JP3097777B2 - Reservoir-filled solid drug and packaging method thereof - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for packaging a solid drug.

[0002]

2. Description of the Related Art Heretofore, as a method of packaging a solid medicine, a method of degassing has been widely known as a method of packaging such that air is not trapped in a packaging material.

[0003]

[Problems to be solved by the present invention] In the conventional packaging method, a means of degassing is used, so that a state in which the packaging material adheres to the surface of the article cannot be obtained. However, air was inevitably left in the air, and it was not sufficient for a packaging method.

[0004] The present invention has been made as a result of earnest research to solve the above-mentioned conventional problems.

[0005]

Means for Solving the Problems The present invention provides the following means
Solved the above problem. (1) A water-soluble film, which is a solid medicine put into a water tank.
Is pressed against the outer surface of a solid drug
Cistern that is wrapped
Injectable solid drug. ( 2 ) A water-filled solid medicine, which is a solid medicine wrapped in a water-soluble film, is heated to melt the surface of the solid medicine, and the water-soluble film is put on the surface of the solid medicine. A method for packaging a solid medicine charged into a water tank, wherein the solid medicine is pressure-bonded to a part.

In the present invention, solid drugs include insecticides, fungicides, detergents, fragrances, deodorants, repellents, fragrances,
A cleaning agent, a bleaching agent, a bathing agent and the like can be used in combination of at least one or more.

In the present invention, the water-soluble film includes
Any water-soluble or hardly water-soluble one can be used as long as it is in the form of a film. Typically, the following can be exemplified. Methylcellulose (MC), hydroxypropylcellulose (HPC), hydroxypropylmethylcellulose (HPMC), carboxymethylcellulose (C
MC), sodium carboxymethylcellulose (CM
Cellulose derivatives such as C-Na), starch derivatives such as soluble starch, sodium starch glycolate and sodium starch phosphate, pectin, carrageenan, furceleran, pullulan (manufactured by Hayashibara), locust bean gum, guar gum, gum arabic , Natural polysaccharides such as tragacanth gum, xanthan gum and sodium alginate, synthetic thickening gelling agents such as sodium polyacrylate, polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG), propylene glycol alginate, gelatin And sodium caseinate.

In the present invention, the heating means for melting the surface of the medicine depends on the kind and shape of the medicine, but as long as a temperature at which the surface of the medicine is melted is obtained, a sheet heater, a fan heater, a dish heater and the like can be used. A container heater, a tubular heater, etc., can be appropriately selected and used depending on the shape and size of the medicine, but since the medicine itself has various shapes, a fan heater capable of performing hot air heating is preferable. .

The heating temperature for melting the surface of the drug is usually 70 to 250 ° C., and the heating time is 5 to 50 ° C.
This is performed within a range of 300 seconds, but is not limited in any way as long as it can be performed.

In the present invention, a device such as a heat press can be used as a means for pressing a film on the surface of the above-mentioned drug, but is not limited to these. The pressure at the time of pressure bonding is usually 0.1 to 1
The reaction is performed within a range of 0 kg / cm ² , but is not limited at all as long as it can be performed.

In the present invention, examples of the material used for the above-mentioned solid medicine include fragrances, surfactants, dyes, fungicides, insecticides, repellents, deodorants, bleaching agents, and the like.

The product of the present invention may further contain, if necessary, a chlorine-based detergent component such as calcium hypochlorite and chlorinated isocyanuric acid, and a chelating agent component such as EDTA and NTA. Further, known additives such as a pH adjuster, a buffer, a disinfectant, a disinfectant, a dechlorinator, a bleach, and a specific gravity adjuster can be added.

The specific gravity adjusting agent adjusts the specific gravity of the product of the present invention. Examples of the specific gravity adjusting agent include water-soluble inorganic compounds having a true specific gravity of 1.50 or more, such as sodium sulfate, calcium sulfate and thiosulfate. Sodium, sodium carbonate, sodium bicarbonate, sodium silicate, sulfamic acid and the like can be advantageously used.

The amount of the compound can be appropriately determined according to the intended specific gravity, but is usually preferably from 5 to 50%.

As the fragrance, various kinds of fragrances conventionally used as fragrances can be used alone or in combination of two or more. Specific examples thereof include natural plant essential oils such as lavender, lemon oil, rose oil, spearmint oil, green oil, etc.
Aldehydes and ketones that are synthetic flavors, such as pipettes,
Examples thereof include esters and mixtures thereof.

The amount of the above fragrance compounded in the solid preparation of the present invention is as follows:
The amount slightly varies depending on the type of the fragrance, the intensity of the fragrance, the size of the product to be obtained, and the like, but it is usually preferable that the content is in the range of about 0.1 to 50% by weight in the product. If the amount of the fragrance is too small, the fragrance is weak and the fragrance is not persistent. If the amount is too large, solidification of the composition at room temperature becomes difficult, and the robustness of the composition itself is reduced, and the composition is easily eluted by running water. Particularly preferred amount of the fragrance is about 1 to 20% by weight.

The pigment is a measure of the effectiveness of the solid drug itself. Examples of the pigment include water-soluble dyes such as methylene blue, cyanine blue, Blue No. 1, Yellow No. 4,
Yellow No. 5, Yellow 202, Red No. 106, Green No. 3, Blue No. 202, Blue No. 203 and the like can be advantageously used. The blending ratio can be appropriately determined according to the type (color tone, density) of the dye, but is usually suitably about 0.5 to 20% by weight. If this is less than the above range, the color of the eluate may be light or may not be colored, and a refreshing feeling, a sense of hygiene, etc. will not be exhibited. May give. In addition, the said pigment does not need to be used according to a use scene.

The surfactant or the soap mainly contributes to the detergency, and also affects the slow solubility of the pigment and the fragrance and the fastness of the composition. Particularly for fragrances, the fragrances can be simultaneously eluted by running water, and as a result, the volatilization area of the fragrances can be increased. Various well-known surfactants can be used as the surfactant. Representative examples thereof include, for example, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene oleyl ether, polyoxyethylene nonylphenol ether, polyoxyethylene sorbitan tristearate,
Examples thereof include polyoxyethylene sorbitan monostearate, polyethylene glycol monostearate, polyoxyethylene distearate, polyoxyethylene polyoxypropylene block polymer, fatty acid glyceride, and fatty acid alkanolamide. These may be used alone or in combination of two or more. Among them, especially polyoxyethylene distearate,
Preferred are polyoxyethylene lauryl ether, polyoxyethylene nonylphenol ether and the like.

The surfactant comprises about 50 to 95% by weight,
Preferably, it is blended in the range of about 60 to 90% by weight to achieve a desired effect. If the amount is less than 50% by weight, the foaming properties are poor, the washing effect cannot be expected, and the dye is difficult to be gradually dissolved, which may lead to a decrease in the fastness of the composition. If the content exceeds 95% by weight, the content of other components, especially the fragrance, will necessarily decrease, and the expression of fragrance will thereby decrease.

The solid drug of the present invention is usually prepared as follows, shaped into an appropriate dosage form, and put to practical use. That is, after mixing the respective components, the mixture is poured into a mold having an arbitrary shape and cooled and solidified to obtain a desired product. In the above mixing, slight heating can be performed. More preferably, first, a predetermined amount of the surfactant is heated and melted, or a predetermined amount of the surfactant is heated and melted, and a fragrance, a dye, and other additives as necessary are mixed with the resulting mixture. Can be advantageously adopted by injecting into a mold and cooling. The dosage form of the product is appropriately determined depending on the use form of the product, but is usually in the form of a solid block formed in a container of an appropriate size, for example, a cylindrical container, and in addition, a rectangular solid, a hemisphere, a square It may have a columnar shape, a polyhedral shape, an irregular shape, or the like, and these are formed by pressing and packaging with a water-soluble film.

[0021] In use of the solid drug packaged in the method of the present invention, by introducing it pool, tub, etc. in the water storage tank of a flush toilet, said agent rapidly reaches the bottom of the reservoir is secured After the fixation, the drug component gradually dissolves, and a predetermined effect corresponding to the type of the component can be obtained. That is, according to the present invention method, by solid drugs are packaged without biting air, that when put into water, or want floating solid drug in water and does not reach the bottom of the easily water tank There is no inconvenience, and the solid medicine reaches the bottom of the water tank promptly and adheres,
It can be used without pinching drain holes on the way.

[0022]

According to the present invention, as described above, the surface of a solid drug is melted, and a water-soluble film is pressed against the surface and packed.
During the packaging process and immediately after the packaging, air is hardly blown into the package, the stability is improved, and extremely effective packaging can be performed.

[0023]

The present invention will be described below in detail with reference to examples and test examples.

[0024]

[Table 1]

Example 1 Polyoxyethylene distearate in the amount shown in Table 1 above was heated to 70 to 80 ° C., and a predetermined amount of lemon flavor, pigment and calcium sulfate was mixed with the mixture to obtain a total amount of 6%.
0 g, top diameter 57 mm, bottom diameter 50 mm, depth 3
The mixture was poured into a 0 mm dish-shaped mold, allowed to cool and solidify, and extracted from the mold at an appropriate time to obtain a solid drug.

The solid medicine obtained was wrapped with a 20 μm-thick PVA water-soluble film and heated with hot air at 170 ° C. for about 13 seconds to melt the surface of the solid medicine, and the film was solidified. It was pressed on the surface of the mold drug and packaged. When the packaged product was put into a water storage tank of a flush toilet, it quickly reached the bottom of the tank and was confirmed to be fixed. Even when the water flowed, the package was fixed to the bottom of the water storage tank.

[0027]

[Table 2]

Examples 2 to 6 Polyoxyethylene distearate and / or monoglyceride stearate and / or polyoxyethylene nonylphenyl ether and / or polyoxyethylene polyoxypropylene blocks mixed in the proportions shown in Table 2 above After the polymer mixture was heated and melted at 70 to 80 ° C., the fragrance and the dye were added at the following compounding ratio, and glauberium or calcium sulfate or sodium thiosulfate was added at the following compounding ratio to a uniform slurry, followed by stirring. I do.

Thereafter, a substantially square prism-shaped mold (48 on each side)
mm and a depth of 28 mm), and after cooling and solidifying, the solid was removed from the mold to obtain a solid aromatic detergent. The obtained solid aroma detergent was wrapped with the water-soluble film shown in Table 2 above, and then dried at 170 ° C.
Was heated for about 13 seconds to melt the surface of the solid medicine, and the film was pressed against the surface of the solid medicine.
When the packaged product was put into a water storage tank of a flush toilet, it immediately reached the bottom of the tank and was confirmed to be fixed. Even when the water was poured, the package was fixed to the bottom of the water storage tank.

[0030]

According to the present invention, as described above, a solid drug can be dissolved in water.
Heating the one wrapped film, to melt the surface portion of the solid drug, the so a water-soluble film and pressed into solid drug surface portion is a method of packaging, in packaging operations, solid drug and water Stable packaging can be performed without blowing air between the conductive films. The solid pharmaceutical packaged in the present invention
When using it, use it in pools, bathtubs, flush toilets
By putting it into a water storage tank, etc., the drug
Quickly arrives and is fixed
Dissolves to obtain a predetermined effect according to the type of the component
Can be. That is, the solid drug is wrapped without blowing air.
When put into water, the solid drug
Floats on the water or reaches the bottom of the water tank
Without the disadvantage of having a solid drug at the bottom of the reservoir.
Swiftly arrives and sticks.
Can be used without distraction.

Continuation of the front page (56) References JP-A-1-287702 (JP, A) JP-A-2-139350 (JP, A) JP-A-62-176269 (JP, U) JP-A-2-84877 (JP) , U) (58) Fields surveyed (Int. Cl. ⁷ , DB name) B65D 35/44-35/54 B65D 39/00-55/16 E03D 9/02

Claims (2)

(57) [Claims] (1) It is a water-filled solid drug that is water-soluble
The film is pressed against the outer surface of a solid drug that melts with heat
Characterized by being packaged so as not to breathe air
Reservoir-type solid drug. 2. A solid medicine loaded into a water tank, wherein the solid medicine is wrapped in a water-soluble film, and the surface of the solid medicine is melted to form the solid medicine. A method for packaging a solid medicine charged into a water tank, the method being pressure-bonded to a surface portion.