JP2981680B2 - Stabilized copper-containing validamycin formulation - Google Patents
Stabilized copper-containing validamycin formulationInfo
- Publication number
- JP2981680B2 JP2981680B2 JP2325190A JP32519090A JP2981680B2 JP 2981680 B2 JP2981680 B2 JP 2981680B2 JP 2325190 A JP2325190 A JP 2325190A JP 32519090 A JP32519090 A JP 32519090A JP 2981680 B2 JP2981680 B2 JP 2981680B2
- Authority
- JP
- Japan
- Prior art keywords
- validamycin
- parts
- copper
- preparation
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Agricultural Chemicals And Associated Chemicals (AREA)
Description
【発明の詳細な説明】 １） 発明の目的 産業上の利用分野 本発明は、銅化合物とバリダマイシンを含有する農薬
製剤中のバリダマイシンの経時安定化をはかるための技
術を提供することに関するものである。DETAILED DESCRIPTION OF THE INVENTION 1) Object of the Invention Field of the Invention The present invention relates to providing a technique for stabilizing baridamycin over time in an agrochemical formulation containing a copper compound and validamycin. .
従来の技術 本発明において使用される水酸化マグネシウムは特開
昭56−79601号公報、特開昭57−112311号公報に記載の
通り銅を含有する製剤の薬害軽減剤として既知である。
また、酸化マグネシウムは特開昭58−201701号公報に記
載の通り農薬粉剤の帯電防止剤として既知である。2. Description of the Related Art Magnesium hydroxide used in the present invention is known as a safener for copper-containing preparations as described in JP-A-56-79601 and JP-A-57-112311.
Also, magnesium oxide is known as an antistatic agent for pesticide dusts as described in JP-A-58-201701.
発明が解決しようとする課題 本発明の製剤中に含まれる農薬活性成分のうち銅化合
物は稲こうじ病のほか変色米、着色米等を起こす病原菌
に対して有効な薬剤であり、またバリダマイシンは稲紋
枯病に特に有効な薬剤である。これらの病害を防除する
に当たって上記の農薬活性成分を含む薬剤をそれぞれ施
用すればよいが実際には防除労力の省力化をはかるため
これらの２つの農薬活性成分を含む２種混合製剤または
更に別の農薬活性成分を加えた３種以上の混合製剤が望
まれることが多い。しかし、バリダマイシンは銅化合物
と共存すると極めて不安定であり従来の技術で製造した
粉剤、水和剤の場合常温１カ年経過で活性成分のバリダ
マイシンは50％以上分解してしまう。このように長期間
貯蔵することができなければ農薬製品として通用しない
ので、活性成分の経時変化の低減はどうしても解決しな
ければならない課題である。したがって、本発明は銅と
バリダマイシンが共存する粉剤、水和剤などの各種製剤
中でバリダマイシンが経時的に分解せず、長期間の貯蔵
にも耐える技術を提供することを目的とするものであ
る。Problems to be Solved by the Invention Among the pesticidal active ingredients contained in the preparation of the present invention, copper compounds are effective agents against pathogens causing rice discoloration, discolored rice, colored rice and the like, and validamycin is used in rice. It is a particularly effective drug for sheath blight. In controlling these diseases, the above-mentioned chemicals containing the pesticidal active ingredient may be applied, respectively. However, in order to save labor for controlling pests, a two-mixed preparation containing these two pesticidal active ingredients or a further mixed preparation may be used. Often, a mixed preparation of three or more kinds to which an agricultural chemical active ingredient is added is desired. However, validamycin is extremely unstable when coexisting with a copper compound. In the case of powders and wettable powders produced by conventional techniques, the active ingredient validamycin is decomposed by 50% or more after one year at room temperature. If it cannot be stored for a long period of time as described above, it cannot be used as a pesticide product, and reduction of the change over time of the active ingredient is a problem that must be solved. Accordingly, an object of the present invention is to provide a technique in which validamycin is not degraded with time in various preparations such as powders and wettable powders in which copper and validamycin coexist, and can withstand long-term storage. .
２） 発明の構成 課題を解決するための手段 本発明者らは、上記した目的を達成するために鋭意研
究をした。その結果、銅化合物とバリダマイシンが共存
する粉剤、水和剤などの各種製剤中に合成法で製造した
水酸化マグネシウムまたは天然産マグネサイトを焼成工
程を経て製造した水酸化マグネシウムもしくは酸化マグ
ネシウムのうち１種または２種を安定化剤として製剤全
量の１〜20重量％程度を添加することにより製剤中での
バリダマイシンの分解を長期間にわたり顕著に抑制し得
ることを見出した。2) Configuration of the Invention Means for Solving the Problems The present inventors have conducted intensive research to achieve the above-mentioned object. As a result, in various preparations such as powders and wettable powders in which a copper compound and validamycin coexist, one of magnesium hydroxide produced by a synthetic method or magnesium hydroxide or magnesium oxide produced by calcination of naturally occurring magnesite was used. It has been found that the degradation of validamycin in the preparation can be significantly suppressed over a long period of time by adding about 1 to 20% by weight of the total amount of the preparation as one or two kinds of stabilizers.
作 用 本発明における安定化剤水酸化マグネシウムまたは酸
化マグネシウムは、銅化合物とバリダマイシンが共存す
る農薬製剤中においてバリダマイシンの経時的な分解防
止剤として作用する。Effect The stabilizer of the present invention, magnesium hydroxide or magnesium oxide, acts as an agent for preventing the degradation of validamycin over time in an agricultural chemical formulation in which a copper compound and validamycin coexist.
実施例 本発明の安定化された製剤を製造するには何ら特別の
方法および装置を必要とせず、農薬製造上で通常用いら
れる各種の担体および補助剤を使用して粉剤および水和
剤を製造すればよい。バリダマイシンの分解防止剤とし
て用いられる水酸化マグネシウムまたは酸化マグネシウ
ムの製剤への添加量は１〜20重量％好ましくは３〜15重
量％である。本発明の製剤に含まれる農薬活性成分のう
ち銅化合物は塩基性塩化銅、塩基性硫酸銅、水酸化第二
銅、塩基性炭酸銅等の無機銅ならびに８−オキシキノリ
ン銅等の有機銅が挙げられる。また担体としては通常農
薬製剤に広く使用されているもの例えばクレー、タル
ク、カオリン、ベントナイト、炭カル、石膏、珪そう土
などの微粉状のものが使用可能であり、これらは単独ま
たは２種以上を混合して使用できる。また本発明の製剤
の有する効果を失わせない範囲で各種物理性改良剤を併
用することができる。以下に本発明を具体的に説明する
ために実施例を挙げるが、本発明はこれらの例示のみに
限定されるものではない。EXAMPLES Manufacturing of the stabilized preparation of the present invention does not require any special method and equipment, and manufactures powders and wettable powders using various carriers and auxiliaries commonly used in the production of pesticides. do it. The amount of magnesium hydroxide or magnesium oxide used as an agent for degrading validamycin in the preparation is 1 to 20% by weight, preferably 3 to 15% by weight. Copper compounds among the pesticidal active ingredients contained in the preparation of the present invention are basic copper chloride, basic copper sulfate, cupric hydroxide, inorganic copper such as basic copper carbonate and organic copper such as 8-oxyquinoline copper. No. As the carrier, those commonly used widely in agricultural chemical formulations such as clay, talc, kaolin, bentonite, charcoal, gypsum, and diatomaceous earth can be used, and these can be used alone or in combination of two or more. Can be used in combination. In addition, various physical property improvers can be used in combination as long as the effects of the preparation of the present invention are not lost. Examples will be given below for specifically describing the present invention, but the present invention is not limited to only these examples.
なお、実施例中に部とあるのはすべて重量部を意味す
る。In the examples, "parts" means "parts by weight".
実施例１ （粉剤） 塩基性塩化銅（金属銅として58.5％を含む；以下の実
施例でも同様）8.6部、バリダマイシン（純度62.3％；
以下の実施例でも同様）0.50部、水酸化マグネシウム12
部、ホワイトカーボン２部、クレー76.9部をハンマーミ
ルで混合粉砕して本発明の粉剤を得る。Example 1 (Powder) 8.6 parts of basic copper chloride (containing 58.5% as metallic copper; also in the following examples), validamycin (purity: 62.3%;
The same applies to the following examples) 0.50 part, magnesium hydroxide 12
Parts, 2 parts of white carbon and 76.9 parts of clay are mixed and pulverized with a hammer mill to obtain the powder of the present invention.
実施例２ （粉剤） 塩基性硫酸銅（金属銅として51.5％を含む；以下の実
施例でも同様）11.7部、バリダマイシン0.50部、水酸化
マグネシウム12部、ホワイトカーボン２部、クレー73.8
部をハンマーミルで混合粉砕して本発明の粉剤を得る。Example 2 (Powder) Basic copper sulfate (containing 51.5% as metallic copper; the same applies to the following examples) 11.7 parts, validamycin 0.50 part, magnesium hydroxide 12 parts, white carbon 2 parts, clay 73.8
The mixture is pulverized with a hammer mill to obtain the powder of the present invention.
実施例３ （水和剤） 塩基性塩化銅77.0部、バリダマイシン5.0部、水酸化
マグネシウム12部、ポリオキシエチレンノニルフェニル
エーテル1.5部、ホワイトカーボン３部、クレー1.5部を
ハンマーミルで混合粉砕して本発明の水和剤を得る。Example 3 (Wettable powder) 77.0 parts of basic copper chloride, 5.0 parts of validamycin, 12 parts of magnesium hydroxide, 1.5 parts of polyoxyethylene nonylphenyl ether, 3 parts of white carbon, and 1.5 parts of clay were mixed and ground with a hammer mill. The wettable powder of the present invention is obtained.
実施例４ （水和剤） 塩基性硫酸銅52.5部、バリダマイシン2.5部、水酸化
マグネシウム６部、ポリオキシエチレンノニルフェニル
エーテル1.5部、ホワイトカーボン３部、クレー34.5部
をハンマーミルで混合粉砕して本発明の水和剤を得る。Example 4 (Wettable powder) 52.5 parts of basic copper sulfate, 2.5 parts of validamycin, 6 parts of magnesium hydroxide, 1.5 parts of polyoxyethylene nonylphenyl ether, 3 parts of white carbon, and 34.5 parts of clay were mixed and ground with a hammer mill. The wettable powder of the present invention is obtained.
３） 発明の効果 銅化合物およびバリダマイシンを含む粉剤、水和剤な
どに水酸化マグネシウムまたは酸化マグネシウムの１種
または２種を１〜20重量％程度添加すると常温で２年間
貯蔵（40℃、相対湿度80％、60日間の苛酷試験による）
したときの当該活性成分の分解率を５％以下に抑制し得
る。この場合、安定化剤の添加量が１％より多くなるに
つれて分解防止効果が向上する傾向にある。しかし20％
以上添加してもそれ以上の向上はほとんど認められな
い。したがってコストと効果の関係から１〜20％の範囲
で添加するのが好ましい。3) Effect of the Invention When one or two kinds of magnesium hydroxide or magnesium oxide are added to a powder or a wettable powder containing a copper compound and validamycin in an amount of about 1 to 20% by weight, they are stored at room temperature for 2 years (40 ° C., relative humidity). 80%, 60 days of severe test)
The decomposition rate of the active ingredient can be suppressed to 5% or less. In this case, as the amount of the stabilizer added exceeds 1%, the effect of preventing decomposition tends to be improved. But 20%
Even with the above addition, little further improvement is observed. Therefore, it is preferable to add in the range of 1 to 20% from the relation between cost and effect.
次に本発明の分解防止効果を試験例により立証する。 Next, the decomposition preventing effect of the present invention will be proved by test examples.
試験例１ 分解防止効果試験 実施例に従って調製した製剤50gを粉剤はクラフト袋
に、水和剤はポリエステル貼り合せ袋に入れ40℃、相対
湿度80％の恒温恒湿器内に放置した。放置30日後（常温
で１年間貯蔵したことに相当する）および60日後（常温
で２年間貯蔵したことに相当する）に取りだしてバリダ
マイシンの含有量を分析し、初期含有量に対する残存率
（％）を求めた。得られた結果を第１表に示す。Test Example 1 Degradation Prevention Effect Test 50 g of the preparation prepared in accordance with the examples were placed in a kraft bag as a powder, and in a polyester lamination bag as a wettable powder, and allowed to stand in a thermo-hygrostat at 40 ° C. and 80% relative humidity. After 30 days (equivalent to storage at room temperature for 1 year) and after 60 days (equivalent to storage at room temperature for 2 years), take out and analyze the content of validamycin. Residual rate (%) to initial content I asked. Table 1 shows the obtained results.
なお、第１表中の銅化合物の種類と製剤の種類は下記
のとおりである。In addition, the kind of copper compound and the kind of preparation in Table 1 are as follows.
銅化合物の種類 Ａ 塩基性塩化銅 Ｂ 塩基性硫酸銅 Ｃ 水酸化第二銅 製剤の種類 １ 粉 剤 ２ 水和剤 Type of copper compound A Basic copper chloride B Basic copper sulfate C Cupric hydroxide Type of preparation 1 Powder 2 Water dispersible
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ Ａ０１Ｎ 59/20 Ａ０１Ｎ 59/20 Ｚ (58)調査した分野(Int.Cl.6，ＤＢ名) A01N 43/16,59/20 A01N 55/02,25/22 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 6 identification symbol FI A01N 59/20 A01N 59/20 Z (58) Investigated field (Int.Cl. 6 , DB name) A01N 43 / 16,59 / 20 A01N 55 / 02,25 / 22
Claims (1)
または有機化合物）およびバリダマイシンを含む製剤に
おいて、バリダマイシンの経時安定化剤として水酸化マ
グネシウムまたは酸化マグネシウムの１種または２種を
添加してなることを特徴とする安定化された銅含有バリ
ダマイシン製剤。1. A preparation containing a copper compound (inorganic compound or organic compound) and validamycin as an active ingredient of a pesticide, wherein one or two kinds of magnesium hydroxide or magnesium oxide are added as a temporal stabilizer of validamycin. A stabilized copper-containing validamycin preparation, characterized by comprising:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2325190A JP2981680B2 (en) | 1990-11-29 | 1990-11-29 | Stabilized copper-containing validamycin formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2325190A JP2981680B2 (en) | 1990-11-29 | 1990-11-29 | Stabilized copper-containing validamycin formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04198109A JPH04198109A (en) | 1992-07-17 |
| JP2981680B2 true JP2981680B2 (en) | 1999-11-22 |
Family
ID=18174019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2325190A Expired - Lifetime JP2981680B2 (en) | 1990-11-29 | 1990-11-29 | Stabilized copper-containing validamycin formulation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2981680B2 (en) |
-
1990
- 1990-11-29 JP JP2325190A patent/JP2981680B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04198109A (en) | 1992-07-17 |
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