JP2938240B2 - Automatic analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer and, more particularly, to preventing an infectious aerosol generated from a test object such as blood or urine of a living body from causing a health hazard to a human body such as an operator during a test. The present invention relates to an automatic analyzer having a structure that performs the following.

[0002]

2. Description of the Related Art In recent years, biohazard (biohazards) has become more and more concerned in relation to biotechnology, medical testing equipment, and the like, and measures to prevent infection have been required. First, in a conventional sample suction device and stirring device, as described in, for example, JP-A-63-187158, a nozzle is directly pierced into a sealed plug portion of a test tube (a piercing method) to suck a sample. There is a way to do it. Furthermore, in the conventional automatic analysis, there is a method of automatically sealing a cuvette that has been measured and discarding it while maintaining its safety and cleanliness. In addition, there is a method of injecting a sample into a reagent cassette in which a reagent is sealed in advance, performing centrifugation, reagent mixing, and stirring in a sealed container, and discarding the entire container after measurement. Furthermore, as in the automatic bottle opener used in the sample test pretreatment system, the sample is dispensed by automatically removing the cap such as a vacuum blood collection tube, test tube rubber stopper, or synthetic resin containing the sample. There is a way.

[0003]

The risk of infection in the automatic analyzer will be described with reference to FIGS. 10 and 11. FIG. FIG. 10 shows the operation of generating an infectious aerosol and the scattering coefficient. This data is an excerpt from the Ministry of Training and Lectures related to the biohazard field sponsored by the 2nd Biomedical Science Study Group. As is clear from the table of FIG. 10, the scattering coefficient is determined in accordance with various operations. In the vicinity of the analysis section of the automatic analyzer, when the sample is automatically dispensed by a pipette, or the reaction reagent is mixed with the reaction reagent by a mixer. Many infectious aerosols are generated, for example, when mixing samples and when cleaning the pipette tip and the reaction vessel. Since infectious aerosols are invisible fine particles, they often adhere to the skin of an operator or are not noticed even when inhaled, and thus have a high risk of infection.

The tables in FIGS. 11 (A) and 11 (B) show the required amount of microorganisms (such as bacteria and viruses) to be infected. The source of this data is the same as the above data. The amount of infectious aerosol generated by the automatic analyzer is 10 ^{-3 of the} required amount of infection.
To a lesser extent, operators are always at risk of infection. Therefore, it is necessary to ensure safety after taking care of the operator himself and protecting the hardware of the apparatus configuration.

[0005] However, in the conventional automatic analyzer, infectious aerosol due to scattering or evaporation of the sample may occur during sample dispensing, mixing with the reagent, and stirring, and the safety near the automatic analyzer may be reduced. Inadequate consideration was given to sex and there was a problem of operator infection.

In a conventional sample aspirating and agitating apparatus using the piercing method, since the nozzle for aspirating the sample is washed and used many times, problems such as scattering of the sample during washing and contamination between samples are caused. was there.

Further, in the method of performing measurement in a reaction vessel in which reagents are sealed in advance, an operator must directly inject a sample using a pipette or a capillary and set the reaction vessel in the main body. At this time, there was a problem of scattering of the sample and a problem of a decrease in sample processing.

In addition, no special consideration has been given to contamination of the apparatus itself due to scattering of the sample when the cap of the examiner is removed, and contamination due to the diffusion of the contents due to tipping over after removing the cap. In addition, there is a problem in that the provision of the automatic bottle opener increases the size of the apparatus.

An object of the present invention is to eliminate the generation of an infected aerosol in the process from aspirating a sample to dispensing a reagent, mixing, stirring and measuring, thereby ensuring operator safety, achieving high-speed processing, and realizing a compact apparatus. An automatic analyzer is provided.

[0010]

SUMMARY OF THE INVENTION An automatic analyzer according to the present invention is an automatic analyzer for analyzing a sample by disposing a tissue fluid separated from a living body as a sample, and a transfer mechanism for transferring a sample container containing the sample. And, a sample container gripping mechanism that removes a sample container located at a predetermined location from the transport mechanism and grips and moves a predetermined movement path in a gripping state, a first disk mechanism provided with a plurality of disposable sample collection tubes, An attaching device for attaching the sample collection tube to a stopper of the sample container which is moved by the sample container gripping mechanism and arranged at a predetermined position;
Attaching a reagent container to a second disk mechanism in which a plurality of disposable reagent containers in which reagents are pre-enclosed are provided, and a reagent collection tube attached to the sample container which is moved by the sample container gripping mechanism and arranged at a predetermined position; After the reagent and the sample are mixed, an attachment / detachment device that removes the reagent container from the sample collection tube and moves it to the measurement unit, a first disposal device that discards the reagent container for which measurement has been completed, and a sample container gripping mechanism And removing the reagent collection tube attached to the sample container placed at a predetermined position from the sample container and discarding it.
And a disposal device. In the above configuration, preferably, the reagent container has a film for preventing the reaction solution from scattering. In the above configuration, preferably, the sample collection tube includes a tube for penetrating the plug of the sample container and a sample collection tube in a double structure. In the above configuration, preferably, the inside of the reagent container has a negative pressure,
It is configured so that the sample in the sample container is automatically injected by inserting the sample collection tube of the sample collection tube having the internal / external dual structure into the inside of the reagent container, and mixes with the reagent to cause a chemical reaction. You. Further, the automatic analyzer according to the present invention is an automatic analyzer that deploys a tissue fluid separated from a living body as a sample and analyzes the sample, and includes a transport mechanism that transports a sample container that contains the sample, and a transport mechanism that is located at a predetermined position. A plurality of sample container holding mechanisms for taking out the sample container from the transport mechanism, holding the sample container, and moving the sample container along a predetermined movement path while holding the sample container, and a disposable sample collection tube and a reagent container having a sample collection tube integrated with the reagent container are provided. The disk mechanism and the reagent container with the sample collection tube are attached to the stopper of the sample container which is moved by the sample container gripping mechanism and placed at a predetermined location. After the reagent and the sample are mixed, only the reagent container is sampled. An attachment / detachment device that removes the reagent container from the tube and moves it to the measurement unit, a first disposal device that discards the reagent container for which measurement has been completed, and a device that is moved by the sample container gripping mechanism to a predetermined position. The reagent extraction tube remaining in the sample container to be location, and a second discarding device for removal discarded from the sample container. In each of the above-described configurations, preferably, the reagent container is maintained at a negative pressure inside, and a portion for accommodating the reaction solution, a portion for mixing the reaction solution and the sample, and a port portion for attaching the sample collection tube are sealed. When the sample collection tube or a part thereof penetrates through the membrane member and penetrates the membrane member, the sample is sucked into the reagent container by the negative pressure, and the reaction solution and the sample are mixed, and thereafter,
When the sample container and the sample collection tube are separated, the inside of the reagent container is sealed again with the membrane member.

[0011]

In the automatic analyzer according to the present invention, as described above,
This is an automatic analyzer that uses the tissue fluid and excrement of a living body as a sample, and analyzes the sample.The disposable sample collection tube is inserted into the tightly-sealed part of the sample container to collect the sample. Automatically injects, mixes, and measures the sample into the disposable reagent container. The inside of the sealed disposable reagent container in which the reagent is sealed in advance has a negative pressure,
It is composed of a part into which the disposable sampling tube is inserted and a part where the sample and the reagent are mixed. Further, the sample collection tube as the sample collection means and the reagent container used as the sample / reagent mixing means are automatically discarded in a closed bag after the measurement is completed. Therefore, in the automatic analyzer according to the present invention, it is possible to eliminate the generation of infectious aerosol in a series of analysis processes from sample collection to reagent dispensing, stirring, and measurement. After the measurement is completed, the used sample collection tube and reagent container can be automatically and safely discarded, and it is possible to eliminate the generation of infected aerosol in washing the sample collection nozzle, the reaction cell, and the like. A membrane member provided inside the reagent container for keeping the inside of the reagent container tightly sealed facilitates insertion of the sample collection tube, prevents scattering of the infected aerosol, and separates the reagent container from the sample collection tube. It is possible to maintain the sealing property later.

[0012]

Embodiments of the present invention will be described below with reference to the accompanying drawings. FIG. 1 shows a schematic device configuration diagram of an automatic analyzer. In FIG. 1, reference numeral 1 denotes a reagent disk provided on a reagent disk mechanism, and the reagent disk 1 is provided rotatably. Various reagent cassettes 2 are arranged on the reagent disk 1. On the outer periphery of the reagent disk 1, a reaction tank 3 is provided. The inside of the reaction tank 3 is maintained at a predetermined temperature by a thermostat 4. Reference numeral 5 denotes a sample container transport mechanism, in which a rack 6 is installed, and the rack 6 transports the sample container 7 to a sampling operation start position of the sample collecting mechanism 8.

The operation of the sampling mechanism 8 will be described. In the illustrated example, a series of operations from the start to the end of the operation of one sample container 7 is shown in four stages. In the sample collecting mechanism 8, first, the sample container 7 is gripped by the hand 9 of the sample container gripping mechanism and pulled up from the rack 6. At this time, the barcode attached to the sample container 7 is read and the ID number of the sample is stored. In FIG. 1, the bar code reading mechanism is not shown for simplicity of illustration.

FIG. 2 shows a specific configuration of the hand 9. The hand 9 has two movable parts 9a, and a rubber 91 is provided at a part of the movable part 9a which comes into contact with the sample container. These movable parts 9a can be opened and closed freely by a hand drive motor 92.
The hand 9 and the hand drive motor 92 are configured to move along the hand moving rail 93 as a whole. A sample container support 13 is disposed below the hand 9 at a predetermined distance. A rubber plate 13a is provided on a portion of the sample container support 13 that receives the sample container. The sample container support 13 is configured to move along a rail 94 for the sample container support.

The hand 9 holding the sample container 7 as described above
Rises along the arrow, moves rightward at a right angle, and temporarily stops at a position in front of the sampling tube mounting mechanism 10. The arm portion 10a of the sample collection tube mounting mechanism 10 is configured to perform up-down movement and rotational movement. The sample collection tube mounting mechanism 10 extracts the sample collection tube 12 provided on the sample collection tube disk 11, transports the sample collection tube 12 to the sample collection / reagent mixing line, and temporarily stops at a position above the sample container 7 held by the hand 9. The operation is controlled as follows. Next, the sample collection tube attaching mechanism 10 descends toward the sample container 7 whose bottom is supported by the sample container support 13, and pierces the lower end of the sample collection tube 12 into the hermetically sealed portion 14 of the sample container 7. After piercing the sample collection tube 12, the sample collection tube mounting mechanism 10 moves upward, and repeats the operation of extracting and piercing the sample collection tube for another sample container that sequentially arrives. The detailed structure of the sampling tube 12 is shown in FIG.
It will be described later with reference to FIG.

Next, the sample container 7 in which the sample collection tube 12 is pierced into the sealing portion 14 moves rightward along the arrow while being held by the hand and the sample container support, and is moved forward of the reagent cassette mounting mechanism 15. Stop once at The arm 15a of the reagent cassette mounting mechanism 15 is configured to perform up-down movement and rotational movement. The reagent cassette mounting mechanism 15 pulls out one reagent cassette 2 arranged on the reagent disk 1, transports the reagent cassette 2 to a sample collection / reagent mixing line while holding the reagent cassette 2, and holds the sample container held by the hand 9. 7 temporarily stops at a position above the sample collection tube 12 pierced by the sealed portion 14. Thereafter, the reagent cassette mounting mechanism 15 descends, and the hermetic plug 1 of the sample container 7 is moved.
The upper end of the sample collection tube 12 pierced into 4 and the end of the reagent cassette 2 are connected, and both are combined. In the reagent cassette 2, a reagent is sealed in advance and a negative pressure is applied. Therefore, the thin film provided at the end of the reagent cassette 2 is broken by the sample collection tube 12, so that the sample is removed from the sample container 7 into the reagent cassette 2. Automatically supplied within. Details of this process will be described later with reference to FIGS.
The reagent cassette mounting mechanism 15 is then moved upward to move the reagent cassette 2 into which the sample has been injected into the sample collection tube 12.
And transport the reagent cassette 2 to the reaction tank 3. After being incubated in the reaction tank 3 for a certain period of time, the reagent cassette 2 moves to the photometric unit 16, where the ID number of the reagent cassette 2 is read, and then the light flux emitted from the light source 16b is passed. Multi-wavelength photometer 1 for physical quantity
6a.

The signal relating to the detected optical physical quantity is:
The signal is converted into a digital signal by an A / D converter 21 and input to a computer 22 through an interface 20.
The detection signal is converted by the computer 22 into data on the concentration of the measurement target in the sample. The density-converted data is printed out by the printer 23 via the interface 20 or displayed on the screen of the CRT 24. The operation panel 26 is used for inputting analysis conditions and data input, and the floppy disk 25 is used as means for collectively recording analysis data.

The reagent cassette 2 for which the measurement has been completed is moved to the position of the reagent cassette discarding section 17 and discarded and stored in the sterilization bag 17 installed here.

On the other hand, the sample container 7 from which the sample has been collected moves to the position of the sampling tube discarding mechanism 18 while being held by the hand 9 and the sample container support 13. Thereafter, the sampling tube disposal mechanism 18 descends, pulls out the sampling tube 12 pierced into the sealed portion 14 of the sample container 7, and rises again.
It is moved to the sample collection tube disposal section 19 by the rotation motion, and the sample collection tube 12 is discarded and stored in the sterilization bag installed therein. Then, the sample container 7 from which the sample collection tube 12 has been extracted is first lowered by the downward movement of the hand 9 while the sample container support 13 is separated and held by the hand 9. At this time, the sample container 7 is stored again in the sample container rack 6 moved by the sample container transport mechanism 5. The sample container 7 housed in the rack 6 is provided with a sample container transport mechanism 5.
It is conveyed to the next inspection device or stored in a sample container storage location (not shown).

FIG. 6 shows a releasing operation by the hand 9. FIG. 6A shows a state in which the hand 9 is closed and the sample container 7 is clamped, and FIG. 6B shows a state in which the hand 9 is opened and the sample container 7 is released and housed in the rack 6.

In FIG. 1, a dashed line L 1 indicates a moving path of the hand 9, and a dashed line L 2 indicates a moving path of the sample container support 13. Therefore, after one inspection operation, the hand 9 and the sample container support 13 return to the initial position and repeat the above operation again. Although the above series of operations has been described for one sample container 7, the inspection is repeated for each sample container since the sample containers are sequentially and continuously fed. Therefore, a plurality of hands 9 and sample container supports 13 are provided at predetermined intervals.

Next, the reagent cassette 2 and the sampling tube 12 will be described in detail with reference to FIGS. FIG.
2 shows an internal configuration of the reagent cassette 2. The reagent cassette 2
Reagent holding portions 27a and 27b, a reagent / sample mixing portion 28 in which a reaction is performed, a sample collection tube insertion portion 30, a thin film 29 for keeping the inside of the cassette at a negative pressure, and a bar code 35 indicating the type of the reagent cassette. It is composed of FIG. 4 shows the configuration of the sampling tube 12. The sample collection tube 12 includes a sample collection thin tube 31, a sample container tightly plugged tube 33, and this tube 33.
It is composed of a thin film 32 for holding a sampling tube 31 provided therein. Capillary tube 33 for penetrating sample container
In order to penetrate a hermetic plug made of a material such as rubber, the shape of the tip is sharp and the material is made of metal such as aluminum or stainless steel. On the other hand, the shape of the tip of the sample sampling tubule 31 is sharp, and a hole 31a is opened in the lateral direction of the tip of the tubule so as not to be clogged with dust or the like. The sample is sucked from the hole 31a. Further, the length of the thin tube 31a is long enough to reach the sample liquid level in the container, and the material may be plastic or the like. FIG. 5 shows a method of sampling using the reagent cassette 2 and the sampling tube 12. First, the reagent cassette mounting mechanism 1
5 is operated and the reagent cassette 2 is taken out from the reagent disk 1, and then inserted into the sample collection tube insertion portion 30 of the reagent cassette 2.
The upper end of the sample collection capillary 31 penetrating through the sample container hermetic plug 14 is pushed in. Then, the thin film 32 of the sample collection tube 12 is broken, and the lower end (sharp portion) of the sample collection thin tube 31 passes through the inside of the sample container hermetic plug penetration tube 33 and reaches below the sample liquid level of the sample container 7. At the same time, the thin film 29 in the sample tube insertion portion 30 of the reagent cassette 2 is broken, and the upper end of the sample sampling tube 31 reaches the sample channel 34 of the reagent cassette 2. At this time, since the inside of the reagent cassette 2 is maintained at a negative pressure, a sample is injected into the reagent cassette 2 from the sample collection thin tube 31, and the reagents in the reagent holding sections 27 a and 27 b in the reagent / sample mixing section 28. And the aspirated and injected sample are mixed. Reagent cassette 2 according to the measurement item
The amount and type of reagents in can be varied. On the other hand, a fixed amount of the sample is automatically injected by keeping the internal structure of the cassette constant, so that quantitative analysis can be performed more accurately. As for the mixing and stirring of the sample and the reagent, since the sample is vigorously injected into the reagent cassette 2 under a negative pressure, it is mixed and stirred with the reagent with the force, and is incubated while being rotated in the reaction tank 3. Is achieved by Further, after the sample is injected, only the reagent cassette 2 is separated by the reagent cassette mounting mechanism 15 while leaving the sample collection tube 12 in the tightly-sealed portion.
At this time, the thin film 29 of the reagent cassette 2 is
And the mixture of the reagent and the sample is completely sealed in the reagent cassette 2. In the above description, for example, the outer diameter of the sample sampling thin tube 31 is about 2.5 mm, the length is 35 to 40 mm, and the outer diameter of the container sealing stopper penetration pipe 33 is about 5 mm, and the length is about 20 mm.

FIG. 7 is a diagram for explaining the internal structure of the sampling tube disposal mechanism 18. As shown in FIG. The inside 36 of the tip of the arm 18a is a grip for gripping the upper part of the sample collection tube 12 attached to the sealed part 14 of the sample container 7, and the reference numeral 38 is a drive motor for moving the grip 36 upward. A spring arm 39 is provided between the drive motor 38 and the grip 36. A vacuum device (not shown) is provided at the base of the sampling tube discarding mechanism 18, and the device performs an exhaust / suction operation.

FIGS. 8 (A), 8 (B) and 8 (C) show an outline of the operation of the sampling tube discarding mechanism 18. FIG. First, the arm 18a of the sampling tube disposal mechanism 18 is lowered, and the sample container 7
The sample collection tube removal grip 6 grasps the tube 33 for penetrating the sample collection tube 12 pierced into the plug portion 14 of FIG. At this time, the inside of the arm 18a is sucked by the vacuum device. The grip 36 ascends inside the arm 18a while holding the plug-penetrating tube 33. At the time of this withdrawal, the vacuum is actuated by a vacuum device so that the sample does not scatter or drop off from the tip of the sample collection thin tube 31. Sampling tube extraction grip 36 is arm 18a
After the sample collection tube 12 is stored in the arm 18a, the lid (not shown) provided at the lower end of the arm 18a is closed, and at the same time, the arm 18a is rotationally moved to the collection tube disposal section 19. I do. At this time, the collection tube extracting grip 36 is lowered again, and the lid is opened at the lower end of the arm 18a, and at the same time, the collection tube 12 is released, thereby disposing the collection tube 12 in the sterilization bag of the collection tube disposal unit 19.

FIG. 9 shows another embodiment having a configuration in which the reagent cassette and the sampling tube are integrated. A sample collection thin tube 31 ′ is supported and attached to the sample collection tube insertion portion 30 of the reagent cassette 2 by a thin film 29. The reagent cassette 2 with a small tube for sampling is attached to the hermetic plug 14 of the sample container 7 by the reagent cassette attaching mechanism 15 as in the case of the above-described embodiment. At this time, since the thin tube 31 'for sampling directly penetrates the hermetic plug 14, the tip 31'a of the thin tube 31 for sampling is sharp and made of metal (aluminum, stainless steel, iron or the like). In this embodiment, the reagent cassette 2
Is pressed strongly, the thin tube 31 ′ for sample collection penetrates the hermetic plug 14, the thin film 29 in the reagent cassette 2 is broken, and the thin tube 31 ′ for sample collection reaches the sample channel 34 in the reagent cassette 2. As in the previous embodiment, since the inside of the reagent cassette 2 is under a negative pressure, a sample is automatically injected into the reagent cassette 2 from the sample collection thin tube 31 ′ and mixed with the reagent in the reagent / sample mixing unit 28. . After the sample is further injected, the reagent cassette 2 is pulled away by the reagent cassette attaching mechanism 15 while leaving the sample collection thin tube 31 ′ in the hermetic plug portion 14, and the thin film 29 of the reagent cassette 2 flows through the sample flow path 34. Completely seal. The method of extracting and discarding the sample collection tubing 31 'is the same as the method described above.

According to each of the above-described embodiments, a sample is collected, a sample is transferred to a reaction container of the reagent cassette, and a sample is mixed with a reagent by using a disposable reagent cassette as well as a disposable sample collection tube. Since the generation of infectious aerosol is prevented in the above, the prevention of infection by the operator can be achieved, and safety can be ensured. Furthermore, after the measurement is completed, the sample collection tube and the reaction vessel are safely discarded, so there is no risk of contamination, maintenance is easy,
In addition, concerns about secondary infection are extremely reduced.

[0027]

As apparent from the above invention, the present invention has the following effects. A disposable sample collection tube is pierced into the sealed stopper of the sample container, and a sealed reagent cassette in which a reagent is previously sealed under negative pressure is inserted into the upper end thereof, whereby the sample is automatically injected into the reaction container, and Since it is measured after being mixed, the generation of infectious aerosol can be prevented in a series of analysis processes, and the safety of the operator can be ensured. After the measurement is completed, the sample collection tube is safely removed so that no infectious aerosol is generated, and the sample container is discarded in a sealed state. There is no contamination, maintenance is easy, and the risk of secondary infection and environmental pollution can be prevented. A membrane member provided inside the reagent cassette for keeping the inside of the reagent cassette hermetically facilitates the invasion and installation of the sample collection tube, prevents the spread of infected aerosol, and separates the reagent cassette from the sample collection tube. It is possible to maintain the tightness of the reagent cassette even after this, thereby further preventing the spread of the infected aerosol. A similar effect is obtained with a configuration in which the sample collection tube and the reagent cassette are integrated.

[Brief description of the drawings]

FIG. 1 is a perspective view showing the entire configuration of an automatic analyzer according to the present invention.

FIG. 2 is an external perspective view showing a specific configuration of a sample container gripping mechanism.

FIG. 3 is a perspective view showing the internal structure of a reagent cassette.

FIG. 4 is a perspective view showing the structure of a sampling tube.

FIG. 5 is a diagram showing a connection state between a reagent cassette and a sample collection tube.

FIG. 6 is a view for explaining a sample container releasing operation of the sample container gripping mechanism.

FIG. 7 is a view for explaining the structure of a sampling tube disposal mechanism.

FIG. 8 is a diagram for explaining the operation of the sampling tube discarding mechanism.

FIG. 9 is a perspective view of a sample cassette with a sample collection tube.

FIG. 10 is a diagram showing an operation of generating an infected aerosol and a scattering coefficient.

FIG. 11 is a table showing types and amounts of bacteria involved in infection and routes of infection.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Reagent disk 2 Reagent cassette 5 Sample container conveyance mechanism 6 Rack 7 Sample container 8 Sample collection mechanism 9 Hand 10 Sample collection tube mounting mechanism 12 Sample collection tube 13 Sample container support 14 Sealing part 15 Reagent cassette mounting mechanism 17 Reagent cassette disposal part 18 Sampling tube disposal mechanism 31 Sampling tube 33 Pipe for penetration

Claims (7)

(57) [Claims] 1. An automatic analyzer for disposing a tissue fluid separated from a living body as a sample and analyzing the sample, comprising: a transport mechanism for transporting a sample container containing the sample; and a sample container located at a predetermined position. A sample container gripping mechanism that is taken out of the transport mechanism, grips the same, and moves along a predetermined movement path in a gripping state, a first disk mechanism having a plurality of disposable sample collection tubes, and the sample container An attaching device that is moved by a gripping mechanism and is attached to a plug portion of the sample container disposed at a predetermined position, a second disk mechanism in which a plurality of disposable reagent containers in which reagents are sealed in advance, and the sample container gripping mechanism The reagent container is attached to a reagent collection tube attached to the sample container which is moved and arranged at a predetermined position, and the reagent and the sample are further mixed. After that, the attachment / detachment device for detaching the reagent container from the sample collection tube and moving it to the measurement unit, a first disposal device for discarding the reagent container whose measurement has been completed, and the sample container gripping mechanism A second disposal device that removes and discards the reagent collection tube attached to the sample container disposed at a predetermined position from the sample container. 2. The automatic analyzer according to claim 1, wherein
The automatic analyzer according to claim 1, wherein the reagent container has a film for preventing a reaction solution from scattering. 3. The automatic analyzer according to claim 1, wherein
The automatic analyzer according to claim 1, wherein the sample collection tube has a double structure including a tube for penetrating the stopper of the sample container and a sample collection tube. 4. The automatic analyzer according to claim 2, wherein
The inside of the reagent container has a negative pressure, and the sample in the sample container is automatically injected by inserting the sample collection tube of the sample collection tube according to claim 3 into the inside of the reagent container. An automatic analyzer characterized in that a chemical reaction takes place when mixed with a reagent. 5. The automatic analyzer according to claim 1, wherein
The reagent container is provided with a portion for holding a reaction solution, a portion for mixing the reaction solution and the sample, and a membrane member for sealing an opening portion for attaching the sample collection tube, while maintaining the inside at a negative pressure. When the sample collection tube penetrates through the membrane member, the sample is sucked into the reagent container by the negative pressure, and the reaction solution and the sample are mixed. Thereafter, the sample container and the sample collection tube are connected to each other. An automatic analyzer wherein the inside of the reagent container is sealed again with the membrane member when separated. 6. An automatic analyzer for disposing tissue fluid separated from a living body as a sample and analyzing the sample, comprising: a transport mechanism for transporting a sample container containing the sample; and a sample container located at a predetermined position. A disk provided with a plurality of reagent containers having a sample collection tube in which a sample container gripping mechanism that is taken out of the transport mechanism and grips and moves along a predetermined movement path in a gripped state, and a disposable sample collection tube and a reagent container are integrated. A mechanism and a reagent container with a sample collection tube are attached to a stopper of the sample container which is moved by the sample container gripping mechanism and arranged at a predetermined position, and further, after the reagent and the sample are mixed, only the reagent container is removed. An attachment / detachment device that detaches from the sample collection tube and moves to the measurement section, a first disposal device that discards the reagent container whose measurement has been completed, and the sample container gripping mechanism A second disposal device that removes the reagent collection tube remaining in the sample container placed at a predetermined position and removed from the sample container and discards the reagent collection tube. 7. The automatic analyzer according to claim 6, wherein
The reagent container is provided with a portion for holding a reaction solution, a portion for mixing the reaction solution and the sample, and a membrane member for sealing an opening portion for attaching the sample collection tube, while maintaining the inside at a negative pressure. When the inner tube of the sample collection tube penetrates through the membrane member, the sample is sucked into the reagent container by the negative pressure, and the reaction solution and the sample are mixed. An automatic analyzer wherein the inside of the reagent container is sealed again with the membrane member when the collection tube is separated from the collection tube.