JP3348866B2 - Intraocular lens and processing method thereof - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an intraocular lens used as a substitute for a lens of ocular tissue and a method of processing the same.

[0002]

2. Description of the Related Art An intraocular lens which is inserted as a substitute for a crystalline lens, for example, after a crystalline lens is extracted due to a cataract, generally includes an optical part serving as a lens and an optical support for holding the optical part in the eye. It generally comprises a loop. Such an intraocular lens includes a so-called single piece in which an optical unit and an optical support unit are integrally processed, and a so-called three-piece unit in which the optical unit and the support unit are separately processed and integrated by caulking. -There is something called a piece.

[0003]

However, the former has the following disadvantages. When a high molecular weight substrate is selected, the support is brittle and easily broken. When selecting a low-molecular-weight one, the support part is flexible, but the optical part is easily damaged by photocoagulation treatment when late cataract occurs. In the latter case, a dedicated device for crimping has to be prepared, which causes an increase in cost. Further, when a high molecular weight optical part and a low molecular weight optical support part are used, there is a disadvantage that the bonding strength by caulking is weak and the fiber is easily broken.

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned drawbacks, and a first object of the present invention is to provide a sleeper type intraocular lens having a high bonding strength between an optical part and an optical support part. is there. A second object is to provide an intraocular lens in which the optical section is not damaged by photocoagulation surgery or the like, the optical support section is rich in flexibility, and the stability during insertion into the eye is good. A third object is to provide a method for processing these intraocular lenses.

[0005]

In order to achieve the above object, the present invention is characterized by the following. That is, (1) an optical part obtained by a cutting process in advance and an optical support part for supporting the optical part at a predetermined position of a surgical eye, and the optical support part is formed around the optical part. In the intraocular lens mounted in the mounting hole, a polymerization initiator is added to a monomer polymerizable with the optical unit and the optical support unit, and radical polymerization is performed by heating, and a polymerization reaction is performed.
Radicals obtained by terminating
After the prepolymer is interposed between the two,
The optical part and the optical support part are chemically bonded by heating and polymerizing again, and the bonding strength between the optical part and the optical support member.
Is 150 g or more in a tensile test .

(2) The optical part of (1) is compared with the optical support part.
That it is composed of relatively high-molecular substances
Features.

(3) A method of processing an intraocular lens in which an optical part and an optical part are separately processed into a predetermined shape, and then an optical support part is mounted in a mounting hole formed in a peripheral part of the optical part. , a polymerization initiator is added to the polymerizable monomer and the optical unit and the optical support portion, Raj by heating
Terminate the polymerization reaction in the middle of the cal polymerization
A step of obtaining a prepolymer in which radicals obtained by remain, an application step of applying the prepolymer to at least one of a mounting hole or an optical support formed in the optical unit, and a tip of the optical support in the mounting hole of the optical unit. It is characterized by comprising a step of inserting, and a step of chemically bonding the optical part and the optical support part by applying heat again to the prepolymer and polymerizing it.

[0008]

[0009]

[0010]

[0011]

[0012]

[0013]

An embodiment of the present invention will be described below with reference to FIG. FIG. 1 is a flowchart showing one embodiment of the present invention. A plate material made of polymethyl methacrylate as a main raw material (an ultraviolet absorber or the like is mixed as necessary) is punched into a disk shape (step 1). Polymethyl methacrylate
The material used has a relatively high molecular weight (molecular weight of about 1,000,000). The optical part of the intraocular lens is made by cutting a so-called core punched into a disk shape to have a predetermined refractive power with a diameter of 4 to 8 mm (step 2). The optical part is machined with holes such as an optical support part mounting hole (0.15-0.25 mm in diameter) and a manipulation hole (step 3). On the other hand, the optical support has a relatively low molecular weight (molecular weight of about 2).
(100,000 to 300,000) polymethyl methacrylate wire is formed into a loop, cut into appropriate lengths, and used (diameter 0.1 to 0.2 mm, length 5 to 8 mm). ) (Step 4).

Further, a prepolymer is prepared as an intermediate substance chemically bonded to the optical part and the optical support part. The prepolymer was prepared by adding benzoyl peroxide as a polymerization initiator to a monomer of methyl methacrylate (step 5), and the temperature was reduced to 70 degrees Celsius.
The reaction was carried out for about 6 to 8 hours before and after the temperature (step 6).

Next, a prepolymer coating step is performed. The prepolymer is applied by dipping the tip of the optical support into the prepolymer liquid (step 7) or by injecting the prepolymer liquid into the optical support mounting hole with a needle-like instrument (step 8). The prepolymer may be applied to at least one of the optical support portion and the optical support portion mounting hole. After the prepolymer application step, the tip of the optical support is inserted into the optical support mounting hole (step 9). In this state, place the intraocular lens in a space heated to 60 to 70 degrees Celsius for 24 hours,
The prepolymer is polymerized and cured (step 10).

The bonding strength between the optical part and the optical support part of the thus obtained intraocular lens was tested by a so-called tensile test. While the joining strength of the conventional joining method by caulking is about 90 g, the joining strength of the present embodiment is remarkably improved to about 150 g or more (by a tensile test). In addition, it was the optical support member itself, not the joint, that was damaged by the 150 g load. In the above-described embodiment, methyl methacrylate was used as the optical part, the optical support part, and the intermediate conjugate, but the constituent molecules of the optical part, the optical support part, and the intermediate conjugate need not necessarily be the same kind. Instead, an intermediate joint that can be polymerized between the optical unit and the optical support unit and that is safe for the body may be selected. Examples of simple substances suitable for the optical part, the optical support part, and the intermediate joint include, in addition to methyl methacrylate, substances such as hydroxyethyl methacrylate and butyl methacrylate.

[0017]

As is clear from the above description, according to the present invention, light is applied to the optical portion obtained by cutting in advance.
Chemical supports are chemically bonded via intermediates,
Stronger joint strength than conventional caulking
You. Also, without the optical unit in such photocoagulation surgery is damaged, it is possible to obtain easily an intraocular lens rich in even flexible optical support.

[Brief description of the drawings]

FIG. 1 is a flowchart showing one embodiment of the present invention.

Claims (3)

(57) [Claims] 1. An optical part obtained by a cutting process in advance and an optical support part for supporting the optical part at a predetermined position of a surgical eye, and the optical support part is formed around the optical part. In the intraocular lens mounted in the mounting hole, a polymerization initiator is added to a monomer that can be polymerized with the optical unit and the optical support unit, and radical polymerization is performed by heating, and polymerization is performed.
The radical obtained by terminating the combined reaction is
After the remaining prepolymer is interposed between the two, heat is applied to the prepolymer again to cause polymerization , whereby the optical portion and the optical support portion are chemically bonded to each other, and the optical portion and the optical support member are connected to each other.
An intraocular lens having a combined strength of 150 g or more in a tensile test . 2. The intraocular lens according to claim 1, wherein the optical section is made of a relatively high-molecular substance as compared with the optical support section. 3. A method for processing an intraocular lens, wherein an optical part and an optical part are separately processed into a predetermined shape, and an optical support part is mounted on a mounting hole formed in a peripheral part of the optical part. A polymerization initiator is added to a monomer polymerizable with the optical unit and the optical support unit, and radical polymerization is performed by heating.
And by terminating the polymerization reaction
A step of obtaining a prepolymer in which the obtained radical remains, a coating step of applying the prepolymer to at least one of a mounting hole or an optical support formed in the optical unit, and inserting a tip of the optical support into the mounting hole of the optical unit. And a step of chemically bonding the optical part and the optical support part by applying heat again to the prepolymer to polymerize the prepolymer.