JP3140624U - Inhalation test device with nasal exposure method - Google Patents

Abstract

A nasal part exposure type inhalation test apparatus in which a laboratory animal holder can be easily attached to and detached from a main body of the inhalation test apparatus.
A laboratory animal holder is detachably attached to a holder attaching / detaching cylinder, and a flange projecting in the center is formed at a proximal end opening of the holder attaching / detaching cylinder, and a distal end of the experiment animal holder is provided. In the vicinity, an elastic ring member 32 capable of contacting the flange when mounted on the holder detachable cylinder is provided, and the inner peripheral surface of the holder detachable cylinder and the inner peripheral surface of the holder detachable cylinder when the experimental animal holder is mounted At least one fixing protrusion 22 is formed on one of the outer peripheral surfaces facing the surface, and a guide groove 34 for guiding the fixing protrusion is formed on the other, and the guide groove is attached to the fixing protrusion from the end. Direction, then in the diagonal mounting direction, then in the circumferential direction, and when guiding from the diagonal mounting direction to the circumferential direction, the elastic ring member presses the flange, making the experimental animal holder airtight To wear.
[Selection] Figure 1

Description

  The present invention relates to an inhalation test apparatus of a nasal part exposure system that can administer a test substance such as mist, gas, powder, etc. by inhalation to the nasal part of a laboratory animal.

  Conventional inhalation experiment methods to examine the effects of drugs on the body by inhalation of drugs to small laboratory animals such as rats, mice, guinea pigs, etc. include whole-body exposure methods and nasal exposure methods, and nasal exposure methods Can be performed, for example, using the inhalation test apparatus of Patent Document 1. As shown in FIG. 4, the nasal part exposure type inhalation test apparatus includes an inner tube 40 supplied with test substance-containing air, a nasal part exposure nozzle 42 attached to the inner tube, and an exposed test substance. Attached to the outer tube 44 provided outside the inner tube 40 and the outer tube 44 at a position facing the nose exposure nozzle 42 to discharge the mixed gas of the residual gas of the contained air and the exhaled breath of the experimental animal The test animal holder 46 is configured to administer the test substance from the nasal portion exposure nozzle 42 to the test animal by inhalation by inhalation of the experimental animal.

  The experimental animal holder 46 is composed of a double cylinder of an inner cylinder 48 that houses the experimental animal and an outer cylinder 50 that fixes the inner cylinder 48 at a predetermined position, and the entire inner cylinder 48 can be inserted into and removed from the outer cylinder 50. Has been inserted. The outer cylinder 50 has a distal end portion 50A outer peripheral surface attached to a holder attaching / detaching cylinder 54 fixed to the outer cylinder pipe 44 in an airtight manner through an O-ring 56, and an inner cylinder is attached to the tip of the outer cylinder 50. An exposure hole 58 for exposing a part of the front end portion of 48 is provided, and a lid body 60 that is detachably screwed is provided at the rear end. A rod 62 of a pressing body for pressing the rear open end surface of the inner cylinder 48 is attached to the lid body 60 so as to be airtight and slidable.

JP-A-9-187192

  As described above, in the conventional inhalation test apparatus, the laboratory animal holder is attached to the holder detachable cylinder in an airtight manner through the O-ring so as to be detachable. Therefore, there is a problem that a certain amount of force is required for detachment. . Therefore, an object of the present invention is to provide an inhalation test apparatus of a nose exposure system in which a laboratory animal holder can be easily attached to and detached from the main body of the inhalation test apparatus.

  In order to achieve the above object, the present invention is designed to test the inner tube supplied with test substance-containing air, the nose exposure nozzle attached to the inner tube, the residual gas of the exposed test substance-containing air, and the experiment. An experimental animal comprising an outer tube provided outside the inner tube for discharging the mixed gas of the animal's breath, and an experimental animal holder attached to the outer tube at a position facing the nose exposure nozzle In a nasal exposure type inhalation test apparatus configured to inject a test substance from a nasal exposure nozzle into a laboratory animal by inhalation of the nasal part, the experimental animal holder is attached to and detached from a holder fixed to the outer tube A flange that protrudes in the center direction is formed at the proximal opening of the holder detachable cylinder, and is attached to the holder detachable cylinder in the vicinity of the distal end of the experimental animal holder. When said hula An elastic ring member capable of abutting the sleeve is provided, and either one of the inner peripheral surface of the holder detachable cylinder and the outer peripheral surface facing the inner peripheral surface of the holder detachable cylinder when the experimental animal holder is mounted , At least one fixing protrusion is formed, and on the other side, a guide groove for guiding the fixing protrusion is formed. The guide groove guides the fixing protrusion from the end in the mounting direction, and then guides in the oblique mounting direction. The elastic ring member is then guided in the circumferential direction, and the elastic ring member presses the flange when guiding in the circumferential direction from the oblique mounting direction, so that the laboratory animal holder is mounted in an airtight manner. .

  In the inhalation test apparatus of the nose exposure method according to the present invention, the experimental animal holder is composed of an inner cylinder that houses the experimental animal and an outer cylinder that fixes the inner cylinder in a predetermined position, and the entire inner cylinder is the outer cylinder. It is preferable that the outer cylinder is removably inserted into the outer cylinder, and the outer cylinder has an exposure hole for exposing a part of the front end portion of the inner cylinder, and is detachably screwed to the rear end. It is preferable to have a covered lid.

  As described above, according to the present invention, it is possible to provide a nose exposure type inhalation test apparatus in which a laboratory animal holder can be easily attached to and detached from an inhalation test apparatus body.

  Next, an embodiment of a nasal part exposure type inhalation test apparatus according to the present invention will be described with reference to the drawings. FIG. 1 is a front view showing a state before the experimental animal holder 10 of the inhalation test apparatus of the nasal part exposure method according to the present embodiment is mounted on the holder attaching / detaching cylinder 12, and FIG. FIG. 3 is a right side view of the holder detachable cylinder 12.

  The nasal part exposure type inhalation test apparatus according to the present embodiment includes an inner tube 14 to which test substance-containing air is supplied, a nasal part exposure nozzle 16 attached to the inner tube 14, and an exposed test substance containing It is attached to the outer tube 18 provided outside the inner tube 14 and the outer tube 18 at a position facing the nasal part exposure nozzle 16 in order to discharge the mixed gas of the residual gas of the air and the breath of the experimental animal. The experimental animal holder 10 is detachably attached to a holder attaching / detaching cylinder 12 fixed to the outer tube 18.

  The holder attaching / detaching cylinder 12 has a flange 20 protruding in the center direction at the proximal end side opening 12A, and has three columnar fixing protrusions 22 on the inner peripheral surface thereof. These fixing protrusions 22 are provided at equal intervals in the circumferential direction. The fixing protrusion 22 is formed of a material that is more flexible than an outer cylinder 26 of the experimental animal holder 10 described later, and is configured to be replaceable when it is consumed by use.

  The experimental animal holder 10 includes an inner cylinder 24 that houses an experimental animal, and an outer cylinder 26 that fixes the inner cylinder 24 at a predetermined position, and the entire inner cylinder 24 is removably inserted into the outer cylinder 26. It is configured as follows. The outer cylinder 26 includes a distal end portion 26A having a slightly longer axial length than the holder attaching / detaching cylinder 12, and a base end portion 26B having an outer diameter larger than the distal end portion 26A. It is formed to be the same as or slightly smaller than the inner diameter of the holder attaching / detaching cylinder 12, and the outer diameter of the base end portion 26 </ b> B is formed to be the same as the outer diameter of the holder attaching / detaching cylinder 12. The outer cylinder 26 has an opening 28 that exposes the front end of the inner cylinder 24 at the front end, and a lid 29 that is detachably screwed at the rear end. A rod 31 of a pressing body for pressing the rear open end surface of the inner cylinder 24 is attached to the lid body 29 so as to be airtight and slidable. A flange 30 protruding in the center direction is formed in the opening 28 of the outer cylinder 26, and the inner peripheral end of the flange 30 protrudes toward the distal end side 30 </ b> A, and the outer side of the protrusion 30 </ b> A of the flange 30 is made of rubber. The ring member 32 is provided. When the experimental animal holder 10 is mounted on the holder attaching / detaching cylinder 12, the outer peripheral surface of the projecting portion 30 </ b> A is in contact with the inner peripheral surface of the flange 20 of the holder attaching / detaching cylinder 12, and the ring member 32 is in contact with the flange 20. It is configured.

  Three guide grooves 34 for guiding the fixed protrusions 22 are formed on the outer peripheral surface of the distal end portion 26A of the outer cylinder 26 at positions facing the fixed protrusions 22 when the experimental animal holder 10 is mounted on the holder detachable cylinder 12. Has been. The guide groove 34 includes a linear portion 34A extending in the proximal direction from the distal end of the outer cylinder 26, an oblique portion 34B extending in the oblique proximal direction from the linear portion 34A, and a circumferential portion 34C extending in the circumferential direction from the oblique portion 34B. The ring member 32 presses the flange 20 when guiding from the oblique portion 34B to the circumferential portion 34C, and is configured to airtightly attach the experimental animal holder 10. In addition, the width of the guide groove 34 is the same as or slightly longer than that of the fixed protrusion 22, and the depth thereof is the same as or slightly longer than the height of the fixed protrusion 22.

  As described above, in the inhalation test apparatus of the nose exposure method according to the present embodiment, when the experimental animal holder 10 is mounted on the holder detachable cylinder 12, the fixing protrusion 22 of the holder detachable cylinder 12 is connected to the straight portion 34A of the guide groove 34, By guiding along the oblique part 34B and the circumferential part 34C, the experimental animal holder 10 can be easily attached in an airtight manner.

It is a front view which shows the state before mounting the experimental animal holder of the Example of the inhalation test apparatus of the nose part exposure system which concerns on this invention to a holder attachment or detachment cylinder. It is front sectional drawing which shows the state which mounted | wore the holder attachment / detachment cylinder with the experimental animal holder. It is a right view of a holder attachment / detachment cylinder. It is front sectional drawing of the inhalation test apparatus of the conventional nose part exposure system.

Explanation of symbols

10 Experimental Animal Holder 12 Holder Detachable Tube 14 Inner Tube 16 Nose Exposing Nozzle 18 Outer Tube 20 Flange 22 Fixed Protrusion 34 Guide Groove

Claims (2)

An inner tube that is supplied with test substance-containing air, a nose exposure nozzle that is attached to the inner tube, and an internal tube for discharging the residual gas of the exposed test substance-containing air and the exhaled breath of the laboratory animal. It has an outer tube provided outside the tube and a laboratory animal holder attached to the outer tube at a position opposite to the nose exposure nozzle. In an inhalation test device with a nasal exposure system configured to be administered via air to a laboratory animal
The experimental animal holder is detachably attached to a holder detachable cylinder fixed to the outer cylinder tube,
A flange protruding in the center direction is formed at the proximal end side opening of the holder detachable cylinder,
Near the tip of the experimental animal holder is provided with an elastic ring member that can contact the flange when mounted on the holder detachable cylinder,
At least one fixing protrusion is formed on one of the inner peripheral surface of the holder detachable cylinder and the outer peripheral surface facing the inner peripheral surface of the holder detachable cylinder when the laboratory animal holder is mounted. A guide groove for guiding the fixing protrusion is formed,
The guide groove guides the fixing protrusion from the end in the mounting direction, then guides it in the oblique mounting direction, then guides it in the circumferential direction, and then guides the elastic ring member in the circumferential direction from the diagonal mounting direction. A nasal part exposure type inhalation test apparatus, wherein the apparatus is configured to press the flange and airtightly mount the experimental animal holder. The laboratory animal holder is composed of an inner cylinder for storing an experimental animal and an outer cylinder for fixing the inner cylinder at a predetermined position, and the entire inner cylinder is removably inserted into the outer cylinder. The nasal part exposure type inhalation test apparatus according to claim 1.

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