JP3066862B2 - Automatic synthesizer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an apparatus for synthesizing a compound, and more particularly, to an automatic synthesizer for synthesizing a plurality of compounds simultaneously.

[0002]

2. Description of the Related Art In research fields such as pharmaceuticals, life sciences, chemistry, and materials, a plurality of compounds are synthesized simultaneously on a trial basis.
In some cases, the properties of the synthesized product, the synthesis conditions, and the like are measured, and a synthesizer that simultaneously synthesizes a plurality of such compounds is known.

[0003] A conventional synthesizer has a plurality of reaction chambers for simultaneous synthesis, and the individual reaction chambers are collectively integrated to form a reaction vessel. This reaction vessel has a function of shutting off the reaction chamber from the external atmosphere and performing filtration.

Further, the temperature of the reaction chamber can be controlled to a desired temperature by pressing a component whose temperature is controlled by a heater or a cooling device.

[0005]

The reaction section of the conventional synthesizer has a structure in which a plurality of reaction chambers are integrally formed in one reaction vessel. If any of the rooms are damaged or contaminated,
There is a problem in that the entire reaction vessel must be replaced for each block, and waste occurs in the reaction vessel.

Further, since the temperature of the reaction vessel is controlled by a reaction temperature control block which is brought into close contact with the reaction vessel via a heat transfer material, a heater and a heat medium passage provided in the reaction temperature control block are provided. There is a problem in that the distance between the reaction vessels becomes long, or the heat conduction efficiency is reduced due to poor contact between the reaction temperature control block and the reaction vessel, and it is difficult to obtain good temperature control characteristics.

Further, since the reaction vessel has a structure in which only a plurality of reaction chambers are integrally formed, the solvent injected together with the reagents into the reaction chamber may be vaporized and evaporated by heating, so that a sufficient reaction is performed. There is also a problem that it is not possible.

Accordingly, the present invention has as its first object to solve the above-mentioned problems of the conventional synthesizing machine and to reduce the uselessness at the time of replacing the reaction vessel, and to improve the control characteristics of the temperature control of the reaction vessel. The second object is to provide a reaction vessel that can be easily washed, and the fourth object is to reduce evaporation of a solvent in the reaction vessel. .

[0009]

The automatic synthesizer of the present invention comprises:
In the reaction section, a problem with the conventional synthesizer is achieved by blocking a plurality of reaction vessels for simultaneously synthesizing a plurality of compounds by a chemical reaction with reaction blocks that individually and detachably accommodate each reaction vessel. Is to solve.

The reaction block of the present invention comprises, for example, temperature,
By controlling reaction conditions such as pressure, shaking, and ambient atmosphere, a plurality of reaction vessels housed in a reaction block can be set to the same reaction conditions to simultaneously synthesize a plurality of compounds.

A first aspect of the present invention is directed to an automatic synthesizer capable of simultaneously synthesizing a plurality of compounds by a chemical reaction, comprising a plurality of reaction vessels and a storage section for individually detachably attaching the reaction vessels. A reaction block is provided, wherein the reaction block controls the reaction conditions of the reaction container housed in the storage section, thereby achieving the first object of reducing waste when replacing the reaction container. It is.

According to the first aspect, the plurality of reaction vessels can be individually attached to and detached from the storage section formed in the reaction block, so that the reaction conditions of the stored reaction vessels are simultaneously controlled by one reaction block. can do. Further, when damage or contamination occurs, only the reaction container can be removed from the reaction block and replaced with a normal reaction container. As a result, unlike the conventional automatic synthesizer, it is not necessary to replace all the reaction vessels together with the reaction blocks, and it is possible to reduce waste when replacing the reaction vessels.

A second invention of the present application is directed to an automatic synthesizer capable of simultaneously synthesizing a plurality of compounds by a chemical reaction, comprising a plurality of reaction vessels, a storage section for individually detachable reaction vessels, and a heat storage section. A reaction block having an exchange means in the heat transfer member, wherein the heat exchange means controls the temperature condition of the reaction vessel stored in the storage section, whereby the temperature control of the reaction vessel is performed. The second object of the present invention is to achieve the second object of improving the control characteristics of the present invention and the third object of providing a reaction vessel that can be easily washed.

According to the second aspect of the present invention, the heat exchange means for controlling the reaction temperature is provided in the reaction block, and the reaction block is formed by the heat transfer member. The distance is shortened, and heat conduction is not performed by contact with a heat transfer material inserted between the reaction vessel and the reaction temperature control block, so that heat conduction efficiency is increased, and control characteristics of temperature control of the reaction vessel are improved. be able to.

According to the second aspect of the present invention, the reaction block is provided with a function of controlling the reaction temperature by the built-in heat exchange means, thereby eliminating the need for the reaction temperature control block. By adopting a structure that can be attached to and detached from the block, it is possible to easily clean a substance attached to the reaction container.

According to a third aspect of the present invention, there is provided an automatic synthesizer capable of simultaneously synthesizing a plurality of compounds by a chemical reaction, comprising: a plurality of reaction vessels; It is provided with a reaction block having exchange means in the heat transfer member, and a reflux block having a plurality of detachable reflux containers corresponding to the reaction containers so that vaporized substances in the reaction container are condensed in the reflux container. This achieves the fourth object of reducing the evaporation of the solvent in the reaction vessel.

According to the third aspect of the invention, by providing a reflux block having a plurality of detachable reflux vessels corresponding to the reaction vessel, components such as a solvent vaporized in the reaction vessel are condensed and liquefied, and are again liquefied. It can be returned to the reaction vessel, and a decrease due to evaporation of the solvent in the reaction vessel can be prevented.

According to a fourth aspect of the present invention, in the first to third aspects, the reaction vessel comprises a reaction chamber, an outlet pipe and an outlet for discharging the compound, a lower side of the reaction chamber and an upper side of the outlet pipe. And a connecting pipe for connecting the reaction chamber and the outlet pipe, and the connecting pipe is arranged to be inclined with respect to a surface formed by the reaction chamber and the outlet pipe. Thus, the first to fourth objects can be achieved, and the diameters of the reaction chamber, the connecting pipe, and the outlet pipe can be expanded.

According to the fourth aspect of the present invention, the connection pipe is disposed at a position deviated from the plane formed by the reaction chamber and the outlet pipe, so that the connection pipe is connected to a space in the reaction vessel that does not interfere with the outlet pipe and the reaction chamber. A tube can be formed, and the diameter of the reaction chamber, the connecting tube, and the outlet tube can be expanded even when the external dimensions of the reaction vessel are limited.

By expanding the diameter of the reaction chamber, it is possible to increase the volume of the product by increasing the volume of the reaction space for producing the compound. It is possible to prevent clogging of a passage portion connecting to the outlet pipe. In addition, by expanding the diameter of the outlet pipe, it is possible to make the liquid discharged from the reaction chamber through the connection pipe drain better.

According to a fifth aspect of the present invention, in the first to fourth aspects, a plurality of recesses are provided in a block for accommodating the reaction vessel, and an opening for inserting the reaction vessel is provided in a part of the bottom surface of the recess. , The recesses are connected by a gas supply groove formed on the upper surface of the block.
In addition to achieving the objects of (1) to (4), it is possible to prevent products overflowing from the reaction vessel from scattering and contaminating other reaction vessels.

An inert gas such as nitrogen or argon is supplied into each reaction vessel through the gas supply groove, and the product is filtered through a filter installed in the reaction vessel by gas pressure, and the liquid in the reaction vessel is supplied. Derivation of components.

According to the fifth invention, the reaction vessel is inserted into the opening formed in the recess formed in the block, and each recess is connected by the gas supply groove. Accumulation in the concave portion prevents outflow to another reaction vessel. Further, even when the product flows out to another reaction vessel, the flow rate of the product is reduced by the concave portion of the reaction container and sinks on the surface of the concave portion, so that it is possible to prevent the product from scattering to the downstream reaction container.

According to the embodiment of the present invention, the heat exchange means can be a heat medium flow path and a heater, the reaction block is provided with a heat medium flow path and a heater, and the reflux block is provided with a heat medium flow path and a heater. Roads can be provided. According to an embodiment of the present invention, the reaction vessel includes a filter, further comprising:
The outlet pipe communicating with the outside through the filter is provided with a maintenance screw.

[0025]

Embodiments of the present invention will be described below in detail with reference to the drawings. FIG. 1 is a cross-sectional view schematically illustrating a reaction vessel and a reflux vessel of the present invention,
FIGS. 2, 3, and 4 are partially cutaway perspective views for explaining the outline of the reaction section of the automatic synthesizer of the present invention, and FIG. 2 shows a state where a reaction block and a reflux block are combined. Shows a reflux block, and FIG. 4 shows a reaction block. FIGS. 5 and 6 are cross-sectional views of the reaction section of the automatic synthesizer shown in FIG. 2, and show cross sections viewed from directions A and B shown in FIG. FIG. 7 is a plan view showing the upper surface of the reflux block and the arrangement of the heat exchange means in the reaction block or the reflux block.

The automatic synthesizer of the present invention includes a plurality of reaction vessels 3 and a plurality of reflux vessels 2 as shown in FIG. The compound is synthesized by injecting the substance, reacting and filtering under conditions such as temperature, pressure, shaking, and ambient atmosphere. The reaction vessel 3 includes a reaction chamber 31 for injecting a substance necessary for the synthesis and synthesizing the compound, an outlet pipe 32 and an outlet 33 for taking out the filtered substance filtered by the filter 35 to the outside,
A maintenance push screw 34 for removing the clogging of a thin tube such as the outlet tube 32 is provided. The reflux vessel 2 is a vessel for condensing and liquefying a substance vaporized in the reaction vessel 3, and is mounted above the reaction vessel 3 and used for injecting the substance into the reaction vessel 3. An opening 21 and a packing 22 such as an O-ring for maintaining airtightness are provided. The reaction vessel 3 and the reflux vessel 2 can be formed of a synthetic resin such as Teflon or polypropylene. When Teflon is used, it has good resistance to a chemical reaction, and when polypropylene is used, it can be formed at a low cost and can be easily disposable.

In FIGS. 2, 5 and 6, the automatic synthesizer reaction section 1 includes a reflux block 4 and a reaction block 5. The reflux block 4 includes, as shown in FIGS. 2 and 3, a reflux block main body 41 formed of aluminum or the like and also serving as a heat transfer member.
It has a heat medium flow channel holder 42 that is attached to the lower surface of the reflux block main body 41 and holds the heat medium flow channel 48.
The heat medium flow channel retainer 42 can also serve as a heat insulating material, and can be formed of Teflon.

A plurality of storage portions 43 for storing a plurality of reflux containers 2 are formed in the reflux block main body 41. On the upper surface, a substance necessary for synthesizing a reagent, a solvent or the like necessary for synthesis into the reaction container 3 is provided. An opening is formed.
Is formed with a flange portion of the reflux container 2 and a concave portion for accommodating the packing 22. In addition, as shown in FIG. 7B, a heat medium flow path 48 is provided in the storage block 4 in the reflux block main body 41.
3 so that they do not intersect. By flowing the heat medium through the heat medium flow path 48, the temperature of the reflux container 2 housed in the housing part 43 is controlled using the reflux block main body 41 as a heat transfer member. For example, if the temperature of the heat medium is 0 ° C., the heat medium flow path 4
The reflux vessel 2 is also cooled to a temperature close to the heat medium via the reflux block main body 41 that is in contact with 8.

The reflux container 2 with respect to the reflux block main body 41
Is carried out through an opening formed in the heat medium flow channel holder 42, the flange portion of the reflux container 2 is sandwiched between the reflux block main body 41 and the heat medium flow channel holder 42, and fixed by a fixture (not shown). The container 2 can be fixed at a predetermined position.

An upper lid 7 made of aluminum or the like is attached to the upper surface of the reflux block 4 with a sealing material 6 made of Teflon, fluoro rubber or the like interposed therebetween. Grooves 45 are formed in the upper surface of the reflux block 4 in order to increase the adhesion between the upper surface of the reflux block 4 and the sealing material 6 to block the outside air.
Formed in the groove 45, and a convex portion 61 formed in the sealing material 6 in the groove 45.
Can be pressed.

A gas groove 44 is formed adjacent to the storage section 43 on the upper surface of the reflux block 4, and an inert gas such as nitrogen or argon is supplied into the reaction vessel 3 through the gas groove 44. Filtered through a filter by pressure,
The liquid component in the reaction vessel 3 can be discharged. Note that, instead of the gas groove 44, a cylindrical needle may be inserted into the sealing material 6 to supply an inert gas. According to this configuration, the contents of the reaction vessel can be individually filtered.

The upper lid 7 is formed with an opening 71 communicating with the reflux vessel 2 and the reaction vessel 3.
A substance necessary for the synthesis of a reagent, a solvent, or the like can be injected into the inside, or an inert gas can be supplied.

The reaction block 5 is, as shown in FIGS. 2 and 4, a reaction block main body 51 made of aluminum or the like and also serving as a heat transfer member. It has a heat medium flow channel holder 54 for holding 58, and a heater holder 52 attached to the lower surface of the reaction block main body 51 and holding a heater 59. Both retainers 52 and 54 can also serve as a heat insulating material, and can be formed of Teflon.

A plurality of storage sections 53 for storing a plurality of reaction vessels 3 are formed in the reaction block main body 51, and an opening for inserting the reaction vessel 3 into the heat medium channel holder 54 and projecting an upper end portion thereof. An opening 55 is formed in the heater retainer 52 to allow the outlet 33 of the reaction vessel 3 to pass outside. Reaction vessel 3 for reaction block body 51
The reaction vessel 3 can be positioned by bringing the bottom of the reaction vessel 3 into contact with the heater retainer 52 through the opening formed in the heat medium flow path retainer 54.

In the reaction block main body 51, a heating medium passage 58 and a heater 59 are arranged. FIG. 7B is a diagram showing the arrangement of the heat medium flow path 58 and the heater 59 in the reaction block main body 51. The heat medium flow path 58 and the heater 59 are arranged so as not to intersect with the storage section 53. By flowing a heat medium into the heat medium flow path 58, the reaction container 3 housed in the housing 53 with the reaction block body 51 as a heat transfer member is cooled or heated. Also, by driving the heater 59,
The reaction vessel 3 housed in the housing 53 with the reaction block body 51 as a heat transfer member is heated.

For example, if the temperature of the heat medium is 60 ° C., the reaction vessel 3 is also heated to a temperature close to the heat medium via the reaction block main body 51 in contact with the heat medium flow path 58. The temperature can be further increased by the heater 59, the temperature can be controlled by a temperature sensor and a controller (not shown), and the temperature can be maintained at a constant value.

The reaction section of the automatic synthesizer according to the present invention may be provided with only a reaction block in which a reaction container is detachable, and the reflux block may be omitted. FIG. 8 is a view for explaining another configuration of the reaction section of the automatic synthesizer of the present invention. In FIG. 8, the reaction section of the automatic synthesizer includes a reaction block 5 having a heater holder 52 and a heat medium passage holder 54 at the upper and lower ends of a reaction block main body 51. A storage section 53 ′ is formed in the heat medium flow channel holder 54, and stores the reaction container 3 in communication with the storage section 53 formed in the reaction block main body 51. Although not shown in FIG. 8, an upper lid 7 is attached above the heat medium flow channel retainer 54 with the sealing material 6 interposed therebetween as in FIGS. 2 and 3.

Another configuration of the reaction vessel of the automatic synthesizer of the present invention will be described with reference to FIGS. 9 (a) is a plan view of the reaction vessel viewed from above, and FIG. 9 (b) is a sectional view of the reaction vessel in a radial direction (AA in FIG. 9 (a)). FIG. 9C is a cross-sectional view taken along line BB in FIG. 9A. FIG. 10 is a perspective view showing the internal space of the reaction vessel.

The reaction vessel 3 shown in FIGS. 9 and 10 has a reaction chamber 31 for injecting a substance necessary for synthesis and synthesizing a compound, and a filter (not shown), as in the configuration shown in FIG. An outlet pipe 32 and an outlet 33 for taking out the filtered substance of the filtered product to the outside, a connecting pipe 36 connecting the lower side of the reaction chamber 31 and the upper side of the outlet pipe 36, and a connecting pipe 36 of the connecting pipe 36. A maintenance push screw 34 for removing the clogging of the thin tube is provided, and the connecting tube 36 is arranged to be inclined with respect to the surface formed by the reaction chamber 31 and the outlet tube 32.

The connecting pipe 36 is inclined with respect to the plane formed by the reaction chamber 31 and the outlet pipe 32.
2 are arranged on the diameter line of the reaction vessel 3 (A-A in FIG. 9A), and a space portion 37 is formed at the lower end of the reaction chamber 31 so as to project laterally from the bottom surface of the reaction chamber 31. The upper end of the connecting pipe 36 is connected to the upper end of the lead-out pipe 32 at a position shifted from the diameter line (A-A in FIG. 9A), and the lower end of the connecting pipe 36 is connected to the space 37 protruding in the lateral direction. Can be configured. The space 37 is shown in FIGS.
The connection pipe 36 is not limited to the shape shown in FIG.

In FIGS. 9 and 10, the upper end of the connecting pipe 36 and the upper end of the outlet pipe 32 are connected by a recess in which the maintenance push screw 34 is stored.

As shown in FIGS. 9 (b), 9 (c) and 10, the connecting pipe 36 is disposed in the space inside the reaction vessel 3 in the space defined by the reaction chamber 31 and the outlet pipe 32. Is done. With this arrangement, the diameter of each chamber and tube can be expanded as compared with the case where the reaction chamber 31, the connection pipe 36, and the outlet pipe 32 are arranged on the diameter line of the reaction vessel 3.

Next, another configuration of the groove for supplying gas to the reaction vessel of the automatic synthesizer of the present invention will be described with reference to FIG.
As described above, the gas supply groove 44 supplies an inert gas such as nitrogen or argon into each of the reaction vessels 3 and filters a product through a filter provided in the reaction vessel 3 by gas pressure. The liquid component of the product in the container 3 is derived.

FIG. 11 shows a case where a gas supply groove 44 is formed on the upper surface of the reaction block main body 5. The heating medium channel holder 54 of the reaction block main body 5 has a housing 5
A reaction vessel 3 is formed in communication with a storage section 53 formed in the reaction block main body 51. Although not shown, an upper lid 7 is attached above the heat medium flow channel retainer 54 with the sealing material 6 interposed therebetween.

On the upper surface of the heat medium flow channel holder 54, a concave portion 46 is formed at a portion where the storage portion 53 'is formed.
An opening is formed in a part of the bottom surface of the concave portion 46, and the opening is used as the upper end of the storage portion 53 '. A plurality of concave portions 46 are provided on the upper surface of the heat medium flow channel retainer 54 in correspondence with the storage portions 53 '. Each of the concave portions 46 is connected by a gas supply groove 44 formed on the upper surface of the heat medium flow channel retainer 54.

The area of the bottom surface of the concave portion 46 is
It is formed sufficiently wider than the area of the upper end face of the reaction chamber 3 housed in 3 ′. When the product in the reaction chamber 3 overflows, the overflowed product accumulates on the bottom surface of the concave portion 46 to prevent the product from flowing into another reaction chamber 3 through the gas supply groove 44. Further, even when the product flows into the other concave portion 46 through the gas supply groove 44, the flow velocity is significantly reduced when flowing into the concave portion 46 from the gas supply groove 44, and further, the flow into the other concave portion is reduced. Prevents inflow.

The concave portion and the gas supply groove can be formed not only in the reaction block main body but also in a block for accommodating a reaction vessel such as a reflux block main body.

Next, the synthesis procedure by the automatic synthesizer of the present invention will be described. A reaction block 51 containing the reaction vessel 3 in the storage section 53 and a reflux block 41 containing the reflux vessel 3 in the storage section 43 are prepared. The sealing member 6 and the upper lid 7 are further attached to the upper surface of the reflux block 41, and are fixed with a fixture to assemble the reaction section 1 of the automatic synthesizer.

In this assembly, reagents and solvents used for the reaction are injected into the reaction vessel 3. After assembling the reaction section 1 of the automatic synthesizer, a needle may be inserted into the sealing material 6 through the opening 71 formed in the upper lid 7 to inject the reagent or solvent used for the reaction into the reaction vessel 3.

By flowing a heat medium through the heat medium flow path 58 of the reaction block 3 or driving the heater 59, the reagent or solvent in the reaction vessel 3 is cooled or heated to control the temperature of the reaction conditions. In addition, an inert gas may be supplied from the gas groove 44 to perform pressure control, or the entire reaction block 3 may be shaken.

When the reaction is carried out by heating, if the boiling point of the solvent is lower than the boiling point of the reagent, the solvent component is vaporized before the reagent. The vaporized solvent component reaches the reflux vessel 2 installed above the reaction vessel 3. At this time, the refrigerant flows through the heat medium flow path 48 in the reflux block 4 to
Is cooled, the vaporized solvent component is cooled and condensed,
It is returned to the reaction vessel 3 as a liquid. by this,
The solvent can be prevented from evaporating and disappearing.

After the reaction, when filtering the synthesized substance, an inert gas is introduced from a gas source (not shown), and is passed through the gas groove 44 into the reaction vessel 3. The inside of the reaction vessel 3 is pressurized while being kept in an inert atmosphere, and the liquid components in the plurality of reaction vessels 3 can be simultaneously taken out through the filters 35. The compound can be taken out as a filtrate or a filtration residue.

In the case where the narrow tube of the outlet tube 32 of the reaction vessel 3 is clogged, the clogging of the hole can be eliminated by removing the maintenance push screw 34 and cleaning the inside of the outlet tube 32 with a thin rod.

When the reaction vessel 3 and the reflux vessel 2 are to be washed, the fixture (not shown) is released and the reflux block 4 is removed.
And the reaction block 5, the reflux container 2 is removed from the reflux block 4, the reaction container 3 is removed from the reaction block 5, and the reflux container 2 and the reaction container 3 can be washed. Further, the reflux block 4 and the reaction block 5 can be washed. After the washing, the reaction vessel of the automatic synthesizer can be assembled by inserting the reflux vessel 2 again into the reflux block 4 and inserting the reaction vessel 3 into the reaction block 5.

By the same procedure as in the above-described washing, only the damaged or contaminated reflux vessel or reaction vessel can be replaced with a normal vessel. In addition, each reaction container provided in the automatic synthesizer may have the same capacity or different capacities. In addition, a combination of reaction vessels sharing a gas groove can be arbitrarily performed.

According to the embodiment of the present invention, by disposing the connecting pipe at a position deviated from the plane formed by the reaction chamber and the outlet pipe, a space that does not interfere with the outlet pipe and the reaction chamber in the reaction vessel is provided. A connection tube can be formed in the reaction space, and the volume of the reaction space for producing the compound is increased to increase the amount of product generated, and the passage portion of the connection tube connecting the reaction chamber and the outlet tube is clogged. Can be prevented, and the product can be desirably drained in the outlet pipe.

According to the embodiment of the present invention, the product overflowing from the reaction vessel is stored in the recess by the recess formed on the block surface and the gas supply groove connecting the recess, and is transferred to another reaction vessel. Outflow can be prevented.

According to the embodiment of the present invention, only the damaged or contaminated vessel can be replaced, so that it is not necessary to replace the entire reflux block or reaction block, and the replacement cost can be reduced. According to the embodiment of the present invention, since no heat transfer block is required, space saving and weight reduction can be achieved, and shaking of the block becomes easy. According to the embodiment of the present invention, the blocking makes it easy to attach and detach heat exchange means such as a heat medium passage and a heater.

[0059]

As described above, according to the automatic synthesizer of the present invention, a reaction in which a plurality of reaction vessels for simultaneously synthesizing a plurality of compounds by a chemical reaction are detachably accommodated in each reaction vessel. Blocking by the block can solve the problems of the synthesizer, and the reaction conditions of the reaction container stored in the storage unit by the reaction block having the storage unit that allows a plurality of reaction containers to be individually attached and detached. By performing the above control, it is possible to reduce waste when exchanging the reaction vessel, and to provide a reaction block having a storage section and a heat exchange means in the heat transfer member, in which a plurality of reaction vessels can be individually attached and detached. By controlling the temperature condition of the reaction container stored in the storage unit by the heat exchange means, the control characteristics of the temperature control of the reaction container can be improved, and the cleaning can be easily performed. Also, a reaction block having a storage section and a heat exchange means in the heat transfer member, in which a plurality of reaction vessels can be individually attached and detached, and a reflux block having a plurality of detachable reflux vessels corresponding to the reaction vessels. And the vaporized substance in the reaction vessel is condensed in the reflux vessel, whereby the evaporation of the solvent in the reaction vessel can be reduced.

[Brief description of the drawings]

FIG. 1 is a sectional view schematically illustrating a reaction vessel and a reflux vessel of the present invention.

FIG. 2 is a partially cutaway perspective view schematically illustrating a reaction section of the automatic synthesizer of the present invention.

FIG. 3 is a perspective view, partially cut away, of a reflux block for explaining an outline of a reaction section of the automatic synthesizer of the present invention.

FIG. 4 is a perspective view of a reaction block of the automatic synthesizer of the present invention, for explaining the outline of the reaction section, with a part of a reaction block cut away.

FIG. 5 is a sectional view of a reaction section of the automatic synthesizer of the present invention.

FIG. 6 is a sectional view of a reaction section of the automatic synthesizer of the present invention.

FIG. 7 is a plan view showing an upper surface of a reflux block of a reaction section of the automatic synthesizer of the present invention and an arrangement of a heat exchange means in the reaction block or the reflux block.

FIG. 8 is a diagram for explaining another configuration of the reaction section of the automatic synthesizer of the present invention.

FIG. 9 is a plan view and a cross-sectional view for explaining another configuration of the reaction vessel of the automatic synthesizer of the present invention.

FIG. 10 is a perspective view for explaining a space portion of another configuration of the reaction vessel of the automatic synthesizer of the present invention.

FIG. 11 is a perspective view for explaining gas grooves and concave portions of the automatic synthesizer of the present invention.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Reaction part of an automatic synthesizer, 2 ... Reflux container, 3 ... Reaction container,
4 ... reflux block, 5 reaction block ..., 6 ... sealing material,
7 top lid, 21, 55 opening, 22 packing, 3
DESCRIPTION OF SYMBOLS 1 ... Reaction chamber, 32 ... Outgoing pipe, 33 ... Outgoing part, 34 ... Maintenance screw, 35 ... Filter, 36 ... Connecting pipe, 37 ...
Space portion, 41: reflux block main body, 42, 54: heat medium flow channel holding member, 43, 53: storage portion, 44: gas groove, 4
5 ... groove, 46 ... concave part, 48, 58 ... heat medium flow path, 52 ... heater press, 59 ... heater, 61 ... convex part.

──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Kenichi Kitamura 380-1 Matsuba, Horiyamashita, Hadano-shi, Kanagawa Inside the Hadano Plant, Shimadzu Corporation (56) References Special Table 8-82-482482 (JP, A) (58) ) Surveyed field (Int. Cl. ⁷ , DB name) B01J 19/00

Claims (4)

(57) [Claims] 1. An automatic synthesizer capable of simultaneously synthesizing a plurality of compounds by a chemical reaction, comprising: a plurality of reaction vessels; a storage section for individually detachably attaching the reaction vessels; and a heat exchange means. An automatic synthesizing apparatus, comprising: a reaction block provided therein; and the heat exchange unit controls temperature conditions of the reaction container housed in the housing. 2. An automatic synthesizer capable of simultaneously synthesizing a plurality of compounds by a chemical reaction, comprising: a plurality of reaction vessels; a storage section capable of individually attaching and detaching the reaction vessels; and a heat exchange means. A reaction block provided therein, and a reflux block having a plurality of detachable reflux containers corresponding to the reaction containers, wherein a vaporized substance in the reaction container is condensed in the reflux container and returned to the reaction container. A special feature of the automatic synthesizer. 3. The reaction vessel includes a reaction chamber, a discharge pipe for discharging a compound, and a connection pipe connecting a lower side of the reaction chamber and an upper side of the discharge section, wherein the reaction chamber and the discharge pipe are connected to each other. Arranged in parallel, the connecting pipe is arranged inclined with respect to the plane formed by the reaction chamber and the outlet pipe,
The automatic synthesizer according to claim 1. 4. A block for accommodating the reaction vessel includes a plurality of recesses, a bottom surface of the recess partially having an opening for inserting the reaction vessel, and the recess is a gas supply groove formed on the top surface of the block. The automatic synthesizer according to claim 1, wherein the automatic synthesizer is connected by: