JP2757467B2 - Chromatographic data processor - Google Patents

Description

The present invention relates to a chromatographic data processing apparatus, and more particularly to a chromatographic data processing apparatus characterized by setting parameters for waveform processing.

(B) Conventional technology Generally, in a chromatographic data processing device, a measured chromatogram is converted into a digital signal by an A / D converter, the chromatogram data is taken in, and various waveform processes are performed. In this type of chromatographic data processor, WIDTH, SLOPE, DRIF
Set waveform processing parameters such as T. WIDTH is the minimum peak width (unit: second), SLOPE is the peak detection sensitivity (unit: μV / min), and DRIFT is the magnitude of the baseline fluctuation (unit: μV / min). In the conventional chromatographic data processing device, the setting of the parameters is performed by operating a keyboard and inputting numerical values.

(C) Problems to be Solved by the Invention Waveform processing parameters need to be changed according to the shape of a chromatogram to be processed. However, if parameters are input numerically as in the past, it is difficult to intuitively determine whether the input parameter values are appropriate for the chromatogram to be processed, and the optimum parameter is obtained. Therefore, it is necessary to perform trial and error to repeat the waveform re-analysis while changing the numerical values variously, and when the chromatogram to be processed is for an unknown sample, there is a problem that it takes time to set parameters especially. .

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and has as its object to provide a chromatographic data processing apparatus that allows parameters to be set visually and that makes parameter setting easy and easy.

(D) Means and Action for Solving the Problems The chromatographic data processing device of the present invention comprises: a data input unit for receiving chromatogram data converted from an analog value to a digital value; Chromatogram storage means for storing, parameter storage means for storing parameters for performing data processing, two-dimensional display means, mode setting means for setting a parameter setting mode, and the two-dimensional display means in a parameter setting mode Display control means for displaying the chromatogram stored in the chromatogram storage means on the two-dimensional display means and displaying the parameters stored in the parameter storage means in a straight line on the two-dimensional display means; Manually changing the parameters displayed in a straight line on the dimension display means It is characteristically provided with parameter adjusting means and parameter fixing operation means for fixing the displayed parameters as setting parameters by operation.

In this chromatographic data processing device, when the parameter setting mode is set by the mode setting means, the chromatogram stored in the chromatogram storage means and the parameters stored in the parameter storage means, for example, WI
DTH is also displayed on the two-dimensional display means. The operator can visually check the displayed chromatogram and parameters to determine whether or not the parameters are appropriate. If it is determined that the parameter is not appropriate, the parameter is adjusted to an appropriate value by the parameter adjustment unit while visually checking the two-dimensional display unit. Then, when the parameter fixing means is operated, the parameter value at that time is set as an appropriate value. Since the adjustment can be made while always looking at the two-dimensional display screen, the parameter can be easily set.

(E) Examples Hereinafter, the present invention will be described in more detail with reference to examples.

FIG. 2 is a block diagram of a chromatographic data processing device according to the present invention.

The data processing apparatus includes an A / D converter 1 for converting a chromatogram input from a chromatograph from an analog value to a digital value, a central processing unit 2 for processing data taken from the A / D converter 1, A signal data storage unit 3 for storing the inserted chromatogram data; a control command unit 4 for giving a control command to the central processing unit 2; a control instruction storage unit 5 for storing a control instruction to be executed by the central processing unit 2; Parameter storage unit 6 for storing parameters such as WIDTH, SLOPE, DRIFT, etc., a keyboard 7 for inputting various numerical values, a mouse 8, a CRT 9 for displaying chromatogram waveforms and parameters, and outputting waveform processing results and the like. And an output device 10 such as a printer.

In the data processing apparatus of this embodiment, a command device for setting a parameter mode in the control command device 4 is provided. When this commander is selected, the data processing device enters a parameter setting mode. However, the parameter setting mode may be automatically selected by the program in the initial operation.

FIGS. 1 (A), 1 (B), and 1 (C) show display examples of parameter settings in the data processing apparatus.

FIG. 1A shows an example of a screen display of the CRT 9 when setting WIDTH. When setting WIDTH parameters, a chromatogram waveform a, two vertical lines b indicating WIDTH, a display area c for displaying the value of WIDTH, and a mouse for instructing the end of setting are set on the screen. A display area d for instructing the end of the setting by operating the mouse is provided. The two vertical lines b indicating WIDTH can be moved in the horizontal direction by a mouse, and have a function of setting the minimum half width of the width of the peak to be detected.

Also, in FIG. 1 (B), the chromatogram waveform a and SL
The OPE line e is displayed, and at the bottom right of the screen, SLO
A display area f for digitally displaying the actual value of PE is provided, and a display area d for positioning and operating the mouse when setting is completed. Arrows on the screen indicate the current position of the mouse 8. When the straight line e is inclined more steeply,
The left button of the mouse 8 may be clipped. Conversely, when the gradient of the straight line e is made gentle, that is, when the parameter is reduced, the right button of the mouse 8 may be clipped. Further, when it is desired to move the straight line e in parallel, the mouse 8 is rolled so that the straight line e is moved in parallel with the movement of the mouse 8 as it is.

Fig. 1 (C) shows the chromatogram waveform a and DRIF
A straight line g of T is displayed, and further, a display area h of a real value of DRIFT and a display area d for operating a mouse when setting is completed. Also on this display screen, the chromatogram waveform a and the DRIFT line g are displayed together, so that an appropriate parameter DRIFT can be set by increasing or decreasing the gradient of the DRIFT line g. If the inclination of the straight line g is to be steep, it can be increased by clicking the left button of the mouse 8, and if it is desired to decrease it, the right button of the mouse 8 can be clicked.

Next, referring to the flowcharts shown in FIGS. 3 to 5,
The operation of setting the above parameters will be described.

FIG. 3 is a flowchart for explaining the WIDTH setting processing operation in the parameter setting mode.

When entering this loop, first, the screen of CRT9 is displayed as shown in Fig. 1 (A).
Display chromatogram a as shown in (step
ST1). Next, an initial value of WIDTH is set from the keyboard 7 (step ST2), and two vertical lines indicating the set WIDTH are displayed as shown in FIG.
Is displayed in the area c (steps ST3 and ST4). The operator looks at the chromatogram a and the two vertical lines b, determines the size of the width surrounded by b and b, and further determines the width WIDTH.
Is increased, the left button of the mouse 8 is clicked. When this click is made, the determination in step ST5 becomes YES, and the value of WIDTH is increased (step ST6). On the other hand, when the value of WIDTH is to be reduced, that is, the width is to be reduced, the right button of the mouse 8 is clicked. As a result, the determination at step ST5 becomes NO and the determination at step ST7 becomes YES, and the value of WIDTH is decreased (step ST8). Then, the vertical lines b and b indicating the decreased WIDTH or the increased value of WIDTH are used. b and b are displayed again (step ST9), and at the same time, the WID is also displayed in the display area c.
The value of TH is displayed again (step ST10). The operator repeats the above processing, and when the value becomes an appropriate value, moves the mouse 8 to the position of the setting end display area d, and clicks here to judge whether the mouse is moved (NO in step ST11), and click the setting end button. The determination in (ST13) is YES, and the WIDTH at that time is stored in the parameter storage 6 as a set value. On the other hand, if it is desired to move the vertical line b in parallel during the processing, the mouse 8 can be rolled. As a result, the determination as to whether the mouse is moving is YES.
Thus, two vertical lines indicating WIDTH are moved (step ST12).

Next, referring to the flowchart of FIG.
The operation when setting E will be described. First, in step ST21, the chromatogram a is displayed on the screen of the CRT 9, the initial value of SLOPE is set from the keyboard 7 (step ST22), and an oblique line e indicating SLOPE is displayed (step ST23). Similarly, the value of SLOPE is digitally displayed in the display area f. In this display state, the operator compares the chromatogram a with the slope straight line e of SLOPE, determines whether the parameter SLOPE is appropriate, and clicks the left mouse button to further increase the slope. Perform (step ST25). Step by this click
The determination as to whether the left button of ST25 is clicked is YES, and the value of SLOPE is increased internally (step ST26). Conversely, if the inclination of the straight line e is to be reduced, the right button of the mouse 8 is clicked. . Thereby, the determination in step ST27 becomes YES, and the value of the slope is reduced (step S27).
T28). The decreased or increased SLOPE value is displayed again on the screen correspondingly (step ST29), and the digital value of the display area f is displayed again (step ST29).
ST30). The above is the case where the slope of the straight line e of the SLOPE is increased or decreased. In this case, the increase or decrease may be performed by selecting and clicking the left and right buttons of the mouse 8 as described above. When the mouse 8 is to be moved, the mouse 8 can be moved in parallel while rolling on the straight line e. In this case, the determination in step ST25 is NO and the determination in step ST27 is NO.
It moves to 31 and it is determined whether or not the mouse is moved.
, This determination becomes YES, and the oblique line indicating SLOPE is translated in accordance with the rolling amount of the mouse (step ST32). When an appropriate parameter SLOPE is obtained by the above-described parallel movement or increase or decrease of the inclination of the straight line e, the operator moves the mouse 8 to the setting end display area d, and performs a click operation here. Is YES, and the operation ends. Through the above series of processing, the current stored value of SLOPE is stored as it is as a new set value.

Next, the processing in the case of setting the parameters of DRIFT is shown in FIG. 5, and the display example is as shown in FIG. 1 (C), and these DRIFT and FIG. (B) S
Since the LOPE can be performed by the same processing, the description is omitted, but the parameters can be set similarly to the SLOPE.

(F) Effect of the Invention According to the present invention, the chromatogram and the waveform processing parameters are displayed side by side on the display screen, and the parameters can be set visually by adjusting the input means such as a mouse while visually confirming the parameters. As in the conventional case, it is not necessary to perform trial and error of repeating the waveform re-analysis by changing various numerical values using the numeric keypad, and parameter setting can be performed in a short time. Furthermore, since the waveform processing parameters are displayed on the screen, there is an advantage that the meaning of the parameters can be easily understood intuitively.

[Brief description of the drawings]

FIG. 1A is a diagram showing an example of setting display of WIDTH in the data processing device according to the embodiment of the present invention. FIG. 1B is a diagram showing an example of setting display of parameter SLOPE in the data processing device. FIG. 1 (C) shows the data processing apparatus.
FIG. 2 is a block diagram of a chromatographic data processing device in which the present invention is implemented. FIGS. 3, 4 and 5 are diagrams showing examples of setting display of DRIFT. FIG. 3 is a flowchart showing a parameter setting process operation, FIG. 3 is a flowchart showing a WIDTH setting process, FIG. 4 is a flowchart showing a SLOPE setting process, and FIG. 5 is a DRIFT setting process It is a flowchart which shows. 1: A / D converter, 2: Central processor, 3: Signal data storage, 6: Parameter storage, 8: Mouse, 9: CRT.

Claims (1)

(57) [Claims] 1. A data input means for taking in chromatogram data converted from an analog value to a digital value, a chromatogram storage means for storing the inputted chromatogram data, and a parameter for performing data processing. Parameter storage means, two-dimensional display means, mode setting means for setting a parameter setting mode, and the two-dimensional display means for storing the chromatogram stored in the chromatogram storage means in the two-dimensional display means under the parameter setting mode. Display control means for displaying the parameters stored in the parameter storage means in a straight line on the two-dimensional display means, and parameter adjusting means for manually changing the parameters displayed in a straight line on the two-dimensional display means And set the displayed parameter by operating Data processing apparatus for chromatography, characterized in that a parameter fixing operation means for fixing the.