JP2818050B2 - Interface for iontophoresis - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a new type of interface for iontophoresis which emphasizes safety.

[0002]

2. Description of the Related Art In a conventional interface for iontophoresis, as shown in FIG. 6, a conductive electrode 71 is opposed to a living body surface MM via a drug solution holding portion 72. Localization of the current density on the surface of the living body may be observed due to the non-uniformity or the non-uniformity of the conductive surface.

[0003]

Therefore, it is necessary to make the distribution of the electric current supplied to the living body surface uniform by securing the distance between the living body surface and the conductive surface.

[0004]

SUMMARY OF THE INVENTION In view of the above, the present invention provides an iontophoretic device having a reservoir for storing contents such as a drug solution or water and an electrode in contact with the contents such as the drug solution or water. In the interface for Reese, the electrode has a conductive surface and a non-conductive surface, by arranging this conductive surface in a direction other than the body surface direction, and by providing an opening penetrating both electrode surfaces, From this opening, we found that the distribution of the current supplied to the living body surface was uniformed,
The present invention has been realized.

FIG. 1 is a sectional view showing an embodiment of the present invention. Reference numeral 5 denotes an electrode, which is a conductive surface 1 formed by printing or applying a conductive substance such as carbon on a sheet-shaped insulating base material 2. The conductive surface 1 does not face the living body surface (the arrow indicates AA) and has an opening 3 in the surface. The shape, size, position on the electrode surface, and the like of the opening 3 are not particularly limited. Similarly, the shape, size, and position of the conductive surface 1 on the electrode surface are not particularly limited.

FIG. 2 is a sectional view of a one-piece iontophoresis interface showing an embodiment of the present invention.
It comprises a reservoir (moisture storage) backing material 4, an electrode 5, a base material 6 of a porous member 10, an adhesive layer 8, and a separator 9. The reservoir (moisture storage unit) backing material 4 and the electrode 5 are joined by a sealer (heat, high frequency) means or an adhesive, but are not particularly limited.

The electrode 5 has the structure shown in FIG. The porous member 10 is formed of a nonwoven fabric, a porous film, or the like.
The base material 6 of the porous member 10 is a sheet-like body having flexibility and non-conductivity, and an opening 7 penetrating both surfaces is provided at the same site as the opening 3 provided in the electrode 5. ing. The adhesive layer 8 is formed by thinly applying an adhesive having an adhesive property such that the present example itself can adhere to the surface of the living body. The component of the pressure-sensitive adhesive is not particularly limited, but any material can be used as long as safety to the skin is considered. The reservoir (moisture storage unit) backing material 4 is a cup-shaped material made of plastic or the like, in which a drug or water 2A is stored. The separator 9 is provided with a silicone coating or the like in order to make the separation from the adhesive layer good.

Further, the porous member 10 may be used by applying or spraying a medicine. Further, the contents of the reservoir (water storage unit) backing material 4 include an aqueous solution, a sol,
Alternatively, a gel is filled, but a drug may be used in some cases. Also, the area of the opening 3 in the opening in the surface of the electrode 5 is:
It is sufficiently larger than the area of the opening 7 of the substrate 6 of the porous member 10. In addition, the separator 9 is peeled off at the time of use, and adheres to the skin.

FIG. 3 is a sectional view showing an embodiment of the present invention, which is a separate type in which a reservoir (moisture storage unit) and a drug holding unit are separated, and an electrode 5 is provided on the reservoir (moisture storage unit) side.
With Reference numeral 3A denotes a reservoir (moisture storage unit), which includes a reservoir (moisture storage unit) backing material 4, an electrode 5, a porous member 11, and a separator 12. 3B
Is a medicine holding part, and a separator 13, an adhesive layer 14,
It comprises a base member 6 of a porous member 10, an adhesive layer 8 and a separator 9.

[0010] The structure and material of the above components are the same as those shown in FIG.

The medicine is applied or sprayed on the porous member 10. The contents of the reservoir (moisture storage unit) backing material 4 are filled with an aqueous solution, sol, or gel. Also, as in the embodiment shown in FIG.
The area of the opening 3 in the surface of the electrode 5 is sufficiently larger than the area of the opening 7 of the base material 6 of the porous member 10. still,
In use, the separator 9 is peeled off and the medicine holding section 3B is adhered to the skin, and then the separators 12 and 13 are peeled off to unite the reservoir (3A) and the medicine holding section (3B).

FIG. 4 is a sectional view showing an embodiment of the present invention, which is a separate type in which a reservoir (moisture storage section) 4A and a medicine holding section 4B are separated, and an electrode 5 is provided on the medicine holding section 4B side.
With Reference numeral 4A denotes a reservoir (moisture storage unit), which comprises a reservoir (moisture storage unit) backing material 4, a porous member 11, and a separator 12. Reference numeral 4B denotes a medicine holding portion, which is composed of a separator 13, an adhesive layer 14, an electrode 5, a base material 6 of a porous member 10, an adhesive layer 8, and a separator 9. The medicine is applied or sprayed on the porous member 10. The contents of the reservoir (moisture storage unit) backing material 4 are filled with an aqueous solution, sol, or gel. Further, as in the embodiment shown in FIG. 2, the area of the opening 3 in the surface of the electrode 5 is sufficiently larger than the area of the opening 7 of the base material 6 of the porous member 10. In use, the separator 9 is peeled off and the drug holding section 4B is adhered to the skin, and then the separator 12 of the reservoir 4A and the separator 13 of the drug holding section 4B are peeled and united. The state is shown in FIG.

[0013]

According to the present invention, the conductive surface 1 of the electrode 5 is
Faces the opposite side to the surface of the living body and has an opening 3 in the surface of the electrode 5.
Is provided to prevent a local current flow due to a local approach between the electrode surface and the skin surface, and to ensure a uniform current density on the skin surface. This greatly reduces the risk of burns. Further, as shown in the embodiment shown in FIGS. 2 to 4, by making the area of the opening 3 in the surface of the electrode 5 sufficiently larger than the area of the opening 7 of the base material 6 of the porous member 10, The above effect can be made more remarkable. In addition, in the embodiment of the present invention shown in FIGS. 3 and 4, the reservoir can be replaced while the drug holding section is adhered to the surface of the living body, so that replenishment and replacement of the medicine can be easily performed.

[Brief description of the drawings]

FIG. 1 is a sectional view showing an embodiment of the present invention.

FIG. 2 is a sectional view of a one-piece iontophoresis interface showing an embodiment of the present invention.

FIG. 3 is a cross-sectional view of an interface for iontophoresis having an electrode on the side of a reservoir (moisture storage section), showing an embodiment of the present invention.

FIG. 4 is a cross-sectional view of a separate type interface for iontophoresis having an electrode on a drug holding part side according to an embodiment of the present invention.

FIG. 5 is a diagram showing a state where the embodiment shown in FIG. 4 is adhered to the surface of a living body.

FIG. 6 is a sectional view showing a conventional example.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Conductive surface 2 Insulating base material 3 Opening part 4 Reservoir (moisture storage part) backing material 5 Electrode 6 Base material 7 Opening part 8 Adhesive layer 9 Separator 10 Porous member 11 Porous member 12 Separator 13 Separator 14 Adhesive layer

Claims (5)

(57) [Claims] 1. An interface for iontophoresis, wherein the conductive surface 1 of the electrode 5 faces the side opposite to the surface of the living body, and has an opening 3 in the surface. 2. The iontophoresis device according to claim 1, wherein the area of the opening in the surface of the electrode is sufficiently larger than the area of the opening in the substrate of the porous member. Interface. 3. The iontophoresis interface according to claim 1, wherein the reservoir (moisture storage unit) and the medicine holding unit are of a single body. 4. The interface for iontophoresis according to claim 1, wherein the reservoir (moisture storage section) and the medicine holding section are separated and have an electrode on the reservoir side. 5. The interface for iontophoresis according to claim 1, wherein the reservoir (moisture storage section) and the drug holding section are separated and have an electrode on the drug holding section side.