400 μm) is put and the temperature is 80
The granules were dried by forming a fluidized bed while blowing air for fluidization at ℃. The dry granules are sized to a particle size of 500
After adjusting to ˜1000 μm, it was placed in a fluidized granulation coating apparatus [Glad GPCG-120 type, manufactured by Paulec Co., Ltd.], and spray coating of an aqueous solution of sucrose was performed. After the completion of coating, the heating was stopped and the temperature of the fluidized bed was cooled to 40 ° C. or lower, which is lower than the melting point of 1-menthol, while maintaining the fluidized state.
【００２２】別に整粒機〔コーミル１９７Ｓ、（株）パ
ウレック社製〕にて３００〜１７００μｍに粗粉砕した
ｌ−メントール粒子０．３ｋｇを、前記流動造粒コーテ
ィング装置のサンプル孔より流動層中に吸引供給し、給
気温度８５℃で再び流動層を加熱し、流動層からの排気
温度が５０℃となったところで加熱を停止した。流動停
止後冷却し、顆粒を取り出し、篩分けした。１２〜４８
メッシュ分（３００〜１４００μｍ）をコンテナ内で均
一混合した。混合顆粒からサンプルを取り出し（ｎ＝
７）、ｌ−メントール濃度を定量した結果、０．０５〜
０．０７質量％の範囲で均一にｌ−メントールが前記造
粒顆粒表面に付着していることが確認された。Separately, 0.3 kg of 1-menthol particles coarsely crushed to 300 to 1700 μm by a sizing machine [COMILL 197S, manufactured by Paulec Co., Ltd.] was put into a fluidized bed through a sample hole of the fluidized granulation coating apparatus. The mixture was suctioned and supplied, and the fluidized bed was heated again at the air supply temperature of 85 ° C., and the heating was stopped when the temperature of the exhaust gas from the fluidized bed reached 50 ° C. After stopping the flow, the mixture was cooled, and the granules were taken out and sieved. 12-48
The mesh portion (300 to 1400 μm) was uniformly mixed in the container. Take a sample from the mixed granules (n =
7), the result of quantifying l-menthol concentration was 0.05 to
It was confirmed that 1-menthol was uniformly attached to the surface of the granulated granules in the range of 0.07% by mass.
【００２３】この顆粒は、口中に含んだ際にもｌ−メン
トールの清涼感が強く、主にイソロイシンとロイシンに
起因する苦味や、不快臭が効果的にマスキングされてい
るものであった。The granules had a strong refreshing sensation of 1-menthol even when contained in the mouth, and the bitterness and unpleasant odor mainly due to isoleucine and leucine were effectively masked.
【００２４】[0024]
【発明の効果】以上に説明したように、本発明の方法に
よれば、不快な臭い、味、風味を呈する粒状物の表面
に、少なくとも一部が融解している状態の低融点矯味、
矯臭剤粒子を付着させる方法を採用することにより、有
機溶媒を使用する被覆方法に比べて、作業者の安全性改
善、環境への負荷低減、製造コストの低減などの付加的
効果を伴って、医薬用又は食品用の粒状物における不快
な臭い、味、風味等を効果的にマスキングすることが可
能となったものである。As described above, according to the method of the present invention, the low melting point taste of a state in which at least a part thereof is melted on the surface of the granular material exhibiting an unpleasant odor, taste and flavor,
By adopting the method of attaching the odorant particles, as compared with the coating method using the organic solvent, with the additional effects of improving the safety of workers, reducing the load on the environment, and reducing the manufacturing cost, It is possible to effectively mask the unpleasant odor, taste, flavor and the like in the granular material for medicine or food.
フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ Ａ６１Ｋ 47/10 Ａ６１Ｋ 47/10 Ａ６１Ｐ 3/02 Ａ６１Ｐ 3/02 // Ａ２３Ｌ 1/305 Ａ２３Ｌ 1/305 (56)参考文献 特開 平５−194193（ＪＰ，Ａ) 特開 平10−236947（ＪＰ，Ａ) 特開 平５−58880（ＪＰ，Ａ) 特開 平４−290532（ＪＰ，Ａ) 特開 平９−65850（ＪＰ，Ａ) 国際公開99／016470（ＷＯ，Ａ１) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 9/14 A23L 1/00 A23L 1/015 A61K 31/198 A61K 47/10 A61P 3/02 A23L 1/305 Continuation of front page (51) Int.Cl. 7 Identification code FI A61K 47/10 A61K 47/10 A61P 3/02 A61P 3/02 // A23L 1/305 A23L 1/305 (56) Reference JP-A-5 -194193 (JP, A) JP-A-10-236947 (JP, A) JP-A-5-58880 (JP, A) JP-A-4-290532 (JP, A) JP-A-9-65850 (JP, A) ) International publication 99/016470 (WO, A1) (58) Fields investigated (Int.Cl. 7 , DB name) A61K 9/14 A23L 1/00 A23L 1/015 A61K 31/198 A61K 47/10 A61P 3 / 02 A23L 1/305
Claims (5)
持しつつ、低融点の矯味・矯臭物質粒子を添加し、次い
で、給気の加熱によって流動層の温度を該矯味・矯臭物
質粒子の融点以上の温度に上昇させ、該矯味・矯臭物質
粒子の少なくとも一部を融解させて前記粒状物表面に付
着させ、しかる後、該粒状物の温度を該矯味・矯臭物質
の融点未満の温度に冷却することを特徴とする、矯味・
矯臭物質が表面に付着した粒状物の製造方法。1. A while maintaining the granules exhibit non-free flavor in a fluid state, was added flavoring material particles having a low melting point, then
Then, the temperature of the fluidized bed is adjusted by heating the air supply .
To a temperature equal to or higher than the melting point of the fine particles, and at least a part of the particles of the taste-masking / flavoring substance are melted to adhere to the surface of the granules. Thereafter, the temperature of the granules is lower than the melting point of the taste-masking / flavor substance. characterized by cooling the temperature, flavoring,
A method for producing a granular material having a odorant attached to the surface .
以下である請求項１記載の矯味・矯臭物質が表面に付着
した粒状物の製造方法。2. The melting point of the low-melting taste and flavor substances is 60.degree.
The method for producing granules according to claim 1, wherein the taste - masking / flavoring substance is attached to the surface of the granules.
ルの粒子である請求項１又は２に記載の矯味・矯臭物質
が表面に付着した粒状物の製造方法。3. A flavoring material according to claim 1 or 2 lower melting point flavoring material particles are particles of menthol
A method for producing a granular material in which particles adhere to the surface .
錠剤、散剤、丸剤及びトローチ剤から選ばれる１種であ
る請求項１〜３のいずれか１項に記載の矯味・矯臭物質
が表面に付着した粒状物の製造方法。4. The granular material exhibiting the unpleasant taste is a granule,
The flavoring / flavoring substance according to any one of claims 1 to 3, which is one kind selected from tablets, powders, pills and troches.
A method for producing a granular material in which particles adhere to the surface .
イシン、ロイシン及びバリンの３種の分岐鎖アミノ酸の
みを有効成分として含有する医薬用顆粒剤であり、低融
点の矯味・矯臭物質粒子がｌ−メントール粒子である請
求項１〜４のいずれか１項に記載の矯味・矯臭物質が表
面に付着した粒状物の製造方法。5. The granular material exhibiting an unpleasant taste is a medicinal granule containing only three kinds of branched chain amino acids of isoleucine, leucine and valine as an active ingredient, and particles of a low-melting flavoring / flavoring substance are 1 -Menthol particles, wherein the taste - masking / flavoring substance according to any one of claims 1 to 4 is
A method of manufacturing a granular material attached to a surface .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001275109A JP3405342B2 (en) | 2001-09-11 | 2001-09-11 | Method for producing granular material to which flavor and odorant are attached |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001275109A JP3405342B2 (en) | 2001-09-11 | 2001-09-11 | Method for producing granular material to which flavor and odorant are attached |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003081813A JP2003081813A (en) | 2003-03-19 |
| JP3405342B2 true JP3405342B2 (en) | 2003-05-12 |
Family
ID=19100030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001275109A Expired - Lifetime JP3405342B2 (en) | 2001-09-11 | 2001-09-11 | Method for producing granular material to which flavor and odorant are attached |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3405342B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201130428A (en) * | 2010-01-25 | 2011-09-16 | Japan Tobacco Inc | Method for making flavoring pellets |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2915590B2 (en) * | 1991-02-15 | 1999-07-05 | 第一製薬株式会社 | Masked granules |
| JP3166202B2 (en) * | 1991-03-15 | 2001-05-14 | 大正製薬株式会社 | Method for producing granulated or coated product |
| JP2915653B2 (en) * | 1991-11-14 | 1999-07-05 | 第一製薬株式会社 | Masked granules |
| JPH0965850A (en) * | 1995-08-31 | 1997-03-11 | T Hasegawa Co Ltd | Production of coating powder |
| JPH10236947A (en) * | 1997-02-21 | 1998-09-08 | Dai Ichi Seiyaku Co Ltd | Masking agent |
| CA2305179A1 (en) * | 1997-09-30 | 1999-04-08 | Daiichi Pharmaceutical Co., Ltd. | Oral administration preparation |
-
2001
- 2001-09-11 JP JP2001275109A patent/JP3405342B2/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| JP2003081813A (en) | 2003-03-19 |
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