JP3025066B2 - Method for producing outer tube closing membrane for cell collection tool - Google Patents
Method for producing outer tube closing membrane for cell collection toolInfo
- Publication number
- JP3025066B2 JP3025066B2 JP3205193A JP20519391A JP3025066B2 JP 3025066 B2 JP3025066 B2 JP 3025066B2 JP 3205193 A JP3205193 A JP 3205193A JP 20519391 A JP20519391 A JP 20519391A JP 3025066 B2 JP3025066 B2 JP 3025066B2
- Authority
- JP
- Japan
- Prior art keywords
- outer tube
- distal end
- tube
- cell collection
- brush
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Description
【０００１】[0001]
【産業上の利用分野】この発明は経内視鏡的に生体腔内
に挿入されて細胞を採取する細胞採取具用の外管閉鎖膜
の製造方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing an outer tube closing membrane for a cell collecting tool which is inserted into a living body cavity endoscopically to collect cells.
【０００２】[0002]
【従来の技術】一般に、内視鏡の処置具挿通チャンネル
内を経て生体腔内にブラシを挿入し、この生体腔内の表
面にブラシを摺擦して細胞を採取する構成の内視鏡用細
胞採取具が知られている。このブラシは通常はチューブ
に内装させた状態で、内視鏡の処置具挿通チャンネル内
に挿通させるようにしている。2. Description of the Related Art In general, a brush is inserted into a living body cavity through a treatment tool insertion channel of an endoscope, and the brush is rubbed on the surface of the living body cavity to collect cells. Cell harvesting devices are known. This brush is usually inserted into a treatment tool insertion channel of an endoscope while being housed in a tube.
【０００３】ところで、内視鏡の挿入部を生体腔内に挿
入した場合には処置具挿通チャンネルの内面に例えば体
液等の粘液が付着する。そのため、内視鏡の挿入部を生
体腔内に挿入したのち、内視鏡の処置具挿通チャンネル
内にチューブに内装させたブラシを挿通させた際に、挿
通チャンネルの内面に付着している粘液等がそのチュー
ブ内に浸入するおそれがあるので、細胞採取時にこのチ
ューブ内からブラシを外部側に突き出す際にブラシにこ
の粘液等が付着して汚染される問題があった。このよう
にブラシに粘液等が付着して汚染された場合にはブラシ
に採取部位以外の不要な細胞が混入するおそれがあり、
細胞検査時には雑菌が入り込み正確な検査ができない問
題があった。When the insertion portion of the endoscope is inserted into a living body cavity, mucus such as a body fluid adheres to the inner surface of the treatment instrument insertion channel. Therefore, after inserting the insertion portion of the endoscope into the body cavity, when the brush inside the tube is inserted into the treatment tool insertion channel of the endoscope, mucus adhering to the inner surface of the insertion channel There is a risk that the mucus may adhere to the brush when the brush is protruded to the outside from the tube at the time of cell collection, since the mucus may infiltrate into the tube. If mucus or the like adheres to the brush and is contaminated in this manner, unnecessary cells other than the collection site may be mixed into the brush,
At the time of cell inspection, there was a problem that various bacteria entered and an accurate inspection could not be performed.
【０００４】そこで、米国特許第４２３５２４４号明細
書には図１３に示すように外側チューブａの先端に生体
腔内で溶解吸収される物質で作った栓ｂを嵌着し、細胞
採取時以外はこの栓ｂによって外側チューブａ内に粘液
等が浸入することを防止するとともに、細胞採取時には
この栓ｂを内側チューブｃによって生体腔内で突き落と
してブラシｄを突き出すことにより、ブラシｄを外部側
に突き出す際にブラシｄにこの粘液等が付着して汚染さ
れることを防止する構成にしたものが提案されている。Therefore, in US Pat. No. 4,235,244, as shown in FIG. 13, a stopper b made of a substance which is dissolved and absorbed in a body cavity is fitted to the tip of an outer tube a as shown in FIG. The plug b prevents the intrusion of mucus and the like into the outer tube a, and at the time of cell collection, the plug b is pushed down in the body cavity by the inner tube c to protrude the brush d, so that the brush d is moved outward. There has been proposed a configuration in which the mucus or the like adheres to the brush d during the protrusion to prevent contamination.
【０００５】また、特公昭５９−２９６９３号公報には
図１４に示すように外管ｅの先端部に円板状の開閉蓋ｆ
を外管ｅと一体的に延出形成させ、それ自体の弾性復元
力によって外管ｅの先端開口部ｇを閉塞させ、細胞採取
時以外はこの開閉蓋ｆによって外管ｅ内に粘液等が浸入
することを防止するとともに、細胞採取時には生体腔内
でこの開閉蓋ｆを内管ｈによって押し開いて先端開口部
ｇを開放させ、この状態でブラシｉを突き出すことによ
り、ブラシｉを外部側に突き出す際にブラシｉに採取部
位以外の不要な粘液等が付着して汚染されることを防止
する構成にしたものが提案されている。Japanese Patent Publication No. 59-29693 discloses a disk-shaped opening / closing lid f at the tip of an outer tube e as shown in FIG.
Is formed integrally with the outer tube e, and the distal opening g of the outer tube e is closed by its own elastic restoring force. When the cells are not collected, mucus and the like are contained in the outer tube e by the opening / closing lid f. In addition to preventing the intrusion, the opening / closing lid f is pushed open by the inner tube h in the body cavity at the time of cell collection to open the distal end opening g. There has been proposed a configuration in which unnecessary mucus or the like other than the collection site is prevented from adhering to and contaminating the brush i when protruding to the brush i.
【０００６】[0006]
【発明が解決しようとする課題】米国特許第４２３５２
４４号明細書のような構成のものでは生体腔内で溶解、
吸収される物質で作った栓ｂが生体腔内に放置されて異
物となり易い問題があった。さらに、外側チューブａと
は別の素材によって栓ｂが形成されているので、外側チ
ューブａとは別に栓ｂ用の材料を準備する必要があると
ともに、外側チューブａの内部にこの栓ｂを形成する作
業が比較的面倒なものとなる問題があった。SUMMARY OF THE INVENTION US Patent No. 42352
No. 44 dissolves in the body cavity,
There is a problem that the plug b made of the substance to be absorbed is easily left as a foreign substance when left in the body cavity. Further, since the stopper b is formed of a different material from the outer tube a, it is necessary to prepare a material for the stopper b separately from the outer tube a, and the stopper b is formed inside the outer tube a. There is a problem that the operation to perform is relatively troublesome.
【０００７】また、特公昭５９−２９６９３号公報のよ
うな構成のものでは開閉蓋ｆの周縁部が外管ｅの外端縁
に密着嵌合する状態に付勢されているようであるが、完
全には密着されておらず、外管ｅの外端縁の一部に略ス
リット状の開口部が形成されているので、例えば極度に
湾曲のかけられた内視鏡の処置具挿通チャンネル内でこ
の細胞採取具を進退させる際に、図１５に示すように開
閉蓋ｆが不必要に開口されるおそれがあった。Further, in the configuration as disclosed in Japanese Patent Publication No. 59-29693, the peripheral edge of the opening / closing lid f is urged to be in a state of being tightly fitted to the outer edge of the outer tube e. Since it is not completely adhered and a substantially slit-shaped opening is formed at a part of the outer end edge of the outer tube e, for example, the inside of the treatment instrument insertion channel of an endoscope that is extremely curved When the cell collection tool is moved forward and backward, the opening / closing lid f may be unnecessarily opened as shown in FIG.
【０００８】そのため、この不必要に開口された開閉蓋
ｆと外管ｅの先端開口部ｇとの間の隙間ｊから挿通チャ
ンネルの内面に付着している粘液等が外管ｅ内に浸入
し、ブラシｉにこの粘液等が付着して汚染される問題が
あった。また、開閉蓋ｆはそれ自体の弾性復元力によっ
て外管ｅの先端開口部ｇを閉塞させているので、この開
閉蓋ｆの製作が難しい問題もあった。Therefore, mucus and the like adhering to the inner surface of the insertion channel enter the outer tube e from the gap j between the unnecessary opening / closing lid f and the distal end opening g of the outer tube e. There is a problem that the mucus and the like adhere to the brush i and become contaminated. In addition, since the opening / closing lid f closes the distal end opening g of the outer tube e by its own elastic restoring force, there is a problem that it is difficult to manufacture the opening / closing lid f.
【０００９】この発明は上記事情に着目してなされたも
ので、細胞採取具の製作の容易化を図ることができると
ともに、細胞採取時に生体腔内の細胞を採取目的部位以
外の雑菌等によって汚染させることなく採取目的部位の
細胞のみを確実に採取することができ、正確な細胞検査
を行なわせることができる細胞採取具用の外管閉鎖膜の
製造方法を提供することを目的とするものである。The present invention has been made in view of the above circumstances, and can facilitate the manufacture of a cell collection tool, and at the time of cell collection, contaminate cells in a living body cavity with various bacteria other than the target site. An object of the present invention is to provide a method for producing an outer tube closing membrane for a cell collection tool, which can reliably collect only cells at a collection target site without causing the cell collection tool to perform an accurate cell test. is there.
【００１０】[0010]
【課題を解決するための手段】この発明は細胞採取用具
を収納状態で保持する可撓性の外管の内部に芯体を前記
外管の先端部近傍部位まで挿入する芯体挿入工程と、前
記外管における前記芯体よりも先端側の部分に前記外管
の素材の融点以上の温度を加えて前記外管の素材を融解
させる外管素材融解工程と、前記外管素材の融解部分を
壁面に押し当て、前記外管素材の融解部分によって前記
外管の先端開口部を閉塞させることにより、前記外管の
先端開口部に前記外管内からの前記細胞採取用具の突き
当てによって破断可能な閉鎖膜を形成させる閉鎖膜形成
工程とを具備した細胞採取具用の外管閉鎖膜の製造方法
である。According to the present invention, there is provided a core-inserting step of inserting a core into a flexible outer tube holding a cell-collecting tool in a stored state up to a portion near the distal end of the outer tube; An outer tube material melting step of applying a temperature equal to or higher than the melting point of the material of the outer tube to a portion of the outer tube closer to the distal end than the core body to melt the material of the outer tube; and By pressing against the wall surface and closing the tip opening of the outer tube with the melting portion of the outer tube material, the outer tube can be broken by abutting the cell collection tool from the inside of the outer tube to the tip opening of the outer tube. A method for producing an outer tube closing film for a cell collection tool, comprising a closing film forming step of forming a closing film.
【００１１】[0011]
【作用】上記の方法において、外管閉鎖膜の製造時には
まず可撓性の外管の内部に芯体を外管の先端部近傍部位
まで挿入し、次に外管における芯体よりも先端側の部分
に外管の素材の融点以上の温度を加えて外管の素材を融
解させ、続いて外管素材の融解部分を壁面に押し当てて
外管素材の融解部分によって外管の先端開口部を閉塞さ
せることにより、外管の先端開口部に外管内からの細胞
採取用具の突き当てによって破断可能な閉鎖膜を形成さ
せる。このように外管の先端面の閉鎖膜を外管自体の素
材によって形成させることにより、製作の容易化を図る
ようにしたものである。In the above method, when manufacturing the outer tube closing membrane, the core is first inserted into the flexible outer tube up to the vicinity of the distal end of the outer tube, and then the distal end of the outer tube with respect to the core relative to the core. A temperature higher than the melting point of the material of the outer tube is applied to the part of the outer tube to melt the material of the outer tube. To form a closed membrane that can be broken by abutment of a cell sampling tool from the inside of the outer tube to the opening at the distal end of the outer tube. In this manner, the closure film on the distal end surface of the outer tube is formed of the material of the outer tube itself, thereby facilitating manufacture.
【００１２】また、細胞採取用具の使用時以外の場合に
は外管の先端面の閉鎖膜によって外管内を閉塞し、外管
内に粘液等が浸入することを防止するとともに、細胞採
取用具の使用時には外管内からの突き当てによって閉鎖
膜を破断させ、細胞採取用具を突き出すことにより、細
胞採取時に生体腔内の細胞を採取目的部位以外の雑菌等
によって汚染させることを防止して採取目的部位の細胞
のみを確実に採取させ、正確な細胞検査を行なわせるよ
うにしたものである。When the cell-collecting device is not used, the inside of the outer tube is closed by a closing film on the distal end surface of the outer tube to prevent invasion of mucus and the like into the outer tube. Occasionally, the closing membrane is broken by abutment from inside the outer tube, and the cell collection tool is protruded to prevent the cells in the body cavity from being contaminated by bacteria other than the collection target site at the time of cell collection to prevent the cell from being collected. This is to ensure that only cells are collected and that accurate cell tests are performed.
【００１３】[0013]
【実施例】以下、この発明の第１の実施例を図１乃至図
４を参照して説明する。図１は内視鏡１の処置具挿通用
チャンネル２に挿通された内視鏡用細胞採取具の概略構
成を示すものである。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A first embodiment of the present invention will be described below with reference to FIGS. FIG. 1 shows a schematic configuration of an endoscope cell collection tool inserted into a treatment tool insertion channel 2 of an endoscope 1.
【００１４】この内視鏡用細胞採取具には例えばＦＥＰ
（ふっ化エチレン−プロピレン共重合体）等の合成樹脂
材料によって形成された可撓性の外管３が設けられてい
る。この外管３の内部には操作ワイヤ４が進退自在に挿
通されている。この操作ワイヤ４の先端部には外管３内
に引き込んで収納できるブラシ（細胞採取用具）５が設
けられており、このブラシ５の先端には先端チップ６が
止着されている。[0014] For example, FEP is used for this endoscope cell collection tool.
A flexible outer tube 3 made of a synthetic resin material such as (ethylene fluoride-propylene copolymer) is provided. An operation wire 4 is inserted into the outer tube 3 so as to be able to advance and retreat. A brush (cell collection tool) 5 that can be pulled into and stored in the outer tube 3 is provided at the tip of the operation wire 4, and a tip 6 is fixed to the tip of the brush 5.
【００１５】また、外管３の手元側端部には操作つまみ
７が設けられている。さらに、操作ワイヤ４の手元側端
部には操作リング８が設けられている。そして、これら
の操作つまみ７と操作リング８とによって外管３に対し
て操作ワイヤ４を進退させ得る操作機構９が形成されて
いる。An operation knob 7 is provided at the proximal end of the outer tube 3. Further, an operation ring 8 is provided at a proximal end of the operation wire 4. The operation knob 7 and the operation ring 8 form an operation mechanism 9 that allows the operation wire 4 to move forward and backward with respect to the outer tube 3.
【００１６】一方、外管３の先端面にはブラシ５の使用
時に外管３内からのブラシ５の突き当てによって破断可
能な外管３自体の素材によって形成される閉鎖膜３ａが
設けられている。On the other hand, a closing film 3a formed of the material of the outer tube 3 itself, which can be broken by abutment of the brush 5 from inside the outer tube 3 when the brush 5 is used, is provided on the distal end surface of the outer tube 3. I have.
【００１７】次に、この外管３の閉鎖膜３ａの製造方法
について説明する。まず、図２（Ａ）に示すように外管
３の内部にこの外管３の長さよりも長い例えばステンレ
ス製の丸棒芯金（芯体）１０をこの外管３の先端部近傍
部位まで挿入する（芯体挿入工程）。この場合、芯金１
０の外径は外管３の内径と略同径に形成されている。そ
して、この芯金１０は外管３の一端部側からこの外管３
の内部に挿入され、この外管３の他端部から例えば５mm
程度内側の位置まで挿入される。Next, a method of manufacturing the closing film 3a of the outer tube 3 will be described. First, as shown in FIG. 2 (A), a round bar 10 made of, for example, stainless steel and having a length longer than the length of the outer tube 3 is inserted into the outer tube 3 to a position near the distal end of the outer tube 3. Insert (core insertion step). In this case, the core metal 1
The outer diameter of 0 is formed to be substantially the same as the inner diameter of the outer tube 3. The core 10 is connected to the outer tube 3 from one end of the outer tube 3.
5 mm from the other end of the outer tube 3
It is inserted up to the position inside.
【００１８】次に、外管３における芯金１０よりも先端
側の部分３ｂをヒートガン１１によって外管３の素材で
あるＦＥＰの融点（２５０〜２８０℃）以上の温度で加
熱して外管３の素材を融解させる（外管素材融解工
程）。この場合、ヒートガン１１からの加熱によって外
管３における芯金１０よりも先端側の部分３ｂが融解す
ると自重によって下方に垂れ下がる。Next, a portion 3b of the outer tube 3 closer to the distal end than the metal core 10 is heated by a heat gun 11 at a temperature higher than the melting point (250 to 280 ° C.) of FEP, which is a material of the outer tube 3, and Is melted (outer tube material melting step). In this case, when the portion 3b of the outer tube 3 closer to the tip end than the core metal 10 is melted by heating from the heat gun 11, the outer tube 3 hangs down by its own weight.
【００１９】この状態で続いて、図２（Ｂ）に示すよう
に外管３の素材の融解部分３ｂ´を平面状の壁面１２に
押し当て、外管３の素材の融解部分３ｂ´によって外管
３の先端開口部を閉塞させる。この場合、外管３の先端
開口部を外管３の素材の融解部分３ｂ´によって閉塞さ
せた状態で芯金１０の先端および外管３を平面状の壁面
１２に対して垂直に突き当てる。この状態で、冷却させ
ることにより、外管３の先端開口部に外管３内からの細
胞採取用具の突き当てによって破断可能な薄膜状の閉鎖
膜３ａを形成させる（閉鎖膜形成工程）。In this state, as shown in FIG. 2B, the molten portion 3b 'of the material of the outer tube 3 is pressed against the flat wall surface 12, and the outer portion 3 is pressed by the molten portion 3b' of the material of the outer tube 3. The distal opening of the tube 3 is closed. In this case, the distal end of the core tube 10 and the outer tube 3 are vertically abutted against the flat wall surface 12 in a state where the opening of the distal end of the outer tube 3 is closed by the melted portion 3b ′ of the material of the outer tube 3. In this state, by cooling, a thin film-like closing film 3a that can be broken by abutting a cell collection tool from the inside of the outer tube 3 is formed at the distal end opening of the outer tube 3 (closing film forming step).
【００２０】その後、図３に示すパイプ状のカッター１
３内に外管３の上端部を挿入させ、この状態で、図２
（Ｃ）に示すようにパイプ状カッター１３を上方から外
管３の外周面に沿って下降させて外管３の素材の融解部
分３ｂ´における外管３の外径よりも外部側にはみ出し
ている余分な部分を切断する。Thereafter, a pipe-shaped cutter 1 shown in FIG.
2 is inserted into the upper end of the outer tube 3 in this state.
As shown in (C), the pipe-shaped cutter 13 is lowered from above along the outer peripheral surface of the outer tube 3 so as to protrude beyond the outer diameter of the outer tube 3 in the molten portion 3b 'of the material of the outer tube 3. Cut off any excess that is.
【００２１】なお、図２（Ｄ）中のＡは外管３の素材の
融解部分の切断か所を示すものである。また、パイプ状
カッター１３の内径は外管３の外径と略同径に形成され
ている。A in FIG. 2 (D) indicates a location where the molten portion of the material of the outer tube 3 is cut. The inner diameter of the pipe-shaped cutter 13 is formed to be substantially the same as the outer diameter of the outer tube 3.
【００２２】次に、上記構成の内視鏡用細胞採取具を使
用して生体腔内の細胞を採取する細胞採取作業について
説明する。まず、内視鏡用細胞採取具は通常時（使用
前）は図１に示すようにブラシ５を外管３内に引き込ん
で収納されるとともに、外管３の先端面が閉鎖膜３ａに
よって閉塞された状態で保持される。Next, a description will be given of a cell collecting operation for collecting cells in a living body cavity using the endoscope cell collecting tool having the above-described configuration. First, during normal operation (before use), the endoscope cell collection tool is retracted by retracting the brush 5 into the outer tube 3 as shown in FIG. 1, and the distal end surface of the outer tube 3 is closed by the closing film 3a. It is kept in the state where it was done.
【００２３】そして、この状態の内視鏡用細胞採取具を
予め生体腔内に挿入された内視鏡１の処置具挿通用チャ
ンネル２に挿通して生体腔内に導入し、外管３先端の閉
鎖膜３ａを生体腔内壁等の目的の細胞採取位置１４に近
づける。Then, the endoscope cell collection tool in this state is inserted into the treatment tool insertion channel 2 of the endoscope 1 previously inserted into the body cavity, and introduced into the body cavity. Is brought close to the target cell collection position 14 such as the inner wall of a living body cavity.
【００２４】この状態で、操作リング８を先端側に押し
込むと、外管３に対して操作ワイヤ４が前進し、先端チ
ップ６が外管３の先端面の閉鎖膜３ａに突き当たる。こ
の位置からさらに操作リング８を先端側に押し込むと、
図４に示すように外管３先端の閉鎖膜３ａが先端チップ
６によって突き破られ、ブラシ５が外管３の前方に突出
される。そして、この状態で、ブラシ５を細胞採取位置
１４の目的の生体腔内壁等に押し付けながら前後動作さ
せて生体腔内壁を擦過し、細胞を採取する。In this state, when the operating ring 8 is pushed toward the distal end, the operating wire 4 advances with respect to the outer tube 3, and the distal tip 6 abuts on the closing film 3 a on the distal end surface of the outer tube 3. When the operation ring 8 is further pushed from this position toward the distal end,
As shown in FIG. 4, the closing film 3a at the tip of the outer tube 3 is pierced by the tip 6, and the brush 5 is projected forward of the outer tube 3. Then, in this state, the brush 5 is moved forward and backward while pressing the brush 5 against the target inner wall of the living body cavity at the cell collecting position 14 to scrape the inner wall of the living body cavity and collect cells.
【００２５】さらに、細胞採取後、操作リング８を手元
側に引き、ブラシ５を外管３内に引き込んで収納させ
る。そして、この状態で内視鏡用細胞採取具を内視鏡１
の処置具挿通用チャンネル２から抜去する。Further, after the cells are collected, the operation ring 8 is pulled toward the user, and the brush 5 is drawn into the outer tube 3 and stored. Then, in this state, the endoscope cell sampling tool is inserted into the endoscope 1.
Is removed from the treatment tool insertion channel 2.
【００２６】そこで、上記方法によれば外管３の先端部
をその材質であるＦＥＰの融点以上の温度で加熱し、溶
解させて外管３の閉鎖膜３ａを外管３自体の素材によっ
て形成させたので、従来のように外管３とは別の素材に
よって閉鎖膜３ａを形成する場合に比べて製作の容易化
を図ることができる。Therefore, according to the above-mentioned method, the tip of the outer tube 3 is heated at a temperature higher than the melting point of FEP, which is the material thereof, and melted to form the closing film 3a of the outer tube 3 from the material of the outer tube 3 itself. Because of this, the manufacturing can be facilitated as compared with the conventional case where the closing film 3a is formed of a material different from the outer tube 3.
【００２７】また、内視鏡用細胞採取具の使用時に外管
３先端が生体腔内の細胞採取位置１４に到達するまで、
外管３の先端面を閉鎖膜３ａによって閉塞させた状態で
保持し、外管３の内部側を外部側に対して確実に隔離さ
せた状態で保持させることができるので、従来のように
ブラシ５が内視鏡１の処置具挿通用チャンネル２の内面
に付着した粘液等によって汚染されることを防止するこ
とができる。そのため、採取目的部位の細胞のみを確実
に採取することができるので、正確な細胞検査を行なわ
せることができ、検査の信頼性を高めることができる。In addition, when the tip of the outer tube 3 reaches the cell collection position 14 in the body cavity when using the endoscope cell collection tool,
The distal end surface of the outer tube 3 can be held in a state of being closed by the closing film 3a, and the inner side of the outer tube 3 can be held in a state of being securely isolated from the outer side. 5 can be prevented from being contaminated by mucus or the like attached to the inner surface of the treatment tool insertion channel 2 of the endoscope 1. Therefore, only the cells at the target site can be reliably collected, so that an accurate cell test can be performed, and the reliability of the test can be improved.
【００２８】また、図５乃至図７はこの発明の第２の実
施例を示すものである。ここでは、第１の実施例の外管
３の内部に例えばＰＴＦＥ（ポリテトラフルオロエチレ
ン）等の合成樹脂材料によって形成された可撓性内管２
１を挿通し、この内管２１の内部に操作ワイヤ４を進退
自在に挿通させ、さらにこの操作ワイヤ４の先端部のブ
ラシ５を内管２１の内部に収納させている。FIGS. 5 to 7 show a second embodiment of the present invention. Here, a flexible inner tube 2 made of a synthetic resin material such as PTFE (polytetrafluoroethylene) is provided inside the outer tube 3 of the first embodiment.
1, the operation wire 4 is inserted into the inner tube 21 so as to be able to advance and retreat, and the brush 5 at the distal end of the operation wire 4 is housed inside the inner tube 21.
【００２９】さらに、外管３の手元側端部には第１の操
作つまみ７ａ、内管２１の手元側端部には第２の操作つ
まみ７ｂがそれぞれ設けられている。そして、これらの
第１，第２の操作つまみ７ａ，７ｂと操作ワイヤ４の手
元側端部の操作リング８とによって外管３に対して内管
２１および操作ワイヤ４をそれぞれ進退させ得る操作機
構２２が形成されている。なお、内管２１の先端にはこ
の内管２１の軸心と直交する方向に対して斜めに傾斜さ
せた状態で切欠させた鋭利部２１ａが形成されている。Further, a first operation knob 7a is provided at a proximal end of the outer tube 3, and a second operation knob 7b is provided at a proximal end of the inner tube 21. The first and second operation knobs 7a and 7b and the operation ring 8 at the proximal end of the operation wire 4 allow the inner tube 21 and the operation wire 4 to advance and retreat with respect to the outer tube 3, respectively. 22 are formed. At the tip of the inner tube 21, there is formed a sharpened portion 21a which is notched while being obliquely inclined with respect to a direction perpendicular to the axis of the inner tube 21.
【００３０】次に、外管３の閉鎖膜３ａの製造方法につ
いて説明する。まず、第１の実施例と同様に外管３の内
部にこの外管３の長さよりも長い例えばステンレス製の
丸棒芯金１０をこの外管３の先端部近傍部位まで挿入す
る。Next, a method for manufacturing the closing film 3a of the outer tube 3 will be described. First, as in the first embodiment, a round bar 10 made of, for example, stainless steel, which is longer than the length of the outer tube 3, is inserted into the outer tube 3 to a position near the distal end of the outer tube 3.
【００３１】次に、図６に示すように外管３の素材であ
るＦＥＰの融点（２５０〜２８０℃）以上の温度（例え
ば３００℃程度）に加熱されたホットプレート（壁面）
２３を用意する。そして、外管３における芯金１０より
も先端側の部分３ｂをこのホットプレート２３に垂直に
突き当て、外管３の素材を先端側の突き当て部分から徐
々に融解させる。Next, as shown in FIG. 6, a hot plate (wall surface) heated to a temperature (for example, about 300 ° C.) or higher than the melting point (250 to 280 ° C.) of FEP which is a material of the outer tube 3
23 is prepared. Then, a portion 3b of the outer tube 3 closer to the distal end than the metal core 10 is vertically abutted against the hot plate 23, and the material of the outer tube 3 is gradually melted from the abutted portion at the distal end.
【００３２】この場合、融解部分３ｂ´の拡大にともな
い外管３の先端側の部分３ｂをホットプレート２３に突
き当てたままの状態で外管３および芯金１０を横方向に
移動させ、図６に示すように外管３の素材の融解部分３
ｂ´によって外管３の先端開口部を閉塞させる。さら
に、この状態で冷却させることにより、外管３の先端開
口部に薄膜状の閉鎖膜３ａを形成させる。In this case, the outer tube 3 and the cored bar 10 are moved in the horizontal direction while the tip 3b of the outer tube 3 is kept in contact with the hot plate 23 as the melting portion 3b 'is enlarged. As shown in FIG. 6, the molten portion 3 of the material of the outer tube 3
The opening at the distal end of the outer tube 3 is closed by b '. Further, by cooling in this state, a thin film-like closing film 3a is formed at the opening of the distal end of the outer tube 3.
【００３３】その後、第１の実施例と同様にパイプ状の
カッター１３を上方から外管３の外周面に沿って下降さ
せて外管３の素材の融解部分３ｂ´における外管３の外
径よりも外部側にはみ出している余分な部分を切断す
る。Thereafter, similarly to the first embodiment, the pipe-shaped cutter 13 is lowered along the outer peripheral surface of the outer tube 3 from above, and the outer diameter of the outer tube 3 at the molten portion 3b 'of the material of the outer tube 3 is reduced. Cut off any excess parts that protrude outside.
【００３４】なお、外管３の先端開口部の周縁部位と外
管素材の融解部分３ｂ´との接合部分は外管３の周方向
に沿って場所毎にその接合強度が異なり、図７に示すよ
うに融解部分３ｂ´の折り曲げ側に当たる部分に接合強
度が高い部分３ｃ、この折り曲げ側の部分３ｃと反対側
の貼り合わせ側に当たる部分に接合強度が低い部分３ｄ
がそれぞれ形成されている。The joining strength between the peripheral portion of the opening at the distal end of the outer tube 3 and the melted portion 3b 'of the outer tube material differs at every location along the circumferential direction of the outer tube 3 and is shown in FIG. As shown, a portion 3c having a high bonding strength corresponds to a portion corresponding to the bent side of the melted portion 3b ', and a portion 3d having a low bonding strength corresponds to a portion corresponding to the bonding side opposite to the bent portion 3c.
Are formed respectively.
【００３５】そして、この実施例では外管３内に内管２
１を挿入する際、図５（Ｂ）に示すように閉鎖膜３ａに
おける外管３の先端開口部の周縁部位と外管素材の融解
部分３ｂ´との接合部分のうち接合強度が低い貼り合わ
せ側部分３ｄに内管２１の鋭利部２１ａの先端が当たる
ように向きを合わせて挿入されている。In this embodiment, the inner pipe 2 is placed inside the outer pipe 3.
At the time of insertion, as shown in FIG. 5 (B), the bonding strength of the joining portion between the peripheral portion of the opening of the distal end of the outer tube 3 in the closing film 3a and the fused portion 3b 'of the outer tube material is low. It is inserted so that the tip of the sharp part 21a of the inner tube 21 may contact the side part 3d.
【００３６】次に、上記構成の内視鏡用細胞採取具を使
用して生体腔内の細胞を採取する細胞採取作業について
説明する。まず、内視鏡用細胞採取具は通常時（使用
前）は図５（Ａ）に示すようにブラシ５が内管２１内に
引き込んで収納される。さらに、外管３の先端開口部の
周縁部位と外管素材の融解部分３ｂ´との接合部分のう
ち接合強度が低い貼り合わせ側部分３ｄに内管２１の鋭
利部２１ａの先端が当たるように向きを合わせて外管３
内に内管２１が挿入されるとともに、外管３の先端面が
閉鎖膜３ａによって閉塞された状態で保持される。Next, a description will be given of a cell collection operation for collecting cells in a living body cavity using the endoscope cell collection tool having the above-described configuration. First, the brush 5 is retracted and stored in the inner tube 21 as shown in FIG. Further, the tip of the sharp portion 21a of the inner tube 21 is brought into contact with the bonding side portion 3d having a low bonding strength among the joining portions between the peripheral portion of the distal end opening of the outer tube 3 and the melted portion 3b 'of the outer tube material. Outer tube 3
The inner tube 21 is inserted therein, and the distal end surface of the outer tube 3 is held closed by the closing film 3a.
【００３７】そして、この状態の内視鏡用細胞採取具を
予め生体腔内に挿入された内視鏡１の処置具挿通用チャ
ンネル２に挿通して生体腔内に導入し、外管３先端の閉
鎖膜３ａを生体腔内壁等の目的の細胞採取位置１４に近
づける。Then, the endoscope cell sampling tool in this state is inserted into the treatment tool insertion channel 2 of the endoscope 1 previously inserted into the body cavity, and is introduced into the body cavity. Is brought close to the target cell collection position 14 such as the inner wall of a living body cavity.
【００３８】この状態で、最初に第２の操作つまみ７ｂ
を先端側に押し込むと、外管３に対して内管２１が前進
し、内管２１の鋭利部２１ａの先端が閉鎖膜３ａにおけ
る外管３の先端開口部の周縁部位と外管素材の融解部分
３ｂ´との接合部分のうち接合強度が低い貼り合わせ側
部分３ｄに突き当たる。In this state, first, the second operation knob 7b
Is pushed toward the distal end side, the inner pipe 21 advances with respect to the outer pipe 3, and the tip of the sharp portion 21a of the inner pipe 21 melts the peripheral part of the opening of the outer pipe 3 at the tip end of the outer pipe 3 and the outer pipe material. It abuts on the bonding side portion 3d having low bonding strength among the bonding portions with the portion 3b '.
【００３９】この位置からさらに第２の操作つまみ７ｂ
を先端側に押し込むと、図５（Ｃ）に示すように閉鎖膜
３ａの接合強度が低い貼り合わせ側部分３ｄが内管２１
の鋭利部２１ａの先端によって容易に突き破られる。From this position, the second operation knob 7b is further moved.
Is pushed to the distal end side, as shown in FIG. 5C, the bonding side portion 3d of the closing film 3a having a low bonding strength is formed into the inner tube 21.
Easily penetrated by the tip of the sharp portion 21a.
【００４０】そして、この状態で続けて操作リング８を
先端側に押し出すと、外管３および内管２１に対して操
作ワイヤ４が前進し、ブラシ５が外管３の前方に突出さ
れる。そして、ブラシ５を細胞採取位置１４の目的の生
体腔内壁等に押し付けながら前後動作させて生体腔内壁
を擦過し、細胞を採取する。When the operation ring 8 is continuously pushed out to the distal end side in this state, the operation wire 4 advances with respect to the outer tube 3 and the inner tube 21, and the brush 5 is projected forward of the outer tube 3. Then, the brush 5 is moved back and forth while pressing the brush 5 against the target inner wall of the living body cavity at the cell collecting position 14 to scrape the inner wall of the living body cavity, and collect cells.
【００４１】さらに、細胞採取後、第１の操作つまみ７
ａおよび第２の操作つまみ７ｂを固定した状態で操作リ
ング８を手元側に引き、ブラシ５を内管２１内に引き込
んで収納させる。Further, after the cells are collected, the first operation knob 7
With the a and the second operation knob 7b fixed, the operation ring 8 is pulled toward the user, and the brush 5 is drawn into the inner tube 21 and stored.
【００４２】そして、この状態で第２の操作つまみ７ｂ
を手元側に引くことにより、内管２１内にブラシ５が収
納されたままの状態で内管２１が外管３内に引き込ま
れ、さらにこの状態で内視鏡用細胞採取具を内視鏡１の
処置具挿通用チャンネル２から抜去する。Then, in this state, the second operation knob 7b
Is pulled toward the user, the inner tube 21 is pulled into the outer tube 3 while the brush 5 is housed in the inner tube 21, and in this state, the endoscope cell collection tool is inserted into the endoscope. 1 is withdrawn from the treatment tool insertion channel 2.
【００４３】そこで、上記実施例では外管３内に内管２
１を挿入する際、閉鎖膜３ａにおける外管３の先端開口
部の周縁部位と外管素材の融解部分３ｂ´との接合部分
のうち接合強度が低い貼り合わせ側部分３ｄに内管２１
の鋭利部２１ａの先端が当たるように向きを合わせて挿
入されているので、第１の実施例に比べて小さな力で閉
鎖膜３ａを突き破ることができる。Therefore, in the above embodiment, the inner pipe 2 is
When the inner tube 21 is inserted, the inner tube 21 is attached to the bonding side portion 3d having a low bonding strength in the joining portion between the peripheral portion of the distal end opening of the outer tube 3 in the closing membrane 3a and the fused portion 3b 'of the outer tube material.
Is inserted so as to be in contact with the tip of the sharp portion 21a, so that the closing membrane 3a can be pierced with a smaller force than in the first embodiment.
【００４４】さらに、閉鎖膜３ａにおける融解部分３ｂ
´の折り曲げ側に当たる接合強度が高い部分３ｃが破れ
ず、接合強度が低い貼り合わせ側部分３ｄのみを破るこ
とができるので、破断した閉鎖膜３ａが生体腔内に脱落
するおそれを少なくすることができる。Further, the melting portion 3b of the closing film 3a
Since the portion 3c having a high bonding strength corresponding to the bending side of ′ is not broken, and only the bonding side portion 3d having a low bonding strength can be broken, it is possible to reduce the possibility that the broken closed membrane 3a will fall into the body cavity. it can.
【００４５】さらに、ブラシ５を内管２１内に収納させ
た状態で、外管３先端の閉鎖膜３ａの突き破り操作およ
び内管２１を外管３内に引き込む操作を行なうことがで
きるので、閉鎖膜３ａの外表面に付着した雑菌等がブラ
シ５に付着することを防止することができる。そのた
め、この場合には第１の実施例に比べて検査の信頼性を
さらに一層高めることができる。Further, in a state where the brush 5 is housed in the inner tube 21, the operation of breaking through the closing film 3a at the tip of the outer tube 3 and the operation of pulling the inner tube 21 into the outer tube 3 can be performed. It is possible to prevent bacteria and the like adhering to the outer surface of the film 3a from adhering to the brush 5. Therefore, in this case, the reliability of the inspection can be further improved as compared with the first embodiment.
【００４６】なお、この発明は上記各実施例に限定され
るものではない。例えば、第２の実施例の内視鏡用細胞
採取具における外管３の閉鎖膜３ａを第１の実施例の製
造方法で製造しても良く、逆に第１の実施例の内視鏡用
細胞採取具における外管３の閉鎖膜３ａを第２の実施例
の製造方法で製造しても良い。The present invention is not limited to the above embodiments. For example, the closing film 3a of the outer tube 3 in the cell sampling tool for an endoscope of the second embodiment may be manufactured by the manufacturing method of the first embodiment, and conversely, the endoscope of the first embodiment. The closing membrane 3a of the outer tube 3 in the cell sampling tool for use may be manufactured by the manufacturing method of the second embodiment.
【００４７】また、上記各実施例では外管３の閉鎖膜３
ａが平面状のものを示したが、先端が球面の芯金１０を
使用するとともに、外管３の素材の融解部分３ｂ´の押
し当て壁面１２に芯金１０の球面に対応する球状凹陥部
を形成することにより、球状の外管３の閉鎖膜３ａを成
形しても良い。In each of the above embodiments, the closing film 3 of the outer tube 3 is used.
a shows a planar shape, but a spherical metal core 10 having a spherical tip is used, and a spherical concave portion corresponding to the spherical surface of the metal core 10 is formed on the pressing wall surface 12 of the molten portion 3b 'of the material of the outer tube 3. May be formed to form the spherical closing film 3a of the outer tube 3.
【００４８】また、図８および図９はこの発明の第３の
実施例を示すものである。図８（Ａ）は内視鏡１の処置
具挿通用チャンネル２に挿通された内視鏡用細胞採取具
の概略構成を示すものである。FIGS. 8 and 9 show a third embodiment of the present invention. FIG. 8A shows a schematic configuration of an endoscope cell collection tool inserted through the treatment tool insertion channel 2 of the endoscope 1.
【００４９】この内視鏡用細胞採取具には例えばＦＥＰ
（ふっ化エチレン−プロピレン共重合体）等の合成樹脂
材料によって形成された可撓性の外管３１が設けられて
いる。この外管３１の内部には例えばＰＴＦＥ（ポリテ
トラフルオロエチレン）等の合成樹脂材料によって形成
された可撓性内管２１を挿通し、この内管２１の内部に
操作ワイヤ４を進退自在に挿通させ、さらにこの操作ワ
イヤ４の先端部のブラシ５を内管２１の内部に収納させ
ている。For example, FEP is used for this endoscope cell collection tool.
A flexible outer tube 31 made of a synthetic resin material such as (ethylene-propylene copolymer) is provided. A flexible inner tube 21 made of a synthetic resin material such as PTFE (polytetrafluoroethylene) is inserted into the outer tube 31, and the operation wire 4 is inserted into the inner tube 21 so as to be able to advance and retreat. Further, the brush 5 at the distal end of the operation wire 4 is housed inside the inner tube 21.
【００５０】この場合、外管３１の手元側端部には第１
の操作つまみ７ａ、内管２１の手元側端部には第１の走
査抓み７ｂがそれぞれ設けられている。そして、これら
の第１，第２の走査抓み７ａ，７ｂと操作ワイヤ４の手
元側端部の操作リング８とによって外管３１に対して内
管２１および操作ワイヤ４をそれぞれ進退させ得る操作
機構２２が形成されている。In this case, the first end of the outer tube 31
The operation knob 7a is provided with a first scanning knob 7b at the proximal end of the inner tube 21. The first and second scanning knobs 7a and 7b and the operation ring 8 at the proximal end of the operation wire 4 allow the inner tube 21 and the operation wire 4 to advance and retreat with respect to the outer tube 31, respectively. A mechanism 22 is formed.
【００５１】一方、外管３１の先端面にはブラシ５の使
用時に外管３１内からの突き当てによって破断可能な外
管３１自体の素材によって形成される閉鎖膜３１ａが設
けられている。この閉鎖膜３１ａは外管３１の軸心と直
交する方向に対して斜めに傾斜させた状態で形成されて
いる。そして、この閉鎖膜３１ａと外管３１の端部との
接合部位には接合強度が低い鈍角部３１ｃと、接合強度
が高い鋭角部３１ｄとが形成されている。On the other hand, on the distal end surface of the outer tube 31, there is provided a closing film 31a formed of the material of the outer tube 31 itself which can be broken by abutting from the inside of the outer tube 31 when the brush 5 is used. The closing film 31a is formed so as to be obliquely inclined with respect to a direction orthogonal to the axis of the outer tube 31. In addition, an obtuse angle portion 31c having a low joining strength and an acute angle portion 31d having a high joining strength are formed at a joining portion between the closing film 31a and the end of the outer tube 31.
【００５２】次に、上記外管３１の閉鎖膜３１ａの製造
方法について説明する。まず、図９（Ａ）に示すように
外管３１の内部にこの外管３１の長さよりも長い例えば
ステンレス製の丸棒芯金（芯体）３２をこの外管３１の
先端部近傍部位まで挿入する（芯体挿入工程）。Next, a method of manufacturing the closing film 31a of the outer tube 31 will be described. First, as shown in FIG. 9 (A), a round bar core (core) 32 made of, for example, stainless steel having a length longer than the length of the outer tube 31 is inserted into the outer tube 31 to a position near the distal end portion of the outer tube 31. Insert (core insertion step).
【００５３】この場合、芯金３２の外径は外管３１の内
径と略同形に形成されている。また、この芯金３２の先
端には、この芯金３２の軸心と直交する方向に対して斜
めに傾斜させた状態で切欠させた傾斜面３２ａが形成さ
れている。そして、この傾斜面３２ａによって芯金３２
の先端の端縁部に鈍角部３２ｂおよび鋭角部３２ｃがそ
れぞれ形成されている。In this case, the outer diameter of the core bar 32 is formed to be substantially the same as the inner diameter of the outer tube 31. Further, an inclined surface 32a which is notched in a state of being inclined obliquely with respect to a direction perpendicular to the axis of the core 32 is formed at the tip of the core 32. The core 32 is formed by the inclined surface 32a.
An obtuse angle part 32b and an acute angle part 32c are respectively formed at the edge of the tip of.
【００５４】また、この芯金３２は外管３１の一端部側
からこの外管３１の内部に挿入され、この外管３１の他
端部から例えば５mm程度内側の適宜の挿入位置まで挿入
された状態にセットされる。The core bar 32 is inserted into the outer tube 31 from one end of the outer tube 31 and is inserted from the other end of the outer tube 31 to an appropriate insertion position, for example, about 5 mm inside. Set to state.
【００５５】次に、図９（Ｂ）に示すように外管３１の
素材であるＦＥＰの融点（２５０〜２８０℃）以上の温
度（例えば３００℃程度）に加熱されたホットプレート
（壁面）２３を用意する。そして、外管３１における芯
金３２よりも先端側の部分３１ｂをこのホットプレート
２３に突き当てる。Next, as shown in FIG. 9B, a hot plate (wall surface) 23 heated to a temperature (for example, about 300 ° C.) or higher than the melting point (250 to 280 ° C.) of FEP, which is a material of the outer tube 31. Prepare Then, a portion 31 b of the outer tube 31 closer to the tip end than the core metal 32 is abutted against the hot plate 23.
【００５６】このとき、芯金３２の傾斜面３２ａがホッ
トプレート２３の面と水平となるように外管３１の素材
を突き当て、外管３１の素材を先端側の突き当て部分か
ら徐々に融解させる（外管素材融解工程）。この場合、
融解部分３１ｂ′の拡大にともない外管３１の先端側の
部分３１ｂをホットプレート２３に突き当てたままの状
態で外管３１および芯金３２を図９（Ｂ）中でＩ方向に
移動させ、芯金３２の傾斜面３２ａの鋭角部３２ｃ側か
ら鈍角部３２ｂ側まで外管３１の素材の融解部分３１
ｂ′によって外管３１の先端開口部を閉塞させる。さら
に、この状態で冷却させることにより、外管３１の先端
開口部に薄膜状の閉鎖膜３１ａを形成させる（閉鎖膜形
成工程）。At this time, the material of the outer tube 31 is abutted so that the inclined surface 32a of the core bar 32 is horizontal to the surface of the hot plate 23, and the material of the outer tube 31 is gradually melted from the abutting portion on the tip side. (Outer tube material melting step). in this case,
With the expansion of the melted portion 31b ', the outer tube 31 and the core metal 32 are moved in the direction I in FIG. 9 (B) while the tip 31b of the outer tube 31 is kept in contact with the hot plate 23, From the acute angle portion 32c side of the inclined surface 32a of the metal core 32 to the obtuse angle portion 32b side, the molten portion 31 of the material of the outer tube 31
The tip opening of the outer tube 31 is closed by b '. Furthermore, by cooling in this state, a thin film-like closing film 31a is formed at the opening of the distal end of the outer tube 31 (closing film forming step).
【００５７】その後、図９（Ｄ）に示す芯金３２の軸心
と、芯金３２の傾斜面３２ａとのなす角θと略同角度の
傾斜端部３３ａを有するパイプ状カッター３３内に外管
３１の上端部を挿入させ、この状態でパイプ状カッター
３３を上方から外管３１の外周面に沿って下降させて外
管３１の素材の融解部分３１ｂ′における外管３１の外
径よりも外部側にはみだしている余分な部分を切断す
る。なお、図９（Ｅ）中のＡは外管３１の素材の融解部
分の切断か所を示すものである。また、パイプ状カッタ
ー３３の内径は外管３１の外径と略同径に形成されてい
る。After that, the inside of the pipe-shaped cutter 33 having an inclined end 33a having substantially the same angle as the angle θ between the axis of the metal core 32 and the inclined surface 32a of the metal core 32 shown in FIG. The upper end of the pipe 31 is inserted, and in this state, the pipe-shaped cutter 33 is lowered from above along the outer peripheral surface of the outer pipe 31 so that the outer diameter of the outer pipe 31 at the melted portion 31b ′ of the material of the outer pipe 31 is smaller than Cut off any extra parts protruding to the outside. Note that A in FIG. 9 (E) indicates a cutting position of a melting portion of the material of the outer tube 31. The inner diameter of the pipe-shaped cutter 33 is formed to be substantially the same as the outer diameter of the outer tube 31.
【００５８】なお、外管３１の先端開口部の周縁部位と
外管素材の融解部分３ｂ′との接合部分は外管３１の周
方向に沿って場所毎にその接合強度が異なり、融解部分
３１ｂ′の折り曲げ側に当たる部分に接合強度が高い部
分、つまり鋭角部３１ｄ、この鋭角部３１ｄと反対側の
貼り合わせ側に当たる部分に接合強度が低い部分、つま
り鈍角部３１ｃがそれぞれ形成されている。The joining strength between the peripheral portion of the opening at the distal end of the outer tube 31 and the melted portion 3b 'of the outer tube material is different from place to place along the circumferential direction of the outer tube 31 at each location. A portion having high bonding strength, that is, an acute angle portion 31d, is formed at a portion corresponding to the bending side of ′, and a portion having low bonding strength, that is, an obtuse angle portion 31c is formed at a portion corresponding to the bonding side opposite to the acute angle portion 31d.
【００５９】次に、上記構成の内視鏡用細胞採取具を使
用して生体腔内の細胞を採取する細胞採取作業について
説明する。まず、内視鏡用細胞採取具は通常時（使用
前）は図８（Ａ）に示すようにブラシ５が内管２１内に
引き込んで収納され、外管３１内に内管２１が挿入され
るとともに、外管３１の先端面が閉鎖膜３１ａによって
閉塞された状態で保持される。Next, a description will be given of a cell collection operation for collecting cells in a living body cavity using the endoscope cell collection tool having the above-described configuration. First, the brush 5 is retracted into the inner tube 21 and stored in the inner tube 21 as shown in FIG. At the same time, the distal end surface of the outer tube 31 is kept closed by the closing film 31a.
【００６０】そして、この状態の内視鏡用細胞採取具を
予め生体腔内に挿入された内視鏡１の処置具挿通用チャ
ンネル２に挿通して生体腔内に導入し、外管３１の先端
の閉鎖膜３１ａを生体腔内壁等の目的の細胞採取位置１
４に近づける。Then, the endoscope cell sampling tool in this state is inserted into the treatment tool insertion channel 2 of the endoscope 1 previously inserted into the body cavity, and introduced into the body cavity. A target cell collection position 1 such as the inner wall of a body cavity or the like is placed on the closing membrane 31a at the tip
Close to 4.
【００６１】この状態で、最初に第２の操作つまみ７ｂ
を先端側に押し込むと、外管３１に対して内管２１が前
進し、内管２１の先端が閉鎖膜３１ａにおける外管３１
の先端開口部の周縁部位と外管素材の融解部分３１ｂ′
との接合部分のうち接合強度が低い貼り合わせ側部分、
つまり鈍角部３１ｃに突き当たる。In this state, first, the second operation knob 7b
Is pushed toward the distal end side, the inner tube 21 advances with respect to the outer tube 31, and the distal end of the inner tube 21
Peripheral part of the opening of the tip and the melting portion 31b 'of the outer tube material
Bonding part with low bonding strength among the bonding parts with
That is, it hits the obtuse angle portion 31c.
【００６２】この位置からさらに第２の操作つまみ７ｂ
を先端側に押し込むと、図８（Ｂ）に示すように閉鎖膜
３１ａの接合強度が低い貼り合わせ側部分、つまり鈍角
部３１ｃが内管２１の先端によって容易に突き破られ
る。From this position, the second operation knob 7b is further moved.
8B, the bonding portion of the closing film 31a having a low bonding strength, that is, the obtuse angle portion 31c is easily pierced by the distal end of the inner tube 21 as shown in FIG.
【００６３】そして、この状態で続けて操作リング８を
先端側に押し出すと、外管３１および内管２１に対して
操作ワイヤ４が前進し、ブラシ５が外管３１の前方に突
出される。そして、この状態で、ブラシ５を細胞採取位
置１４の目的の生体腔内壁等に押し付けながら前後動作
させて生体腔内壁を擦過し、細胞を採取する。Then, when the operation ring 8 is continuously pushed out to the distal end side in this state, the operation wire 4 advances with respect to the outer tube 31 and the inner tube 21, and the brush 5 protrudes forward of the outer tube 31. Then, in this state, the brush 5 is moved forward and backward while pressing the brush 5 against the target inner wall of the living body cavity at the cell collecting position 14 to scrape the inner wall of the living body cavity and collect cells.
【００６４】さらに、細胞採取後、第１の操作つまみ７
ａおよび第２の操作つまみ７ｂを固定した状態で操作リ
ング８を手元側に引き、ブラシ５を内管２１内に引き込
んで収納させる。Further, after the cells are collected, the first operation knob 7
With the a and the second operation knob 7b fixed, the operation ring 8 is pulled toward the user, and the brush 5 is drawn into the inner tube 21 and stored.
【００６５】そして、この状態で第２の操作つまみ７ｂ
を手元側に引くことにより、内管２１内にブラシ５が収
納されたままの状態で内管２１が外管３１内に引き込ま
れ、さらにこの状態で内視鏡用細胞採取具を内視鏡１の
処置具挿通用チャンネル２から抜去する。Then, in this state, the second operation knob 7b
Is pulled toward the user, the inner tube 21 is pulled into the outer tube 31 while the brush 5 is housed in the inner tube 21, and in this state, the endoscope cell collection tool is inserted into the endoscope. 1 is withdrawn from the treatment tool insertion channel 2.
【００６６】そこで、上記実施例では、外管３１内に内
管２１がどのような向きで挿入されても、閉鎖膜３１ａ
における外管３１の先端開口部の周縁部位と外管素材の
融解部分３１ｂ′との接合部分のうち接合強度が低い貼
り合わせ側部分３１ｂに内管２１の先端が突き当たるの
で、内視鏡用細胞採取具の組立て作業を簡略化すること
ができるとともに、小さな力で閉鎖膜３１ａを突き破る
ことができる。Therefore, in the above embodiment, no matter what direction the inner tube 21 is inserted into the outer tube 31,
Since the tip of the inner tube 21 abuts on the bonding side portion 31b having a low bonding strength among the joining portions between the peripheral portion of the opening portion of the distal end of the outer tube 31 and the melted portion 31b 'of the outer tube material, the endoscope cell The assembling operation of the sampling tool can be simplified, and the closing membrane 31a can be broken through with a small force.
【００６７】さらに、閉鎖膜３１ａにおける融解部分３
１ｂ′の折り曲げ側に当たる接合強度が高い部分３１ｃ
が破れず、接合強度が低い貼り合わせ側部分３１ｄのみ
を破ることができるので、破断した閉鎖膜３１ａが生体
腔内に脱落するおそれを少なくすることができる。Further, the melting portion 3 in the closing film 31a
A portion 31c having a high bonding strength corresponding to the bending side of 1b '
Can be broken, and only the bonding side portion 31d having a low bonding strength can be broken, so that the possibility that the broken closing film 31a falls off into the living body cavity can be reduced.
【００６８】さらに、ブラシ５を内管２１内に収納させ
た状態で、外管３１先端の閉鎖膜３１ａの突き破り操作
および管内２１を外管３１内に引き込む操作を行なうこ
とができるので、閉鎖膜３１ａの外表面に付着した雑菌
等がブラシ５に付着することを防止することができる。
そのため、この場合には第１の実施例に比べて検査の信
頼性をさらに一層高めることができる。Further, in a state where the brush 5 is housed in the inner tube 21, the operation of breaking through the closing film 31a at the tip of the outer tube 31 and the operation of drawing the inside 21 into the outer tube 31 can be performed. It is possible to prevent germs and the like adhering to the outer surface of the brush 31a from adhering to the brush 5.
Therefore, in this case, the reliability of the inspection can be further improved as compared with the first embodiment.
【００６９】また、図１０乃至図１２はこの発明の第４
の実施例を示すものである。これは、図１０（Ａ）に示
すように第３の実施例における内管２１の先端にこの内
管２１の軸心と直交する方向に対して斜めに傾斜させた
状態で切欠された鋭利端部２１ａを形成したものであ
る。FIGS. 10 to 12 show a fourth embodiment of the present invention.
FIG. This is because, as shown in FIG. 10 (A), the sharp end cut off at the tip of the inner tube 21 in the third embodiment in a state of being obliquely inclined with respect to a direction perpendicular to the axis of the inner tube 21. The portion 21a is formed.
【００７０】さらに、外管４１の先端面には外管４１の
軸心と直交する方向に対して斜めに傾斜させた状態で閉
鎖膜４１ａが形成されている。そして、この閉鎖膜４１
ａと外管４１の端部との接合部位には接合強度が高い鈍
角部４１ｃと、接合強度が低い鋭角部４１ｄとがそれぞ
れ形成されている。Further, a closing film 41a is formed on the distal end surface of the outer tube 41 in a state where the closing film 41a is inclined with respect to a direction perpendicular to the axis of the outer tube 41. And, this closing film 41
An obtuse angle portion 41c having a high joint strength and an acute angle portion 41d having a low joint strength are formed at the joint portion between the a and the end of the outer tube 41, respectively.
【００７１】次に、上記外管４１の閉鎖膜４１ａの製造
方法について説明する。まず、第３の実施例と同じ芯金
３２を外管４１内に挿入する。続いて、外管４１の素材
の先端部をホットプレート２３に突き当てて融解させる
際に、外管４１の素材の融解部分４１ｂ′の拡大にとも
ない外管４１の先端側の部分４１ｂをホットプレート２
３に突き当てたままの状態で外管４１および芯金３２を
第３の実施例とは逆方向、つまり、図１１（Ａ）中でＪ
方向に移動させ、芯金３２の傾斜面３２ａの鈍角部３２
ｂ側から鋭角部３２ａ側まで外管４１の素材の融解部分
４１ｂ′によって外管４１の先端側開口部を閉塞させ
る。Next, a method of manufacturing the closing film 41a of the outer tube 41 will be described. First, the same core bar 32 as in the third embodiment is inserted into the outer tube 41. Subsequently, when the distal end portion of the material of the outer tube 41 is abutted against the hot plate 23 to be melted, the portion 41b on the distal end side of the outer tube 41 is hot-plated with the expansion of the molten portion 41b 'of the material of the outer tube 41. 2
In the state where the outer tube 41 and the core bar 32 are kept in contact with each other, the outer tube 41 and the core bar 32 are moved in the opposite direction to that of the third embodiment, that is, in FIG.
In the direction of the oblique angle 32 of the inclined surface 32a of the metal core 32.
From the b side to the acute angle portion 32a side, the distal end side opening of the outer tube 41 is closed by the molten portion 41b 'of the material of the outer tube 41.
【００７２】この方法によると外管４１の素材の融解部
分４１ｂ′の折り曲げ側に当たる部分に接合強度が高い
部分、つまり鈍角部４１ｃ、この鈍角部４１ｃと反対側
の貼り合わせ側に当たる部分に接合強度が低い部分、つ
まり鋭角部４１ｄがそれぞれ形成され、第３の実施例の
閉鎖膜３１ａの鈍角部３１ｃおよび鋭角部３１ｄの各接
合強度とは逆の関係となる。According to this method, the joining strength is high at the portion corresponding to the bent side of the melted portion 41b 'of the material of the outer tube 41, that is, at the obtuse angle portion 41c, and at the portion corresponding to the bonding side opposite to the obtuse angle portion 41c. Are formed, that is, the acute angle portions 41d are formed, respectively, and have a relationship opposite to the bonding strength of the obtuse angle portions 31c and the acute angle portions 31d of the closing film 31a of the third embodiment.
【００７３】次に、上記構成の内視鏡用細胞採取具を使
用した細胞採取作業について説明する。まず、第３の実
施例と同様に、本内視鏡用細胞採取具を、採取部位に近
づける。Next, a description will be given of a cell collection operation using the endoscope cell collection tool having the above-described configuration. First, in the same manner as in the third embodiment, the endoscope cell collection tool is brought closer to the collection site.
【００７４】この状態で第２の操作つまみ７ｂを先端側
に押し込むと、外管４１に対して内管２１が前進し、図
１０（Ａ）に示すように内管２１の鋭利端部２１ａの先
端が閉鎖膜４１ａの、ある一部分に突き当たる。In this state, when the second operation knob 7b is pushed toward the distal end, the inner tube 21 moves forward with respect to the outer tube 41, and as shown in FIG. The tip abuts a part of the closing membrane 41a.
【００７５】この位置から更に第２のつまみ７ｂを先端
側に押し込むと、図１０（Ｂ）に示すように内管２１の
鋭利端部２１ａが外管４１内で回転し、外管４１の鋭角
部４１ｄの向きと、内管２１の鋭利端部２１ａの向きが
合い、この状態で、更に第２の操作つまみ７ｂを先端側
に押し込むと、内管２１の鋭利端部２１ａの先端が閉鎖
膜４１ａにおける外管４１の先端開口部の周縁部位と外
管素材の融解部分４１ｂ′との接合部分のうち接合強度
が低い貼り合わせ側の鋭角部４１ｂに突き当たる。When the second knob 7b is further pushed into the distal end from this position, the sharp end 21a of the inner tube 21 rotates in the outer tube 41 as shown in FIG. The direction of the sharp end 21a of the inner tube 21 matches the direction of the sharp end 21a of the inner tube 21. In this state, when the second operation knob 7b is further pushed toward the front end, the end of the sharp end 21a of the inner tube 21 is closed. In the joint portion between the peripheral portion of the distal end opening portion of the outer tube 41 and the melted portion 41b 'of the outer tube material at 41a, the joint portion abuts on the acute angle portion 41b on the bonding side where the bonding strength is low.
【００７６】さらに、この位置から第２の操作つまみ７
ｂを先端側に押し込むと、図１０（Ｃ）に示すように閉
鎖膜４１ａの接合強度が低い貼り合わせ側の鋭角部４１
ｄが内管２１の鋭利端部２１ａの先端によって容易に突
き破られる。後の操作は第３の実施例と同様である。Further, from this position, the second operation knob 7
b is pushed into the distal end side, and as shown in FIG. 10C, the acute angle portion 41 on the bonding side where the bonding strength of the closing film 41a is low.
d is easily pierced by the tip of the sharp end 21a of the inner tube 21. The subsequent operation is the same as in the third embodiment.
【００７７】そこで、上記実施例では、第１〜第３の各
実施例と同様に細胞採取具の製作の容易化を図ることが
できるとともに、細胞採取時に生体腔内の細胞を採取目
的部位以外の雑菌等によって汚染させることなく採取目
的部位の細胞のみを確実に採取することができ、正確な
細胞検査を行なわせることができる。Therefore, in the above-described embodiment, it is possible to facilitate the manufacture of the cell collection tool as in the first to third embodiments, and at the time of cell collection, to collect cells in the body cavity other than the target site. It is possible to reliably collect only the cells at the collection target site without being contaminated by various bacteria and the like, and to perform an accurate cell test.
【００７８】さらに、上記実施例では、特に図１２
（Ａ）に示すように、閉鎖膜４１ａが突き破られ、完全
に開口するまでの角度θ2 が、同図（Ｂ）で示す第３の
実施例の閉鎖膜３１ａの開口時の移動角度θ2 ´よりも
小さいので、閉鎖膜４１ａの折り曲げ側の鈍角部４１ｃ
に加わる負担が小さく、閉鎖膜４１ａの体内への脱落の
おそれを第３の実施例よりもさらに低くすることができ
る。さらに、その他この発明の要旨を逸脱しない範囲で
種々変形実施できることは勿論である。Further, in the above embodiment, in particular, FIG.
As shown in (A), the angle θ 2 from when the closing film 41a is pierced and completely opened is the moving angle θ when the closing film 31a is opened in the third embodiment shown in FIG. 2 ′, the obtuse angle portion 41c on the bending side of the closing film 41a.
And the risk of the closing film 41a falling into the body can be further reduced as compared with the third embodiment. Further, it goes without saying that various modifications can be made without departing from the spirit of the present invention.
【００７９】[0079]
【発明の効果】この発明によれば細胞採取具の製作の容
易化を図ることができるとともに、細胞採取時に生体腔
内の細胞を採取目的部位以外の雑菌等によって汚染させ
ることなく採取目的部位の細胞のみを確実に採取するこ
とができ、正確な細胞検査を行なわせることができる。According to the present invention, it is possible to facilitate the manufacture of the cell collection tool, and at the time of cell collection, the cells in the body cavity are not contaminated with bacteria other than the collection target site. Only cells can be reliably collected, and an accurate cell test can be performed.
【図１】 内視鏡の処置具挿通用チャンネルに挿通され
た第１の実施例の細胞採取具の概略構成を示す縦断面
図。FIG. 1 is a longitudinal sectional view showing a schematic configuration of a cell collection tool of a first embodiment inserted into a treatment tool insertion channel of an endoscope.
【図２】 この発明の第１の実施例の製造方法による外
管閉鎖膜の製造工程を示すもので、（Ａ）は外管素材の
加熱状態を示す縦断面図、（Ｂ）は外管素材の融解部分
を壁面に押し当てた状態を示す斜視図、（Ｃ）は外管素
材の融解部分から閉鎖膜以外の余分な部分を切断して閉
鎖膜を形成させる状態を示す斜視図、（Ｄ）は外管素材
の融解部分の切断か所を示す横断面図。FIGS. 2A and 2B show a manufacturing process of an outer tube closing film according to the manufacturing method of the first embodiment of the present invention, wherein FIG. 2A is a longitudinal sectional view showing a heating state of an outer tube material, and FIG. FIG. 3C is a perspective view showing a state in which a molten portion of the material is pressed against a wall surface, and FIG. 3C is a perspective view showing a state in which an excess portion other than the closing film is cut from the molten portion of the outer tube material to form a closing film; D) is a transverse cross-sectional view showing a cut portion of a melting portion of the outer tube material.
【図３】 カッターを一部破断して示す側面図。FIG. 3 is a side view showing a cutter partially broken away.
【図４】 細胞採取具の使用状態を示す要部の縦断面
図。FIG. 4 is a longitudinal sectional view of a main part showing a use state of the cell collection tool.
【図５】 第２の実施例の細胞採取具の概略構成を示す
を示すもので、（Ａ）は内視鏡の処置具挿通用チャンネ
ルに挿通された細胞採取具を示す縦断面図、（Ｂ）は外
管内の内管の配設状態を示す縦断面図、（Ｃ）は閉鎖膜
の破断状態を示す縦断面図。FIG. 5 shows a schematic configuration of a cell collection tool according to a second embodiment, in which (A) is a longitudinal sectional view showing a cell collection tool inserted into a treatment tool insertion channel of an endoscope, (B) is a longitudinal sectional view showing an arrangement state of the inner tube in the outer tube, and (C) is a longitudinal sectional view showing a broken state of the closing membrane.
【図６】 外管素材の融解状態を示す斜視図。FIG. 6 is a perspective view showing a molten state of the outer tube material.
【図７】 外管素材の融解部分の切断か所を示す横断面
図。FIG. 7 is a cross-sectional view showing a cutting place of a melting portion of the outer tube material.
【図８】 第３の実施例の細胞採取具の概略構成を示す
を示すもので、（Ａ）は内視鏡の処置具挿通用チャンネ
ルに挿通された細胞採取具を示す縦断面図、（Ｂ）は閉
鎖膜の破断状態を示す縦断面図。FIG. 8 shows a schematic configuration of a cell collection tool according to a third embodiment, in which (A) is a longitudinal sectional view showing a cell collection tool inserted into a treatment tool insertion channel of an endoscope; (B) is a longitudinal sectional view showing a broken state of the closing membrane.
【図９】 この発明の第３の実施例の製造方法による外
管閉鎖膜の製造工程を示すもので、（Ａ）は外管素材の
加熱部分を示す縦断面図、（Ｂ）は外管素材の融解部分
を壁面に押し当てた状態を示す斜視図、（Ｃ）はカッタ
ーを示す縦断面図、（Ｄ）は芯金を示す縦断面図、
（Ｅ）は外管素材の融解部分の切断か所を示す横断面
図。9A and 9B show a manufacturing process of an outer tube closing film by a manufacturing method according to a third embodiment of the present invention, wherein FIG. 9A is a longitudinal sectional view showing a heated portion of an outer tube material, and FIG. A perspective view showing a state in which a molten portion of the material is pressed against a wall surface, (C) is a longitudinal sectional view showing a cutter, (D) is a longitudinal sectional view showing a cored bar,
(E) is a cross-sectional view showing a cutting place of a melting portion of the outer tube material.
【図１０】 第４の実施例の細胞採取具の概略構成を示
すを示すもので、（Ａ）は内視鏡の処置具挿通用チャン
ネルに挿通された細胞採取具を示す縦断面図、（Ｂ）は
内管の回転状態を示す縦断面図、（Ｃ）は閉鎖膜の破断
状態を示す縦断面図。FIG. 10 shows a schematic configuration of a cell collection tool according to a fourth embodiment, in which (A) is a longitudinal sectional view showing a cell collection tool inserted into a treatment tool insertion channel of an endoscope; (B) is a longitudinal sectional view showing a rotating state of the inner tube, and (C) is a longitudinal sectional view showing a broken state of the closing membrane.
【図１１】 この発明の第４の実施例の製造方法による
外管閉鎖膜の製造工程を示すもので、（Ａ）は外管素材
の融解部分を壁面に押し当てた状態を示す斜視図、
（Ｂ）は外管素材の融解部分の切断か所を示す横断面
図。FIG. 11 is a perspective view showing a manufacturing process of an outer tube closing film by a manufacturing method according to a fourth embodiment of the present invention, in which (A) shows a state in which a molten portion of an outer tube material is pressed against a wall surface,
(B) is a cross-sectional view showing a cut portion of a melting portion of the outer tube material.
【図１２】 （Ａ）は第４の実施例の製造方法による外
管閉鎖膜の破断時の変形状態を示す縦断面図、（Ｂ）は
第３の実施例の製造方法による外管閉鎖膜の破断時の変
形状態を示す縦断面図。12A is a longitudinal sectional view showing a deformed state of the outer tube closing film at the time of breakage by the manufacturing method of the fourth embodiment, and FIG. 12B is an outer tube closing film by the manufacturing method of the third embodiment. FIG. 3 is a longitudinal sectional view showing a deformed state at the time of breaking.
【図１３】 従来例を示す要部の縦断面図。FIG. 13 is a longitudinal sectional view of a main part showing a conventional example.
【図１４】 別の従来例を示す要部の縦断面図。FIG. 14 is a longitudinal sectional view of a main part showing another conventional example.
【図１５】 極度に湾曲のかけられた内視鏡の処置具挿
通チャンネル内で図１４の細胞採取具を進退させた状態
を示す縦断面図。FIG. 15 is a longitudinal sectional view showing a state in which the cell collection tool of FIG. 14 is advanced and retracted in the treatment instrument insertion channel of the endoscope that is extremely curved.
３，３１，４１…外管，３ａ，３１ａ，４１ａ…閉鎖
膜，３ｂ´，３１ｂ´，４１ｂ´…外管素材の融解部
分，５…ブラシ（細胞採取用具），１０，３２…丸棒芯
金（芯体），１２…壁面，２３…ホットプレート（壁
面）。3, 31, 41 ... outer tube, 3a, 31a, 41a ... closing film, 3b ', 31b', 41b '... melting portion of outer tube material, 5 ... brush (cell collection tool), 10, 32 ... round rod core Gold (core), 12 ... wall surface, 23 ... hot plate (wall surface).
Claims (1)
性の外管の内部に芯体を前記外管の先端部近傍部位まで
挿入する芯体挿入工程と、前記外管における前記芯体よ
りも先端側の部分に前記外管の素材の融点以上の温度を
加えて前記外管の素材を融解させる外管素材融解工程
と、前記外管素材の融解部分を壁面に押し当て、前記外
管素材の融解部分によって前記外管の先端開口部を閉塞
させることにより、前記外管の先端開口部に前記外管内
からの前記細胞採取用具の突き当てによって破断可能な
閉鎖膜を形成させる閉鎖膜形成工程とを具備したことを
特徴とする細胞採取具用の外管閉鎖膜の製造方法。1. A core insertion step of inserting a core into a flexible outer tube holding a cell collection tool in a housed state up to a position near a distal end of the outer tube, and the core in the outer tube. An outer tube material melting step of applying a temperature equal to or higher than the melting point of the material of the outer tube to a portion closer to the distal end to melt the material of the outer tube, and pressing the melted portion of the outer tube material against a wall surface, A closing membrane for closing a tip opening of the outer tube with a molten portion of a tube material to form a closing film that can be broken by abutting the cell collection tool from inside the outer tube at the tip opening of the outer tube. A method for producing an outer tube-closing membrane for a cell-collecting device, comprising a forming step.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3205193A JP3025066B2 (en) | 1990-08-22 | 1991-08-15 | Method for producing outer tube closing membrane for cell collection tool |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2-218927 | 1990-08-22 | ||
| JP21892790 | 1990-08-22 | ||
| JP3205193A JP3025066B2 (en) | 1990-08-22 | 1991-08-15 | Method for producing outer tube closing membrane for cell collection tool |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05143A JPH05143A (en) | 1993-01-08 |
| JP3025066B2 true JP3025066B2 (en) | 2000-03-27 |
Family
ID=26514905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3205193A Expired - Fee Related JP3025066B2 (en) | 1990-08-22 | 1991-08-15 | Method for producing outer tube closing membrane for cell collection tool |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3025066B2 (en) |
-
1991
- 1991-08-15 JP JP3205193A patent/JP3025066B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05143A (en) | 1993-01-08 |
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