JP3066611B2 - Sterile retaining mixing device of the two agents were housed in separate sealed container - Google Patents

Sterile retaining mixing device of the two agents were housed in separate sealed container

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Publication number
JP3066611B2
JP3066611B2 JP3128729A JP12872991A JP3066611B2 JP 3066611 B2 JP3066611 B2 JP 3066611B2 JP 3128729 A JP3128729 A JP 3128729A JP 12872991 A JP12872991 A JP 12872991A JP 3066611 B2 JP3066611 B2 JP 3066611B2
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container
plug
partition
box
sealed
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JPH04329954A (en
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則夫 白井
修司 盛本
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武田薬品工業株式会社
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Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【産業上の利用分野】本発明は、それぞれ個別に密封収容された2種の薬剤を無菌状態下で混合する装置に関する。 The present invention relates to an apparatus for mixing two agents sealed individually housed respectively under sterile conditions.

【0002】 [0002]

【発明の背景】病院等の医療機関で点滴注射などにより患者に薬剤を投与する場合、バイアルに密封収容した抗生物質等の薬剤を生理食塩水やブドウ糖液等の薬剤で溶解して投薬される。 BACKGROUND OF THE INVENTION If due drip injection in medical institutions such as hospitals to administer drugs to a patient, is dosed to dissolve the drug antibiotic or the like sealed housed in a vial with an agent such as physiological saline or glucose solution . このとき、これらの薬剤は混合溶解されると不安定になり易く、比較的短時間に薬剤の効力を失うので、薬剤の混合操作は投薬直前に行われる。 At this time, tends to become unstable when these agents are mixed and dissolved, so a relatively short time lose potency of the drug, mixing operation of the agent takes place immediately before dosing.

【0003】従来、この混合操作は、それぞれ別々に供給される薬剤と注射器により、次の手順で行われる。 Conventionally, this mixing operation, the drug syringe which is supplied separately, takes place in the following steps.
両薬剤の各包装及び注射器の包装をそれぞれ解いて準備する。 Both agents each packaging and syringe packaging of preparing solving respectively. アンプルを破封するなど液剤容器を開封して、注射器で液剤容器内の溶解用薬剤を吸入する。 And opening the liquid container such as Yabufu ampoules, inhale the pharmaceutical dissolved in the liquid container with a syringe.
バイアルのゴム栓に注射針を突き通し、溶解用薬剤を注入する。 Piercing an injection needle into the rubber stopper of the vial, injecting a dissolving agent. バイアルを震蕩させてバイアル内で抗生物質を溶解させる。 By Shin蕩 the vial to dissolve the antibiotic in the vial. 溶解した両薬剤を注射器に吸入して患者への投薬に準備される。 Both agents dissolved sucked to the syringe is prepared medication to the patient.

【0004】しかし、上記の混合操作には、次の問題点があった。 [0004] However, in the above-mentioned mixing operation, it has the following problems. イ. B. 包装を解いた注射器は直接外気に触れるので雑菌に汚染され易く、しかも、この注射器の針を容器内に突入させて薬剤を移送混合するため、混合した薬剤に雑菌が混入する虞れがある。 Syringe unpacked is liable to be contaminated with bacteria because directly exposed to the outside air, moreover, the needle of the syringe is plunged into the container for transferring mixed medication, there is a possibility that bacteria in mixed agent is mixed. ロ. B. 別々に供給される両薬剤と注射器とを、それぞれ包装を解いて準備しなければならず、また、注射器の針を突き通すゴム栓表面を滅菌消毒する必要が有るうえ、液状薬剤を一旦注射器に吸入して移すことから、混合操作が極めて煩雑である。 Inhalation and both agents and the syringe supplied separately, must be prepared by solving the respective packaging, also after the rubber stopper surface piercing the syringe needle to be sterilized is present, once syringe liquid medicament from the fact that the transfer, the mixing operation is very complicated. ハ. Ha. 別々の容器に収容されている薬剤を投与直前に混合するので、煩雑な操作を短時間で行わなければならず、 Since the medicament contained in separate containers and mixed immediately prior to administration, it must be performed in a short time a complicated operation,
混合薬剤の組み合わせを誤る可能性がある。 There is a possibility of mistaking a combination of mixing drugs. ニ. Two. 液状の薬剤はしばしばアンプル容器に封入されており、この場合にはアンプルを破封する際に生じるガラス屑が薬剤に混入し易いうえ、薬剤が直接外気に触れるので雑菌に汚染される虞れが多い。 Drug in liquid form is often enclosed in ampules container, after easily glass waste that occurs when Yabufu the ampoule is mixed into the agent in this case, possibility is drug to be contaminated with bacteria because directly exposed to the outside air many.

【0005】 [0005]

【従来技術】そこで、上記の問題を解消し、簡単な操作で2種の薬剤を混合できるものとして、特開昭62−2 BACKGROUND OF THE INVENTION Therefore, as to solve the above problems, can mix the two agents with a simple operation, JP 62-2
81947号公報に示される混合装置が提案されている。 Mixing apparatus shown in 81947 JP has been proposed.

【0006】この混合装置は、図6に示すように、1つの薬剤容器に、第1薬剤を密封収容した下方の第1容器室(1)と、第2薬剤を密封収容した上方の第2容器室 [0006] The mixing device as illustrated in FIG. 6, in one medicament container, the first container chamber of the lower a sealed housing a first agent and (1), the upper a sealed housing the second agent second container chamber
(2)とを、中央の栓箱(3)で連通連結して形成してある。 (2) and, it is formed by communicatively connected in the middle of the plug box (3). そして、この栓箱(3)内に中仕切り栓(4)を摺動可能に内嵌し、第1容器室(1)内と第2容器室(2)内との連通を封止してある。 Then, the plug box and (3) a partition plug (4) was in the slidably and fitted to seal the communication between the first container chamber (1) in the second container chamber (2) in is there. 第2容器室(2)の上部には押圧機構(31)が外気遮断状に設けてあり、図6の右半図に示すように、この押圧機構(31)を第2容器室(2)内面に気密摺動させて、押圧部(32)下端に取付けた中仕切り栓(4) The upper portion of the second container chamber (2) pressing mechanism (31) is provided with the outside air cutoff shape, as shown in the right half of FIG. 6, the pressing mechanism (31) second container chamber (2) by hermetically sliding on the inner surface, the pressing portion (32) a partition plug in attached to the lower end (4)
を第1容器室(1)側へ押し込み、上記の封止を解除して2種の薬剤を混合するように構成してある。 Pushing the first container chamber (1) side, it is arranged to mix the two agents to release the sealing of the.

【0007】 [0007]

【発明が解決しようとする課題】しかしながら、上記の混合装置では、第1容器室(1)と第2容器室(2)とが連結部で一体となった1つの薬剤容器に形成されており、 [SUMMARY OF THE INVENTION However, in the mixing device described above has the first container chamber (1) and the second container chamber (2) and is formed on one drug containers together by a connecting portion ,
両容器室(1・2)内同士を連通させるには内部に配設した中仕切り栓(4)を容器外部から遠隔操作して摺動させなければならず、このため第2容器室(2)の上方に複雑な押圧機構(31)を設ける必要がある。 It must slide by remotely operating the partition plug (4) from the outside of the container in which is disposed inside the communicating with each other in both container chamber (1, 2), Thus the second container chamber (2 it is necessary to provide a complicated pressing mechanism (31) above the).

【0008】しかも、この押圧機構(31)は、両薬剤を無菌状態下に保持する必要から、第2容器室(2)に対して気密摺動しなければならず、この結果、中仕切り栓(4) [0008] Moreover, the pressing mechanism (31), the need to hold both agents under sterile conditions, must be hermetically slidable relative to the second container chamber (2), as a result, the middle partition stopper (4)
が栓箱(3)内の摺動面(5)を摺動する抵抗と合わさって摺動抵抗が大きくなり、両容器室(1・2)を連通させるために強い操作力を必要とする問題があった。 Problem but the sliding resistance increases combine the resistance to sliding the sliding surface (5) in the plug box (3), which requires a strong operating force both containers chamber (1, 2) in order to communicate was there.

【0009】また、一般に抗生物質などの粉末薬剤は溶解用の液状薬剤とは薬剤供給者が異なるので、この場合には、無菌状態を維持しながら1つの薬剤容器内に2種の薬剤を中仕切り栓で仕切ってそれぞれ密封し、さらに押圧機構の組付けることは極めて困難である。 Further, since generally powdered medicament such as an antibiotic drug supplier is different from the liquid drug for dissolving, in this case, the middle of two drugs in a single pharmaceutical vessel while maintaining sterility sealed each partitioned by a partition plug, it is very difficult to assemble more of the pressing mechanism.

【0010】本発明はこのような点に着目してなされたもので、容器連結部に設けた中仕切り栓を簡単な操作で摺動させることができ、両容器内同士を容易に連通できるうえ、装置全体をコンパクトで簡単な構造にした、個別密封容器に収容した2種薬剤の無菌保持混合装置を提供することを目的とする。 [0010] The present invention has been made in view of such point, it is possible to slide the partition stopper by a simple operation in which is provided on the container coupling part, after which the two container together can be easily communicated and a simple structure the entire apparatus compact, and to provide a sterile holding mixing device of the two agents were housed in separate sealed container.

【0011】 [0011]

【課題を解決するための手段】 本発明は上記の目的を達 Means for Solving the Problems The present invention is our purpose of the
成するために、例えば、本発明の実施例を示す図1から To formed, for example, from FIG. 1 illustrating an embodiment of the present invention
図5に基づいて説明すると、個別密封容器に収容した2 To explain with reference to FIG. 5, 2 accommodated in separate sealed container
種薬剤の無菌保持混合装置を次のように構成したもので Which was constructed sterile holding mixing device type drugs as follows
ある。 is there. 即ち本発明は、第1薬剤を密封収容した第1容器 That is, the present invention is first sealed containers containing a first agent
(1)と第2薬剤を密封収容した第2容器(2)とを栓箱 (1) and the second container (2) and the plug box sealed housing the second agent
(3)を介して外気遮断状に連通連結し、この栓箱(3)内 (3) communicatively connected to the outside air cutoff shape through, this plug box (3) in
で、上記第1容器(1)を第1容器側栓体(4a)で密封する In, to seal the first container (1) in the first container side stopper (4a)
とともに上記第2容器(2)を第2容器側栓体(4b)で密封 Together with sealing said second container (2) in the second container side stopper (4b)
して、上記第1容器(1)と第2容器(2)との連通を遮断 To, cut off the communication between the first container (1) and the second container (2)
するように構成し、上記第1容器側栓体(4a)と第2容器 Configured to, the first container side stopper and (4a) second container
側栓体(4b)とを連結手段(16)で互いに連結固定して中仕 Baggagemaster linked fixed to each other by Gawasentai (4b) connecting means (16)
切り栓(4)を形成し、この中仕切り栓(4)を、上記栓箱 Forming a cut plug (4), the partition stopper therein (4), the plug box
(3)内で気密状に回転摺動させることにより閉栓位置 (3) plugging position by rotating slide in an airtight manner in the
(A)と開栓位置(B)とに切換可能に構成し、この中仕切り栓(4)から栓回動レバー(6)を栓箱(3)外部へ突設す (A) and configured to earnestly 換可 ability and unplugging position (B), to butt set the plug turning lever from the partition plug among the (4) (6) plug box (3) to the outside
るとともに、この中仕切栓(4)に連通路(7)を設け、 Rutotomoni, the communicating passage (7) in the intermediate partition Ri plug (4) is provided,
この中仕切り栓(4)を栓回動レバー(6)により上記閉栓位置(A)に切換え操作した状態では、上記連通路(7)の路端開口部(8)を栓箱との摺動面(5)に臨ませて前記第1容器(1)と第2容器(2)との連通を遮断し、この中仕切り栓(3)を栓回動レバー(6)により上記開栓位置(B) Sliding of the inside partition plug (4) in the state where the switching operation to the plugging position (A) with a plug turning lever (6), the road-edge opening of the communication passage (7) and (8) and plug box to face the surface (5) to block the communication between the first container (1) and the second container (2), the cap removal position by the inside partition plug (3) plugs turning lever (6) ( B)
に切換え操作した状態では、上記連通路(7)の摺動面 In the state where the switching operation, the sliding surface of the communicating passage (7)
(5)による遮断を解除して、前記第1容器(1)と第2容器(2)とがこの連通路(7)を介して連通するように構成したことを特徴とする。 (5) to release the blocking by the first container (1) second container (2) and is characterized by being configured to communicate via a communication passage (7).

【0012】 [0012]

【作用】 中仕切り栓を形成する第1容器側栓体と第2容 The first container-side stopper to form a middle partition stopper [action] and second volumes
器側栓体はそれぞれ第1容器と第2容器とを密封してお Vessel side plug are contact sealed the first container and the second container, respectively
り、連結手段で互いに連結固定しただけであるので、栓 Ri, Since the connection means are only coupled fixed to each other, the plug
箱を介して連結された第1容器と第2容器とは、以下の The first container and the second container is connected through the box, the following
連通操作をする前はそれぞれが各栓体により密封されて Each Prior to the communication operation is sealed by the stopper
いる。 There. そして連通操作は、簡単な構造の栓回動レバー The communication operation, a plug rotating lever having a simple structure
中仕切り栓を直接回転摺動させて閉栓位置と開栓位置とに切換え操作することにより行われる。 The middle partition stopper is directly rotated and slid performed by switching operation in the stoppered position and unplugging position. このとき、栓回動レバーは中仕切り栓から栓箱外部に突設してあるので、梃子の倍力作用により、長い栓回動レバーの先端に加える操作力で中仕切り栓に強い回動力が生ずる。 At this time, since the stopper pivoting lever are projected from the intermediate partition stopper into the plug box outside, the lever boosting action, a strong rotational force to the intermediate partition stopper in operation force applied to the tip of the long stopper rotating lever arise. そして、 上記栓回動レバーの操作で中仕切り栓が気密摺動し The middle partition stopper hermetically slide operation of the stopper rotating lever
閉栓位置から開栓位置に切換わることにより、この中仕切り栓内に設けた連通路を介して第1容器内と第2容器内とが連通する。 Be switched in stoppered position or RaHiraku stopper position Te by this in the first container via a communication passage provided in the partition stopper and the second container are communicated with each other.

【0013】 [0013]

【実施例】以下、本発明の実施例を図面に基づき説明する。 BRIEF DESCRIPTION OF THE PREFERRED EMBODIMENT Examples of the present invention with reference to the drawings. 図1から図5は本発明の実施例を示し、図1は混合装置の縦断面図、図2は中仕切り栓の斜視図、図3は図1のIII−III線断面図、図4は中仕切り栓を開栓位置に切換えた状態の縦断面図、図5は点滴セット取付け状態の正面図である。 Shows an embodiment of FIG. 5 is the invention from FIG. 1, longitudinal sectional view of FIG. 1 is a mixing device, Figure 2 is a perspective view of the middle partition plug, Figure 3 is sectional view taken along line III-III of Figure 1, Figure 4 longitudinal sectional view of a state in which switching medium partition stoppered unplugging position, FIG 5 is a front view of the infusion set attached state.

【0014】この無菌保持混合装置は、図1に示すように、第1容器(1)内に生理食塩水などの溶解液が密封収容してあり、この第1容器(1)の上部に設けた容器口部 [0014] The sterile retaining mixing device, as shown in FIG. 1, solution, such as saline into the first vessel (1) is Yes sealed housing, provided on top of the first container (1) the opening of the container
(11)に栓箱(3)の下部が気密固定してある。 Bottom of Senbako (3) to (11) are hermetically fixed. この栓箱 The plug box
(3)は抗生物質などの第2薬剤を収容した第2容器(2) (3) a second container containing a second agent such as an antibiotic (2)
の下部から下方に一体状に延設してあり、従って、第1 Yes from the bottom of and integrally extending form a lower, therefore, the first
容器(1)内と第2容器(2)内とは栓箱(3)を介して連通連結されている。 The container (1) in the second container (2) in which is communicatively connected via a plug box (3).

【0015】なお、本実施例では栓箱(3)を第2容器 [0015] Incidentally, the plug box in this Example (3) the second container
(2)に延設したが、これを別体に形成して栓箱(3)を第2容器(2)の下部に気密固定してもよい。 (2) it has been extended, which may be hermetically fixed to the bottom of the plug box formed in separate bodies (3) the second container (2). また、第1容器(1)の下部には点滴セットの容器側注射針を突き通すためのゴム栓(28)が付設してあり、第2容器(2)の上部は密封蓋(10)で封止してある。 Further, the bottom of the first container (1) Yes with attached rubber stopper for piercing the container side needle infusion set (28), the upper portion of the second container (2) is sealed with sealing lid (10) seals are.

【0016】上記栓箱(3)内には中仕切り栓(4)が回転摺動可能に内嵌されており、この栓箱(3)の一側部には上記中仕切り栓(4)との摺動面(5)に上下に長い溝部(1 [0016] The plug box (3) and the middle partition plug (4) is fitted into rotatably sliding in, this plug box (3) in said partition stopper on one side (4) vertically long groove in the sliding surface (5) of (1
2)が形成され、また、他側部の周壁には開口部(13)が形成されている。 2) is formed, also, the opening (13) is formed in the peripheral wall of the other side.

【0017】上記中仕切り栓(4)は、第1容器(1)を密封する第1容器側栓体 (4a)と、第2容器(2)を封止する第2容器側栓体 (4b)とからなり、連結ピン(16)で一体にされている。 [0017] The in partition plug (4), the first container side plug and (4a), the second container side plug (4b sealing the second container (2) for sealing the first container (1) ) becomes from a are integrally by a connecting pin (16). このように構成することにより、 上記第1 With this configuration, the first
薬剤を収容した第1容器(1)を第1容器側栓体(4a)で、 The first container (1) a first container side stopper containing a drug in (4a),
上記第2薬剤を収容した第2容器(2)を第2容器側栓体 Second container (2) a second container side stopper accommodating the second agent
(4b)で、それぞれ個別に密封することができる。 In (4b), can each be tightly sealed individually. この結果、無菌状態を維持したまま、第2容器(2)を第1容器 As a result, while maintaining sterility, the second container (2) the first container
(1)に栓箱(3)を介して簡単に組付けることができる。 (1) can be assembled easily through the plug box (3).

【0018】また、この中仕切り栓(4)は、図2に示すように、下端(14)と上端(15)のそれぞれ中央から周側の一側部に向かって連通路(7・7)が透設してあり、周側の他側部には栓回動レバー(6)が付設してある。 [0018] The inside partition plug (4), as shown in FIG. 2, the lower end (14) and the upper communication passage respectively from the center to one side of the peripheral side of (15) (7.7) There Yes and Toru設, the other side of the circumferential side plug turning lever (6) are additionally provided.

【0019】この栓回動レバー(6)は、上記開口部(13) [0019] The plug turning lever (6), said opening (13)
を通って栓箱(3)外部に突出させてある。 Through the plug box (3) are to protrude to the outside. そして、この開口部(13)は、図3に示すように、周方向に長く開口してあり、上記栓回動レバー(6)を平面視で反時計方向に回動して中仕切り栓(4)を閉栓位置(A)に操作した閉栓状態では、上記連通路(7・7)の周側路端(8・8)が前記溝部(12)から外れた位置で摺動面(5)に臨むように開口してある。 Then, the opening (13), as shown in FIG. 3, circumferentially Yes and long opening, the plug rotation lever (6) rotate in the counterclockwise direction in a plan view to middle partition plug ( 4) the plugging position (in the plugging state of being operated in a), the peripheral side passage end of the communication passage (7.7) (8.8) is the sliding surface at the position deviated from the groove (12) (5) It is opened to face the. 従って、この閉栓状態では上記連通路(7 Therefore, the communication passage in the plugging state (7
・7)の周側路端(8・8)が栓箱(3)との摺動面(5)で閉塞されており、第1容器(1)内と第2容器(2)内とは連通が遮断されている。 · 7 peripheral path end of) (8.8) is closed by the sliding surface (5) between the plug box (3), a first container (1) in the second container (2) in communication is interrupted.

【0020】次に、混合操作の手順について説明する。 [0020] Next, a description is given of the procedure of mixing operation.
第1容器(1)内と第2容器(2)内との連通操作は、栓回動レバー(6)を平面視で時計方向に回動して上記中仕切り栓(4)を開栓位置(B)に移動することにより行う。 Communication operation between the first container (1) in the second container (2) in the unplugging position the partition plug (4) in the plug turning lever (6) rotates in the clockwise direction in a plan view It carried out by moving the (B).

【0021】この操作により、中仕切り栓(4)が栓箱 [0021] With this operation, the middle partition plug (4) is plug box
(3)内の摺動面を回転摺動して、第4図に示すように、 (3) in the sliding surface by rotating sliding, as shown in Figure 4,
上記連通路(7・7)の周側路端(8・8)が前記溝部(12) It said peripheral path end of the communication passage (7.7) (8.8) is the groove (12)
に臨む位置に移動し、第1容器(1)内と第2容器(2)内とが連通路(7・7)を介して連通する。 Moves to a position facing the a first container (1) in the second container (2) inside communicate with each other through the communicating passage (7, 7). なお、本実施例では、栓箱(3)の摺動面(5)に上下に長い溝部(12)を形成したが、この溝部(12)は上記連通路(7・7)が連通すればよく、凹部にするなど適当な形状にすることができる。 In the present embodiment has formed the sliding face vertically long groove portion (5) (12) of the plug box (3), the groove (12) when the communicating passage (7, 7) is communicated with well, it can have a suitable shape such as a concave portion.

【0022】上記の操作により、第1容器(1)内と第2 [0022] By the above operation, the first container (1) in the second
容器(2)内とが連通すると、第1容器(1)内の溶解液を一部分第2容器(2)内へ移動させて容器内の第2薬剤を溶解させ、この溶液を再び連通路(7)を通して第1容器 When the container (2) is communicated, a solution of the first container (1) in moving to a portion the second container (2) in the dissolved second medicament container and, again the communication passage of this solution ( the first container through 7)
(1)内へ移動させ、両薬剤の無菌状態下での混合を完了する。 (1) it is moved into the complete mixing under sterility of both drugs.

【0023】混合された薬剤は全て第1容器(1)内に移され、図5に示すように、第1容器(1)の下部に設けたゴム栓(28)に点滴セット(26)の容器側針(27)を突き刺して、点滴注射に用いる。 The mixed medication is all transferred to the first vessel (1), as shown in FIG. 5, infusion set into the rubber stopper provided at the bottom of the first container (1) (28) (26) pierce the container side needle (27), used for drip injection. この点滴用のゴム栓は、第1容器(1)の下部に設ける代わりに、第2容器(2)上端の密封蓋(10)を使用してもよく、この場合には、混合装置全体を上下反転させ、混合された薬剤を第1容器(1)から連通路(7)及び第2容器(2)を通して点滴セット(26)に送る。 Rubber plug of the drip, instead of providing the lower portion of the first container (1), may be used a second container (2) the upper end of the sealing lid (10), in this case, the entire mixing apparatus It turned upside down, and sends the mixed drug communicating passage (7) from the first container (1) and the second container (2) through infusion set (26).

【0024】なお、混合した薬剤を注射器に吸入して患者に投薬する場合には、連通路(7)を介して両容器(1 [0024] In the case where the mixed drug inhaled by the syringe for dosing a patient, via a communication passage (7) both containers (1
・2)内が連通した後に第2容器(2)内へ溶解液を移動させ、第2薬剤を溶解させたものをそのまま注射器に吸入して用いることができる。 · 2) within it can be used by inhalation to move the solution into the second container (2) after the communication, it is a syringe which is dissolved a second agent.

【0025】 [0025]

【発明の効果】本発明では、上記のように構成され作用することから次の効果を奏する。 In the present invention, the following effects from acting constructed as described above. 栓箱内の中仕切り栓は、極めて簡単な構造の栓回動レバーにより直接回動されるので、中仕切り栓を移動させるための複雑な押圧機構等を必要とせず、混合装置全体をコンパクトで簡単な構造にすることができ、安価に実施することができる。 Partition plug among the plug box, since it is rotated directly by plugs pivot lever a very simple structure, without requiring a complicated pressing mechanism or the like for moving the middle partition plug, the entire mixing device is compact can be a simple structure, it can be inexpensively implemented.

【0026】しかも、中仕切り栓の切換え操作により気密摺動する部分が1つであり、摺動抵抗が少ないうえ、 [0026] In addition, the part to be air-tight sliding by the switching operation of the middle partition plug is one, after a small sliding resistance,
栓回動レバーの先端に加える操作力は、梃子の倍力作用で中仕切り栓に強い回動力を生じることから、中仕切り栓を軽く回動させることができ、極めて容易に開栓して両容器内同士を連通することができる。 Operating force applied to the tip of the plug rotating lever, since it results in a strong rotating force to the intermediate partition stopper with lever boosting action can be lightly pivoted medium partition plug, both by unplugging very easily it can communicate with each other in the container.

【0027】また、第1容器内と第2容器内との連通操作は、栓回動レバーを回動させるだけの簡単な操作で済むうえ、この操作により中仕切り栓が閉栓位置から開栓位置へ気密摺動することから、無菌状態を保持したまま2種の薬剤を混合することができる。 Further, communication operation between the first container and the second container immediately, requires only a simple operation of the plug rotating lever only by rotating, unplugging position middle partition plug from plugging position by the operation since the hermetically slid, it is possible to mix two types of drug while maintaining sterility.

【0028】さらに、第1容器と第2容器とが別体に形成されているので、2種の収容薬剤のそれぞれの性質に適合した薬剤容器を用いることができる。 Furthermore, since the first container and the second container are formed separately, it is possible to use a drug container which is adapted to the respective properties of the two housing agent. 従って、例えば一方の薬剤が吸湿により変質しやすい場合には、この薬剤を収容する容器のみを防湿性容器に形成すればよく、他方の薬剤容器は一般のプラスチックボトル等を用いることができ、製造コストを低減することができる。 Thus, for example, if one of the drug is easily altered by moisture absorption may be formed only container containing the agent to moisture-proof container, the other medicament container can be used in general plastic bottles, produced it is possible to reduce the cost.
さらに、薬剤供給者が異なる場合も、各薬剤が個別の容器に収容されるので、組付時に無菌状態を容易に維持し Furthermore, even if the drug supplier is different, since the drug is contained in a separate container, sterility and easily maintained when assembling
ながら簡単に組み付けることができるうえ、この組み付 After that it can be easily assembled that while, with this set
けにより栓箱を介して両容器を互いに連結した後も、上 After linked together the two containers through a plug box by only the upper
記連通操作をする前は、各容器をそれぞれ第1容器側栓 Killen communication operation before the first container side closure each container respectively
体と第2容器側栓体とで個別に密封しておくことができ It can remain sealed individually in the body and a second container side stopper
る。 That.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明の実施例を示す、混合装置の縦断面図である。 Figure 1 shows an embodiment of the present invention, is a longitudinal sectional view of the mixing device.

【図2】実施例の中仕切り栓の斜視図である。 2 is a perspective view of a partition plug in the embodiment.

【図3】図1のIII−III線断面図である。 3 is a sectional view taken along line III-III in FIG.

【図4】実施例の中仕切り栓を開栓位置に切換えた状態の縦断面図である。 4 is a longitudinal sectional view of a state in which switching the partition stoppered cap removal position in the embodiment.

【図5】実施例の混合装置に、点滴セットを取付けた状態の正面図である。 The mixing device of Figure 5 embodiment, is a front view of a state in which mounting the infusion set.

【図6】従来例を示す、混合装置の縦断面図であり、左半図は混合操作前の状態を示し、右半図は混合操作後の状態を示す。 6 shows a conventional example, a longitudinal sectional view of the mixing device, the left half view shows a state before the mixing operation, the right half view shows the state after the mixing operation.

【符号の説明】 DESCRIPTION OF SYMBOLS

1…第1容器、 2…第2容器、 3…栓箱、 4…中仕切り栓、 5…摺動面、 6…栓回動レバー、 7… 1 ... first vessel 2 ... second vessel 3 ... plug box, 4 ... middle partition plug, 5 ... sliding surface, 6 ... stopper turning lever 7 ...
連通路、 8…路端、 A…閉栓位置、 B…開栓位置。 Communication path, 8 ... the road-edge, A ... stoppered position, B ... unplugging position.

───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl. 7 ,DB名) A61J 1/20 A61J 3/00 312 A61J 1/05 ────────────────────────────────────────────────── ─── of the front page continued (58) investigated the field (Int.Cl. 7, DB name) A61J 1/20 A61J 3/00 312 A61J 1/05

Claims (1)

    (57)【特許請求の範囲】 (57) [the claims]
  1. 【請求項1】 第1薬剤を密封収容した第1容器(1)と第2薬剤を密封収容した第2容器(2)とを栓箱(3)を介して外気遮断状に連通連結し、 この栓箱(3)内で、上記第1容器(1)を第1容器側栓体 1. A first container (1) and second container (2) and which second agent were sealed housing communicatively connected to the outside air cutoff shape via plug box (3) is a sealed housing a first agent, in this plug box (3) in said first container (1) a first container side stopper
    (4a)で密封するとともに上記第2容器(2)を第2容器側 The second container side the second container (2) with sealed with (4a)
    栓体(4b)で密封して、上記第1容器(1)と第2容器(2) Plug was sealed with (4b), the first container (1) and the second container (2)
    との連通を遮断するように構成し、 上記第1容器側栓体(4a)と第2容器側栓体(4b)とを連結 Configured to cut off the communication, connecting the said first container side stopper and (4a) second container side stopper (4b) and
    手段(16)で互いに連結固定して中仕切り栓(4)を形成 Forming a middle partition plug (4) and connected and fixed to each other by means (16)
    し、 この中仕切り栓(4)を、上記栓箱(3)内で気密状に回転 And, rotating the partition plug therein (4), in an airtight manner within the plug box (3)
    摺動させることにより閉栓位置(A)と開栓位置(B)とに<br/>切換可能に構成し、 この中仕切り栓(4)から栓回動レバー(6)を栓箱(3)外部へ突設するとともに、この中仕切栓(4)に連通路 Configured to <br/> switching 換可 ability to plugging position (A) and unplugging position and (B) by sliding the plug rotation lever (6) the plug box from the inside partition plug (4) ( 3) impact setting to Rutotomoni outside, the communication passage in the intermediate partition Ri plug (4)
    (7)を設け、 この中仕切り栓(4)を栓回動レバー(6)により上記閉栓位置(A)に切換え操作した状態では、上記連通路(7)の路端開口部(8)を栓箱との摺動面(5)に臨ませて前記第1容器(1)と第2容器(2)との連通を遮断し、 この中仕切り栓(3)を栓回動レバー(6)により上記開栓位置(B)に切換え操作した状態では、上記連通路(7)の摺動面(5)による遮断を解除して、前記第1容器(1)と第2容器(2)とがこの連通路(7)を介して連通するように構成したことを特徴とする、個別密封容器に収容した2種薬剤の無菌保持混合装置。 (7) is provided, in the state where the switching operation to the plugging position (A) by a partition plug therein (4) plug turning lever (6), the road-edge opening of the communication passage (7) and (8) sliding surface of the plug box (5) on to face to block the communication between the first container (1) and the second container (2), the inside partition plug (3) plugs turning lever (6) the in the state where the switching operation to the cap removal position (B), to release the block by the sliding surface (5) of the aforementioned connecting channel (7), and the first container (1) and the second container (2) There characterized by being configured to communicate via a communication passage (7), a sterile holding the mixing device of the two agents were housed in separate sealed container.
JP3128729A 1991-04-30 1991-04-30 Sterile retaining mixing device of the two agents were housed in separate sealed container Expired - Fee Related JP3066611B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3128729A JP3066611B2 (en) 1991-04-30 1991-04-30 Sterile retaining mixing device of the two agents were housed in separate sealed container

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3128729A JP3066611B2 (en) 1991-04-30 1991-04-30 Sterile retaining mixing device of the two agents were housed in separate sealed container

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JPH04329954A JPH04329954A (en) 1992-11-18
JP3066611B2 true JP3066611B2 (en) 2000-07-17

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IL182605D0 (en) 2007-04-17 2007-07-24 Medimop Medical Projects Ltd Fluid control device with manually depressed actuator
CN101778614B (en) 2007-08-16 2012-11-28 株式会社松风 Medicines-mixing container with eccentric communication holes
JP2010538744A (en) 2007-09-18 2010-12-16 メディモップ・メディカル・プロジェクツ・リミテッド Drug mixing injection device
IL186290D0 (en) 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
USD641080S1 (en) 2009-03-31 2011-07-05 Medimop Medical Projects Ltd. Medical device having syringe port with locking mechanism
USD630732S1 (en) 2009-09-29 2011-01-11 Medimop Medical Projects Ltd. Vial adapter with female connector
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IL225734D0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor
CN105228676B (en) 2013-05-10 2018-01-05 麦迪麦珀医疗工程有限公司 Comprising a medical device having a dried pharmaceutical inline vial adapter assembly
JP6358724B2 (en) 2015-01-05 2018-07-18 ウエスト・ファーマ.サービシーズ・イスラエル,リミテッド Dual vial adapter assembly with easy removable pill adapter to ensure accurate use
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