JP3243103B2 - Blood glucose control device - Google Patents

Abstract

PURPOSE:To provide a controller of a good sugar value which is reduced in size and simplified in operation so as to make it possible to make automatic blood sugar management over many sections in a hospital and is little in blood taking amt. and is safe. CONSTITUTION:This controller consists of an air pump 2 for taking blood and returning the blood from and to a first indwelling needle inserted into the body of a patient M, an insulin injector 4 for injecting insulin into the first indwelling needle 9, a glucose injector 5 for injecting glucose into a second indwelling needle 12 to be inserted into the body of the patient M, a glucose sensor 3 formed by disposing plural sensors for measuring the blood sugar value and a control means 6 for controlling the prescribed injection amt. of the insulin or glucose. The first indwelling needle 9, a glucose sensor 3 and a physiological salt bag 8 for a physiological salt soln. for periodic flushing of the first and second indwelling needles 9, 12 are communicated with each other by a blood taking tube 10, a sensor tube 15 and a chamber tube 16.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood sugar level control device. More specifically, the present invention relates to a blood sugar level control device capable of automatically and easily managing a blood sugar level of a diabetic patient or the like.

[0002]

2. Description of the Related Art For patients with unstable blood sugar levels, for example, diabetic patients, treatment of blood sugar during hospitalization or before, during or after surgery, such as fasting, administration of high-calorie infusion, and administration of insulin. Is appropriately performed.

For example, as a conventional treatment apparatus, blood is continuously collected from a needle inserted into a vein of a patient's arm by a pump, and a heparin solution is added thereto to prevent coagulation. In some cases, after measuring a blood sugar level with a sensor, necessary insulin or glucose is administered into a patient's body by a pump in accordance with a calculation by a computer.

[0004] Therefore, the apparatus is equipped with a dedicated pump for collecting, for injecting heparin solution, for a waste liquid after blood glucose measurement, and a standard solution for calibrating and washing the electrodes of the blood glucose measurement sensor.

[0005]

However, since the device itself is heavy and tends to be large due to a large number of dedicated pumps and calibration liquids, the treatment of patients in hospitals requires medical treatment, surgery, ICU, CCU, etc. If it is performed over a long time, there is a problem that it is difficult to carry.

There is also a problem that the number of setting keys for calibration, cleaning, etc. increases, making it difficult to operate the apparatus.

[0007] Furthermore, since the above-mentioned device continuously measures the blood sugar level, there is a problem that the total amount of blood to be collected is likely to increase.

In view of the circumstances described above, the present invention provides a small, simple operation, and a safe blood glucose level with a small amount of blood collected so that blood glucose management can be automatically performed across multiple departments in a hospital. It is an object to provide a control device.

[0009]

SUMMARY OF THE INVENTION The present invention provides a blood glucose level control device comprising: (a) an air pump for collecting blood from a first indwelling needle inserted into a patient's body and returning blood to the indwelling needle; ,
(B) an insulin injector for injecting insulin into the first indwelling needle; and (c) a second insulin inserted into the patient's body.
A glucose injector for injecting glucose into the indwelling needle of
(D) a glucose sensor for measuring a blood glucose level contained in the blood; and (e) a required infusion amount of insulin or glucose is calculated according to the measured blood glucose level, and administered to a patient's body based on the calculated value. Control means for controlling the amount of injection to be performed, the first indwelling needle, the glucose sensor, a saline ingestion bag for flushing the first indwelling needle and the second indwelling needle, Are connected to each other, and a plurality of sensors capable of intermittently measuring the glucose sensor are arranged.

[0010] Further, the blood sugar level control device of the present invention comprises (a)
An air pump for collecting blood from a first indwelling needle inserted into the patient's body and returning blood to the indwelling needle; (b) an insulin injector for injecting insulin into the first indwelling needle; A) a glucose injector for injecting glucose into a second indwelling needle inserted into the patient's body, and (d) a glucose sensor for measuring a blood glucose level contained in the blood.
(E) control means for calculating a required injection amount of insulin or glucose in accordance with the measured blood sugar level, and controlling the injection amount to be administered to the patient's body based on the calculated value; The indwelling needle, the glucose sensor, and a saline saline bag for periodically flushing the first indwelling needle and the second indwelling needle are connected with tubes communicating with each other, and A chamber formed in a tube communicating with the saline bag, and a pressure comprising a constant volume container and a three-way solenoid valve arranged in parallel with the constant volume container between the chamber and the air pump. A control mechanism is provided.

[0011]

The air pump operates the air pump to draw blood from the first indwelling needle. The collected blood is sent to a tube on the glucose sensor side and then spotted on the sensor. The glucose sensor measures the blood sugar level contained in the blood, and transmits the measured blood sugar level to the control means. In addition, the glucose sensor sets the next sensor at a predetermined position and moves the blood sensor to the blood spot for the next measurement of the blood glucose level. In addition, you may move before measurement.

The control means calculates the amount of insulin or glucose to be infused according to the measured blood glucose level, and activates the insulin infusion device or glucose infusion device based on the calculated value to appropriately supply the patient with insulin or glucose. Controls dosing.

Next, the air pump is evacuated to return the collected blood to the patient.

[0014] Then, in order to prevent coagulation of the blood that has invaded and diffused, physiological saline is periodically infused (flushing) from the first and second indwelling needles into the patient's body.

The blood collection and the blood return are performed by operating the air pump by the negative pressure and the positive pressure in the chamber. During blood collection, the maximum blood collection amount is limited by the constant volume container of the pressure control mechanism to prevent excessive blood collection.

[0016]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram of a blood sugar control apparatus according to the present invention.

FIG. 1 is a perspective view showing an embodiment of a blood sugar level control apparatus according to the present invention, FIG. 2 is an explanatory view showing a glucose sensor in FIG. 1, and FIG. 3 is an explanatory view showing a pressure control mechanism in FIG. is there.

As shown in FIG. 1, a blood glucose level control device 1 of the present invention includes an air pump 2 for collecting blood from a patient M and returning blood to the patient M, and a glucose sensor 3 for measuring a blood glucose level. A control means 6 for calculating an amount of insulin or glucose to be injected from the blood sugar level and controlling a required amount of injection to be administered to the body from the insulin injector 4 or the glucose injector 5 based on the calculated value. .

The blood sugar level control device 1 is fixed to a movable stand 7. Above the stand 7, a saline bag 8 containing physiological saline is suspended.

A blood collection tube 10 and an insulin infusion tube 11 drawn out from the insulin infusion device 4 are connected to a first indwelling needle 9 inserted into the arm of the patient M. Further, to the second indwelling needle 12 inserted into the arm of the patient M, a glucose infusion tube 13 from the glucose infusion device 5 and a saline tube 14 inserted into the saline bag 8 are connected.

The blood collection tube 10 has a sensor tube 15 extending at one end into the glucose sensor 3.
And a chamber tube 16 inserted into the raw food bag 8.

The tip of the sensor tube 15 is inserted into the waste liquid bag 17.

On the other hand, a chamber 18 is formed in the chamber tube 16, and the air pump 2 is connected to the chamber 18 via a pressure control mechanism 19 and an air filter 20.

The blood collection tube 10 and the saline tube 1
4. Sensor tube 15 and chamber tube 1
6 are connected to solenoid valves (hereinafter, simply referred to as valves) 21, 22, 23, and 24, respectively.

The inner diameters of the blood collection tube 10, the sensor tube 15, and the chamber tube 16 are not particularly limited in the present invention, but are approximately 0.1 to 3.0 mm and 0.1 to 1.5 mm, respectively. , 0.5-
5.0 mm is a standard.

The glucose sensor 3 is housed in a sensor box 25 as shown in FIGS.
A rotatable disk 27 in a case 26, and a plurality of disposable sensors 2 arranged on the disk 27 at equal circumferential intervals.
And 8. Further, the case 26 is formed with a cutout portion 31 so that the electrode 29 of the sensor 28 can face the blood spotting portion 30 provided in the sensor tube 15.

As the sensor 28, an enzyme electrode type glucose sensor (for example, G2 electrode manufactured by A & D Corporation), an oxygen electrode type glucose sensor, a hydrogen peroxide electrode type glucose sensor and the like are used.

As shown in FIG. 3, the pressure control mechanism 19 includes a constant volume container 32 and three-way solenoid valves (hereinafter, simply referred to as solenoid valves) 33, 3 arranged in parallel with the constant volume container 32.
And 4.

The constant volume container 32 has an upper portion communicating with an intake passage 35 and an exhaust passage 36 of the air pump 2. The electromagnetic valves 33 and 34 are connected to the intake passage 35 and the exhaust passage 36, respectively. Are linked. The lower part of the constant volume container 32 communicates with the air filter 20. Further, in the constant volume container 32, an inner balloon portion 37 capable of expanding and contracting inside is connected to the lower tube. The arrows in the figure indicate the flow of air.

The control means 6 includes an arithmetic circuit for calculating the amount of insulin and glucose to be injected, and the insulin injector 4 based on the arithmetic value calculated by the arithmetic circuit.
And a control circuit for controlling a required amount of insulin or glucose to be injected from the glucose injector 5, switching between intake and exhaust of the air pump 2 and valves 21, 22, 23, 24.
And a switching circuit for controlling the opening and closing of the solenoid valves 33 and 34.

Reference numeral 38 denotes a touch operation display, and 39 denotes a printer.

Although the glucose injector 5 is externally provided in FIG. 1, it may be incorporated in the control device 1 itself.

Next, the operation of the blood sugar level control device of the present invention will be described.

First, when the power is turned on, the valve 2
1, 22, 23, and 24 are opened (hereinafter simply referred to as ON). Next, a circuit (flow path) such as a raw tubing is set in the valves 21, 22, 23, and 24. After confirming the set, use the confirmation key on the touch operation display 38 to
The valves 21, 22, 23, and 24 are closed (hereinafter simply referred to as O
FF). The electromagnetic valve 34 is turned on, and the air pump 2 is operated to perform a leak test in order to confirm a circuit around the chamber 18 and a connection state to the valve. After the end of the leak test, the operation of the air pump 2 is stopped. Here, program setting values such as the amount of insulin to be injected in the control means 6 are confirmed. After that, the chamber tube 16 and the raw tube 14
Is punctured into the raw food bag 8. The valve 24 is turned on.
Then, the valve 23 is turned on for a certain period of time, and when the physiological saline flows from the chamber tube 16 to the sensor tube 15 and seeps into the waste liquid bag 17, the valve 2 is turned on.
Close 3.

Next, the valve 21 is turned on. If the physiological saline flows toward the blood collection tube 10 and seeps out from the first indwelling needle 9, the valve 21 is turned off.

As described above, the blood collection tube 10, the sensor tube 15, and the chamber tube 16 are washed with physiological saline and filled with physiological saline.

Next, the valve 22 is turned on, and when the physiological saline seeps out of the second indwelling needle 12 after a predetermined time, the valve 22 is turned off. As a result, the saline tube 14 is washed with the physiological saline and filled with the physiological saline.

Next, the insulin injector 4 is operated, and after a predetermined time, when the insulin is filled in the insulin injection tube 11, the insulin injector 4 is stopped by the stop key. Similarly, when the glucose injector 5 is operated and the glucose infusion tube 13 is filled with glucose after a predetermined time, the glucose injector 5 is stopped by the stop key.

When connecting to the indwelling needle after the priming, it is necessary to fill the blood collection tube 10 or the edible tube 14 with the physiological saline up to the very tip of the opening side.
There is a case where physiological saline needs to be additionally injected into the blood collection tube 10 or the saline tube 14. In this case, the operation of adding the required amount by the key setting on the touch operation display 37 is performed by turning the valve 22 from ON to OFF by the stop key or by turning the valve 21 from ON to OFF by the stop key. Can be. After that, the injection amount of insulin and glucose was reduced to 0.
Set.

Thus, the initial preparation for managing the blood sugar level is completed.

Next, the operation of administering insulin and glucose will be described.

First, the first indwelling needle 9 and the second indwelling needle 12 are punctured into the arm of the patient M.

For blood collection, the air pump 2 is operated to turn on the solenoid valve 33, and the solenoid valve 34 is turned on.
FF, and after a certain time, the electromagnetic valve 33 is turned off. Thus, after a negative pressure is generated in the chamber 18, the valve 21 is turned on to collect blood into the blood collection tube 10. The amount of blood collected at this time is
It depends on the capacity of the inner balloon portion 37 of the constant volume container 32. First, before starting blood collection, the air in the inner balloon portion 37 is completely evacuated. Next, a negative pressure is applied to the constant volume container 32 by the air pump 2, and a negative pressure is also generated in the inner balloon portion 37. This negative pressure is applied to the line of the blood collection tube 10 as it is, so that it becomes a blood collection suction pressure. Here, the inner balloon part 3
Since the capacity of 7 is determined, it is possible to take out at most the capacity of the constant capacity container 32 outside the body.

If the valve 21 is turned off before taking out the blood corresponding to the volume, the amount of blood collected can be controlled. In addition, as for blood, the valves 21 and 23
By setting N, the blood pressure alone can be extracted from the body, so that the blood pressure can also be used.

After the blood collection is completed, the solenoid valve 34 is turned on.
Then, the negative pressure in the chamber 18 is released.

Next, when the valve 23 is turned on, the collected blood is sent to the sensor tube 15 side by the blood pressure of the patient M. Blood is blood spot 30
The glucose sensor 3 moves forward (see FIG. 2).
(A direction in the middle), and the electrode 29 of the new sensor 28 moves and is located at the blood spotting part 30. When the blood is spotted, the blood glucose measurement is started, the glucose sensor 3 is moved to the original position (the direction B in FIG. 2), and is separated from the blood spotting unit 30.

After the measurement is completed, the blood glucose measurement value is transmitted to the control means 6 of the control device 1 and is calculated to a predetermined insulin or glucose infusion amount which must be administered to the patient M according to the blood glucose level. At this time, the injection speed is also determined.

Then, the insulin injector 4 or the glucose injector 5 is operated by the control means 6, and the administration of insulin or glucose to the patient M is started.

When the control means 6 receives the blood glucose level signal from the glucose sensor 3, it turns on the valve 24, turns off the valve 21 after a certain time has passed,
A signal is issued to turn on the valve 23. As a result, the physiological saline flows from the chamber tube 16 to the sensor tube 15 due to its head pressure (gravity). As a result, the blood in the sensor tube 15 is
7, and the sensor tube 15 can be washed. After the cleaning, the valves 23 and 24 are turned off.

Next, the solenoid valve 33 is turned off, the solenoid valve 34 is turned on, and the inside of the chamber 18 is made positive by the action of the air pump 2. And the valve 21
Is turned on, the positive pressure causes the chamber tube 16
The physiological saline solution is pushed out, and the blood in the blood collection tube 10 is returned to the patient M. This also serves to wash the blood collection tube 10 at the same time. In addition, chamber 1
For the positive pressure in 8, the valve 24 can be opened to use the drop pressure of physiological saline.

Further, by providing a valve below the chamber 18, blood can be prevented from flowing to the chamber 18, so that there is no fear of blood remaining in the chamber 18 at the time of blood return, and thus the blood can be returned in a short time. Blood is formed, and blood collection and blood return can be performed more smoothly.

The above operations of blood collection, administration of insulin and glucose, and blood return are periodically performed within a set time.

Further, in this embodiment, the flushing of the first indwelling needle 9 and the second indwelling needle 12 is performed periodically.

Flushing refers to a physiological saline solution for preventing blood from entering the first and second indwelling needles 9 and 12 and the connection tube thereof, which are connected to the body, and coagulating due to blood pressure and diffusion. Water to the first and second indwelling needles 9,
The operation of injecting blood into the body 12 and returning blood to the body.

The flushing of the first indwelling needle 9 is performed by turning on the valve 24 and the valve 21. That is, the physiological saline is pushed out of the raw food bag 8 by the pressure drop, and the blood diffused in the first indwelling needle 9 is returned to the body. If the pressure drop of the physiological saline is insufficient (for example, if there is not much difference between the position of the raw food bag 8 and the heart position of the patient or if the patient's blood pressure is high), the air pump 2 is operated. You may. Generally, it does not need to be activated.

The flushing of the second indwelling needle 12 is performed by turning on the valve 22. That is, the physiological saline in the saline tube 14 is pushed out by the pressure drop of the physiological saline as described above, and the blood in the second indwelling needle 12 is returned to the body.

When the flushing is completed, the valve 2
1, 22, and 24 are turned off.

[0058]

As described above, the present invention eliminates the need for calibration and maintenance such as cleaning before use of each sensor and after use of calibration, and storage when the apparatus is stopped. It is not necessary to equip a liquid or a dedicated pump, and the apparatus can be made compact and easy to operate without the need for operations such as calibration setting and key input.

Since most of the blood except for the amount of blood necessary for measuring the blood sugar level is returned to the patient's body, the total amount of collected blood can be minimized and the burden on the patient can be reduced. Further, since there is no need to provide a dedicated pump for injecting a heparin solution for coagulation, further miniaturization can be achieved.

The blood is returned using physiological saline, and the blood collection tube and the like are filled with physiological saline except during blood collection. For this reason, blood that will gradually enter the blood collection tube from the indwelling needle, which is the connection part with the body, is periodically flushed with physiological saline, so that the blood flows out of the body. Thus, the time during which the foreign substance is in contact with the foreign matter can be made as short as possible, so that blood coagulation can be suppressed as much as possible.

Further, since a tubing pump or the like is not used for blood collection, pressure is generated in the constant volume container and blood is collected at a maximum amount corresponding to the pressure, thereby preventing excessive blood collection due to a malfunction due to an accident or the like. be able to.

[Brief description of the drawings]

FIG. 1 is a perspective view showing one embodiment of a blood sugar level control device of the present invention.

FIG. 2 is an explanatory diagram showing the glucose sensor in FIG.

FIG. 3 is an explanatory diagram showing a pressure control mechanism in FIG. 1;

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 control device 2 air pump 3 glucose sensor 4 insulin injector 5 glucose injector 6 control means 8 saline bag 9 first indwelling needle 10 blood collection tube 11 insulin infusion tube 12 second indwelling needle 13 glucose infusion tube 14 saline infusion tube 15 Sensor tube 16 Chamber tube 18 Chamber 19 Pressure control mechanism 28 Sensor 32 Constant volume container 33, 34 Solenoid valve

Continuing on the front page (72) Inventor Yuzo Nozoe 3-23-14 Higashiikebukuro, Toshima-ku, Tokyo Inside A & D Corporation (72) Inventor Susumu Kobayashi 3-9-1, Honjo Nishi, Kita-ku, Osaka-shi No. Nissha Corporation (56) References JP-A-54-82885 (JP, A) JP-A-51-225993 (JP, A) JP-A-53-132198 (JP, A) (58) Fields investigated ( Int.Cl. ⁷ , DB name) A61M 1/36 565 G01N 21/35

Claims (2)

(57) [Claims] (A) an air pump for collecting blood from a first indwelling needle inserted into a patient's body and returning blood to the indwelling needle; and (b) injecting insulin into the first indwelling needle. (C) a glucose injector for injecting glucose into a second indwelling needle inserted into a patient's body, (d) a glucose sensor for measuring a blood glucose level contained in the blood, and (e) ) Calculate the required infusion of insulin or glucose according to the measured blood sugar level,
Control means for controlling the injection amount to be administered to the patient's body based on the calculated value, the first indwelling needle,
Tubes communicating with each other are connected to the glucose sensor and a saline saline bag for periodically flushing the first indwelling needle and the second indwelling needle, and the glucose sensor is A blood glucose level control device, comprising a plurality of sensors that can be intermittently measured. 2. An air pump for collecting blood from a first indwelling needle inserted into a patient's body and returning blood to the indwelling needle, and (b) injecting insulin into the first indwelling needle. (C) a glucose injector for injecting glucose into a second indwelling needle inserted into a patient's body, (d) a glucose sensor for measuring a blood glucose level contained in the blood, and (e) ) Calculate the required infusion of insulin or glucose according to the measured blood sugar level,
Control means for controlling the injection amount to be administered to the patient's body based on the calculated value, the first indwelling needle,
Tubes communicating with each other are connected to the glucose sensor and a saline saline bag for periodically flushing the first indwelling needle and the second indwelling needle, and the saline bag is A chamber is formed in the communicating tube, and a pressure control mechanism including a constant volume container and a three-way solenoid valve arranged in parallel with the constant volume container is provided between the chamber and the air pump. A blood sugar level control device, comprising: