JP3313428B2 - Spray dispenser for spray administration of intranasal drugs - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION In the pharmaceutical field, single or multi-use special packs have been developed for intranasal spray administration of drugs. All of these containers / dispenser packs are manually operated by the user pressing the slider. This operation requires rapid and strong movements or the spray jet will not spray properly.

[0002]

BACKGROUND OF THE INVENTION This rapid, intense movement is not achieved by some patients, and thus the drug is not administered properly and loses its efficacy. Also, single-use packs are very popular now because it is easy to calculate the number of doses during a predetermined period,
It is not possible to split the drug delivery into two doses, one for each nostril. Such divided administration is the most efficient and therefore most desirable. The requirements for drug administration are therefore the calculation of the number of drug deliveries over a period of time, the drug delivery that divides each dose into two nostrils, and a complete spray independent of the speed and intensity of the user's movement. Known multi-use devices solve the twin feeding problem, and single-use devices solve the computational problem, none of which solves the spraying problem.

[0003]

Accordingly, the use of dispensers can be simplified and inaccurate by dividing the drug administration into two deliveries, one for each nostril, and simultaneously facilitating the operation of the sprayer. It became clear that there was a need to prevent unreasonable transmission. This means partial servo assisted spraying that is not completely dependent on the speed and intensity of the user's movement.

[0004] Such needs necessitate a twin dose dispenser, ie, the dose can be split in two halves to split the drug administration first into one nostril and then into the other nostril, and to ensure nebulization. Research was undertaken to develop a dispenser with additional servo assist means. The applicant discloses the features and details of the present invention in this patent application, as the results of this study are very satisfactory from a usage and manufacturing cost standpoint.

[0005]

SUMMARY OF THE INVENTION A container / dispenser pack according to the present invention for intranasal spraying of a particular medicament includes a body that acts as a slider, which is held by a user at the tip of two fingers. The slider has a spray nozzle at the top and a protruding cylindrical neck at the bottom, in which a cup-shaped housing is axially slidably disposed. This housing also acts as a control push button for the user to press with his thumb. The cup-shaped housing encloses a cylindrical drug solution container, which includes an axially slidable piston / pump therein, the piston / pump characteristically including a stem, each of which has a recess. It comprises two mutually spaced grooves with profiled bottoms, each said groove forming a sheet holding a resilient detent ring with radial slits.

[0006] These two elastic detent rings are sequentially snapped out of their respective retaining grooves by the force of the user's finger to control the piston stroke so as to divide the piston stroke in the case of twin use into two halves. I do. Further, the light stress required to cause the two resilient detent rings to snap out of their respective seats accumulates precise energy in the user's finger, which is momentarily released by the snap out of each ring,
It produces the exact operating speed required to produce the best spray in any condition. Hereinafter, the present invention will be described in detail with reference to embodiments shown in the drawings, but the present invention is not limited thereto.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS As shown in FIG. 1, a container / dispenser for intranasal spray administration according to the present invention substantially comprises a body or slider 1, which body is a radially flat extension for a finger hold down operation. And an upwardly projecting tubular cylinder having a spray nozzle (not shown) at the upper end. A cylindrical neck 2 protrudes from the lower part of the slider 1,
Disposed in this neck is an axially slidable cup-shaped push button / housing element 3 against which the lower end of the stem 4 of the piston / pump 12 is supported against the bottom of the housing element. It is slidable in the liquid medicine container 5 in the axial direction. The stem 4 of said piston / pump 12 has two different diameters, the larger diameter being the upper diameter and the smaller diameter being the lower diameter. Said stem 4 is provided at its respective diameter part with annular grooves 6, 7 having a concave bottom, which respectively hold elastic detent rings 8 and 9 as sheets.

The diameter of the bottom of the upper groove 6, and thus of the upper elastic detent ring 8, is larger than the corresponding diameter of the groove 7 and the ring 9 and slightly larger than the diameter of the lower part of the stem 4. The two diameters of the stem 4 are joined by a bevel 10, thereby facilitating snap-out of the resilient detent ring 8 and facilitating assembly of the detent ring 8 into the groove 6 during the manufacturing process. 2
The two elastic detent rings 8, 9 each have a radial slit 11 which promotes elasticity, as shown in FIG. A unit consisting of a piston / pump 12 and its stem 4, elastic detent rings 8, 9 carried in grooves 6, 7 of this stem and the lower edge 13 of the container 5
It provides a servo assist device that allows for safer, complete spraying, and a control system that allows for double feed or two-half split feed.

The operation of this system will be described below with reference to FIGS. 1, 3 and 4. In the position shown in FIG. 1, the upper elastic detent ring 8 bears against the lower edge 13 of the container 5. When the push button / housing 3 is pushed in the direction of the arrow to achieve the first drug delivery, pressure is exerted on the piston / pump 12 abutting the bottom of the push button / housing 3 by the end of the stem 4. In this state, the movement of the piston / pump 12 is
Resisted by an elastic detent ring 8 abutting 3.

In order to achieve the first delivery of the medicament, it is necessary to apply sufficient pressure to expand the elastic detent ring 8 and snap it out of the groove 6, which causes the ring 8 to slide downward. It is then stopped by the resilient detent ring 9 still in the groove 7 and thus the piston / pump 12 makes a half stroke inside the container 5 as shown in FIG. The pressure is set based on the elasticity of the elastic detent ring 8 and this pressure stores energy in the user's hand, which is released momentarily when the ring 8 snaps out of the groove 6. You. The same operation may be repeated to perform the second delivery of the medicine. Since the resilient detent ring 9 exhibits the same resistance as the ring 8, it is necessary to store energy in the user's hand in order to snap the ring 9 out of the groove 7 as shown in FIG. . Such an instantaneous release of stored energy results in the best spraying effect independent of the user's depressing speed on slider 1 and housing / container 3.

FIGS. 5, 6, 7 and 8 show another embodiment of the invention, in which the housing / container 103 has two stop projections 114 and the slider 101
Protruding neck 102 has two vertical slots 115,
Each slot 115 includes a stopper shoulder 118 as shown in FIGS. All other components and functions are the same as in the basic embodiment described above. As shown in FIG.
At the end of the stroke, the stroke of the housing / container 113 and thus the piston / pump 12 is stopped by the detent action of the ring 9 on the ring 8 and also by the detent action of the shoulder 116 on the stop projection 114 of the housing / container 103. . To accomplish the second stroke, it is first necessary to rotate the housing / container 113 as shown by the arrows in FIGS. 6 and 7 to remove the obstruction of the shoulder 116 against the stopper 114, and then to Apply downward force to.

This alternative embodiment improves safety in the control of the first stroke and prevents the accidental possibility of delivering two doses in the same stroke. Obviously, further modifications are possible within the basic principles of the invention. For example, a pushbutton / housing 3 with a groove / seat holding a resilient detent ring having the same function and operating principle as implemented for the stem 4 of the piston / pump 12
It can be made on the inner wall body. Furthermore, within the basic principles of the invention, instead of the grooves / seats and the elastic detent rings, there are provided suitable ledges projecting from the outer surface of the pushbutton / housing 3, these ledges being the neck 2 of the slider 1. And the ledges can be suitably conditioned by notches to self-shear and disengage in response to a predetermined operating pressure of the user. In this way, energy can be stored and the snap action required for accurate spraying can occur. Similarly, instead of the abutment ledge described above, an elastic element which can be curved with suitable slits can be used integral with the push button / housing 3 or the neck 2 of the slider 1.

Finally, the device described above and its variants can be used as a single use version. That is, a single resilient detent ring or element may be provided. In each case, a complete servo assisted spraying action can occur. The other parts shown above are made of any appropriate material, and can be arbitrarily changed within the scope of the present invention.

[Brief description of the drawings]

FIG. 1 is a partial elevational-partial vertical sectional view of the lower portion of a container / dispenser assembly according to the present invention prior to a first operating stroke, the upper elastic detent ring of which comprises a cylinder of a drug container, a ring seat and The figure which shows the state which contact | abutted.

FIG. 2 is a plan view of an elastic detent ring having elastic support radial slits.

FIG. 3 shows that after a first operating stroke has occurred, an upper elastic detent ring snaps out of its seat and abuts a lower elastic detent ring, which lower elastic detent ring engages a first half stroke of the piston / pump. FIG. 2 is a view similar to FIG.

FIG. 4 is similar to FIGS. 1 and 3 showing the lower ring also snapped out of its seat after the second last maneuver has taken place and the second half-stroke has been performed at the proper servo assist speed; Figure.

FIG. 5 is a view similar to FIG. 1 of another embodiment including a push button / housing with an auxiliary stop element and a slider.

6 is a plan view of the bottom of the embodiment of FIG.

FIG. 7 is a view similar to FIG. 3 of the embodiment of FIG. 5 after a first operating stroke;

FIG. 8 is a view similar to FIG. 4 of the embodiment of FIG. 5 after a second last operating stroke;

[Explanation of symbols]

 1, 101 body or slider 2, 102 body neck 3, 103 push button / housing 4 stem 5 drug container 6, 7 groove 8, 9 detent ring 10 bevel 11 slit 12 piston / pump 114 stopper 115 slot 116 slot Shoulder

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int. Cl. ⁷ , DB name) B65D 83/00 A61J 1/00

Claims (7)

(57) [Claims] 1. An upwardly projecting tubular cylinder with a spray nozzle at the apex, comprising a body (1) normally acting as a slider with a radially flat extension for holding down. A housing (3), which is constituted by a downwardly projecting neck (2) and acts as a control push button, is axially slidably disposed in said neck, said push button / housing (3) being a cylindrical drug solution container. A spray dispenser for spraying an intranasal medication, wherein the piston / pump (12) is configured to be axially slidable in the container (5). The pump (12) comprises a stem (4) having two different diameters, said stem (4) acting as a seat of a resilient detent ring (8, 9) on each diameter. With concave concave circular grooves (6, 7), said rings each having radial slits (11) for elastic support and said elastic detent rings (8, 9) being provided with piston / pump (6). 1
A spray dispenser characterized in that the step (2) is controlled so as to carry out medicine delivery twice, once for each nostril of the user. 2. An upper detent ring (8) abuts the rim (13) of the drug solution container (5), and a piston / pump (12) slides axially within the container (5). The distal end of its stem (4) abuts the bottom of the pushbutton / housing (3), and thus the resilient detent ring (8) provides for the delivery of medicament the pushbutton / housing (3). Opposing the movement of the piston / pump (12) and the push button / housing (3) when is pushed, the elastic detent ring (8) is expanded out of the groove / seat (6) so that the user Resisting the actuation force and thus accumulating energy in the user's hand to overcome the resistance during the first half-stroke or servo-assisted half-feed stroke and to place the resilient detent ring (8) in the groove / sheath. The piston / pump (12) is momentarily advanced into the medicament solution container (5) by popping out of (g) the second elastic detent by the first ring (8), now acting as a shoulder. A spray dispenser according to claim 1, characterized in that the ring (9) is stopped. 3. When the push button / housing (3) is pressed again for the second spray delivery of the medicament, the lower second elastic detent ring (9) is similar to the first ring (8). Expanded to resist the point of popping out of the groove / sheet (7) and then momentarily advance the piston / pump (12) at high speed into the drug solution container to provide a second dose of drug. 3. A spray dispenser according to claim 1, wherein the dispenser produces a half-dose servo-assisted delivery. 4. The housing / container (103) is provided with two stopper projections (114), and the protruding neck (102) of the slider (101) has two corresponding vertical slots (115).
And each slot (115) is provided with a stopper shoulder (11).
6) so that during the first actuation stroke the stopper projection (114) slides into the slot (115) and abuts the stopper shoulder (116) of the slot, thus the push button / housing (103) and the safety stop of the piston / pump (12), whereby the user consciously rotates the push button / housing (103) to disengage the stopper projection (114) from the shoulder (116). The spray dispenser according to any one of claims 1 to 3, wherein the second drug delivery is performed in two strokes. 5. Grooves for supporting elastic detent rings (8) and (9) within the operating principle of the system.
4. The seat according to claim 1, wherein the seat is formed not on the piston / pump stem but on the inner surface of the push button / housing. Spray dispenser. 6. Instead of said grooves / seats (6, 7) and said resilient detent rings (8, 9), use is made of a ledge suitably arranged on the outer surface of said pushbutton / housing (3). , These ledges are pre-formed to self-break upon reaching a predetermined operating energy,
4. A spray dispenser according to any of the preceding claims, characterized in that it breaks momentarily at the operating energy to provide a similar servo assist for the compression and spraying of the drug solution. 7. A method according to claim 1, wherein the number of elastic detent rings or elements or the number of corresponding grooves / sheets can be varied in a variety of configurations from single dose to multiple dose. A spray dispenser according to claim 1.