JP3170250B2 - Dentifrice composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition having an excellent effect of removing plaque adhering to fine irregularities on the tooth surface.

[0002]

2. Description of the Related Art A dentifrice is usually mixed with an abrasive or a cleaning agent for the purpose of removing dirt on the surface of teeth. Generally, calcium carbonate, dibasic calcium phosphate, tribasic calcium phosphate, calcium pyrophosphate, hydroxy, etc. Apatite is used. Particles widely used as abrasives and cleaning agents have an average particle diameter of 5 to 20 μm.
m primary particles.

[0003]

In recent years, teeth have become whiter,
There has been a strong demand for maintaining cleanliness, and there has been a demand for a dentifrice composition having a higher plaque-removing effect than these conventional dentifrices containing an abrasive and a cleaning agent.

[0004]

The inventor of the present invention has enlarged the surface of a tooth with a microscope and observed it closely. As a result, many irregularities of 20 to 100 μm existed on the surface of the tooth. It was found that plaque was formed at the center. It was also found that, with conventional abrasives and cleaning agents, plaque that appeared to have fallen cleanly to the naked eye after cleaning still had plaque remaining in the depressions.
The plaque on the uneven portion could not be sufficiently removed by particles having an average primary particle diameter of 5 to 20 μm or agglomerated particles having an average particle diameter of 3 μm or less conventionally used as abrasives and cleaning agents. This time, dentifrices that are agglomerated particles of fine particles and that contain agglomerated particles having a certain particle size range and disintegration strength have a high removal effect on plaque adhering to this uneven portion I found that.

[0005] That is, the present invention provides an agglomeration of only fine particles of calcium carbonate having an average primary particle diameter of 0.5 to 2 µm, an average particle diameter of 3.5 to 10 µm, and a collapse strength of 0.1 to 2 µm. It is intended to provide a dentifrice composition containing 5 g / piece of calcium carbonate aggregated particles.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The aggregated calcium carbonate particles used in the dentifrice composition of the present invention are particles formed by aggregating fine primary particles, and have an average particle diameter of 3.5 to 10 μm and a disintegration strength of 0.1.特性 5 g / piece.

[0007] When the average particle diameter of the aggregated particles is less than 3.5 μm or more than 10 μm, the ability to remove dirt (hereinafter referred to as “micro dirt”) on the fine irregularities on the tooth surface is not sufficient. A more preferred average particle size is 5 to 8 μm. The average particle diameter can be measured with a laser diffraction / scattering particle size distribution analyzer.

[0008] When the disintegration strength of the aggregated particles is less than 0.1 g / piece, the micro soil removal power is not sufficient, and when it exceeds 5 g / piece, powdery feeling is felt in the mouth and the palatability of the dentifrice decreases. I do. A more preferred collapse strength is 0.1 to 2 g / piece.
The collapse strength is a load at which one particle collapses, and can be measured using, for example, a micro compression tester.

Such aggregated particles can be prepared, for example, by aggregating fine particles having an average primary particle diameter of 0.5 to 2 μm.

[0010] As aggregate particles used in the present invention has a specific surface area of 1 to 10 m ² / g, and particularly preferably viewpoint those 2 to 8 m ² / g is micro soil removal force. The specific surface area is BE
It can be obtained by measuring the N ₂ gas adsorption amount by the T method.

The agglomerated particles are contained in the dentifrice composition of the present invention in an amount of 2 to 50% by weight (hereinafter simply referred to as%), particularly 2 to 3% by weight.
0%, more preferably 4 to 10%, is preferred from the viewpoint of the effect of removing micro-dirt.

In addition, the dentifrice composition of the present invention contains, in addition to the agglomerated particles, granules having an average particle diameter of 100 to 500 μm and a disintegration strength of 0.1 to 10 g / piece. This is more preferable because it can remove plaque adhering to uneven portions that are difficult to polish between the teeth.

[0013] As the primary particles used in the production of the granules, any one can be used as long as it is generally used as a tooth polishing agent. Specific examples thereof include dibasic calcium phosphate and tribasic calcium phosphate. , Calcium pyrophosphate, magnesium phosphate, insoluble sodium metaphosphate, silica, hydroxyapatite,
Examples include powders of aluminum hydroxide, alumina, calcium carbonate, magnesium carbonate, calcium sulfate, zeolite, composite aluminosilicate, red iron oxide and the like, and mixtures thereof. The particle size of these primary particles is 0.1 to 20 μm.
m, particularly preferably about 1 to 5 μm.

As a binder for producing granules, any of an organic binder and an inorganic binder can be used. Such organic binders include, for example, water-soluble polymers such as polyacrylic acid, polyvinyl alcohol, and polyethylene glycol, polysaccharides such as hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, xanthan gum, and carrageenan, natural fibers, polyvinyl chloride, and polyethylene. ,polypropylene,
Examples include water-insoluble polymers such as polystyrene, polymethyl methacrylate, nylon, and silicone, and oils and fats such as paraffin, higher alcohol, and wax. Examples of the inorganic binder include, for example, water-soluble metal salts such as sodium chloride and potassium chloride, water-soluble metal salts of organic acids such as sodium citrate, sodium tartrate, and sodium succinate, colloidal silica, magnesium aluminate metasilicate, and the like.
Examples include water-insoluble compounds such as bentonite, montmorillonite, kaolin, synthetic aluminum silicate, calcium silicate, aluminum hydroxide gel, alumina sol, magnesium carbonate, synthetic hydrotalcite, magnesium oxide, and magnesium hydroxide. One or more of these binders can be used, but from the viewpoint of the stability of the granules in the dentifrice, it is preferable to use an inorganic water-insoluble compound, especially colloidal silica or synthetic aluminum silicate. It is preferred to use. In addition, as the granules, a granular salt having a large particle size described in JP-A-62-265214 or a granular salt having a small particle size described in JP-A-4-368319 is bound using a binder. Granulated saline salt can be used.

The granules have an average particle size of 100 to 500.
It is necessary that the average particle diameter is μm, but the average particle diameter here refers to a somewhat average diameter calculated for a weight distribution by a sieving method using a JIS standard sieve.

The granules have a disintegration strength of 0.1 to 1
It is necessary to be 0 g / piece, and it is particularly preferable to be 1 to 5 g / piece. If the disintegration strength is less than 0.1 g / piece, plaque cannot be removed, and the disintegration strength is 1 g / piece.
If it exceeds 0 g / piece, it may be perceived as a foreign substance in the mouth, may not be disintegrated at all by brushing, and may damage tooth enamel.

The average particle size and disintegration strength of the above granules can be controlled by appropriately changing the kind, combination, blending amount, production conditions and the like of the binder.

In view of controlling the shape, disintegration strength, particle size, etc. of the granules, the spray granulation method is particularly preferable, and when a flammable or thermoplastic binder is used. Is preferably a spray cooling method, an extrusion method, a pressing method, a cutting method, or the like.

The granules are used in the dentifrice composition of the present invention.
It is preferable to mix 50%, especially 3３０30%.

The dentifrice composition of the present invention can be prepared by a conventional method.
For example, by appropriately mixing the agglomerated particles, the aforementioned granules, other abrasive powders, and binders, surfactants, wetting agents, sweeteners, medicinal ingredients, fragrances, water, etc., for example, toothpaste It can be manufactured as a form.

[0021]

Example 1 Toothpaste having the composition shown in Table 1 was prepared using particles having the properties shown in Table 2, and the micro soil removal power was evaluated. Table 2 shows the results.

(1) Measurement of Average Particle Size A sample was put into ion-exchanged water and measured with a laser diffraction / scattering type particle size distribution analyzer (HORIBA). (2) Measurement of Collapse Strength The collapse strength of one particle was measured using a micro compression tester (MCTM-500, Shimadzu Corporation). (3) Evaluation method of micro-dirt removing power A width of 20 to 5 is used as a model of a fine depression existing on the tooth surface.
Using frosted glass with irregularities of 0 μm and depth of about 5 μm,
An oil-based ink was applied thereto as model plaque, brushed under the following conditions, the amount of the model plaque attached was evaluated by an image analyzer, and the micro stain removal power was calculated. (3-1) Apparatus / brushing conditions Glass plate: polished glass, 15 × 25 × 1.0 mm Brushing machine: brush wear tester HEIDON
-14 Stroke width: 30 mm Stroke speed: 120 times / min Toothbrush: PC Clinica (round cut, normal) (3-2) Procedure of micro stain removal force test (I) Apply oil-based ink as model plaque to polished glass After drying sufficiently, set it on the sample table. (II) Apply a certain amount (0.5 g) of toothpaste to a toothbrush,
Brushing was performed for 200 strokes under a load of 500 g, and the amount of oil-based ink before and after the test was image-analyzed to calculate the removal power (removal rate of oil-based ink (%)).

(4) The aggregated particles used were prepared by a liquid reaction method.

[0024]

[Table 1]

[0025]

[Table 2]

From Table 2, it can be seen that the dentifrice containing the aggregated particles having an average particle diameter and a disintegration strength within the range of the present invention is superior in removing the micro-dirt to the dentifrice containing the primary particles. . Further, when the dentifrice of the present invention was used, the teeth became whiter and the smoothness of the teeth was improved.

Example 2 A toothpaste having the composition shown in Table 3 was prepared using calcium carbonate having the properties shown in Table 4, and the micro soil removal power was evaluated. Table 4 shows the results. The properties of the particles and the micro-dirt removing power were measured in the same manner as in Example 1 except for the specific surface area. Measurement of specific surface area Specific surface area measurement device (Yuasa Ionics, NOVA10
00) using N ₂ gas. (BET method)

[0028]

[Table 3]

[0029]

[Table 4]

Table 4 shows that the dentifrice containing the agglomerated particles having the average particle diameter and the disintegration strength within the range of the present invention has superior micro soil removal ability as compared with the dentifrice containing the primary particles. . Further, when the dentifrice of the present invention was used, the teeth became whiter and the smoothness of the teeth was improved.

Example 3 A toothpaste having the composition shown in Table 5 was prepared, and the micro soil removal power was measured in the same manner as in Example 1.

[0032]

[Table 5]

As a result, when a granule was blended with the agglomerated particles, the micro-dirt removing power was further improved, and the dirt between teeth was good.

[0034]

The use of the dentifrice composition of the present invention makes it possible to remove plaque on microscopic irregularities on the tooth surface, thereby making the teeth whiter and smoother.

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (3)

(57) [Claims] An aggregate obtained by aggregating only fine particles of calcium carbonate having an average primary particle diameter of 0.5 to 2 μm,
Average particle size 3.5 to 10 μm and disintegration strength 0.1 to 5
A dentifrice composition comprising g / calcium carbonate aggregated particles. 2. The specific surface area of the calcium carbonate aggregated particles is 1
Through 10m ² / g and is claim 1 dentifrice composition. 3. Further, the average particle diameter is 100 to 500 μm.
The dentifrice composition according to claim 1 or 2, comprising granules having a disintegration strength of 0.1 to 10 g / piece.