JP2740985B2 - Infusion container - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion container used for infusion injection, and more particularly to an improvement in an infusion container for aseptically dissolving and mixing a powdered drug in a drug container with a dissolving solution.

[0002]

2. Description of the Related Art Japanese Patent Publication No. 2-1277 and Japanese Patent Publication No. 61-501129 describe infusion containers used for infusion. Tokuhei 2
In the infusion container of No. 1277, after first piercing one needle of the communication means into the medicine container filled with powder, piercing the other needle of the communication means into the flexible container, the powder in the medicine container and The solution in the flexible container is circulated.

For this reason, when the medicine container and the flexible container are communicated with the medicine container filled with the powder facing upward, the powder remains in the rubber stopper on the flexible container side for a moment, but the solution is dissolved. It was pointed out that the powder medicine was lost because of no contact with the powder. Powder type, dissolution,
Depending on the conditions such as the degree of dilution, the loss of the powdered medicine may increase, so it is necessary to devise a shape of the infusion container in which the powder does not collect.

In the infusion container disclosed in JP-T-61-501129, a communication piece is arranged between the flexible container and the medicine container, and the communication piece is broken to connect the flexible container and the medicine container. Because of the communication, a problem is pointed out that a broken piece of the communication piece is mixed into the solution. The inventors of the present invention have made intensive studies to solve the above-mentioned problems, and as a result, have arrived at the next invention.

[0005]

According to the present invention, a communicating means 4 is arranged between a medicine container 2 and a flexible container 3, and the medicine container 2 is housed in an upper capsule 5, and the upper capsule 5 The communication means 4 is attached, the upper capsule 5 is fitted into the lower capsule 6, the liquid flow port 7 of the drug solution container 3 is inserted into the bottom of the lower capsule 6, and the drug container 2 has a drug outlet 8 at the bottom. Is formed and a stopper 8a is attached to the medicine outlet 8;

The flexible container 3 has a bag body 9 formed with a liquid flow opening 7 at the upper end and a drug outlet 10 formed at the lower end. 10, a stopper 10a is attached to the upper capsule 5, an insertion groove 12 of the communication means 4 is formed on an inner peripheral surface of the upper capsule 5, and a locking groove 13 of the lower capsule 6 is formed on an outer peripheral surface of the upper capsule 5.

The lower capsule 6 has an engaging portion 14 of the locking groove 13 formed at the uppermost end, and the liquid communication port 7 formed at the bottom.
The communication means 4 is provided with the plug 8.
a of the puncture needle 21 and the puncture needle 22 of the stopper 7a
Puncture needle 21 and puncture needle 2
The present invention provides an infusion container 1 in which a braking means 4a is formed so that the stopper 8a can penetrate the stopper 8a and the stopper 7a at the same time, and is formed substantially vertically symmetric with respect to a center line O. Further, the braking means 4a is provided with the mounting portion 17 of the insertion groove 12, the engaging portion 18 of the medicine outlet 8, and the insertion port 15.
Is provided.

[0008]

In the state before the communication between the medicine container 2 and the flexible container 3, the engaging portion 14 is engaged with the lowermost portion of the locking groove 13, and the mounting portion 17 of the braking means 4a It is fixed to the lowermost part of the insertion groove 12, the engaging part 18 is engaged with the lowermost part of the medicine outlet 8, and the engaging part 19 is
At the top.

When the medicine container 2 and the flexible container 3 are communicated with each other, the lower capsule 6 is slightly rotated to slide the engaging portion 14 in the lateral direction to engage the engaging groove 13 of the upper capsule 5. When the upper capsule 5 is removed and the upper capsule 5 is slid downward, the mounting portion 17 slides upward along the insertion groove 12 and the medicine outlet 8 (insertion portion 15) is connected to the engaging portion 1.
Pushes open 8 (engagement portions 19), a drug outflow port 8 is lower lateral, slot 15 moves forward almost simultaneously on side. Therefore, the puncture needle 21 and the puncture needle 22 are
a is simultaneously pierced.

[0010]

FIG. 1 is a schematic view of an infusion container 1 according to the present invention.
The infusion container 1 is composed of a medicine container 2, a flexible container 3, and a communicating means 4 arranged between them. The medicine container 2 is housed in an upper capsule 5, and the communication means 4 is attached to an end of the upper capsule 5. The upper capsule 5
Is fitted into the lower capsule 6, and the liquid flow port 7 of the drug solution container 3 is inserted into the bottom of the lower capsule 6.

The medicine container 2 has a medicine outlet 8 formed at the bottom and a stopper 8a attached to the medicine outlet 8. The medicine container 2 is, for example, a glass vial or the like, and is filled with, for example, a powder medicine, a lyophilized medicine, or the like. The flexible container 3 has a liquid flow opening 7 formed at the upper end of the bag body 9 and a medicine outlet 10 formed at the lower end. An engaging portion 11 for engaging with the lower capsule 6 is formed on the outer peripheral surface around the middle of the liquid flow opening 7.
A stopper 7a is attached to the liquid flow opening 7, and a stopper 10a is attached to the medicine outlet 10. The inside of the flexible container 3 is filled with a chemical solution such as a solution or a diluting solution.

The upper capsule 5 has an insertion groove 12 for the communication means 4 formed on the inner peripheral surface of the lower half portion, and a plurality of locking grooves 13 for the lower capsule 6 formed on the outer peripheral surface near the middle. I have. The insertion groove 12 is formed in the length direction of the capsule 5 and may be formed in a partially elongated groove shape, or may be formed on the entire peripheral surface. The locking groove 13 is formed in an L shape as shown in FIG. 2 (partial right side view of FIG. 1), a horizontal groove 13a is formed at the lowest part, and a bottom wall of the vertical groove 13b is formed. Has a plurality of steps 13c. The engaging portion 14 may be formed so as to protrude from the inner peripheral surface of the lower capsule 6 as shown in FIG. 2, or may be formed as shown in FIG.
May be formed so as to protrude from the upper end. As shown in FIG. 4 ((a) is a front view, and (b) is a cross-sectional view taken along line AA of FIG. 4 (a)), the locking groove 13 has a step 13d on all or a part of the side wall surface of the groove. It may be formed.

A suspension portion 25 is formed on the top surface of the upper capsule 5. The lower capsule 6 has an engaging portion 14 of the locking groove 13 formed at the uppermost end, and the liquid flow port 7 at the bottom.
The insertion opening 15 is vertically protruded. Around the lower half of the insertion port 15, the engaging portion 1 of the liquid flow port 7 is provided.
6 are protrudingly provided. Upper capsule 5 and lower capsule 6
Is made of a hard synthetic resin. The engaging portion 14 is formed so as not to slide downward (reverse) with respect to the locking groove 13 when sliding upward with respect to the locking groove 13.

The communication means 4 includes the puncture needle 2 of the stopper 8a.
1 and the puncture needle 22 of the plug 7a are formed on the flange 20, and the puncture needle 21 and the puncture needle 22 can penetrate the flange 20 through the plug 8a and the plug 7a at the same time.
a is formed. Flange 2 constituting communication means 4
0 and the braking means 4a are made of an elastic hard synthetic resin. The puncture needle 21 and the puncture needle 22 are
And may be implanted in the flange 20. The puncture needle 21 and the puncture needle 22 may be made of hard synthetic resin or metal.

The braking means 4a is mounted on the mounting portion 1 of the insertion groove 12.
7 and an engaging portion 18 of the medicine outlet 8 and an engaging portion 19 of the insertion opening 15. The puncture needle 21 (puncture needle 2)
The sealing member 23 (24) is attached to the cutting edge 2). The communication means 4 is formed substantially vertically symmetric with respect to the center line O. Substantially vertical symmetry means that the function or basic structure is substantially vertical symmetry, but does not mean that the shape itself is vertical symmetry. In addition, for example, the puncture needle 21 and the puncture needle 22 and the vertical lengths of the engaging portion 18 and the engaging portion 19 are formed to be the same. The lateral width may be slightly different depending on the width of the medicine outlet 8 and the insertion port 15.
It is sufficient that the puncture needle 22 has a function capable of penetrating the stopper 8a and the stopper 7a almost simultaneously. Also, the sealing member 23 (2
4) may be anything as long as it can completely block the liquid passage of the puncture needle 21 (puncture needle 22), and for example, a rubber ball, a bag-like rubber tube, a rubber tube, or the like is used.

Next, a method of using the infusion container 1 will be described. Before the infusion container 1 communicates the flexible container 3 with the medicine container 2, the infusion container 1 has a lateral groove 13 of the locking groove 13.
a is engaged with the engaging portion 14, and the braking means 4a
, The mounting portion 17 is fixed to the lowermost portion of the insertion groove 12, the engaging portion 18 is engaged with the lowermost portion of the medicine outlet 8,
The engaging portion 19 is engaged with the uppermost portion of the insertion portion 15. Therefore, these states are reliably maintained as long as the respective engagements are not released.

When the medicine container 2 and the flexible container 3 are communicated with each other, the lower capsule 6 is slightly rotated to slide the engaging portion 14 in the horizontal direction as shown in FIG. To move the engaging portion 14 along the longitudinal groove 13b by disengaging the lateral groove 13a of the locking groove 13 and the engaging portion 14 of the lower capsule 6 by moving the engaging portion 14 into the vertical groove 13b. ,
When the upper capsule 5 is slid downward, as shown in FIG. 5, the mounting portion 17 slides upward along the insertion groove 12, and the medicine outlet 8 (insertion portion 15) is moved to the engagement portion 18 ( When the engaging portion 19) is pushed open, the medicine outlet 8 advances downward and the insertion portion 15 advances upward almost simultaneously.
For this reason, the puncture needle 21 and the puncture needle 22 are simultaneously pierced through the stopper 8a and the stopper 7a.

With the flexible container 3 up and the drug container 2 down, a dissolving solution is introduced from the flexible container 3 into the drug container 2 via the communicating means 4, and the dissolving solution and the powder in the drug container 2 are introduced. (Drug)
And mix well. The mixed and dissolved drug solution is transferred to the flexible container 3 via the communication means 4 and taken out from the drug outlet 10.

FIG. 6 is a partial schematic view showing another embodiment of the infusion container of the present invention. The infusion container 101 has a fitting projection 111 formed on the outer periphery of the liquid flow opening 7 instead of the engaging portion 11 and the engaging portion 16 of the infusion container 1, and a fitting projection formed on the inner peripheral surface of the insertion port 15. The fitting groove 116 of the portion 111 is formed.

FIG. 7 is a partial schematic view showing another embodiment of the infusion container of the present invention. The infusion container 201 has a spiral engagement groove 213 formed in place of the L-shaped engagement groove 13 of the infusion container 1. Spiral engagement groove 2
Since 13 is formed on the front and back of the upper capsule 5, so rotating the upper capsule 5 engaging portion 14 moves upward along the spiral engagement groove 213, the infusion vessel 1
The puncture needle 21 and the puncture needle 22 are simultaneously pierced through the stopper 8a and the stopper 7a as in the case of (1).

[0021]

As described above, according to the present invention, the powder agent does not accumulate in the communication means 4a and the medicine container 2
Can be transferred to the flexible container 3 in a straight line, so that the powder is not lost. Also, there is no leakage of the solution (chemical solution). The mixing operation of the drug and the solution (chemical solution) can be performed in a short time.

[Brief description of the drawings]

FIG. 1 is a schematic view of an infusion container of the present invention.

FIG. 2 is a partial side view of FIG. 1;

FIG. 3 is a partial schematic view showing another embodiment of the infusion container of the present invention.

FIG. 4 is a partial schematic view showing another embodiment of the infusion container of the present invention.

FIG. 5 is a schematic view of a use state of the infusion container of the present invention.

FIG. 6 is a partial schematic view showing another embodiment of the infusion container of the present invention.

FIG. 7 is a partial schematic view showing another embodiment of the infusion container of the present invention.

[Description of sign]

 DESCRIPTION OF SYMBOLS 1 Infusion container 2 Drug container 3 Flexible container 4 Communication means 4a Braking means 5 Upper capsule 6 Lower capsule 7 Liquid flow port 7a plug 8 Drug flow port 8a plug 9 Bag body 10 Drug outlet 11 Engagement groove 12 Insertion groove DESCRIPTION OF SYMBOLS 13 Lock groove 14 Engagement part 15 Insertion opening 16 Engagement part 17 Attachment part 18 Engagement part 19 Engagement part 20 Flange 21 Puncture needle 22 Puncture needle 23 Sealing member 24 Sealing member 25 Suspension member

Claims (5)

(57) [Claims] 1. A communication means 4 is arranged between a medicine container 2 and a flexible container 3, the medicine container 2 is housed in an upper capsule 5, and the communication means 4 is attached to the upper capsule 5. The upper capsule 5 is fitted into the lower capsule 6, the liquid flow opening 7 of the liquid medicine container 3 is inserted into the bottom of the lower capsule 6, and the medicine container 2 has a medicine outlet 8 formed at the bottom and a medicine outlet 8. The outlet 8 is provided with a stopper 8a. The flexible container 3 has a liquid passage 7 formed at the upper end of the bag body 9 and a medicine outlet 10 formed at the lower end thereof. The stopper 7a is attached to the liquid passage 7. A stopper 10a is attached to the medicine outlet 10, and the upper capsule 5 is provided on the inner peripheral surface of the insertion groove 1 of the communication means 4.
2 and an engaging groove 13 of the lower capsule 6 is formed on the outer peripheral surface. The lower capsule 6 has an engaging portion 14 of the engaging groove 13 formed at the uppermost end, and the liquid circulation is formed at the bottom. Insertion port 15 of mouth 7
The communication means 4 comprises a puncture needle 21 of the stopper 8a and the stopper 7
a puncture needle 22 is formed on the flange 20, and the puncture needle 21 and the puncture needle 22 are attached to the flange 20 by the stopper 8 a and the stopper 7.
a is formed at the same time so that a
An infusion container 1 formed substantially vertically symmetrically with respect to a center line O. 2. The infusion container 1 according to claim 1, wherein said braking means 4a is provided with a mounting portion 17 of said insertion groove 12, an engaging portion 18 of said medicine outlet 8 and an engaging portion 19 of said insertion port 15. An infusion container 1 characterized by comprising: 3. The infusion container 1 according to claim 1, wherein the puncture needle 21 (puncture needle 22) has a sealing member 23 (2)
4) An infusion container 1 characterized by being mounted. 4. An infusion container 1 according to claim 1, wherein an outer peripheral surface of said liquid flow port 7 is engaged with said lower capsule 6.
The liquid transfusing container 1 is provided with an engaging portion 16 of the liquid flowing port 7 formed around the insertion port 15. 5. An infusion container 201, wherein a helical locking groove 213 is formed in place of the locking groove 13 according to claim 1.