JP3233738B2 - Blood or blood component storage container - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a container for storing blood or blood components.

[0002]

2. Description of the Related Art In recent years, as a blood storage container for transfusion, a hard glass container has been changed from a hard glass container to a soft polyvinyl chloride soft bag mainly to reduce damage to red blood cells. Furthermore, various anticoagulants and blood preservatives have been developed and used to improve the preservability thereof. The obtained blood is stored as a concentrated erythrocyte preparation, platelet-poor plasma, platelet-rich plasma, a platelet-rich preparation, etc. by centrifugation or membrane separation depending on the use. Among them, particularly when storing a large amount of platelets, it is necessary to supply sufficient oxygen to the platelet cells since the platelets are stored at 22 ° C. where irreversible deformation does not occur. Therefore, a polyolefin bag having good oxygen permeability has been developed as a container instead of a polyvinyl chloride bag and has been put on the market.

As a polyolefin bag material, as shown in Japanese Patent Publication No. 62-19461,
A hydrogenated block copolymer (hereinafter referred to as “SEB”) obtained by hydrogenating a polybutadiene portion of a polystyrene-polybutadiene-polystyrene block copolymer known as a thermoplastic elastomer exhibiting excellent elastomer elasticity at room temperature.
S ") and a mixture of a polymer containing polypropylene as a main component. However, the balance of various physical properties such as heat resistance, workability, transparency, flexibility, and gas permeability is not sufficient. For example, workability,
A composition containing a softening agent for improving flexibility is disclosed in
No. 0-14742 and Japanese Patent Application Laid-Open No. 63-57661, but the bleed out of the softener and the decrease in mechanical strength cannot be ignored. Furthermore, it has been recognized that the stored blood components, especially platelets, are activated, and it is not necessarily suitable as a container for storing blood.

[0004] On the other hand, it is quite natural in the modern medical community to check the health of a person by examining the components and properties of the sample using blood as a sample, but the sample is temporarily stored. As the container, a glass test tube or a Spitz tube made of a plastic such as polystyrene, polyethylene, polypropylene, polymethyl methacrylate, or polyethylene terephthalate is used. In addition, vacuum blood collection tubes made of glass or plastic such as polymethyl methacrylate or polyethylene terephthalate, which perform blood collection and storage with the same material, are marketed and used.

[0005]

As described above, a conventional blood storage container, especially a bag for storing platelets, has a temperature of 22 ° C.
In some cases, a polyolefin bag having oxygen permeability several times higher than that of a conventionally used soft polyvinyl chloride bag has been used. However, the inner surface of the olefin bag is a surface on which platelets are easily adhered, in other words, the activation of platelets is easily promoted, so that there is a problem that the storage state cannot be said to be the best. That is, heat resistance, processability, transparency, flexibility,
There is a problem that there is no container for storing blood and blood components, which is excellent in balance of various properties such as gas permeability and blood preservability.

[0006] Spitz tubes and vacuum blood collection tubes that temporarily store blood also tend to adhere platelets due to the properties of their inner surfaces, and cannot be said to be particularly good for investigating the number and morphology of platelets. There was a problem.

[0007] It is an object of the present invention to provide a blood or blood component storage container which achieves the best storage state by suppressing the activation of platelets during storage. Another object of the present invention is to provide a manufacturing method thereof.

[0008]

SUMMARY OF THE INVENTION The present invention is a blood or blood storage container having a multilayer structure in which at least a part of a layer (I) in contact with blood or blood components is composed of a block copolymer. The block copolymer of the layer (I) in contact with blood or blood components according to the present invention is characterized by having a microphase-separated structure. The block copolymer of the layer (I) in contact with blood or blood components of the present invention is at least one selected from the group consisting of polyamide elastomers, polyester elastomers, polyurethane elastomers, and block copolymers of hydroxyethyl methacrylate and styrene. The above is the feature.

At least one other layer (II) of the present invention comprises the following hydrogenated diene copolymer (1) and / or (2), (3)
It is characterized by comprising a thermoplastic resin composition (ii) mainly containing 90% by weight and 60 to 10% by weight of a polyolefin resin (4): hydrogenated diene copolymer (1): Polymer block in molecule
(A), (B) and (C) have at least one each.
(A) is a polymer block mainly composed of an aromatic vinyl compound containing 90% by weight or more of an aromatic vinyl compound, and (B) is a conjugated diene polymer block or an aromatic vinyl compound-conjugated diene copolymer block. A polymer block having a conjugated diene moiety having a vinyl bond content of 30 to 90%;
(C) shows a polybutadiene polymer block having a vinyl bond content of less than 30%. The content of the polymer block (A) in the block copolymer is 3 to 30% by weight, and the polymer block (B)
Is 40 to 80% by weight, and the content of the polymer block (C) is 10 to 40% by weight. (A), (B) or (C), which is bonded to a polymer comprising at least one polymer block, and a block copolymer in which the polymer molecular chain is extended or branched is hydrogenated to form a conjugated diene moiety. Hydrogenated diene copolymer in which at least 80% of the double bonds are saturated and have a number average molecular weight of 50,000 to 300,000; hydrogenated diene copolymer (2): a vinyl bond content of 20 % Or less of a polybutadiene polymer block (D), a conjugated diene polymer block or an aromatic vinyl compound-conjugated diene copolymer block, wherein the vinyl bond amount of the conjugated portion is 30 to 90% ( E)
A block copolymer whose block structure is represented by [(D)-(E)-(D)] p or [(D)-(E)] p (where p is an integer of 1 or more), or The block copolymer unit is obtained by hydrogenating a block copolymer in which the polymer molecular chain is extended or branched via a coupling agent residue, so that at least 80% of the double bonds of the conjugated diene portion are saturated. A hydrogenated diene-based copolymer having a number average molecular weight of 50,000 to 400,000; and a hydrogenated diene-based copolymer (3):
A polymer block (F) mainly containing an aromatic vinyl compound in an amount of 30% to 90% by weight;
% Of a conjugated polymer block (G) having a block structure represented by (F)-[(G)-(F)] q (A, where q is an integer of 1 or more) The copolymer or the block copolymer in which the block copolymer unit is extended or branched through a coupling agent residue via a coupling agent residue is hydrogenated to reduce the number of double bonds in the conjugated diene portion. Both are 80% saturated and have a number average molecular weight of 50,000 to 400,000.

The polyolefin resin (4) is a resin obtained by polymerization of one or more monoolefins as a main component by either a high-pressure method or a low-pressure method. Here, the monoolefin includes ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 4-methyl-1-pentene, and 2-methyl-1-pentene.
Propene, 3-methyl-1-pentene, 5-methyl-1
-Hexene, and mixtures thereof, preferably ethylene, propylene, 4-methyl-1-pentene, more preferably ethylene, propylene. More preferred polyolefin-based resins (4) are polyethylene, polypropylene and poly-4-methyl-1-pentene, and copolymer types are ethylene, 1-butene, 1-hexene, 4-methyl-1-pentene, 2-
Polypropylene having at least one copolymer selected from the group consisting of methyl-1-propene, 3-methyl-1-pentene, and 5-methyl-1-hexene;
Butene, 1-pentene, 1-hexene, vinyl acetate, methyl acrylate, ethyl acrylate, acrylic acid, methacrylic acid, methyl methacrylate, ethyl methacrylate,
Examples include polyethylene copolymerized with at least one member selected from the group consisting of maleic acid and maleic anhydride. More preferably, the polyolefin-based resin (4) is polypropylene or polyethylene, or the copolymer type polypropylene or polyethylene. Furthermore, a layer (I) in contact with blood or blood components of the sheet having a multilayer structure of the present invention and a hydrogenated diene copolymer (1),
The configuration other than the layer (II) composed of the thermoplastic resin composition (ii) containing (2), (3) and the polyolefin-based resin (4) as the main components does not need to be particularly limited. It is preferable to constitute a modified or copolymerized polyethylene, polypropylene or the like as the adhesive layer (III) of the two layers (I) and (II).

Further, the present invention provides a multi-layered blood or blood in which at least a part of the layer (I) in contact with blood or blood components is constituted by a block copolymer by extrusion molding, blow molding, injection molding or coating. This is a method for producing a storage container for components. Further, the block copolymer has a microphase-separated structure. Further, the block copolymer of the present invention is a block copolymer selected from at least one selected from the group consisting of a polyamide elastomer, a polyester elastomer, a polyurethane elastomer, and a block copolymer of hydroxyethyl methacrylate and styrene. It is assumed that.

[0012] The present invention relates to a layer in contact with blood or blood components.
(I) A multi-layered blood storage container comprising at least part of a block copolymer. Therefore, when blood or blood components are put into the storage container of the present invention, blood components, especially platelets, are prevented from being activated at the interface due to the blood compatibility of the block copolymer, and adhesion of platelets to the material surface is prevented. The blood or blood components can be stored mildly to prevent it.

As the block copolymer for suppressing the adhesion of the platelets to the material surface, a block copolymer having a microphase-separated structure is suitable. Further, as the block copolymer, polyamide elastomer, polyester elastomer,
Particularly preferred are polyurethane elastomers, block copolymers of hydroxyethyl methacrylate and styrene, and the like.

The microphase-separated structure is described in various documents. For example, as described in page 3 of “High Performance Polymer Alloy” (Advanced Polymer Material Series 3, edited by The Society of Polymer Science, 1991). Further, it is a dispersion system of a fine phase having a molecular order of several hundred angstroms.

[0015] As the polyamide elastomer, polyamide having a crystalline and high melting temperature as a hard segment,
A multi-block copolymer using an amorphous polyether or polyester having a low glass transition temperature for the soft segment, that is, a so-called polyetheramide (also referred to as polyetheresteramide) or polyesteramide is suitable.

The high-melting crystalline polyamide unit, which is a hard segment of the polyamide elastomer, is formed from a lactam or an amino acid having 4 to 14 carbon atoms in a hydrocarbon chain, or a condensation product of a dicarboxylic acid and a diamine and a dicarboxylic acid. You. Among them, the lactam component is caprolactam, lauryl lactam, enantholactam, dodecalactam, undecalactam, dodecalactam, and the like, and preferably caprolactam, lauryl lactam and the like. The amino acid component is 11-amino-
Undecanoic acid, 12-amino-dodecanoic acid and the like.

The dicarboxylic acid used for the condensation product of the dicarboxylic acid and the diamine is adipic acid, azelaic acid, sebacic acid, 1,12-dodecane diacid, etc., and the diamine is hexamethylene diamine, nonadiamine. Methylene diamine and the like can be mentioned. This condensate is preferably a condensate of adipic acid and hexamethylenediamine.

The above-mentioned dicarboxylic acid is necessary for obtaining a polyamide having a carboxylic acid terminal, and is an aliphatic dicarboxylic acid having 4 to 20 carbon atoms, for example, succinic acid, adipic acid, suberic acid, azelaic acid, sebacine and the like. Acid, undecanoic acid, dodecanediic acid, etc., and preferably adipic acid.

The average molecular weight of the aliphatic polyamide is usually
300 to 15,000, preferably 800 to 5,000
It is.

The aliphatic polyether unit having a low glass transition temperature, which is a soft segment of the polyamide elastomer, is formed of a polyalkylene glycol having an average molecular weight in the range of 200 to 6,000. As the polyalkylene glycol, for example, polyethylene glycol, polypropylene glycol, polytetramethylene glycol, polyethylene glycol-polypropylene glycol block copolymer and the like are preferable, and polytetramethylene glycol is particularly preferable.

These are Daiamide-PAE manufactured by Daicel Huls, UBE polyamide elastomer manufactured by Ube Industries, Grillon ELX and Grillon EL manufactured by Ms Japan.
Y, available from Dainippon Ink and Chemicals, Inc. as GREAK A, Mitsubishi Kasei's Novamid EL, and Toray or Atochem's Pebax.

As the polyether terminal of the soft segment, those having an amino group and those having a hydroxyl group are used. The amino group has an amide bond with the terminal carboxyl group of the polyamide portion of the hard segment. Further, those having a hydroxyl group form an ester bond with the terminal carboxyl group of the polyamide portion.

As the polyester elastomer, an aromatic polyester is used for the hard segment, for example, 1,4-
Condensates of butanediol and terephthalic acid, etc., polyester-polyether type using aliphatic polyether polytetramethylene glycol and terephthalic acid as the soft segment, polyester using aliphatic polyester as the soft segment, Polyester type is suitable. They are available as Toyobo's Perprene, Toray Dupont's Hytrel, Dainippon Ink and Chemicals, Inc.'s Gleek E, Nippon GE Plastics' Lowmod, and Nippon Synthetic Rubber's Pibiflex.

As the polyurethane elastomer, those using polyurethane for the hard segment and polyol or polyester for the soft segment are suitable. These include Pandex of Dainippon Ink and Chemicals, Miractran of Nippon Milactran, Rezamine P of Dainichi Seika Kogyo, Takelac and Elastran of Takeda Birdish Urethane Industries, Ufine of Asahi Glass, Kyowa Hakko Kogyo Available from Desmopan and Texin of Sumitomo Bayer Urethane and Bayer Japan, Mobilon of Nisshinbo Industries, Hyprene of Mitsui Nisso Urethane, and Chramylon U of Kuraray.

The block copolymer of styrene and hydroxyethyl methacrylate can be made into a block copolymer by using anionic living polymerization or a coupling method. Here, a manufacturing method using a coupling method will be briefly described. Photopolymerization of styrene using diisocyanate diphenyl disulfide as an initiator (30 ° C., 15
Time) to synthesize oligostyrene having isocyanate groups at both ends. Next, azobisisobutyronitrile (AIBN) was used as an initiator, and aminoethanethiol was used as a chain transfer agent to obtain hydroxyethyl methacrylate (H).
EMA) is polymerized to synthesize oligohydroxyethyl methacrylate having an amino group at one end. The oligostyrene was reacted with 2-fold mol of oligohydroxyethyl methacrylate in dimethylformamide to obtain an ABA-type block copolymer linked by urethane bonds.

Layers in contact with blood or blood components of the present invention
The thermoplastic resin composition (ii) used in at least one layer other than (I) (II) will be described.

The thermoplastic resin composition layer comprises 40 to 90% by weight, preferably 50 to 85% by weight, more preferably 5 to 85% by weight of the hydrogenated diene copolymer (1) and / or (2), (3).
5 to 85% by weight, polyolefin resin (4) 60 to 1
It is composed of a layer comprising a thermoplastic resin composition (ii) containing 0% by weight, preferably 50 to 15% by weight, more preferably 45 to 15% by weight as a main component. When the content of the polyolefin resin (4) is less than 10% by weight in the total composition, fluidity and heat resistance are poor, while when it exceeds 60% by weight, flexibility and gas permeability are poor.

Here, the thermoplastic resin composition (ii) will be described separately for the constituent hydrogenated diene copolymers (1) to (3) and the polyolefin resin (4).

Hydrogenated diene copolymer (1): As the aromatic vinyl compound used in the hydrogenated diene copolymer (1), styrene, t-butylstyrene, α-methylstyrene, p-methylstyrene are used. , Divinylbenzene, 1,1-
Diphenylstyrene, N, N-dimethyl-p-aminoethylstyrene, N, N-diethyl-p-aminoethylstyrene, vinylpyridine and the like.
α-Methylstyrene is preferred.

The conjugated diene used in the hydrogenated diene copolymer (1) includes 1,3-butadiene, isoprene, 2,3-dimethyl-1,3-butadiene, 1,3
-Pentadiene, 2-methyl-1,3-pentadiene,
1,3-hexadiene, 4,5-dimethyl-1,3-octadiene, 3-butyl-1,3-octadiene, chloroprene, and the like can be mentioned, but hydrogenated diene systems which can be used industrially and have excellent physical properties To obtain the copolymer, 1,3-
Butadiene, isoprene and 1,3-pentadiene are preferred, and 1,3-butadiene and isoprene are more preferred.

The polymer block (A) constituting the hydrogenated diene copolymer is a polymer block of an aromatic vinyl compound or a polymer of a conjugated diene with 90% by weight or more of an aromatic vinyl compound. It is a block. When the content of the aromatic vinyl compound in the polymer block (A) is less than 90% by weight,
Mechanical strength and heat resistance are undesirably reduced. When the polymer block (A) is a copolymer block with a conjugated diene, the conjugated diene portion is a polymer block in which 80% or more is hydrogenated. In addition, the polymer block (A)
Is 3 to 30% by weight, preferably 5 to 30% by weight.
If the content is less than 3% by weight, the heat resistance is insufficiently improved, while if it exceeds 30% by weight, the flexibility is reduced. In addition, the number average molecular weight of the polymer block (A) is preferably 5,000 to 70,000.

The polymer block (B) constituting the hydrogenated diene copolymer is a conjugated diene polymer block or a copolymer block of an aromatic vinyl compound of 50% by weight or less and a conjugated diene. The conjugated diene moiety has a vinyl bond content of 30 to 90%, preferably 40 to 80%.
And a conjugated diene moiety of 8
0% or more is a hydrogenated polymer block. If the conjugated diene content of the polymer block (B) is less than 50% by weight, the flexibility is undesirably reduced. On the other hand, if the vinyl bond content is less than 30%, a polyethylene chain is formed by hydrogenation to lose rubber properties, and if it exceeds 90%, the glass transition temperature becomes high when hydrogenated, and the rubbery properties are increased. Is not preferred. The content of the polymer block (B) is from 40 to 80% by weight, preferably from 45 to 75% by weight. When the content is less than 40% by weight, the flexibility is reduced. descend. In addition,
The number average molecular weight of the polymer block (B) is preferably 2
It is from 000 to 3,000,000.

Further, the polymer block (C) constituting the hydrogenated diene copolymer has a double bond in the butadiene portion of the polybutadiene block having a vinyl bond content of less than 30%, preferably 3 to 20%. % Or more are hydrogenated polymer blocks. The polybutadiene in the polymer block (C) before hydrogenation has a vinyl bond content of 30%
In the above, the resinous properties are lost when hydrogenated, and the properties of the thermoplastic elastomer as the block copolymer are lost. Further, the content of the polymer block (C) in the block copolymer before hydrogenation is 10 to 40% by weight, preferably 10 to 35% by weight, and if less than 10% by weight, the mechanical strength is reduced. On the other hand, if it exceeds 40% by weight, the flexibility is poor, which is not preferable. The number average molecular weight of the polymer block (C) before hydrogenation is 10,000 to
150,000.

The hydrogenated diene copolymer of the present invention has a number average molecular weight of 50,000 to 300,000, preferably 100,000 to 250,000.
If it is less than 00, the mechanical strength and heat resistance of the obtained composition decrease, while if it exceeds 300,000, the fluidity and processability decrease, leading to a decrease in surface appearance.

The block copolymer constituting the hydrogenated diene copolymer (1) is at least one of the polymer blocks (A), (B) and (C) via a coupling agent residue. It may be a block copolymer in which polymer units composed of one polymer block are bonded and the polymer molecular chain is extended or branched, for example, as represented by the following general formula.

[(A)-(B)-(C)] nX or [(A)-(B)-(C)] X [(A)-(B)] (where n is An integer of 2 to 4, and X represents a residue of the coupling agent.) Examples of the coupling agent in this case include diethyl adipate, divinylbenzene, tetrachlorosilicon, butyltrichlorosilicon, tetrachlorotin, butyltrichlorotin, and dimethyl. Chlorosilicon, tetrachlorogermanium, 1,2-dibromoethane, 1,4-chloromethylbenzene, bis (trichlorosilyl) ethane, epoxidized linseed oil, tolylene diisocyanate 1,2,
4-benzenetriisocyanate and the like.

The hydrogenated diene copolymer (1) used in the present invention can be obtained, for example, by the method disclosed in JP-A-2-133406.

Hydrogenated diene copolymer (2): The aromatic vinyl compound and conjugated diene used in hydrogenated diene copolymer (2) are used in hydrogenated diene copolymer (1). It is the same as what is done.

The hydrogenated diene copolymer (2) used in the present invention comprises a polybutadiene polymer block (D) having a vinyl bond content of 20% or less, a conjugated diene polymer block or an aromatic polymer. A vinyl compound-conjugated diene copolymer block, wherein the vinyl bond amount of the conjugate portion is 3
Consisting of 0 to 90% of a conjugated polymer block (E),
And a linear or branched block structure represented by [(D)-(E)-(D)] p or [(D)-(E)] p (where p is an integer of 1 or more). It is obtained by hydrogenating the double bond of the conjugated diene portion of the above block copolymer by 80% or more.

The block (D) in the hydrogenated diene copolymer (2) becomes a crystalline block having a structure similar to ordinary low density polyethylene (LDPE) by hydrogenation. The vinyl bond content in the block (D) is 20% or less, preferably 18% or less, more preferably 15% or less.
It is as follows. If the vinyl bond content of the block (D) exceeds 20%, the crystal melting point of the crystal after hydrogenation drops significantly, and the mechanical properties of the hydrogenated diene copolymer (2) are unfavorably deteriorated.

The block (E) in the hydrogenated diene copolymer (2) is a conjugated diene polymer block or an aromatic vinyl compound-conjugated diene copolymer block. The block shows a structure similar to that of the ethylene-butene copolymer block or the aromatic vinyl compound-ethylene-butene copolymer.

The amount of the aromatic vinyl compound used in the block (E) is 35% by weight or less, preferably 30% by weight or less, more preferably 25% by weight of the monomer constituting the block (E). % Or more, and if it exceeds 35% by weight, the glass transition temperature of the block (E) increases, and the mechanical properties of the hydrogenated diene copolymer (2) are inferior.

The butadiene portion of the block (E) has a vinyl bond content of 30 to 90%, preferably 30 to 85%.
%, More preferably from 30 to 80%, and if it is less than 30% or more than 90%, after hydrogenation, it shows a crystal structure derived from a polyethylene chain and a polybutene-1 chain, respectively, and becomes a resin-like property. It is not preferable because the mechanical properties of the diene copolymer (2) are inferior.

The ratio of the block (D) and the block (E) in the hydrogenated diene copolymer (2) is usually
Block (D) 5 to 90% by weight, preferably 10 to 85
Weight, block (E) 95 to 10% by weight, preferably 9
0 to 15% by weight. When the content of the block (D) is less than 5% by weight and the content of the block (E) exceeds 95% by weight, the crystalline polymer block is insufficient, and the mechanical properties of the hydrogenated diene copolymer (2) are inferior. Therefore, it is not preferable. The content of the block (D) exceeds 90% by weight, and the content of the block (E) is 1%.
If less than 0% by weight, hydrogenated diene copolymer (2)
Is undesirably increased in hardness.

Further, the hydrogenated diene copolymer (2) used in the present invention has at least 80 double bonds of the butadiene portion of the blocks (D) and (E).
%, Preferably 90% or more, more preferably 95 to 1%.
It is necessary that 00% be hydrogenated and saturated, and if it is less than 80%, heat resistance and weather resistance become poor. The average molecular weight of the block (D) and the block (E) is usually 5,000 or more, preferably 10,000.
It is preferably at least 00, more preferably at least 15,000, and if it is less than 5,000, the mechanical properties of the hydrogenated diene copolymer (2) are inferior, which is not preferred.

The hydrogenated diene copolymer (2) of the present invention has a number average molecular weight of 50,000 to 400,000, preferably 100,000 to 400,000.
If it is less than 0, the mechanical strength, heat resistance, fluidity and workability are reduced, and the surface appearance is reduced. On the other hand, if it exceeds 400,000, the fluidity and workability are reduced and the surface appearance is reduced. Becomes

The (D)-(E)-(D) block copolymer or the (D)-(E) block copolymer, which is the block copolymer before hydrogenation, is used as a coupling agent residue. A polymer having at least one polymer block selected from the above (D) and (E), and having an extended or branched polymer molecular chain represented by the following general formula. It may be: [(D)-(E)] nx [(D)-(E)-(D)] nx (where n and X are the same as above). And the same compounds as those used in the hydrogenated diene copolymer (1).

The hydrogenated diene copolymer (2) used in the present invention can be obtained, for example, by the method disclosed in JP-A-3-128957.

Hydrogenated diene copolymer (3): The aromatic vinyl compound and conjugated diene used in hydrogenated diene copolymer (3) are used in hydrogenated diene copolymer (1). It is the same as what is done.

Here, the hydrogenated diene-based copolymer (3) used in the present invention is a polymer block mainly composed of at least 90% by weight of an aromatic vinyl compound. F) and the conjugated diene moiety has a vinyl bond content of 30 to
90% of the conjugated diene polymer block (G), and the block structure is (F)-[(G)-(F)] q
(Where q represents an integer of 1 or more) obtained by hydrogenating 80% or more of the double bond of the conjugated diene portion of the linear or branched block copolymer represented by the following formula: .

The block (F) in the hydrogenated diene copolymer (3) is a polymer block mainly composed of at least 90% by weight of an aromatic vinyl compound. If the content of the aromatic vinyl compound in the polymer block (F) is less than 90% by weight, the mechanical strength and heat resistance are undesirably reduced. The number average molecular weight of the polymer block (F) is preferably from 5,000 to
70,000.

The polymer block (G) constituting the hydrogenated diene copolymer (3) has a conjugated diene polymer having a vinyl bond content of 30 to 90%, preferably 40 to 80% in the conjugated diene portion. The polymer block is a coalesced block in which 80% or more of the conjugated diene portion is hydrogenated. If the vinyl bond content is less than 30%, polyethylene chains are formed when hydrogenated, and the rubbery properties are lost, while if it exceeds 90%, the glass transition temperature becomes high when hydrogenated, and the rubbery properties are lost. Is not preferred. The content of the polymer block (G) is 40 to 80% by weight, preferably 45 to 75% by weight. When the content is less than 40% by weight, the flexibility is reduced.
The number average molecular weight of the polymer (G) is preferably in the range of 20,000 to 300,000.

The hydrogenated diene copolymer (3) of the present invention has a number average molecular weight of 40,000 to 300,000, preferably 50,000 to 250,000.
If the ratio is less than 0, the mechanical strength and heat resistance of the composition obtained are reduced. On the other hand, if it exceeds 300,000, the fluidity and processability are reduced, and the surface appearance is reduced.

The hydrogenated diene copolymer (3) of the present invention comprises
It is available as Clayton G and Califlex from Shell Chemical Company, JSR-TR from Japan Synthetic Rubber Co., Ltd., Tufprene and Tuftec from Asahi Kasei Corporation, and Septon from Kuraray Co., Ltd.

Polyolefin resin (4): The polyolefin resin (4), which is the other component of the thermoplastic resin composition (ii) of the present invention, comprises one or more monoolefins as a main component and a high pressure method. Or a resin obtained from polymerization by either the low pressure method. Here, as the monoolefin, ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 4-methyl-1-pentene, 2
-Methyl-1-propene, 3-methyl-1-pentene,
Examples include 5-methyl-1-hexene and mixtures thereof, preferably ethylene and propylene. More preferred polyolefin-based resins (4) are polyethylene, polypropylene and poly-4-methyl-1-pentene, and copolymer types are ethylene, 1-butene, 1-pentene, 1-hexene and 4-methyl- 1-pentene, 2-methyl-1-propene, 3-methyl-1-
Polypropylene copolymerized with at least one selected from the group consisting of pentene and 5-methyl-1-hexene, 1-butene, 1-pentene, 1-hexene, vinyl acetate, methyl acrylate, ethyl acrylate, acrylic acid And methacrylic acid, methyl methacrylate, ethyl methacrylate, maleic acid, and polyethylene copolymerized with at least one selected from the group consisting of maleic anhydride. More preferably, the polyrefin-based resin (4) is polypropylene, polyethylene, and the copolymer type pyropropylene and polyethylene.

The melt index (230 ° C., 2.16 kg load) of the polyolefin resin (4) is usually
0.1-70 g / 10 min, preferably 0.2-55 g /
10 minutes.

The above thermoplastic resin composition (ii) is obtained by previously kneading a hydrogenated diene-based copolymer and a polyolefin-based resin using a usual kneading apparatus, for example, a rudder, a twin-screw extruder or the like. Is more preferred. The kneading temperature is usually 1
The temperature ranges from 60 to 250 ° C, preferably from 180 to 240 ° C.

The blood or blood component storage container of the present invention
Layer (I) in contact with blood or blood components, hydrogenated diene copolymers (1), (2) and (3) and polyolefin resin
The configuration other than the thermoplastic resin composition layer (II) containing (4) as a main component is not particularly limited, but a method of joining both layers via an adhesive resin layer (III) is also preferable. is there.
As the adhesive resin (iii), a functional group-containing polyolefin is preferable.

The functional group-containing polyolefin used for the adhesive layer (III) is obtained by modifying a polyolefin resin or rubber with a functional group. The polyolefin resin or rubber is a resin or rubber polymerized mainly with α-olefin. Examples of the α-olefin include ethylene, propylene, 1-butene, 4-methyl-1-butene, 4-methyl-1-pentene, and the like, and a mixture thereof, and ethylene and propylene are preferable.

Examples of the functional group include unsaturated carboxylic acids and unsaturated carboxylic acid derivatives. Specific examples of the functional group-containing compound include maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, nadic acid, Examples include methylnadic acid, maleic anhydride, fumaric anhydride, and itaconic anhydride, and preferably maleic anhydride.

As a modification method, a polyolefin resin or rubber is dissolved in an alkyl aromatic hydrocarbon solvent in a 115
A method in which the above-mentioned functional group-containing compound is grafted using a radical initiator at a temperature of not less than ℃, or a very small amount of an alkyl peroxide, preferably an aliphatic bifunctional peroxide, a functional group-containing compound, and a polyolefin Resin and / or
Alternatively, a method of kneading a rubber at a temperature of 200 ° C. or more may be used.

Specific examples of the functional group-containing polyolefin include maleic anhydride-modified LDPE (low-density polyethylene), maleic anhydride-modified HDPE (high-density polyethylene), maleic anhydride-modified LLDPE (linear low-density polyethylene), and maleic anhydride. Modified EVA (ethylene-vinyl acetate copolymer), maleic anhydride-modified PP (polypropylene), ethylene-acrylate ester-maleic anhydride copolymer, and the like, preferably maleic anhydride-modified LLDPE.

For example, Admer of Mitsui Petrochemical Co., Moddick of Mitsubishi Yuka, Bondine of Sumitomo Chemical Co., Ltd., etc. are available.

The blood or blood component storage container of the present invention is preferably manufactured by extrusion molding, blow molding, injection molding, or coating.

The extrusion molding is preferably performed by a usual molding method such as inflation molding or T-die molding. In particular, in order to perform multilayering, multilayer inflation molding configured so that a block copolymer (i) having a microphase-separated structure on the inner surface comes, coextrusion molding using T-die molding, wet lamination, dry lamination, It is appropriate to produce a blood or blood component storage container configured so that the block copolymer comes to the inner surface by performing heat lamination or the like.

It is also preferable to manufacture the blood storage container of the present invention by an extrusion blow or injection blow method. Also suitable is a method for producing a blood or blood component storage container in which a parison is formed by multi-layer extrusion blow molding and multi-color injection molding of the blow molding and injection molding is used to form a multi-layer parison.

It is also preferable to manufacture the blood or blood component storage container of the present invention by injection molding.

Also, a method for producing a multi-layered blood or blood component storage container by performing multicolor injection molding so that the block copolymer (i) comes to the inner surface of the blood or blood component storage container is also suitable.

It is also preferable to form a block copolymer (i) having a microphase-separated structure on the inner surface of a single- or multi-layered blood or blood component storage container by a coating method. At this time, either coating before forming into a container or coating after forming into a container may be used. Further, it is also appropriate to form the block copolymer (i) having a microphase-separated structure by various methods, and then coat the outer surface of the block copolymer (i) with another material so as to form an inner surface, thereby forming a multilayer.

The block copolymer layer (I) having a microphase-separated structure on the inner surface which is in contact with blood according to the present invention is not limited by its thickness, and prevents the activation of blood components, in particular, the adhesion (adhesion) of platelets. It suffices if a sufficient thickness to prevent the occurrence is ensured. Furthermore, if it is sufficient to prevent the activation of blood components, even if it is not uniform, for example, a sea-island pattern (either), a mesh shape, or an irregular pattern is suitable. Furthermore, it is not necessary that the block copolymer having the microphase-separated structure be present on the entire inner surface in contact with blood, and it is sufficient if only part of the block copolymer has the effect. Also,
The block copolymer having a microphase-separated structure may be somewhat thick as long as it can be manufactured as a blood or blood component storage container.

The block copolymer having a microphase-separated structure of the present invention has the effect of preventing the activation of blood components.
The method for measuring and evaluating the effect is not particularly limited. Here, as an example, a method of a so-called platelet dilatation test will be described as a method for measuring the degree of activation caused by contact of platelets, which are one of blood components, with the material surface.

From a human vein, a 1/9 volume of a 3.8% aqueous sodium citrate solution as an anticoagulant is added to blood and blood is collected. The platelet-rich plasma (PRP) is separated by centrifugation at 800 rpm for 5 minutes, and the platelet count is measured with a blood cell measuring device (for example, Sysmex NE-6000 manufactured by Toa Denpa Kogyo Kogyo). This PRP was diluted with a diluent (0.01 M PBS [pH 7.0]:
3.8% aqueous sodium citrate solution = 9 Contents: diluted with 1 volume), to prepare a platelet count of 10 ⁵ cells / [mu] l. 200μ
l of diluted PRP is dropped on the sample, and the thickness of the PRP layer is 2
Press down with the lid of the Petri dish from above so that it becomes mm. After leaving at room temperature for 30 minutes, the plate is washed twice with a diluent and fixed in a 1% glutaraldehyde in PBS solution at 4 ° C. for 24 hours. After washing with PBS, an ascending ethanol series (50, 7
0, 80, 90, 95, 100, 100%)
Air dry overnight at room temperature. Scanning electron microscope (SEM)
After performing ion sputtering and coating with gold, observation with a scanning electron microscope and photography (1000 times, 5 visual fields) are performed. Observe the printed photographs and calculate the classification and number of adherent platelets. The classification of the form at this time is based on the following criteria. Type I: no deformation-one with a relatively short pseudofoot, type II: two or three pseudofoot, type III: four or more pseudofoot, type IV : The shape is greatly expanded and flattened and closely adhered to the material surface. The type I to type IV are assigned 1 to 4 points, respectively, and the morphological score is obtained by dividing the sum of the score of the type and the number of adherent platelets by the total number of adherent platelets. At this time, a material having a small total number of adherent platelets and a small morphological score can be said to be a material for preventing platelet activation. When the blood or blood component storage container of the present invention is applied to a container for storing platelets in particular, it is necessary to pay attention to the gas permeability of the container itself. In other words, the layer in contact with blood or blood components has a low platelet activation, especially the adhesion (adhesion) of platelets, and creates a good state. At the same time, it is important to supply a sufficient oxygen gas to the platelet cells. The oxygen gas permeation amount is 100 at a typical position of the container.
0ml / m ²・ day ・ atm (22 ℃) or more, especially 1500ml / m ²・ d
ay · atm (22 ° C) or more is effective. This numerical value is G
This was measured by a gas permeation measuring device GMP-250 manufactured by L Science. At the same time, if the water vapor permeability is high, the water content of the blood in the container evaporates, which is unsuitable as a storage container. Further, a multilayer structure is appropriate because it is necessary to secure a necessary oxygen gas permeation amount and maintain the mechanical strength as a storage container. That is,
The platelet storage container consists of a block copolymer (i) having a microphase-separated structure and a thin layer forming the inner surface.
(I), the other layer is a hydrogenated diene copolymer having good gas permeability (1), (2), (3) and a thermoplastic resin composition (ii) containing a polyolefin resin as a main component. It is also preferable to form a multi-layered structure having layers.

The blood or blood component storage container of the present invention
At least a part of the layer in contact with blood or blood components is a multi-layered blood storage container composed of a block copolymer having a microphase-separated structure, and thus has an effect of preventing activation of blood or blood components, particularly platelets. , Blood bags,
It is desirable to use it for vacuum blood collection tubes, Spitz tubes, and the like. Among them, a blood bag for storing platelets, a vacuum blood collection tube or a Spitz tube for examining the number and morphology of platelets in blood, and examining the coagulation system of blood are particularly suitable. Hereinafter, the present invention will be described in more detail with reference to Examples.

[0074]

【Example】

(Example 1) Polypropylene EX-6 manufactured by Mitsubishi Yuka Corporation
30% by weight, 68% by weight of a styrene elastomer manufactured by Shell Chemical Co., Ltd., Clayton G1652, 1.9% by weight of liquid paraffin of Wako Pure Chemical Reagent grade, 0.1% by weight of Ciba-Geigy's antioxidant Irganox 1010,
After mixing with a twin-screw extruder (PCM, manufactured by Ikegai Iron Works Co., Ltd.), extruding into a strand, and cutting with a pelletizer, a base material pellet for a platelet storage bag was obtained. A 120 mm T-die was attached to an extruder Labo Plastomill manufactured by Toyo Seiki Seisaku-sho, Ltd., and a sheet having a thickness of about 200 μm was obtained using the above-mentioned raw materials. Using a similar apparatus, a polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd.
m sheet. Further, an adhesive resin Bondine TX-8 similarly available from Sumitomo Chemical Co., Ltd.
030 was formed into a sheet having a thickness of about 15 μm. Then, the sheets were stacked in the order of the base sheet of the bag / bondine / polyamide elastomer, and a laminated sheet was obtained through a heat roll of a heat laminating apparatus. When the oxygen permeation amount of this laminate sheet was measured by the above-mentioned apparatus, it was 2
It was 200 ml / m ² · day · atm (22 ° C). Two sheets of this sheet were laminated so that the polyamide elastomer surface was on the inside, and the mold temperature of the heat sealing machine (self-made) was 220 ° C.
The sealing time was set to 3 seconds, and a platelet storage bag having a content of about 300 ml was prepared.

The platelet storage bag material was cut into a square of 8 mm and subjected to the above-described platelet dilatation test. Table 1 shows the results
It was shown to.

400 ml of whole blood was collected from a healthy person into a bag containing an anticoagulant (CPD solution) and centrifuged at 800 rpm for 5 minutes to aseptically obtain platelet-rich plasma (PRP) in the platelet storage bag. 3000 rpm, 1
After submerging the platelet pellet in a centrifuge for 0 minutes, the platelet pellet is loosened and resuspended with about 50 to 60 ml of supernatant plasma. Although the platelet concentration at this time varies depending on the person, it is about 1 to 2 million / mm ³
It is. The platelet storage bag containing the platelet suspension obtained in this manner is stored at 22 ° C. in a stroke width of 20 mm and at a rate of 90 min / min.
It was stored for 5 days with gentle shaking as soon as possible.

The state of the platelet suspension stored for 5 days was good without any change as long as it was visually observed. In addition, there was no change in platelet count per unit volume, average platelet volume, or platelet volume distribution width that was problematic for platelet preparations.

After the storage experiment, the inner surface of the stored platelet storage bag is washed twice with a PBS solution, and then fixed in a 1% glutaraldehyde PBS solution at 4 ° C. for 24 hours. PBS
After washing with ethanol, the ascending ethanol series (50, 70, 80, 90, 95, 100, 1
00%) and air-dry at room temperature all day and night. After performing ion sputtering for a scanning electron microscope (SEM) and coating with gold, observation with a scanning electron microscope and photographing (1000 times, 5 fields of view) are performed. Observe the printed photographs and calculate the classification and number of adherent platelets. The classification of the form at this time is based on the following criteria. Type I: no deformation ~
Form where one pseudofoot is relatively short, Type II: 2 pseudofoot
Three types, III type: Four or more false feet are formed, and IV type: A shape that spreads greatly and becomes flat and adheres to the material surface. The results are summarized in Table 1.

Example 2 In the same manner as in Example 1 except that ABECHEM PEBAX 3533SA, a polyamide elastomer available from Toray Co., Ltd., was used instead of the polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd. To obtain a platelet storage bag. The storage of the platelet suspension was successfully completed without any problems. The results are summarized in Table 1.

Example 3 Instead of the polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd., a polyester elastomer manufactured by Dupont Toray, Hytrel 4047 was used.
Was carried out in the same manner as in Example 1 except that a platelet storage bag was obtained. The storage of the platelet suspension was successfully completed without any problems. The results are summarized in Table 1.

(Example 4) In place of the polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd., a polyurethane elastomer manufactured by Nippon Milactran Co., Ltd., Milactran E-39 was used.
A platelet storage bag was obtained in the same manner as in Example 1 except that Example No. 5 was used. The storage of the platelet suspension was successfully completed without any problems. The results are summarized in Table 1.

Comparative Example 1 A single-layer bag consisting of only a base sheet was used without using the polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd. and the adhesive resin Bondine TX-8030 available from Sumitomo Chemical Co., Ltd. A platelet storage bag was obtained in the same manner as in Example 1 except for the above. Table 1 summarizes the results
Shown in

(Comparative Example 2) A single layer of polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd. was formed into a sheet of 250 μm by T-die molding, and the same procedure as in Example 1 was carried out to obtain a platelet storage bag. The platelet suspension was stored for 5 days, but lactic acid production was accelerated due to insufficient oxygen permeation, the pH dropped, and irreversible damage of platelets occurred, making the platelet unsuitable as a platelet storage container. It is 800ml when the amount of oxygen permeation is measured.
/ m ² · day · atm.

Comparative Example 3 PEBAX, a polyamide elastomer available from Toray Industries, Inc.
X) 3533SA was formed into a single layer into a sheet of 250 μm by T-die molding in the same manner as in Comparative Example 2, and the platelet storage bag was obtained in the same manner as in Example 1. The platelet suspension was stored for 5 days, but the evaporation of water was so large that the platelet preparation concentration was too high to be visible, the osmotic pressure balance of platelet cells was lost, and the platelet morphology was greatly deformed, making it unsuitable as a platelet storage container Met.

(Example 5) Base pellets of a blood bag obtained in the same manner as in Example 1, polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd. and adhesive resin Bondine TX- available from Sumitomo Chemical Co., Ltd. Using 8030, three layers of inflation extrusion were performed to obtain a sheet for a bag. Although the thickness of each layer was not measured, the total thickness of the three layers was 240 μm. Thereafter, it was formed into a blood bag in the same manner as in Example 1, and the platelet suspension was actually put in for evaluation. The preservation was completed successfully and there were no problems. The results are summarized in Table 1.

(Example 6) Base pellets of a blood bag obtained in the same manner as in Example 1, polyamide elastomer PAE1200 manufactured by Ube Industries, Ltd., and adhesive resin Bondine TX- available from Sumitomo Chemical Co., Ltd. Using 8030, three-layer extrusion blow molding was performed to make a container. The thickness of five representative parts was measured and the average value was obtained.
It was 0 μm. Thereafter, it was formed into a bag in the same manner as in Example 1, and the platelet suspension was actually put in for evaluation. The results are summarized in Table 1.

[0087]

[Table 1]

The following hydrogenated diene copolymer was prepared in place of the styrene elastomer Clayton G1652 of Example 1.

In the examples, parts and% are by weight unless otherwise specified. In the examples, the analysis of the copolymer and the evaluation of various physical properties were measured by the following methods.

The amount of 1,2-vinyl bond in polybutadiene was calculated by the Morero method using infrared analysis.

Styrene content The absorption based on the phenyl group at 699 cm ^{-1 was} determined by an infrared analysis method by preparing a calibration curve.

The number average molecular weight was determined in terms of polystyrene using gel permeation chromatography (GPC) at 135 ° C. using trichlorobenzene as a solvent.

Hydrogenation rate 100 MHz, ¹ H using ethylene tetrachloride as a solvent.
-Calculated from NMR spectrum.

Tensile Properties (Tensile Breaking Strength, Tensile Breaking Elongation) Measured according to JIS K6301.

Flexibility According to JIS K6301, JIS A hardness was measured.

[0096] Using transparency Suga Test Co., Ltd. Multi light source spectrophotometer, of about 0.
The haze of a 6 mm sheet was measured. The lower the number, the more transparent.

Heat resistance A 2 cm square sample having a thickness of 2 mm was subjected to air drying at 140 ° C. for 30 minutes in a gear oven under a load of 500 g / cm ^2.
After aging, the samples after aging were evaluated for the presence or absence of blocking. ○ indicates no blocking, and X indicates the case where the film cannot be peeled off by blocking.

Gas permeability (oxygen permeability, carbon dioxide permeability)
Properties) Measured under the conditions of 23 ° C. and 50% RH according to ASTM D1434.

[0099] One end of the sheet of peelable prefabricated layers of the laminate, and hot-melt adhesive at a pressure of 50 Kg / cm ² at 230 ° C. hot press, width 15
Take a test specimen of ± 0.1 mm
After opening at 0 degree, both ends were attached to both grips of a tensile tester, and a tensile load was applied at a pulling speed of 20 mm / min until the hot pressed portion was broken or peeled off, and the maximum load therebetween was determined.

(Reference Example) Various polymers used in the compounding formulations of Examples and Evaluations are as follows. Hydrogenated
Diene-based copolymer Hydrogenated diene-based copolymer (Q-1 to Q-6) is manufactured by Nippon Synthetic Rubber Co., Ltd., and has microstructure, number average molecular weight, The hydrogenation rate is as shown in Table 2.

[0101]

[Table 2]

Q-6 is a random copolymer of styrene and 1,3-butadiene.

Polyolefin resin PP-1: Highball J85, manufactured by Mitsui Petrochemical Co., Ltd.
8Y PP-2: Highball F60 manufactured by Mitsui Petrochemical Co., Ltd.
1 EVA-1: Mitsubishi Yuka Corporation, Mitsubishi Polyethylene-EV
A X501 thermoplastic polyamide elastomer W-1: manufactured by Ube Industries, Ltd., PAE 1200 W-2: manufactured by Atochem, PEBAX 4033SA (functional group-containing) polyolefin V-1: manufactured by Mitsui Petrochemical Co., Ltd., Admer NF520V -2: manufactured by Sumitomo Chemical Co., Ltd., Bondyne TX8030 V-3: manufactured by Mitsui Petrochemical Co., Ltd., Admar LF530 V-4: manufactured by Tosoh Corporation, Ultracene 710 (polyolefin containing no functional group: ethylene-acetic acid) (Vinyl copolymer) (Examples 7 to 19, Comparative examples 4 to 10) Using the compounding formulations shown in Tables 3 to 6 below, each layer was separately extruded with a multilayer T-die extrusion method using an extruder. Produced.

The thickness of each layer is 0.4 mm for the thermoplastic composition layer (III), 0.1 mm for the polyamide elastomer layer (I) in contact with blood and blood components, and 0.1 mm for the adhesive layer (II).
Was 0.1 mm. Various physical properties were evaluated using the obtained sheet. Further, after forming into a bag shape in the same manner as in Example 1, blood containing platelets was stored at 22 ° C. for 5 days as in Example 1, and the bag surface thereafter was subjected to SEM.
Observed. The results are shown in Tables 3 to 6.

[0105]

[Table 3]

[0106]

[Table 4]

[0107]

[Table 5]

[0108]

[Table 6]

As is clear from Tables 3 and 4, Examples 7 to
Reference numeral 19 denotes a laminate of the present invention, which is excellent in tensile properties, transparency, flexibility, releasability of the laminate, and gas permeability, and the laminate of the present invention is obtained.

On the other hand, as is apparent from Tables 5 and 6, Comparative Examples 4 and 5 show that the blending amount of the hydrogenated diene copolymer in the thermoplastic polymer composition layer (III) is less than that of the present invention. And the transparency, flexibility and gas permeability are inferior. Comparative Example 6 is an example in which the blended amount of the hydrogenated diene-based copolymer in the thermoplastic polymer composition layer (III) exceeds the range of the present invention. Poor in peelability and workability.

In Comparative Example 7, the thermoplastic polymer composition layer (II
(I) is an example using a hydrogenated diene copolymer outside the scope of the present invention, and is inferior in mechanical strength and transparency. Comparative Example 8
Is an example in which the adhesive (II) is not used, and the peelability of the laminate is poor. Comparative Example 9 is an example in which a polyolefin outside the scope of the present invention was used for the adhesive layer (II), and the laminate was inferior in peelability. Comparative Example 10 is an example in which the polyamide elastomer layer (II) is not used, and is inferior in heat resistance.

[0112]

The blood or blood component storage container of the present invention has a multilayer structure in which at least a part of the inner layer in contact with the blood is formed of a block copolymer. This has the effect of improving the storage stability. In addition, since the method for producing a blood or blood component storage container of the present invention is performed by extrusion molding, blow molding, injection molding or coating, the activation of blood, especially platelets, is easily prevented, and the storage stability of platelets is improved. The effect is that a blood storage container having a multilayer structure can be obtained.

Continued on the front page (72) Inventor Akira Mochizuki 1500 Inoguchi, Nakai-machi, Ashigara-kami, Kanagawa Prefecture Inside Terumo Corporation (72) Inventor Osamu Shinonome 818 Misonodaira, Fujinomiya-shi, Shizuoka Prefecture Inside Terumo Corporation (56) References JP-A Heisei 3 -15470 (JP, A) JP-A-55-38126 (JP, A) JP-A-63-82665 (JP, A) JP-A-2-133406 (JP, A) JP-A-3-128957 (JP, A) JP-A-61-34030 (JP, A) JP-A-63-214260 (JP, A) JP-A-50-14742 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61J 1/10 A61J 3/00

Claims (2)

(57) [Claims] 1. A container for storing blood or blood components, wherein the container is formed of a sheet having a multilayer structure, and at least a part of the layer (I) in contact with the blood or blood components of the sheet is made of polyamide elastomer or polyester elastomer.
Tomer, polyurethane elastomer, hydroxyethyl
Consists of methacrylate and styrene block copolymer
A block copolymer (i) comprising at least one microphase-separated structure selected from the group, and at least one other layer (II) comprising the following hydrogenated diene copolymer (1) and / or
Or a blood or blood storage container composed of a thermoplastic resin composition (ii) containing (2), (3) 40 to 90% by weight and a polyolefin resin (4) 60 to 10% by weight as a main component: hydrogenated diene type Copolymer (1): Polymer block in molecule
(A), (B) and (C) have at least one each.
(A) is a polymer block mainly composed of an aromatic vinyl compound containing 90% by weight or more of an aromatic vinyl compound, and (B) is a conjugated diene polymer block or an aromatic vinyl compound-conjugated diene copolymer block. A polymer block having a conjugated diene moiety having a vinyl bond content of 30 to 90%;
(C) shows a polybutadiene polymer block having a vinyl bond content of less than 30%. The content of the polymer block (A) in the block copolymer is 3 to 30% by weight, and the polymer block (B)
Is 40 to 80% by weight, and the content of the polymer block (C) is 10 to 40% by weight. (A), (B) or (C), which is bonded to a polymer comprising at least one polymer block, and a block copolymer in which the polymer molecular chain is extended or branched is hydrogenated to form a conjugated diene moiety. Hydrogenated diene copolymer in which at least 80% of the double bonds are saturated and have a number average molecular weight of 50,000 to 300,000; hydrogenated diene copolymer (2): a vinyl bond content of 20 % Or less of a polybutadiene polymer block (D), a conjugated diene polymer block or an aromatic vinyl compound-conjugated diene copolymer block, wherein the vinyl bond amount of the conjugated portion is 30 to 90% ( E)
A block copolymer whose block structure is represented by [(D)-(E)-(D)] p or [(D)-(E)] p (where p is an integer of 1 or more), or The block copolymer unit is obtained by hydrogenating a block copolymer in which the polymer molecular chain is extended or branched via a coupling agent residue, so that at least 80% of the double bonds of the conjugated diene portion are saturated. A hydrogenated diene-based copolymer having a number average molecular weight of 50,000 to 400,000; and a hydrogenated diene-based copolymer (3):
A polymer block (F) mainly containing an aromatic vinyl compound in an amount of 30% to 90% by weight;
% Of a conjugated diene copolymer block (G)
A block copolymer having a block structure represented by (F)-[(G)-(F)] q (where q is an integer of 1 or more), or the block copolymer unit is a coupling agent residue. A block copolymer in which the polymer molecular chain is extended or branched through a group,
To at least 8 double bonds in the conjugated diene moiety.
A hydrogenated diene polymer having 0% saturation and a number average molecular weight of 50,000 to 400,000. 2. The container has an oxygen gas permeation amount of 1000 m.
The blood or blood component storage container according to claim 1, wherein the blood or blood component storage container is at least 1 / m ² · day · atm (22 ° C).