JP3399645B2 - Fecal occult blood detector - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fecal occult blood detecting apparatus for detecting fecal occult blood by an immunization method utilizing an antigen-antibody reaction.

[0002]

2. Description of the Related Art A fecal occult blood detection device that can be easily operated by anyone, not only a technician but also an ordinary person (examinee) in colorectal cancer examinations such as mass examinations and next-generation OTC (over-the-counter) medicines, has no doubt. Is being considered. In this case, the fecal occult blood detection device should not be associated with discomfort and insufficiency.

The detection of occult blood in fecal excrement is a very valuable means as a screening method for colorectal cancer with poor initial subjective condition, and it is widely used for early detection and treatment in diagnosis of many pathological conditions such as digestive system. It is carried out in various medical institutions.

Detection methods can be roughly classified into two types. These consist of a chemical method for detecting the iron ion of hemoglobin and an immunization method using an antibody (SPIA method etc.). Due to the fact that there is no need to limit diets and drugs, and because of their high specificity and sensitivity, immunoassays are becoming the mainstream of occult blood detection methods. This immunization method uses a metal sol (SPI, such as gold colloid) as a labeling substance for sensitizing an antibody.
Method A), non-metal sol such as selenium and dye sol, colored latex, alkaline phosphatase, horseradish peroxidase, and other occult blood detection methods.

The detection of occult blood in fecal excrement has hitherto been mainly carried out by a person involved in a medical institution, and it is carried out through each step of a stool collection step, a suspension step, a filtration step and a detection judgment step. . Each step is carried out using its own device (stool collection stick, suspension device, etc.). However, nowadays, there is a strong tendency to manage one's own health,
Further, since it leads to early detection of colorectal cancer, which is increasing year by year, it is desired to make the diagnostic agent OTC (over-the-counter drug). Furthermore, if colorectal cancer screening is institutionalized as a health care service for the elderly,
It is considered that the demand for in-situ occult blood detection device will increase more and more in the future in mass screening and the like, and the next OTC will be realized.

[0006]

As described above, the detection of fecal occult blood is carried out by a person involved in a medical institution, but the medical institution alone has few opportunities for screening, and it is necessary to visit a medical institution. There is.

[0007] Further, in the case of OTC, the conventional fecal occult blood test is carried out through various steps such as a stool collection step, a suspension step, a filtration step, a detection determination (coloration determination) step, each with its own device. Since it is used, many operations are required. For this reason, the operation is complicated and cumbersome, and problems such as an operation error or an unsanitary feeling may occur. As described above, the conventional inspection device is not suitable for home use because the operation at the time of use is complicated.

The present invention has been made in view of the above points, and an object thereof is to provide a fecal occult blood detection apparatus which is easy to operate and excellent in hygiene.

[0009]

The invention according to claim 1 is
A container filled with a mixing solution inside and having one side open,
A detection body mounted on one side opening of the container, the detection body being mounted on the one side opening of the container, and a detection body projecting outside the case and housed in the container. The fecal occult blood detection device is characterized by having a stool stick and a determination unit that is provided in the case and determines whether occult blood is present.

The invention according to claim 2 is characterized in that the case has a communication hole on the side of the fecal collection stick, and the communication hole is sealed with a water-soluble film. It is a device.

According to a fifth aspect of the present invention, the case is attached to the container in two stages of a shallow engagement position and a deep engagement position, and the case is tightly closed at one side opening of the container with the stool stick. A body is provided, the fecal sampling stick being located outside the closure when the case is in a shallow engagement position with respect to the container and inside the closure when the case is in a deep engagement position The fecal occult blood detection device according to claim 1, further comprising a section.

According to a seventh aspect of the present invention, a projecting portion projecting inward is provided at one opening of the container, and the stool collection stick has a cylindrical portion having an open tip and communicating with the case, and the outer circumference of the tip of the cylindrical portion. The outer cylinder part having a brim that engages with the protrusion provided on the outer cylinder part, and a fixed quantity body that is provided inside the outer cylinder part and forms a fixed quantity space for fecal collection. It is a fecal occult blood detection device.

[0013]

According to the first aspect of the invention, after the stool collection stick is used for stool collection, the case of the detection body is attached to one side opening of the container to store the stool collection stick in the container. Shake to mix the stool and the mixing solution to prepare a stool suspension. Next, the fecal suspension flows into the case from the container side, and the presence / absence of occult blood is determined by the determination unit.

According to the second aspect of the invention, the fecal suspension in the container dissolves the water-soluble film provided in the communication hole of the case, and then flows into the case.

According to the fifth aspect of the present invention, the case of the detection body is attached to the container at a shallow engagement position, and the container and the detection body are shaken to mix with the stool mixing solution and the stool suspension. To create. Next, it is mounted at the deep engagement position, and the fecal suspension in the container is allowed to flow into the case through the permeation part.

According to the seventh aspect of the present invention, when the stool collecting stick is stored in the container, the collar of the outer tube portion of the stool collecting stick engages with the protruding portion in the container and the outer tube portion stops. The feces stored in the fixed volume formed by the fixed body in the outer cylinder part can be supplied to the container side by the cylindrical part.

[0017]

DESCRIPTION OF THE PREFERRED EMBODIMENTS First Embodiment An embodiment of the present invention will be described below with reference to the drawings. 1 and 2 are views showing a first embodiment of the fecal occult blood detection apparatus according to the present invention. As shown in FIGS. 1 and 2, the fecal occult blood detection apparatus includes a cylindrical synthetic resin container 11 having an opening on one side.
1 is pre-filled with a solution to be mixed with feces.
The container 11 is provided with an inner screw 11a on the inner surface on the opening side and an outer screw 11b on the outer surface on the opening side.

A sealing lid 13 having an inner screw 13a on the inner surface is attached to the opening side of the container 11 by engaging the inner screw 13a with the outer screw 11b of the container 11.

At the time of use, the sealing lid 13 is removed from the container 11, and the detecting body 20 is attached to the container 11 instead. Next, the detection body 20 will be described in detail.

The detector 20 has a cylindrical case 21 provided with an external screw 21a.
The case 21 is attached to the container 11 by engaging with the inner screw 11b of the case 21. The case 21 is made of a transparent synthetic resin material, and a communication hole 22 sealed with a water-soluble film 23 is formed on the case 11 side of the case 21.

Further, on the outside of the communication hole 22 side of the case 21,
A stool collection stick 42 having a measuring hole 43 is fixed. The stool collection stick 42 is housed in the container 11 when the case 21 is attached to the opening of the container 11.

In the case 21, the filter portion 25 and the developing spacer 32a are arranged in this order from the side of the communication hole 22.
Is provided. Further, the case 21 is enlarged at the end portion on the opposite side of the communication hole 22, and the annular pad chamber 3 is formed at the enlarged end portion.
3 is formed. Absorption pad 3 in pad chamber 33
2b is arranged, and the detection body 27 to which the antibody fixing portion 30 is attached is arranged between the developing spacer 32a and the absorption pad 32b orthogonally to the axial direction (longitudinal direction) of the case 21. Of these, the detection body 27 to which the antibody fixing portion 30 is attached and the absorption pad 32b constitute a determination portion.

Further, the filter portion 25 and the developing spacer 3
An antibody-sensitized particle portion 29 is provided between the 2a and 2a. As the particles forming the antibody-sensing particle portion 29, a metal sol such as gold or silver, a non-metal sol such as selenium, or a colored latex is used, and the particle size is 1 nm to 100 nm.
Is preferred.

Next, each component will be described. The filter part 25 removes impurities in the fecal suspension flowing from the container 11 side, and is configured in three stages in FIG. 1, but the filter part 25 is not limited to three stages and the number is less than this. , Or more. Further, the detection plate 27 is disposed between the developing spacer 32a and the absorption pad 32b so as to be orthogonal to the longitudinal direction of the case 21, and the container 11
The stool suspension flowing in from the side is permeated, and the antibody-sensitized particles passing with the stool suspension are trapped by the antibody fixing unit 30 when positive. The detection plate 27 is made of nitrocellulose, glass fiber filter, chromatography paper, PVDF (trade name), nylon-based or polyester-based nonwoven fabric, or the like.
An anti-hemoglobin antibody is fixed to the antibody fixing portion 30. Further, excess stool suspension and antibody-sensitized particles pass through the detection plate 27 and are absorbed by the absorption pad 32b.

Next, the operation of this embodiment having such a configuration will be described. First, stool collection is performed using the stool collection stick 42 of the detection body 20. In this case, stool collection stick 4
2 is stabbed in the stool from the side of the measuring hole 43. Then, the stool collection stick 42 of the detection body 20 is pulled out from the stool, and the squeegee (not shown) wipes the stool collection stick 42. In this way, a certain amount of feces is collected in the measuring hole 43.

Next, the sealing lid 13 is removed from the container 11,
The case 21 of the detection body 20 is attached to the opening of the container 11 which is filled with the mixing solution in advance. In this case, the container 11
A stool collection stick 42 is stored inside. Next, case 21
The container 11 sealed by is shaken well, the stool and the solution are mixed, and a stool suspension is thus obtained. Then, after a while, the water-soluble film 23 provided in the communication hole 22 of the case 21 is dissolved by the fecal suspension, and the container 1
The fecal suspension in 1 flows into the case 21 side through the communication hole 22. The stool suspension that has flowed into the case 21 then passes through the filter unit 25. During this period, impurities in the fecal suspension are removed by the filter unit 25.

Next, the stool suspension that has passed through the filter portion 25 passes through the developing spacer 32a together with the antibody-sensitized particles, and permeates into the detection plate 27 toward the absorption pad 32b. When the stool is positive, the antibody-sensitized particles in the stool suspension are trapped in the antibody-fixing section 30 via hemoglobin. The antibody-sensitized particles thus trapped in the antibody-fixing part 30 exhibit coloration in the antibody-fixing part 30, and the result can be confirmed from the outside of the case 21.

During this period, the excess fecal suspension and antibody-sensitized particles that have penetrated the detection plate 27 are absorbed by the absorbent pad 32b, so that the fecal suspension and antibody-sensitized particle detection plate 27 is detected.
The inside can be smoothly permeated.

As described above, according to this embodiment,
After collecting the stool with the stool collection stick 42, the detection body 20 is attached to the opening of the container 11, and the occult blood can be detected easily and simply by shaking the container 11. Therefore, an operation error can be eliminated and occult blood can be detected without any hygiene problem.

Next, a modification of the present invention will be described with reference to FIGS. 3 and 4. The modified examples shown in FIGS. 3 and 4 are
Only the structure of the detection body is different, and the others are the same as in FIG. 1 and FIG.
It is almost the same as the embodiment shown in FIG.

As shown in FIG. 3 and FIG.
Has a cylindrical case 21, and a communication hole 22 sealed by a water-soluble film 23 is provided in the case 21. In addition, in the case 21, a detection plate 27 to which a filter portion 25 and an antibody fixing portion 30 are attached in order from the communication hole 22 side.
And an absorbent pad 32 is provided. Further, an antibody-sensitized particle portion 29 is provided between the filter portion 25 and the detection plate 27.
And the detection plate 27 is arranged along the axial direction of the case 21.

According to the present embodiment, when the result is positive, the antibody-sensitized particles are trapped in the antibody-immobilized portion 30 through hemoglobin to show a color. In this case, since the detection plate 27 to which the antibody fixing part 30 is attached is arranged along the axial direction of the case 21, the color change of the antibody fixing part 30 can be easily and clearly confirmed from the side of the case 21. . Second Embodiment Next, a second embodiment of the present invention will be described with reference to FIGS. In this embodiment, the same parts as those in the first embodiment shown in FIGS. 1 to 4 are designated by the same reference numerals and detailed description thereof will be omitted.

In FIGS. 5 (a) and 5 (b), the fecal occult blood detection device is a container 11 which is filled with a mixing solution inside and has one side opened, and a detection body 20 which is attached to one side opening of the container 11.
It has and.

As shown in FIG. 8, the container 11 is provided with a rubber sealing body 52 for sealing the one side opening, and the outside of the sealing body 52 is tapered toward the inside of the container 11. A guide recess 52a is formed. The bottom of the guide recess 52a is a thin portion 52b. Further, a hermetic seal 70 is attached to one open end of the container 11.

Further, inside the container 11, a scraping brush 51 for scraping the inside of the weighing section 50 provided at the tip of the fecal sampling stick 42 described later is provided extending in the radial direction (FIG. 5 (b)). ).

On the other hand, as shown in FIG. 7, the detection body 20 includes a transparent case 21 which is attached to one side opening of the container 11, and a stool collection stick which projects outward from the case 21 and is housed in the container 11. And 42. Case 2 again
A cylindrical portion 48 extending in a cylindrical shape is provided on the side of the stool collection stick 42 of No. 1, and a concave portion 55 formed on the outer surface of the container 11 when attached to the container 11 is formed on the inner surface of the cylindrical portion 48.
Projections 56a and 56b that engage with a and 55b are provided, respectively.

That is, the case 21 can be attached to the container 11 in two stages, a shallow engagement position and a deep engagement position. When the case 21 is attached at the shallow engagement position, the case 55 and the case 55a of the container 11 can be attached together. 21 is engaged with the convex portion 56b (FIG. 5).
(See (a)). When it is mounted at a deep engagement position, the concave portions 55a and 55b of the container 11 and the convex portions 56a and 56b of the case 21 are engaged with each other (see FIG. 6).

Next, the stool collection stick 42 of the detector 20 will be described. The stool collection stick 42 protrudes from the partition wall 49 of the case 21 in the axial direction of the case 21, and has a stool collection part composed of a weighing part (a groove extending in the axial direction) 50 at its tip. The stool collection stick 42 has a penetrating portion 53 extending from the inside to the outside of the case 21 at the base end portion thereof, and an intermediate member 59 at the middle portion. The permeation part 53 is formed by sintering ceramic particles, or is made of polyethylene terephthalate or cellulose fiber, and is adapted to quickly permeate water. Also,
On the outer periphery of the permeation portion 53, a plastic protective cover 53a for barriering moisture, leaving a portion on the intermediate member 59 side.
Is installed.

When the case 21 is attached to the container 11 at a shallow engagement position (in the case of FIG. 5A), the exposed portion 53b of the permeation portion 53 which is not covered by the protective cover 53a is the sealing body 52. When the case 21 is attached to the container 11 at a deep engagement position (in the case of FIG. 6), the exposed portion 53b of the permeation portion 53 is located inside the sealing body 52. .

In the case 21, an antibody-sensitized particle portion 29, a detection body 27 having an antibody fixing portion 30, and an absorption pad 32 are arranged in this order from the permeation portion 53.

Next, the operation of this embodiment having such a configuration will be described. First, the stool collection stick 42 of the detection body 20 is pierced in the stool to collect stool. Next, by wiping off the stool collection stick 42 with a stage (not shown),
Stool is stored in the weighing unit 50 of the stool collection unit.

Next, the hermetic seal 70 is peeled off from one open end of the container 11, and the stool collection stick 42 is inserted into the guide recess 52a of the hermetically sealed body 52 from the tip side. In this case, the guide recess 52a of the sealing body 52 can reliably guide the tip of the fecal sampling stick 42 to the thin portion 52b. Next, the thin portion 52b of the sealing body 52 is pierced by the tip of the stool collection stick 42,
2 enters the inside of the container 11. In this case, the outer circumference of the stool collection stick 42 and the sealing body 52 are in close contact with each other, and a sealing function is exhibited.

Next, the weighing section 5 at the tip of the stool collection stick 42
0 is scraped off by the scraping brush 51, and the weighing unit 50
The stool inside flows out into the container 11.

Next, the recess 55a of the container 11 is
The case 21 is attached to the container 11 at a shallow engagement position by engaging with the convex portion 56b (see FIG. 5A). In this case, the outer peripheral exposed portion 53b of the permeation portion 53 is located outside the sealing body 52, so that the solution in the container 11 may be the case 2
It does not penetrate to the 1 side. In this state, the container 11 and the detection body 20 are shaken well, the feces and the solution are mixed in the container 11, and a fecal suspension is thus obtained.

Next, by further pushing the detection body 20 toward the container 11, the concave portions 55a and 55b of the container 11 are engaged with the convex portions 56a and 56b of the case 21, respectively, and the case 21 is deeply engaged with the container 11. It is installed at the mating position (Fig. 6).
In this case, the sealed body 52 of the container 11 abuts on the protrusion 58 of the case 21, and the exposed portion 53b of the permeation portion 53 is formed.
Is located inside the sealing body 52. Therefore, the fecal suspension in the container 11 permeates from the outer peripheral exposed portion 53b of the permeation portion 53 to the case 21 side through the inside of the permeation portion 53. At this time, the permeation section 53 also functions as a filter.

The stool suspension then sequentially penetrates into the antibody-sensitized particle portion 29, the detection plate 27 and the absorption pad 32 in the case 21.

When the stool is positive, the antibody-sensitized particles in the stool suspension are trapped in the antibody-immobilized portion 30 via hemoglobin, and the antibody-sensitized particles thus trapped are colored in the antibody-immobilized portion 30. Show. This result can be confirmed from the outside of the case 21.

According to this embodiment, the container 21 and the case 21 are
Container 1 at a shallow engagement position and shake well
The stool suspension can be easily obtained within the container 1, and the case 21 is attached to the container 11 at a deep engagement position so that the stool suspension inside the container 11 can surely permeate into the case 21 side. You can Further, when the thin portion 52b of the sealing body 52 is pierced by the tip of the stool collection stick 42, the stool collection stick 42 can be wiped off, and the scraping brush 51 scrapes the inside of the weighing section 50 sufficiently to remove the stool in the weighing section 50. Can flow out into the container 11.

In the above embodiment, the permeation part 53 of the detection body 20 also has a function as a filter,
Although the filter portion is not provided in the case 21, the filter portion may be provided separately from the permeation portion 53. Third Embodiment Hereinafter, a third embodiment of the present invention will be described with reference to FIGS. 9 to 13. In this embodiment, the same parts as those in the first embodiment shown in FIGS. 1 to 4 are designated by the same reference numerals and detailed description thereof will be omitted.

In FIGS. 9 to 13, the fecal occult blood detection apparatus comprises a container 11 filled with the mixing liquid 72 and having one side opened, and a detection body 20 attached to the one side opening of the container 11. I have it.

Of these, as shown in FIG. 13, the container 11 is made of synthetic resin, and a rubber-made projecting portion 60 projecting inward is provided circumferentially at one side opening, and this projecting The portion 60 is engaged with and supported by a step portion 74 formed on the inner surface of the container 11. An aluminum foil 68 is attached to the upper end surface of the rubber protrusion 60 with a heat sealing agent to seal the inside of the container 11.

On the other hand, as shown in FIG. 12, the detection body 20 has a transparent case 21 which is attached to one side opening of the container 11, and when this case 21 is attached to one side opening of the container 11, The upper end of 11 is abutted. Further, a stool collection stick 42 housed in the container 11 is provided outside the case 21 so as to project therefrom. The tip of the stool collection stick 42 is open and the base end is the case 21.
Has a cylindrical portion 63 communicating with the outer cylindrical portion 63 and an outer cylindrical portion 66 provided on the outer periphery of the distal end of the cylindrical portion 63. Of this, the cylindrical portion 63
Is made of a synthetic resin such as ABS and has a predetermined length. The outer cylinder portion 66 has a flange 67 that engages with the protrusion 60 of the container 11 and protrudes outward in the radial direction. The outer tubular portion 66 has a circumferential projection 66 a that projects inward at a position corresponding to the collar 67. And protrusion 6
By engaging 6a with a groove (not shown) formed on the outer periphery of the cylindrical portion 63, the cylindrical portion 63 and the outer cylindrical portion 66 are integrally connected.

Further, a lower end of the outer cylinder portion 66 is opened, and a synthetic resin having a fixed amount concave portion 65a in the outer cylinder portion 66,
A quantitative body 65 made of glass or metal is attached. The metering body 65 is arranged with the metering concave portion 65a facing downward, and the metering body 65 is held in the outer cylinder portion 66 by a projection 66b circumferentially provided in the outer cylinder portion 66.

A fixed quantity space for accommodating a predetermined amount of feces is formed by the outer cylinder portion 66 and the fixed quantity recess 65a of the fixed quantity body 65.

In the case 21, the filter portion 25 and the antibody-sensitized particle portion 2 are arranged in this order from the side of the stool collection stick 42.
9, the detection body 27 to which the antibody fixing portion 30 is attached, and the absorption pad 32 are provided.

Next, the operation of this embodiment having such a configuration will be described. First, the stool collection stick 42 of the detection body 20 is pierced in the stool to collect stool. In this case, a predetermined amount of feces 73 is stored in the fixed volume formed by the outer cylinder portion 66 and the fixed portion 65a of the fixed body 65.

Next, the detection body 20 is attached to the one side opening of the container 11. In this case, as shown in FIG. 9, the aluminum foil 68 is first broken by the lower end of the outer tube portion 66 of the fecal sampling stick 42, and the outer tube portion 66 enters the container 11. This time,
The aluminum foil 68 can be easily broken by providing a protrusion on the lower end of the outer tubular portion 66. Further, when the outer tube portion 66 breaks the aluminum foil, the feces 73 protruding outward from the outer tube portion 66 go around the outer tube portion 66 and therefore do not enter the container 11 and thereby the predetermined amount. The feces can be supplied into the container 11.

Next, as shown in FIG. 10, when the stool collection stick 42 is inserted into the container 11, the collar 6 of the outer cylinder portion 66 is inserted.
7 contacts the protruding portion 67 of the container 11, and the outer cylinder portion 66 stops. When the stool collection stick 42 is further advanced into the container 11, the protrusion 66a of the outer cylinder portion 66 and the cylindrical portion 63 are disengaged, and only the cylindrical portion 63 descends. Due to the lowering of the cylindrical portion 63, the quantitative body 65 is pushed downward, and the quantitative body 65 is disengaged from the projection 66b of the outer tubular portion 66 and descends downward. In this way, the feces 73 in the fixed volume are supplied into the container 11.

When the cylindrical portion 63 further descends, the detection body 20
The lower end of the case 21 comes into contact with the upper end of the container 11, and the work of mounting the detection body 20 on the container 11 is completed in this manner (see FIG. 11).

In this case, the cylindrical portion 63 and the outer cylindrical portion 66 are
Since the projections 66a and 66b are sealed and the projecting portion 60 and the outer tubular portion 66 are sandwiched between the container 11 and the cylindrical portion 63, the inside of the container 11 is completely sealed at the projecting portion 60. In this state, the container 11 and the detection body 20 are shaken well, and the feces 73 and the mixing solution 72 are mixed in the container 11 to obtain a fecal suspension. In this case, the quantitative body 65
Vibrates in the container 11 and assists in mixing the stool 73 and the mixing solution 72.

Next, the container 11 and the detection body 20 are repeated, and the fecal suspension in the container 11 is transferred from the cylindrical portion 63 to the case 21.
Flows to the side. The stool suspension that has flowed into the case 21 side then sequentially penetrates into the antibody-sensitized particle portion 29, the detection plate 27, and the absorption pad 32 in the case 21. The penetration amount of the fecal suspension into the case 21 can be adjusted by the protruding length L of the cylindrical portion 63 from the protruding portion 60. That is, when the protrusion length L is long, the permeation amount of the stool suspension is small, and when the protrusion length L is short, the permeation amount of the stool suspension is large.

When the stool is positive, the antibody-sensitized particles in the stool suspension are trapped in the antibody-immobilized portion 30 via hemoglobin, and the antibody-sensitized particles thus trapped are presented in the antibody-immobilized portion 30. Indicates a color. This result can be confirmed from the outside of the case 21.

According to this embodiment, the stool collection stick 42 is pierced into the stool, and the fixed amount recess 6 of the outer cylinder portion 66 and the fixed amount body 65 is inserted.
A predetermined amount of stool 73 can be reliably supplied into the container 11 simply by inserting the stool collection stick 42 into the container 11 after storing the stool 73 in the fixed volume formed by the inside of 5a. Further, when the feces 74 and the mixing solution 73 are mixed in the container 11, the quantitative body 65 vibrates in the container 11 to assist the mixing.

[0064]

As described above, according to the first aspect of the present invention, the occult blood is easily and easily simply attached to the opening of the container after the stool is collected by the stool stick and the container is shaken. Detection can be performed. Therefore, it is possible to prevent an operation error and avoid a hygiene problem associated with the operation error.

According to the second aspect of the invention, the water-soluble film can be dissolved by the fecal suspension in the container and easily flowed into the case of the detector.

According to the fifth aspect of the present invention, by mounting the case of the detection body on the container at a shallow engagement position and mixing, the liquid in the container does not flow into the case side during mixing. Then, by mounting the case on the container at a deep engagement position, the fecal suspension in the container can easily flow into the case.

According to the seventh aspect of the present invention, the feces stored in the fixed volume in the outer cylinder are accurately supplied to the container side by a predetermined amount only by storing the fecal sampling stick of the detection body in the container. be able to.

[Brief description of drawings]

FIG. 1 is a side sectional view showing a first embodiment of a fecal occult blood detection apparatus according to the present invention.

FIG. 2 is a sectional view of the fecal occult blood detection device of FIG. 1 taken along the line II-II.

FIG. 3 is a partial side sectional view showing a modified example of the fecal occult blood detection device according to the present invention.

FIG. 4 is a sectional view taken along line IV-IV of the fecal occult blood detection device of FIG. 3.

FIG. 5 is a view showing a second embodiment of the fecal occult blood detection apparatus according to the present invention and showing a state where a case and a container are shallowly engaged with each other.

FIG. 6 is a view showing a state in which the case and the container are deeply engaged with each other in the second embodiment.

FIG. 7 is a side sectional view showing a detector according to a second embodiment.

FIG. 8 is a side sectional view showing the container of the second embodiment.

FIG. 9 is a diagram showing a third embodiment of the fecal occult blood detection apparatus according to the present invention, showing a state in which a fecal sampling stick has started to be inserted into a container.

FIG. 10 is a view showing a state in which a fecal sampling stick is further inserted.

FIG. 11 is a view showing a state in which the stool collection stick has been inserted.

FIG. 12 is a side sectional view showing a detector according to a third embodiment.

FIG. 13 is a side sectional view showing the container of the third embodiment.

[Explanation of symbols] 11 containers 13 Sealing lid 20 detector 21 cases 22 communication holes 23 Water-soluble film 25 Filter section 27 Detection plate 30 Antibody fixing part 42 stool stick 52 Sealed body 53 Penetration part 55a, 55b Recess 56a, 56b convex part 60 Projection 63 Cylindrical part 65 Quantitative body 66 Outer cylinder 67 brim 72 Mixing solution Flight 73

─────────────────────────────────────────────────── ─── Continuation of the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) G01N 33/50 G01N 1/04 G01N 33/48 G01N 33/53

Claims (7)

(57) [Claims] 1. A container, which is filled with a mixing solution inside and is open on one side, and a detector attached to one opening of the container, wherein the detector is attached to one opening of the container. Fecal occult blood detection, comprising: a case, a fecal sampling stick projecting outside of the case and capable of being stored in the container, and a determination unit provided in the case for determining the presence or absence of occult blood. apparatus. 2. The fecal occult blood detection device according to claim 1, wherein the case has a communication hole on the side of the fecal collection stick, and the communication hole is sealed with a water-soluble film. 3. The determination unit includes a detection plate that allows a stool suspension to penetrate,
It consists of an antibody fixing part attached to this detection plate that traps antibody-sensitized particles that pass with the stool suspension when positive, and an absorber for absorbing the stool suspension and antibody-sensitized particles that have passed through. The fecal occult blood detection device according to claim 1. 4. The in-stool occult blood detection device according to claim 1, further comprising a filter part for removing impurities in the stool suspension between the communication hole in the case and the determination part. 5. The case is attached to the container in two stages, a shallow engaging position and a deep engaging position, and a sealing body that is in close contact with a stool stick is provided at one side opening of the container.
The stool collection stick has a penetrating portion that is located outside the sealing body when the case is in a shallow engagement position with respect to the container and inside the sealing body when the case is in a deep engagement position. The fecal occult blood detection device according to claim 1. 6. The stool collection stick has a stool collection part having a metering property at its tip, and a scraping brush capable of scraping the stool collection part inside the container is provided. In-stool occult blood detector. 7. A container having a projecting portion projecting inwardly at one opening of the container, the stool collection stick having a cylindrical portion having an open tip and communicating with the inside of the case, and the projecting portion provided on the outer periphery of the tip of the cylindrical portion. The fecal occult blood detecting device according to claim 1, further comprising: an outer cylinder part having a collar that engages with the outer cylinder part, and a quantitative body that is provided in the outer cylinder part and forms a quantitative space for collecting feces.