JP2807469B2 - Leukocyte separation material - Google Patents
Leukocyte separation materialInfo
- Publication number
- JP2807469B2 JP2807469B2 JP63199372A JP19937288A JP2807469B2 JP 2807469 B2 JP2807469 B2 JP 2807469B2 JP 63199372 A JP63199372 A JP 63199372A JP 19937288 A JP19937288 A JP 19937288A JP 2807469 B2 JP2807469 B2 JP 2807469B2
- Authority
- JP
- Japan
- Prior art keywords
- leukocyte
- blood
- separating material
- fiber
- fibrous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000000265 leukocyte Anatomy 0.000 title claims description 88
- 239000000463 material Substances 0.000 title claims description 78
- 238000000926 separation method Methods 0.000 title description 5
- 239000000835 fiber Substances 0.000 claims description 33
- 210000004369 blood Anatomy 0.000 claims description 28
- 239000008280 blood Substances 0.000 claims description 28
- 239000008187 granular material Substances 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 13
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 230000009931 harmful effect Effects 0.000 claims description 4
- 239000002657 fibrous material Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 8
- 239000000306 component Substances 0.000 description 7
- 239000011148 porous material Substances 0.000 description 7
- 238000001914 filtration Methods 0.000 description 5
- 238000011045 prefiltration Methods 0.000 description 5
- 239000012503 blood component Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- -1 for example Substances 0.000 description 3
- 229920002994 synthetic fiber Polymers 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000012209 synthetic fiber Substances 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- SJIXRGNQPBQWMK-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-methylprop-2-enoate Chemical compound CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000012784 inorganic fiber Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は、血液中の白血球を選択的に分離する白血球
分離材に関するものであり、血液に対して偽害性のない
材質からなる素材繊維表面に、粒状物、繊維状物質を形
成して、該白血球分離材の表面積を大きくするとともに
実孔を小さくして白血球のくっつきを増大させて、血液
中から効率的に白血球を除去できる白血球分離材であ
る。Description: TECHNICAL FIELD The present invention relates to a leukocyte separating material for selectively separating leukocytes in blood, and a material fiber made of a material having no harmful effect on blood. Leukocyte separation that forms granular materials and fibrous substances on the surface, increases the surface area of the leukocyte separating material, reduces the actual pores and increases the adhesion of leukocytes, and can efficiently remove leukocytes from blood. Material.
また前記白血球分離材表面に白血球選択付着性物質を
コーティングして、より一層効率的に白血球を除去でき
るようにした白血球分離材である。Further, there is provided a leukocyte separating material in which the leukocyte separating material is coated on the surface of the leukocyte separating material so that leukocytes can be more efficiently removed.
さらに、基幹支持体としての素材繊維に、粒状物、繊
維状物質を付着させた構造により、白血球分離材の嵩ば
りを抑え、また血液の濾過時間を短くすることのできる
白血球分離材である。Further, the leukocyte separating material is capable of suppressing bulkiness of the leukocyte separating material and shortening a blood filtration time by a structure in which a granular material or a fibrous substance is adhered to a material fiber as a base support.
［従来の技術および従来技術の課題］ 現在、全血輸血に代わって、赤血球、白血球、血小
板、血漿等の特定成分のみを、各患者の症状に応じて輸
血する成分輸血が行なわれている。[Related Art and Problems of Related Art] Currently, instead of whole blood transfusion, component transfusion is performed in which only specific components such as red blood cells, white blood cells, platelets, and plasma are transfused according to the symptoms of each patient.
通常、赤血球あるいは血小板を必要とする患者に、輸
血を行う際に、白血球成分の混入による発熱あるいは輸
血後の重大な障害である移植片宿主反応（GVH反応）な
どの副作用を伴うおそれがあるので、全血中から白血球
のみを選択的に除去する必要がある。Normally, patients who require red blood cells or platelets may have side effects such as fever due to the incorporation of leukocyte components or graft host reaction (GVH reaction) which is a serious obstacle after blood transfusion when performing transfusion. It is necessary to selectively remove only leukocytes from whole blood.
他方、白血球の成分輸血は、白血球数が異常に低下し
て細菌等の感染により発熱した患者に対して輸血するの
に必要である。On the other hand, transfusion of leukocyte components is necessary for transfusing a patient who has a fever caused by infection with bacteria due to abnormally low white blood cell count.
そこで、白血球を選択的に除去するための手段とし
て、遠心分離あるいは白血球に対して粘着性を有する繊
維フィルターを用いる方法が実施されている。Therefore, centrifugal separation or a method using a fiber filter having adhesiveness to leukocytes has been implemented as a means for selectively removing leukocytes.
遠心分離による方法では、各血液成分の比重の差によ
って分離するものであるが、白血球成分は、全血中に微
少量しか存在せず、完全に全血中から除去するのは困難
で、完全に除去しようとすると、他の血液成分も同時に
廃棄しなければならないので、好ましい方法ではない。In the method by centrifugation, blood components are separated based on the difference in specific gravity of each blood component.However, leukocyte components are present only in a very small amount in whole blood, and it is difficult to completely remove them from whole blood. This is not a preferred method because other blood components must be discarded at the same time.
また、血球を付着しやすい性質を有するナイロン、ポ
リエステル、天然綿等の繊維を用いて白血球を除去する
方法は、これら繊維自体の白血球に対する粘着性能が弱
く、白血球を完全に除去することができなかった。In addition, the method of removing leukocytes using fibers such as nylon, polyester, and natural cotton, which have a property of easily adhering blood cells, has a weak adhesive performance on leukocytes of these fibers themselves, and cannot completely remove leukocytes. Was.
この場合、白血球の除去効率を上げる目的で、繊維使
用量を多くする場合は、繊維フィルターが嵩ばるという
難点があり、またこの嵩ばりを抑制するため、圧縮や稠
密編織等の手段を用いると、血液の濾過速度が著しく低
下するという難点があった。In this case, in order to increase the efficiency of removing leukocytes, when using a large amount of fiber, there is a disadvantage that the fiber filter is bulky, and in order to suppress this bulking, when using means such as compression or dense knitting. However, there was a problem that the blood filtration rate was significantly reduced.
そこで、本発明者は以上の課題を解決するために鋭意
検討を重ねた結果、白血球の除去効率をより向上させる
ことのできる次の白血球分離材を開発した。Therefore, the present inventor has conducted intensive studies in order to solve the above problems, and as a result, has developed the following leukocyte separating material capable of further improving the leukocyte removal efficiency.
［課題を解決するための手段］ 本発明は、基本的に素材繊維表面に、粒状物、繊維状
物を形成した白血球分離材および該白血球分離材表面に
白血球選択付着性物質をコーティングした白血球分離材
を提供するものである。Means for Solving the Problems The present invention basically provides a leukocyte separating material in which a granular material or a fibrous material is formed on the surface of a material fiber, and a leukocyte separating material in which a leukocyte selective adhesive substance is coated on the surface of the leukocyte separating material. Materials.
素材繊維は、織布、不織布、不定形塊状物で、血液に
対して偽害性のない材質であれば何でも良く、例えば、
ポリアミド、ポリエステル、ポリアクリロニトリル、ポ
リテトラフルオロエチレン、ポリスチレン、ポリブチレ
ンフタレート等の合成繊維、アセテート等の半合成繊
維、銅アンモニアレーヨン等の再生人造繊維、綿、絹
糸、羊毛等の天然繊維、ガラス等の無機繊維、ヒドロキ
シアパタイトが用いられる。The material fiber is a woven fabric, a nonwoven fabric, an amorphous mass, and may be any material that is not harmful to blood, for example,
Synthetic fibers such as polyamide, polyester, polyacrylonitrile, polytetrafluoroethylene, polystyrene, and polybutylene phthalate; semi-synthetic fibers such as acetate; regenerated artificial fibers such as cuprammonium rayon; natural fibers such as cotton, silk thread, wool, and glass Inorganic fiber, hydroxyapatite is used.
粒状物は、球状、立方体、直方体、その他不定形状物
であって、最短径が15μ以下のものが良い。粒状物は最
短径が15μを越えると素材繊維２間に空隙が素材繊維２
のみにより形成される空隙よりも相対的に大きくなりす
ぎて、素材繊維２の表面に白血球が付着しにくくなるの
で好ましくない。また最短径が15μを越える粒状物を素
材繊維２に付着させても白血球分離材１全体の嵩ばりが
大きくなりかつ実孔も大きくなりすぎて、三次元網目構
造となりにくくなるので好ましくない。The granular material is a sphere, a cube, a rectangular parallelepiped, or any other irregular shaped material, and preferably has a minimum diameter of 15 μm or less. When the shortest diameter of the granular material exceeds 15μ, a void is formed between the material fibers 2.
This is not preferable because the voids are relatively larger than the voids formed only by the white blood cells and the white blood cells hardly adhere to the surface of the material fiber 2. Further, even if particles having a shortest diameter exceeding 15μ are adhered to the material fiber 2, the bulk of the leukocyte separating material 1 as a whole becomes too large and the actual pores become too large, so that it is difficult to form a three-dimensional network structure.
繊維状物は、直径が１μ以上でかつ長さが１μ以上の
ものが良い。繊維状物は直径が１μ未満でかつ長さが１
μ未満のものは、径が細くかつ長さが短かすぎて、素材
繊維の表面に付着させても、素材繊維２間の間隔があき
すぎて、白血球分離材１全体の実孔を十分に小さくする
ことができず、三次元網目構造となりにくくなるので好
ましくない。The fibrous material preferably has a diameter of 1 μ or more and a length of 1 μ or more. The fibrous material has a diameter of less than 1μ and a length of 1
If the diameter is less than μ, the diameter is too small and the length is too short, and even if it adheres to the surface of the material fiber, the space between the material fibers 2 is too large, and the actual holes of the whole leukocyte separating material 1 are sufficiently formed. It is not preferable because it cannot be reduced in size and becomes difficult to form a three-dimensional network structure.
これら粒状物、繊維状物は素材繊維の表面に付着させ
ても良くあるいは素材繊維製造の際に素材繊維の表面に
一体に形成させても良い。These granules and fibrous materials may be adhered to the surface of the material fiber, or may be integrally formed on the surface of the material fiber during production of the material fiber.
また、これら粒状物および繊維状物は、血液に対して
偽害性のない材質であれば何でも良く、例えば、キチ
ン、キトサン、ヒドロキシアパタイト、シリカゲル、ポ
リメチルメタクリレート、シリコーン、セルロース微粉
等が良く、繊維状物質の場合は、素材繊維と同じ材質を
使用することができる。In addition, these granular materials and fibrous materials may be anything as long as they are not harmful to blood, such as chitin, chitosan, hydroxyapatite, silica gel, polymethyl methacrylate, silicone, and cellulose fine powder. In the case of a fibrous substance, the same material as the material fiber can be used.
これらの粒状物および繊維状物は、血液に対して偽害
性のない、例えばポリアミノ酸、ゼラチン、コラーゲ
ン、ハイドロン等から成る粘結剤やあるいは静電植毛等
の方法により、該素材繊維に均一に分散付着することが
できる。These granules and fibrous materials are non-hazardous to blood, and are uniformly applied to the material fibers by a method such as a binder made of polyamino acid, gelatin, collagen, hydron, or the like, or electrostatic flocking. Can be dispersed and adhered to.
該素材繊維に均一に分散付着することができる方法で
あればこれらの方法に限定されるものではなく、何でも
良い。The method is not limited to these methods as long as it can be uniformly dispersed and attached to the material fibers, and any method may be used.
このように形成した白血球分離材１では、第１図およ
び第２図に示すように素材繊維２間の空隙は、粒状物
３、繊維状物４により埋められているので、繊維単体の
みにより形成されている白血球分離材と比較して、表面
積を大きくすることができかつ実孔を小さくすることが
できる。In the leukocyte separating material 1 formed in this manner, the gaps between the material fibers 2 are filled with the granular materials 3 and the fibrous materials 4 as shown in FIGS. The surface area can be increased and the actual pores can be reduced as compared with the used leukocyte separating material.
このように粒状物３、繊維状物４は、素材繊維２間の
空隙を埋めるため白血球捕捉材としての役割を果たす。As described above, the granular material 3 and the fibrous material 4 play a role as a leukocyte capturing material to fill the gap between the material fibers 2.
またこのように形成した白血球分離材１を用いると、
白血球フィルターの組み立てを困難にする嵩ばりが少な
くなると共に該白血球フィルターを実用する際、きわめ
て重要な血液濾過時間が短くなるという利点がある。When the leukocyte separating material 1 thus formed is used,
There is an advantage that the bulkiness which makes it difficult to assemble the leukocyte filter is reduced, and when the leukocyte filter is put to practical use, the blood filtration time which is extremely important is shortened.
さらに、素材繊維２と粒状物３または繊維状物４から
なる白血球分離材１全体に、白血球選択付着性物質、例
えばヒドロキシエチルメタクリレートとジエチルアミノ
エチルメタクリレートの共重合体や白血球抗体をコーテ
ィングして、白血球除去効率を向上させることができ
る。Further, the whole leukocyte separating material 1 composed of the material fiber 2 and the granular material 3 or the fibrous material 4 is coated with a leukocyte selective adhesive substance, for example, a copolymer of hydroxyethyl methacrylate and diethylaminoethyl methacrylate or a leukocyte antibody, Removal efficiency can be improved.
白血球分離材１は、塊状または層状に積層して、例え
ば第３図または第４図に示す様に、平板状のカラム5aま
たは筒状のカラム5bに装填される。The leukocyte separating material 1 is stacked in a lump or a layer and loaded into a flat column 5a or a tubular column 5b, for example, as shown in FIG. 3 or FIG.
すなわち、プレフィルター６とポストフィルター７間
に挟持されて血液導入口８および血液導出口９を隔離す
るようにして装填される。That is, it is inserted between the pre-filter 6 and the post-filter 7 so as to isolate the blood inlet 8 and the blood outlet 9.
プレフィルター６は、異物等の透過を阻止できる程度
の孔径（10〜50μ）を有し、ポストフィルター７は、血
液濾過中に、素材繊維２から遊離した粒状物３および繊
維状物４の透過を阻止できる程度の孔径を有するもので
ある。The prefilter 6 has a pore size (10 to 50 μ) that can prevent the penetration of foreign matter and the like, and the postfilter 7 transmits the granular material 3 and the fibrous material 4 released from the material fiber 2 during blood filtration. Having such a pore diameter as to be able to prevent the occurrence of a crack.
以上の様にして、組み立てられた白血球フィルター10
を用いて血液を次のように処理する。The leukocyte filter 10 assembled as described above
The blood is processed as follows.
［実施例］ 血液を血液導入口８から導入して、プレフィルター
６、白血球分離材１、ポストフィルター７を経て血液を
透過させて、血液導出口９より血液を回収する。[Example] Blood is introduced from the blood inlet 8, passes through the prefilter 6, the leukocyte separating material 1, and the post filter 7, and is collected from the blood outlet 9.
血液導入口８から導入された血液中の血液凝集塊ある
いは微小異物等は、プレフィルター６によって透過を阻
害され、血液成分のみが白血球分離材１内にはいる。The blood aggregates or minute foreign substances in the blood introduced from the blood inlet 8 are inhibited from passing by the prefilter 6, and only the blood components enter the leukocyte separating material 1.
白血球分離材１の素材繊維２表面には、白血球よりも
細径の繊維状物質４が、三次元網目状に張り巡らされて
いるために、該白血球分離材１の実孔が小さくなり白血
球成分が、該繊維状物質４にくっつきやすいと考えられ
る。Since the fibrous substance 4 having a diameter smaller than that of the white blood cells is spread over the surface of the material fiber 2 of the white blood cell separating material 1 in a three-dimensional network, the actual pores of the white blood cell separating material 1 become small and the white blood cell component However, it is considered that it is easy to adhere to the fibrous substance 4.
さらに、素材繊維２表面に粒状物３を付着させた場合
も素材繊維２間に、粒状物３が三次元立体状に配置され
ることになり、白血球分離材１の実孔が小さくなり、白
血球成分が該粒状物３にくっつきやすくなると考えられ
る。Further, when the granular material 3 is adhered to the surface of the material fiber 2, the granular material 3 is arranged three-dimensionally between the material fibers 2, the actual holes of the leukocyte separating material 1 become small, and the leukocyte It is considered that the components tend to stick to the granular material 3.
また、白血球分離材１を白血球選択付着性物質でコー
ティングした場合は、前記との相乗作用によりさらに白
血球除去効率が向上する。Further, when the leukocyte separating material 1 is coated with the leukocyte-selective adhesive substance, the leukocyte removal efficiency is further improved by the synergistic action with the above.
表面に粒状物３および繊維状物質４を形成した白血球
分離材１では、92±３％の白血球が補捉された。In the leukocyte separating material 1 having the particulate matter 3 and the fibrous substance 4 formed on the surface, 92 ± 3% of leukocytes were captured.
また、白血球選択付着物質をコーティングした白血球
分離材１で、95±３％の白血球が補捉された。Further, with the leukocyte separating material 1 coated with the leukocyte selective adherent, 95 ± 3% of leukocytes were captured.
さらに、白血球分離材１内に回収液として生理食塩水
を通して、白血球分離材１内に補捉された白血球を回収
した。回収液の中には、白血球分離材１に補捉された白
血球が、90±５％回収された。Further, a physiological saline solution was passed through the leukocyte separating material 1 as a collecting liquid, and the leukocytes captured in the leukocyte separating material 1 were collected. In the recovered liquid, 90 ± 5% of the leukocytes captured by the leukocyte separating material 1 were recovered.
［発明の効果］ 以上説明したように本発明の白血球分離材１において
は、 （１）素材繊維２の表めに、粒状物３、繊維状物４を付
着させているので、該白血球分離材１の表面積を大きす
することができかつ実孔を小さくすることができる。[Effects of the Invention] As described above, in the leukocyte separating material 1 of the present invention, (1) Since the granular material 3 and the fibrous material 4 are adhered to the surface of the material fiber 2, the leukocyte separating material 1 can have a large surface area and a small actual hole.
これより、白血球が粒状物３、繊維状物４に粘着しや
すくなり、白血球の除去効率が向上する。Thereby, the white blood cells easily adhere to the granular material 3 and the fibrous material 4, and the efficiency of removing the white blood cells is improved.
（２）白血球分離材１の表面を白血球選択付着性物質を
コーティングすることにより、前述の表面積の増大なら
びに実孔の小径化との相乗作用により白血球の除去効率
が向上する。(2) By coating the surface of the leukocyte separating material 1 with the leukocyte-selective adhesive substance, the efficiency of leukocyte removal is improved by synergistic action with the above-described increase in surface area and reduction in the diameter of the actual pores.
（３）基幹支持体としての素材繊維２の表面に粒状物
３、繊維状物４を付着させた構造により、白血球分離材
１の嵩ばりが減少して、白血球フィルターとして組み立
て易くなり、また白血球分離材１の血液濾過速度が大き
くなるので、白血球分離材１を装填した白血球フィルタ
ーを用いての輸血操作時間が短くなるという実用上の利
点が大きい。(3) Due to the structure in which the granular material 3 and the fibrous material 4 are adhered to the surface of the material fiber 2 as the base support, the bulk of the leukocyte separating material 1 is reduced, so that the leukocyte filter can be easily assembled and the leukocyte filter can be easily assembled. Since the blood filtration speed of the separation material 1 is increased, there is a great practical advantage that the blood transfusion operation time using the white blood cell filter loaded with the white blood cell separation material 1 is shortened.
等を効果を有する優れた発明である。It is an excellent invention having the effects as described above.
第１図および第２図は本発明の白血球分離材１の一部拡
大図、第３図および第４図は、白血球分離材１をカラム
に装填して形成した血液フィルターの概略図を示す。 図中、１は白血球分離材、２は素材繊維、３は粒状物、
４は繊維状物、５はカラム、６はプレフィルター、７は
ポストフィルター、10は白血球フィルターを示す。1 and 2 are partially enlarged views of the leukocyte separating material 1 of the present invention, and FIGS. 3 and 4 are schematic views of a blood filter formed by loading the leukocyte separating material 1 in a column. In the figure, 1 is a leukocyte separating material, 2 is a material fiber, 3 is a granular material,
4 is a fibrous material, 5 is a column, 6 is a prefilter, 7 is a post filter, and 10 is a leukocyte filter.
Claims (3)
材繊維表面に、最短径が15μ以下の粒状物を形成したこ
とを特徴とする白血球分離材。1. A leukocyte separating material characterized in that a granular material having a shortest diameter of 15 μm or less is formed on the surface of a material fiber made of a material which is not harmful to blood.
上でかつ長さが１μ以上の繊維状物質を形成したことを
特徴とする白血球分離材。2. A leukocyte separating material, wherein a fibrous substance having a diameter of 1 μ or more and a length of 1 μ or more is formed on the surface of the material fiber according to claim 1.
白血球選択付着性物質をコーティングしたことを特徴と
する白血球分離材。3. A leukocyte separating material, wherein the leukocyte separating material according to claim 1 is coated with a leukocyte selective adhesive substance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63199372A JP2807469B2 (en) | 1988-08-10 | 1988-08-10 | Leukocyte separation material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63199372A JP2807469B2 (en) | 1988-08-10 | 1988-08-10 | Leukocyte separation material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0246857A JPH0246857A (en) | 1990-02-16 |
| JP2807469B2 true JP2807469B2 (en) | 1998-10-08 |
Family
ID=16406663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63199372A Expired - Fee Related JP2807469B2 (en) | 1988-08-10 | 1988-08-10 | Leukocyte separation material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2807469B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0811412B1 (en) * | 1995-12-26 | 2003-07-30 | Asahi Medical Co., Ltd. | Filter medium for leukocyte removal |
| ATE364413T1 (en) * | 1999-11-01 | 2007-07-15 | Asahi Kasei Medical Co Ltd | FILTER FOR SELECTIVE REMOVAL OF LEUKOCYTES |
| JP5855337B2 (en) * | 2010-10-07 | 2016-02-09 | 北越紀州製紙株式会社 | Porous material and method for producing the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61276564A (en) * | 1985-05-30 | 1986-12-06 | 旭メデイカル株式会社 | Blood treatment apparatus |
| JP2627500B2 (en) * | 1987-02-16 | 1997-07-09 | 旭光学工業株式会社 | Abnormality transmission device of optical unit for laser printer and laser printer |
-
1988
- 1988-08-10 JP JP63199372A patent/JP2807469B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0246857A (en) | 1990-02-16 |
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