JP2901057B2 - Non-insulin dependent diabetes animal feed - Google Patents

Non-insulin dependent diabetes animal feed

Info

Publication number
JP2901057B2
JP2901057B2 JP9222220A JP22222097A JP2901057B2 JP 2901057 B2 JP2901057 B2 JP 2901057B2 JP 9222220 A JP9222220 A JP 9222220A JP 22222097 A JP22222097 A JP 22222097A JP 2901057 B2 JP2901057 B2 JP 2901057B2
Authority
JP
Japan
Prior art keywords
feed
diabetes
insulin
dependent diabetes
onset
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP9222220A
Other languages
Japanese (ja)
Other versions
JPH1156251A (en
Inventor
正彦 西村
章弘 山崎
博史 伊藤
政弘 金子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON NOSAN KOGYO KK
Original Assignee
NIPPON NOSAN KOGYO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by NIPPON NOSAN KOGYO KK filed Critical NIPPON NOSAN KOGYO KK
Priority to JP9222220A priority Critical patent/JP2901057B2/en
Publication of JPH1156251A publication Critical patent/JPH1156251A/en
Application granted granted Critical
Publication of JP2901057B2 publication Critical patent/JP2901057B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

Landscapes

  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【0001】[0001]

【発明の属する技術分野】本発明は、インシュリン非依
存性糖尿病モデル動物用飼料に関する。
TECHNICAL FIELD The present invention relates to a feed for an animal model of non-insulin-dependent diabetes mellitus.

【0002】[0002]

【従来の技術】近年、各種の疾患解明に実験動物が有効
に活用されている。例えば、高血圧症、免疫不全、筋ジ
ストロフィー、てんかん等にマウス、ラット、モルモッ
トあるいはハムスター等が利用されている。なかでも糖
尿病は我が国で非常に多い疾患と位置づけられており、
実験動物を利用して種々の研究が進められている。糖尿
病はインシュリンの作用不足によって起こる代謝異常に
より血糖が慢性的に高くなる病気で、発症に遺伝的要素
と生理環境が関わっていることは明らかであり、遺伝的
要因・生理環境の影響の解析に糖尿病モデル動物が多数
使用されている。糖尿病は、大別してI型糖尿病として
インシュリン依存性糖尿病とII型糖尿病としてのインシ
ュリン非依存性糖尿病があるが、疾患モデル動物におい
てもこの2型に分けることができる。
2. Description of the Related Art In recent years, experimental animals have been effectively utilized for elucidating various diseases. For example, mice, rats, guinea pigs, hamsters and the like are used for hypertension, immunodeficiency, muscular dystrophy, epilepsy and the like. Among them, diabetes is regarded as a very common disease in Japan,
Various studies are being conducted using experimental animals. Diabetes is a disease in which blood sugar is chronically increased due to metabolic abnormalities caused by insufficient action of insulin, and it is clear that genetic factors and physiological environment are involved in the onset, and analysis of genetic factors and effects of physiological environment is Many diabetes model animals are used. Diabetes is roughly classified into insulin-dependent diabetes as type I diabetes and non-insulin-dependent diabetes as type II diabetes, and can be divided into these two types in disease model animals.

【0003】糖尿病研究においては早期にその症状を発
症する動物が必要とされている。インシュリン依存性糖
尿病モデル動物は、遺伝的要因が大きく作用するので、
比較的早く症状を発症するが、インシュリン非依存性糖
尿病モデル動物は、遺伝、免疫、ホルモンなどの点で、
インシュリン依存性糖尿病モデル動物と大きく異なるた
め、一般的に症状の発症が遅い。その原因の1つが、糖
尿病モデル動物に給与される飼料が通常の実験動物の飼
料と同一であることによる。従って、インシュリン非依
存性糖尿病モデル動物の発症時期を早めるような飼料の
開発が待たれているところである。
[0003] In diabetes research, animals that develop the symptoms early are needed. Insulin-dependent diabetes model animals are affected by genetic factors.
Symptoms develop relatively quickly, but non-insulin-dependent diabetes model animals have genetic, immune, hormonal, etc.
In general, the onset of symptoms is slow because it is significantly different from insulin-dependent diabetes model animals. One of the causes is that the feed fed to the diabetic model animal is the same as that of a normal experimental animal. Therefore, development of a feed that hasten the onset of an insulin-independent diabetes model animal is awaited.

【0004】[0004]

【発明が解決しようとする課題】本発明は、糖尿病の早
期発症を促進する、インシュリン非依存性糖尿病モデル
動物用の飼料を提供することを課題とする。
SUMMARY OF THE INVENTION It is an object of the present invention to provide a feed for an insulin-independent diabetes model animal, which promotes the early onset of diabetes.

【0005】[0005]

【課題を解決するための手段】本発明者等は、上記課題
を達成するため鋭意研究を行ったところ、飼料中の、可
消化エネルギー(DE)に対する粗蛋白質(CP)の比
が一定値以下とすることあるいは更に糖類を一定以上加
えることによって解決できることを見出した。
Means for Solving the Problems The present inventors have conducted intensive studies in order to achieve the above object, and found that the ratio of crude protein (CP) to digestible energy (DE) in feed was below a certain value. Or furthermore, it can be solved by adding a certain amount of saccharides.

【0006】すなわち、本発明は、(1)穀類・糟糠類
・植物油粕類・油脂類等の慣用原料を主体とした飼料中
可消化エネルギー(DE)に対する飼料中粗蛋白質(C
P)の比CP(%)/DE(kcal/g)を5.0以
下としたことを特徴とするインシュリン非依存性糖尿病
モデル動物用飼料、(2)穀類・糟糠類・植物油粕類・
油脂類等の慣用原料を主体とした飼料中可消化エネルギ
ー(DE)に対する飼料中粗蛋白質(CP)の比CP
(%)/DE(kcal/g)を5.0以下としかつ糖
類を10%以上配合してあることを特徴とするインシュ
リン非依存性糖尿病モデル動物用飼料、(3)糖類がシ
ュークロース、グルコース、フルクトース、ラクトー
ス、トリハロース、ガラクトース、マンノースのいずれ
か一種以上である(2)に記載のインシュリン非依存性
糖尿病モデル動物用飼料、に関するものである。
That is, the present invention relates to (1) Crude protein in feed (C) against digestible energy (DE) in feed mainly composed of conventional raw materials such as cereals, rice bran, vegetable oil cakes and fats and oils.
P) ratio CP (%) / DE (kcal / g) of not more than 5.0, feed for animal model of insulin-independent diabetes, (2) cereals, rice bran, vegetable oil cake,
Ratio of crude protein (CP) in feed to digestible energy (DE) in feed mainly composed of conventional raw materials such as oils and fats CP
(%) / DE (kcal / g) is not more than 5.0 and saccharides are blended in not less than 10%, animal feed for an insulin-independent diabetes model animal, (3) sucrose and glucose are saccharides , Fructose, lactose, trihalose, galactose, and mannose. 2. The non-insulin-dependent diabetes animal feed according to (2).

【0007】ここにおいて、可消化エネルギー(DE)
とは、飼料の粗エネルギーから糞中へのエネルギーを差
し引いたもので、飼料のエネルギーがどれほど動物に利
用されるかを示すものである。本発明者等は、インシュ
リン非依存性糖尿病モデル動物に対して穀物・糟糠類・
植物油粕類・油脂類等の慣用原料を主体とした飼料中可
消化エネルギー(DE)に対する飼料中粗蛋白質(C
P)の比CP(%)/DE(kcal/g)を5.0以
下とし、あるいは更に糖類を10%以上配合した飼料を
給与することにより、糖尿病の早期発症を促進すること
ができることを見出した。
Here, digestible energy (DE)
Is the crude energy of the feed minus the energy in the feces and indicates how much of the energy of the feed is used by the animal. The present inventors have studied cereals, rice bran,
Crude protein in feed (C) against digestible energy (DE) in feed mainly composed of conventional raw materials such as vegetable oil cakes and fats and oils
It has been found that early onset of diabetes can be promoted by setting the ratio CP (%) / DE (kcal / g) of P) to 5.0 or less, or by feeding a feed containing 10% or more of saccharides. Was.

【0008】なお、CP(%)/DE(kcal/g)
は2.0よりも大きいことが望ましい。インシュリン非
依存性糖尿病は、生理環境の変化により発症することが
知られている。生理環境のなかでも栄養環境の及ぼす影
響は大きく、実験動物においては飼料の影響は極めて大
きい。本発明の飼料をインシュリン非依存性糖尿病モデ
ル動物に給与すると、通常の飼料よりも若齢時に尿糖が
検出され血糖値も上昇した。従って、本発明の飼料は、
血糖値の上昇と尿糖出現の早期化を生じ、糖尿病の発症
を促進する働きを持っている。
Incidentally, CP (%) / DE (kcal / g)
Is preferably greater than 2.0. It is known that non-insulin-dependent diabetes develops due to changes in the physiological environment. Among physiological environments, the effect of the nutritional environment is significant, and the effect of feed is extremely large in experimental animals. When the feed of the present invention was fed to a non-insulin-dependent diabetic model animal, urine sugar was detected at an early age compared to a normal feed, and the blood sugar level also increased. Therefore, the feed of the present invention
It raises blood sugar and accelerates the appearance of urine sugar, and has a function to promote the onset of diabetes.

【0009】次に、糖類の摂取により血糖が上昇するた
め糖尿病の発症促進効果を奏することができる。シュー
クロース、グルコース、フルクトース、ラクトース、ト
リハロース、ガラクトース、マンノース等のいずれか一
種以上の糖類を10%以上飼料に添加すれば、摂取した
動物の血糖値を上昇させ、糖尿病の発症を促進させるこ
とが可能である。糖類が10%未満の場合は、その効果
が明白に出てこない。糖尿病に関する研究は盛んに行わ
れており、糖尿病を発症している動物の需要は多いが、
発症するためにはかなりの時間を要しているので、本発
明による飼料を給与して発症を促進させることは、糖尿
病の研究開発をより進展させることの一端を担うことと
なる。
[0009] Next, since blood sugar is increased by ingestion of saccharides, the onset of diabetes can be promoted. Addition of at least 10% of saccharides such as sucrose, glucose, fructose, lactose, trihalose, galactose, mannose, etc. to the feed can increase the blood sugar level of the ingested animal and promote the onset of diabetes. It is possible. When the saccharide content is less than 10%, the effect is not apparent. There is a lot of research on diabetes, and there is a great demand for animals that have diabetes,
Since the onset of the disease takes a considerable amount of time, feeding the feed according to the present invention to accelerate the onset will play a part in furthering the research and development of diabetes.

【0010】[0010]

【発明の実施の形態】以下、本発明を実施例によりさら
に具体的に説明するが、これに限定されるものではな
い。
DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail with reference to Examples, but it should not be construed that the invention is limited thereto.

【0011】[0011]

【実施例】〔表1〕の成分になるように、穀物・糟糠類
・植物油粕類・油脂類等の慣用原料を主体として飼料を
製造し試験を実施した。インシュリン非依存性糖尿病モ
デル動物のWBN/kob雄ラットを各区9頭ずつ使用
し、7週齢時から52週齢時まで各々〔表1〕の飼料を
給与した。13週齢時、26週齢時、39週齢時、52
週齢時に各区3頭ずつ糖負荷試験(GTT)・採血に供
試し、血糖値・血液生化学的性状について測定した。ま
た全動物の尿糖のチェックを試験開始より毎週実施し、
糖尿病の発症について調べた。
EXAMPLES Feeds were manufactured mainly from conventional raw materials such as cereals, rice bran, vegetable oil cakes, oils and fats, etc. so as to have the components shown in Table 1, and tests were conducted. Nine male WBN / kob rats as non-insulin-dependent diabetes mellitus model animals were used in each group, and the feeds of Table 1 were fed from the age of 7 weeks to the age of 52 weeks. 13 weeks old, 26 weeks old, 39 weeks old, 52
At the age of three weeks, three animals in each group were tested for glucose tolerance test (GTT) and blood collection, and blood sugar level and blood biochemical properties were measured. Also, urine sugar of all animals was checked weekly from the start of the test,
The onset of diabetes was examined.

【0012】[0012]

【表1】試験飼料成分 [Table 1] Test feed ingredients

【0013】試験区は、本発明のもので飼料中可消化エ
ネルギー(DE)に対する飼料中粗蛋白質(CP)の比
CP(%)/DE(kcal/g)を5.0以下とし、
砂糖を10%添加したものである。比較区1及び2は、
砂糖10%を添加していないものである。また、比較区
3、4、5は、CP(%)/DE(kcal/g)が
5.0以上のものである。結果は〔表2〕及び〔表3〕
に示した。〔表2〕からわかるように、試験区は、比較
区3・4・5より血糖値が上昇しており(13週齢を除
く)、〔表3〕では、試験区の方が比較区より低週齢時
から尿糖が検出されており、糖尿病の発症が促進されて
いることを示している。また砂糖が10%配合されてい
る試験区は、同様に飼料中粗蛋白質(CP)の比CP
(%)/DE(kcal/g)を5.0以下であるが、
砂糖が添加されていない比較区1・2よりもさらに発症
が促進された。
In the test plot, the ratio of the crude protein (CP) in the feed to the digestible energy (DE) in the feed according to the present invention is set to be not more than 5.0, ie, CP (%) / DE (kcal / g),
Sugar is added at 10%. Comparison areas 1 and 2
10% of sugar was not added. Further, the comparison groups 3, 4, and 5 have a CP (%) / DE (kcal / g) of 5.0 or more. The results are shown in Table 2 and Table 3.
It was shown to. As can be seen from [Table 2], in the test plot, the blood glucose level was higher than in the control plots 3.4.5 (excluding the age of 13 weeks). In [Table 3], the test plot was higher than the control plot. Urine sugar was detected from a low age, indicating that the onset of diabetes was promoted. In the test plot containing 10% sugar, the ratio of crude protein (CP)
(%) / DE (kcal / g) is 5.0 or less,
The onset was further promoted as compared with Comparative Groups 1 and 2 to which no sugar was added.

【0014】[0014]

【表2】血糖値測定結果(mg/100ml) [Table 2] Blood glucose measurement results (mg / 100ml)

【0015】[0015]

【表3】尿糖測定結果からの糖尿病発症率 [Table 3] Diabetes incidence from urinary glucose measurement results

【0016】[0016]

【発明の効果】本発明による実験動物用飼料を、インシ
ュリン非依存性糖尿病モデル動物に給与すると、糖尿病
の発症を促進させることができ、糖尿病の研究開発に資
することができ、ひいては糖尿病の治療に効果を奏する
ものである。
The feed for experimental animals according to the present invention can be applied to non-insulin-dependent diabetic model animals to promote the onset of diabetes and contribute to the research and development of diabetes. It is effective.

───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6,DB名) A23K 1/00 - 1/18 JICSTファイル(JOIS)──────────────────────────────────────────────────続 き Continuation of front page (58) Field surveyed (Int. Cl. 6 , DB name) A23K 1/00-1/18 JICST file (JOIS)

Claims (3)

(57)【特許請求の範囲】(57) [Claims] 【請求項1】 穀類・糟糠類・植物油粕類・油脂類等の
慣用原料を主体とした飼料中可消化エネルギー(DE)
に対する飼料中粗蛋白質(CP)の比CP(%)/DE
(kcal/g)を5.0以下としたことを特徴とする
インシュリン非依存性糖尿病モデル動物用飼料。
1. Digestible energy (DE) in feed mainly composed of conventional raw materials such as cereals, rice bran, vegetable oil cakes, oils and fats, etc.
Of crude protein (CP) in feed to the ratio CP (%) / DE
(Kcal / g) is 5.0 or less, a feed for an insulin-independent diabetes model animal.
【請求項2】 穀類・糟糠類・植物油粕類・油脂類等の
慣用原料を主体とした飼料中可消化エネルギー(DE)
に対する飼料中粗蛋白質(CP)の比CP(%)/DE
(kcal/g)を5.0以下としかつ糖類を10%以
上配合してあることを特徴とするインシュリン非依存性
糖尿病モデル動物用飼料。
2. Digestible energy in feed (DE) mainly composed of conventional raw materials such as cereals, rice bran, vegetable oil cakes and fats and oils.
Of crude protein (CP) in feed to the ratio CP (%) / DE
(Kcal / g) is 5.0 or less, and a saccharide is blended at 10% or more.
【請求項3】 糖類がシュークロース、グルコース、フ
ルクトース、ラクトース、トリハロース、ガラクトー
ス、マンノースのいずれか一種以上である請求項2に記
載のインシュリン非依存性糖尿病モデル動物用飼料。
3. The feed for an insulin-independent diabetes model animal according to claim 2, wherein the saccharide is any one or more of sucrose, glucose, fructose, lactose, trihalose, galactose, and mannose.
JP9222220A 1997-08-19 1997-08-19 Non-insulin dependent diabetes animal feed Expired - Fee Related JP2901057B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9222220A JP2901057B2 (en) 1997-08-19 1997-08-19 Non-insulin dependent diabetes animal feed

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9222220A JP2901057B2 (en) 1997-08-19 1997-08-19 Non-insulin dependent diabetes animal feed

Publications (2)

Publication Number Publication Date
JPH1156251A JPH1156251A (en) 1999-03-02
JP2901057B2 true JP2901057B2 (en) 1999-06-02

Family

ID=16779014

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9222220A Expired - Fee Related JP2901057B2 (en) 1997-08-19 1997-08-19 Non-insulin dependent diabetes animal feed

Country Status (1)

Country Link
JP (1) JP2901057B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104642734A (en) * 2013-11-15 2015-05-27 中国科学院过程工程研究所 Broiler feed additive and use thereof
CN104642735A (en) * 2013-11-15 2015-05-27 中国科学院过程工程研究所 Complex carbohydrate preparation for forage, forage containing complex carbohydrate preparation, and use of forage

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104642734A (en) * 2013-11-15 2015-05-27 中国科学院过程工程研究所 Broiler feed additive and use thereof
CN104642735A (en) * 2013-11-15 2015-05-27 中国科学院过程工程研究所 Complex carbohydrate preparation for forage, forage containing complex carbohydrate preparation, and use of forage
CN104642735B (en) * 2013-11-15 2018-05-22 中国科学院过程工程研究所 A kind of feed is with glycoconjugate preparation and containing its feed and application
CN104642734B (en) * 2013-11-15 2018-05-22 中国科学院过程工程研究所 A kind of broiler chicken feed additive and its application

Also Published As

Publication number Publication date
JPH1156251A (en) 1999-03-02

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