JP2732409B2 - Vacuum blood collection device - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a vacuum blood collecting apparatus for collecting blood into a blood container previously loaded with a drug solution.

[Prior Art] Conventionally, a vacuum blood sampling device as described in JP-B-51-3153 has been proposed. The vacuum blood collection apparatus is decompressed by a vacuum pump, and has a vacuum blood collection chamber in which a blood container formed of a soft material and previously loaded with a drug solution (for example, an anticoagulant) can be set, and is generated in the vacuum blood collection chamber. A negative pressure is applied to the blood container, and blood is collected from the soft blood collection tube connected to the blood container.

Here, the negative pressure generated in the vacuum blood collection chamber and applied to the blood container acts as a blood collection suction force on the blood vessel of the donor via a blood collection needle provided at the tip of a soft blood collection tube connected to the blood container.

Thus, in the conventional vacuum blood collection device, at the end of blood collection, the intermediate portion of the blood collection tube is clamped and closed by a tube clamp provided in the vacuum blood collection device to stop the blood collection operation to the blood container. Then, the middle part of the blood collection tube is closed with a heat seal or a clamp, and is subjected to a blood test or stored.

[Problems to be Solved by the Invention] However, in the conventional vacuum blood collection apparatus, in the case where the blood container is connected to the soft blood collection tube, in the case of a drug solution, in particular, an anticoagulant, it is difficult to cope with blood. The mixture with the coagulant was not sufficient, and there was a possibility that coagulation of blood would occur at the site.

Also, in the conventional vacuum blood collection device, after the blood collection to the blood container, simply close the middle part of the blood collection tube, etc.,
It merely restricts the free movement of the blood remaining in the blood collection tube to prevent leakage of the collected blood.

For this reason, it communicates with the contents area of the blood container at the stage of blood test, storage and the like after blood collection. For example, blood remaining in the blood collection tube near the connection with the blood container stays forever in the blood collection tube even though the blood collection tube communicates with the content region of the blood container, and remains in the content region. It does not mix with preloaded drug solutions, such as anticoagulants and red blood cell preservatives.

This means that the blood remaining in the blood collection tube does not obtain the medicinal effects of the anticoagulant or the red blood cell preservative, coagulates the blood, destroys red blood cells, and impairs the effective use of valuable collected blood. .

Furthermore, after the blood collection is completed, a predetermined amount of blood collected in a blood test blood collection tube is transferred for testing.In this case, the transferred blood is mixed with an anticoagulant in relation to the drug in the blood test blood collection tube. Not what is needed.

Therefore, as the blood to be transferred, the blood in the soft blood collection tube that is not mixed with the anticoagulant in the blood container is transferred from the blood collection needle connected to the tip of the soft blood collection tube. Here, since the volume of the blood collection tube for blood test is slightly smaller than the volume of blood in the soft blood collection tube, the blood not mixed with the anticoagulant is transferred into the blood collection tube for test even after transfer to the blood collection tube for test. Will leave a small amount of blood that is not mixed with the anticoagulant. Therefore, the remaining blood may coagulate in the soft blood collection tube.

The present invention relates to a method of loading a blood solution in a blood container in advance and performing vacuum blood collection from the soft blood collection tube connected to the blood container to the blood container. And also in the blood remaining in the blood collection tube,
It is an object of the present invention to make it possible to extremely easily and surely impart the medicinal effect of the drug solution in the blood collection tube.

It is a further object of the present invention to allow all blood in the soft blood collection tube to be replaced with blood mixed with the anticoagulant in the blood container when the blood is transferred to a blood test blood collection tube after the blood collection.

Means for Solving the Problems The present invention according to claim 1 is provided with a vacuum blood collection chamber in which a blood container formed of a soft material and pre-loaded with a drug solution can be set while being depressurized by a vacuum pump. Applying a negative pressure generated in the vacuum blood collection chamber to the blood container,
In a vacuum blood collecting apparatus configured to perform blood collection from the soft blood collection tube connected to the blood container to the blood container, after the blood collection to the blood container is completed, the blood collection tube is crushed to at least communicate with the blood container. There is provided a tube crushing device for causing blood in the blood collection tube near the connection portion to flow into the blood container.

The present invention according to claim 2 is configured such that a blood collection stop device that closes the blood collection tube at the end of blood collection and stops the blood collection operation to the blood container is connected to the tube crushing device. It was done.

According to a third aspect of the present invention, in the vacuum blood collecting apparatus, the tube crushing block is capable of pressing the blood collection tube, and the tube crushing block sandwiches the blood collection tube in the first stage of the pressing operation. It comprises a pressing projection for closing and pressing, and a pressing flat portion for crushing the blood collection tube over a certain length range in a second stage following the first stage.

[Action] (1) According to the present invention as set forth in claim 1, the blood collection tube crushing action of the tube crushing device after blood collection is completed,
At least the blood in the blood collection tube near the connection with the blood container is caused to flow into the blood container. As a result, the blood that has flowed into the blood container is mixed with the blood previously collected in the blood container and mixed sufficiently with the blood that is sufficiently mixed with the drug solution, and as a result, the blood solution is sufficiently mixed with the drug solution. Will be mixed.

After the above-described tube crushing action by the tube crushing device is released, blood already sufficiently mixed with the drug solution in the blood container flows into the blood collection tube. For this reason, even if the above-described tube crushing action of the tube crushing apparatus does not cause all the blood in the blood collection tube to flow into the blood container, the blood spill from the blood container into the blood collection tube by releasing the above-described tube crushing action. The mixed drug solution in the blood is easily diffused in the blood collection tube, so that all the blood in the blood collection tube is mixed with the drug solution.

That is, a blood solution is pre-loaded into the blood container, and when performing vacuum blood collection from the soft blood collection tube connected to the blood container to the blood container, after the blood collection is completed, the connection portion between the blood container and the blood collection tube, and The medicinal effect of the drug solution in the blood collection tube can be extremely easily and reliably applied to the blood remaining in the blood collection tube.

In addition, when blood is transferred to a blood test blood collection tube after blood collection, all blood in the soft blood collection tube can be replaced with blood mixed with an anticoagulant in the blood container.

(2) According to the present invention as set forth in claim 2, by the blood collection tube clamping pressure closing action of the blood collection stopping device at the blood collection end stage,
The above-described operation of stopping the blood collection operation to the blood container and causing blood in the blood collection tube at least near the connection with the blood container to flow into the blood container by the blood collection tube crushing action of the tube crushing device after the blood collection is completed. As in the first aspect of the present invention, it is possible to obtain a sufficiently mixed state of the drug solution with the blood.

It should be noted that the tube crushing device may or may not also serve as the blood collection stopping device.

(3) According to the present invention as set forth in claim 3, the tube crushing block clamps and closes the blood collection tube by the pressing protrusion at the first stage of the pressing operation, and at the second stage of the pressing operation. The blood collection tube is crushed over a certain length range by the pressing flat portion. Therefore, with a simple structure using a single tube crushing block, the clamping operation of the blood collection tube to stop the blood collection operation at the blood collection end stage, and the blood remaining in the blood collection tube after the blood collection is completed, The squeezing action of the blood collection tube for flowing into the inside can be performed continuously.

FIG. 1 is a front view showing a blood collecting apparatus according to an embodiment of the present invention, FIG. 2 is a side view showing a main part of FIG.
FIG. 1 is a plan view of FIG. 1, FIG. 4 is a plan view showing a main part of FIG. 1 cut away, FIG. 5 is a vacuum circuit diagram, FIG. 6 is a control block diagram, and FIG. FIG. 8 is a schematic diagram illustrating a standby state of the block, FIG. 8 is a schematic diagram illustrating a first stage state of the pressing operation of the tube crushing block, and FIG. 9 is a schematic diagram illustrating a second stage state of the pressing operation of the tube crushing block. It is.

As shown in FIGS. 1 to 4, the blood collection apparatus 10 includes a display panel 12 on the front of a housing 11, and forms a vacuum blood collection chamber 13 inside the housing 11. Reference numeral 14 denotes an opening / closing lid of the blood collection chamber 13, reference numeral 15 denotes a hinge of the lid 14, and reference numeral 16 denotes sealing rubber for sealing the blood collection chamber 13. 14A is a handle of the lid 14. In addition, the blood collection device 10 has a vacuum pump 17 and a control device 18 built-in below the housing 11.

The vacuum blood collection chamber 13 of the blood collection device 10 is
It is provided with a bag tray 19 which is connected to 17A and can be decompressed and which supports a blood bag (blood container) 1 formed of soft polyvinyl chloride or the like and pre-loaded with an anticoagulant such as heparin. The blood collection device 10 applies a predetermined negative pressure to the blood collection bag 1 supported by the bag receiving tray 19 to collect blood under a reduced pressure of the vacuum blood collection chamber 13. At this time, the blood collection apparatus 10 swings the bag tray 19 to stir the anticoagulant in the blood bag 1 and the blood, and measures the weight of the blood bag 1 to measure the blood collection amount.

The structure for swinging the bag tray 19 and the structure for measuring the weight of the blood bag 1 in the blood collecting apparatus 10 are as follows.

First, a gantry 20 is installed at the bottom of the vacuum blood collection chamber 13, and a oscillating frame 22 that is rotatable via a support shaft 21 is supported on the gantry 20. Further, a swing motor 23 is fixed to the gantry 20, and a driving shaft 24 driven by the swing motor 23 is provided.
Is supported. 25 and 26 are toothed pulleys, and 27 is a toothed belt. A crank wheel 28 is fixed to one end of the driving shaft 24, and one end of a link 29 is connected to the rotation radius of the crank wheel 28, and the other end of the link 29 is connected to a connecting piece 30 integrated with the swing frame 22. Are linked.

On the other hand, a pair of scale mounting blocks 31 is fixed to the upper surface of the swing frame 22, and a scale (blood collection amount measuring means) 33 is cantilevered on a support plate 32 that is bridged over the ends of both mounting blocks 31. . The scale 33 includes a strain gauge 34 as a weight sensor attached to each of two positions on the upper surface and two positions on the lower surface to form a Wheatstone bridge circuit. Thus, the above-mentioned bag tray 19 is fixed. 37 is a stopper for preventing the scale 33 from swaying left and right, and 38 is a weight sensor amplification unit.

That is, the blood sampling device 10 rotates the driving shaft 24 and the crankshaft 28 by the operation of the swing motor 23, thereby swinging the swing frame 22, and supported by the swing frame 22 via the scale 33. The bag tray 19 is swung. The blood collection device 10 also supports the bag tray 19 on a balance 33 that is cantilevered via a mounting block 31 and a support plate 32 on a swing frame 22, and the blood bag 1 is deformed by the scale 33. Of the blood, and thus the blood collection volume.

The blood collection device 10 detects the rotation position of the detection cam 39 provided at the other end of the driving shaft 24 by the optical sensor 40, thereby controlling the driving of the swing motor 23, and moving the bag tray 19 to the lowest point ( The weight of the blood bag 1 is measured as described above in a state where the blood bag 1 is temporarily stopped at (bottom dead center) and held under a constant posture condition.

As shown in FIG. 5, the blood collection device 10 connects the suction port 17A of the vacuum pump 17 and the vacuum blood collection chamber 13 with a vacuum pipe 41, and is closed at an intermediate portion of the vacuum pipe 41 by turning on an exhaust solenoid 42. An exhaust valve 43 is opened by gravity when the exhaust solenoid 42 is turned off. The blood collection apparatus 10 forms a constant negative pressure (degree of vacuum) in the vacuum blood collection chamber 13 by on / off control of the vacuum pump 17, and opens the exhaust valve 43 at the end of blood collection to release the vacuum blood collection chamber 13 to the atmosphere.

The blood collecting apparatus 10 includes a tube holder 44 at a portion adjacent to the vacuum blood collecting chamber 13 at an upper portion on the front side of the housing 11 so that the blood collecting tube 2 connected to the blood bag 1 housed in the vacuum blood collecting chamber 13 can be pulled out. Tube holder
44 includes a tube crushing block (a blood collection stopping and tube crushing device) 46 driven by a tube pressing solenoid 45.
As shown in FIG. 7, the tube crushing block 46 can swing around the support shaft 101 by the operation of the solenoid 45 to press the blood collection tube 2, and in the first stage of the pressing operation (see FIG. 8). The pressure protruding portion 46A for stopping the blood collection operation to the blood bag 1 at the blood collection end stage by closing the blood collection tube 2 with the clamping pressure, and the blood collection in the second stage (see FIG. 9) following the first stage. By crushing the tube 2 over a certain length range, after the blood collection to the blood bag 1 is completed, the blood in the blood collection tube 2 at least near the connection with the blood bag 1 is replaced with the blood in the blood bag 2. And a flat portion 46B that can flow into the bag 1. 47
Is a pressing release button for the tube crushing block 46, and 48 is a pressing button for operating the tube crushing block 46 in an emergency.

The display panel 12 of the blood collection device 10 includes a blood collection amount / vacuum degree changeover display lamp 49, a blood collection amount / vacuum degree changeover switch 50, and 400 ml / 20.
0ml switch display lamp 51, 400ml / 200ml switch 52, stop switch 53, start switch 54, used bag display lamp
55, use bag changeover switch 56, blood collection amount / vacuum level display
With 57. The blood collection device 10 includes a power switch 58 and a fuse holder 59 on the lower front part of the housing 11 and a power connector 60 on the lower rear part of the housing 11.

Next, the control device 18 of the blood collection device 10 will be described. The control device 18 mainly includes a main control circuit 6 as shown in FIG.
1, a drive circuit 62 and a display circuit 63. In addition, 6
4 is a power supply unit.

The main control circuit 61 includes a CPU (central processing unit) [including a memory in which a control program for a series of operations of the device 10 is written] 65, a memory (storage means) 66, an input / output control unit 6
7, LED (light emitting diode) drive circuit 68, buzzer 69,
It has a fail-safe circuit 70. The input / output control unit 67 has an optical sensor for detecting the swing position of the bag tray 19.
40. Each detection signal of the blood leak sensor 71 for detecting blood leak from the blood bag 1 is transferred.

The memory 66 is composed of a non-volatile memory such as an EA-ROM and an EEP-ROM, and can rewrite and read stored data, and can hold stored data without applying a power supply voltage. The data stored in the memory 66 includes the negative pressure generated in the vacuum blood collection chamber 13, the set blood collection amount in the blood bag 1, the extended swing time of the bag tray 19 after the blood collection is completed, and the like.

The buzzer 69 completes blood collection, a negative pressure error formed in the vacuum blood collection chamber 13, a rotation error of the swing motor 23,
In accordance with the detection of blood leakage by the blood leakage sensor 71, the sound is generated in different sounding modes.

The fail-safe circuit 70 monitors the occurrence of runaway of the CPU 65, and stops the apparatus safely when runaway occurs.

The drive circuit 62 is connected to the main control circuit 61, and the A / D
The conversion circuit 72 is provided. The above-mentioned weight sensor amplification unit 38 is connected to the A / D conversion circuit 72, and a pressure sensor 73 provided in the above-mentioned vacuum pipe 41 and detecting the negative pressure of the vacuum blood collection chamber 13 is connected to the pressure sensor amplification circuit 74. Connected via.

The drive circuit 62 includes a solenoid drive circuit 75 for controlling the pipe pressing solenoid 45, a solenoid drive circuit 76 for controlling the exhaust solenoid 42, a pump drive circuit 78 for turning on / off a power supply switch 77 of the vacuum pump 17,
A motor drive circuit 80 for turning on / off a power supply switch 79 of the swing motor 23 is provided.

Note that the CPU 65 of the control device 18 obtains the detected pressure of the pressure sensor 73 and the set pressure of the vacuum blood collection chamber 13 that is the data stored in the memory 66, and performs vacuum control so that the detected pressure matches the set pressure. The power supply switch 77 of the pump 17 is turned on / off as described above.

The display circuit 63 is connected to the main control circuit 61, and includes various displays such as the display lamp 49 provided on the display panel 12 and various switches such as the changeover switch 50 provided on the display panel 12 as described above.

Next, a blood collecting operation procedure by the blood collecting apparatus 10 will be described.

 The power switch 58 is turned on.

The blood collection amount is selected by the 400 ml / 200 ml changeover switch 52. This selection result is displayed on the switching display lamp 51.

The used bag is selected by the used bag switch 56. This selection result is displayed on the display lamp 55. still,
The types of bags used include single (S) of only the parent bag, double (D), triple (T), and quadruple (Q), which also include one or more small bags.

A blood collection needle provided at the end of the blood collection tube 2 is punctured by a blood donor to collect blood to some extent.

The blood bag 1 is put into the vacuum blood collection chamber 13 and the bag pan 19
And set the blood collection tube 2 in the tube holder 44.

The start switch 54 is turned on. The control device 18 controls the driving of the vacuum pump 17 and the swing motor 23 to perform blood sampling by decompression of the vacuum blood sampling chamber 13 and swing the bag tray 19. The controller 18 obtains the output of the weight sensor amplifying unit 38 at the timing when the bag tray 19 temporarily stops at the lowest point, detects the measured blood collection amount of the blood bag 1, and
The remaining blood collection volume (volume) is calculated by the following equation (1) using the set blood collection volume, the blood specific gravity, and the pre-registered weight of the blood bag 1 written in.

Remaining blood collection volume (ml) = [set blood collection volume (g) + pre-registered weight (g) −measured blood collection volume (g)] / specific gravity (g / ml) (1) The controller 18 calculates the above calculation result. Under the condition that the residual blood collection amount has reached zero, the pressing operation of the tube crushing block 46 is started, and in the first stage, the blood collection tube 2 is clamped and closed by the pressing protrusion 46A, and the blood collection operation to the blood bag 1 is performed. Is stopped, and in the second stage, the blood collection tube 2 is crushed by the pressing flat portion 46B over a certain length range, and at least the blood collection tube 2 in the vicinity of the connection portion with the blood bag 1.
The blood inside the blood bag 1 flows into the blood bag 1. At this time, the control device 18 stops the vacuum pump 17 and opens the exhaust valve 43 as described above to open the vacuum blood collection chamber 13 to the atmosphere.

After the end of the blood collection, the control device 18 drives the swing motor 23 by extending it for a certain period of time, and swings the bag tray 19. Then, the buzzer notifies the end of blood collection.

Turn on the clamp release button 47, remove the blood collection tube 2 from the tube holder 44, and remove the blood bag 1 from the vacuum blood collection chamber.
Take out from 13.

 Next, the operation of the above embodiment will be described.

(1) According to the above embodiment, the blood in the blood collection tube 2 at least in the vicinity of the connection with the blood beck 1 is introduced into the blood bag 1 by the blood collection tube crushing action of the tube crushing block 46 after the blood collection is completed. Let it flow in. As a result, the blood that has flowed into the blood bag 1 is mixed with the blood that has been previously collected in the blood bag 1 and is sufficiently mixed with the anticoagulant so as to be mutually stirred,
As a result, it is well mixed with the anticoagulant.

After the tube crushing action by the tube crushing block 46 is released, the blood in the blood bag 1 already sufficiently mixed with the anticoagulant flows into the blood collection tube 2. For this reason, the tube crush block 46
Even if the above-mentioned crushing action of the tube does not cause all the blood in the blood collection tube 2 to flow into the blood bag 1, the blood spilled into the blood collection tube 2 from the blood bag 1 by releasing the crushing action. The mixed anticoagulant in the blood easily diffuses in the blood collection tube 2 and the blood collection tube 2
The anticoagulant can be mixed with all the blood in it.

That is, when an anticoagulant is previously loaded into the blood bag 1 and vacuum blood is collected from the soft blood collection tube 2 connected to the blood bag 1 to the blood bag 1, the blood remains in the blood collection tube 2 after the blood collection is completed. The effect of the anticoagulant in the blood collection bag 1 can be extremely easily and reliably applied to the blood to be collected.

(2) According to the above embodiment, the tube crushing block 46 clamps and closes the blood collection tube 2 by the pressing protrusion 46A in the first stage of the pressing operation, and presses and closes the pressing plane in the second stage of the pressing operation. The blood collection tube 2 is crushed over a certain length range by the part 46B. Therefore, with a simple structure using the single tube crushing block 46, the clamping operation of the blood collection tube 2 for stopping the blood collection operation at the blood collection end stage and the blood collection tube 2 remaining in the blood collection tube 2 after the blood collection is completed. The squeezing action of the blood collection tube 2 for allowing the blood to flow into the blood bag 1 can be performed continuously.

In the embodiment of the present invention, the tube crushing device does not need to double as the blood collection stopping device.

Further, in the practice of the present invention, the drug solution previously loaded into the blood container may be any other drug such as a red blood cell preservative in addition to the anticoagulant.

[Effects of the Invention] As described above, according to the present invention, when a blood solution is previously loaded into a blood container and vacuum blood is collected from the soft blood collection tube connected to the blood container to the blood container, after blood collection is completed. The medicinal effect of the medicinal solution in the blood collection tube can be extremely simply and reliably applied to the connection portion of the blood container with the blood collection tube and the blood remaining in the blood collection tube.

According to the present invention, when blood is transferred to a blood test blood collection tube after blood collection is completed, all blood in the soft blood collection tube can be replaced with blood mixed with the anticoagulant in the blood container. .

[Brief description of the drawings]

FIG. 1 is a front view showing a blood collecting apparatus according to one embodiment of the present invention, FIG. 2 is a side view showing a main part of FIG.
FIG. 1 is a plan view of FIG. 1, FIG. 4 is a plan view showing a main part of FIG. 1 cut away, FIG. 5 is a vacuum circuit diagram, FIG. 6 is a control block diagram, and FIG. FIG. 8 is a schematic diagram illustrating a standby state of the block, FIG. 8 is a schematic diagram illustrating a first stage state of the pressing operation of the tube crushing block, and FIG. 9 is a schematic diagram illustrating a second stage state of the pressing operation of the tube crushing block. It is. 1 ... blood bag (blood container), 2 ... blood collection tube (blood collection tube), 10 ... blood collection device, 13 ... vacuum blood collection room, 17 ...
… Vacuum pump, 46… tube crushing block (blood sampling stop and tube crushing device), 46A… pressing protrusion, 46B… pressing flat portion.

Claims (3)

(57) [Claims] 1. A vacuum blood collection chamber, which is set by a vacuum pump and in which a blood container formed of a soft material and pre-loaded with a drug solution can be set, and the negative pressure generated in the vacuum blood collection chamber is reduced by the blood container. In a vacuum blood collection device configured to perform blood collection from the soft blood collection tube connected to the blood container to the blood container, after the blood collection to the blood container is completed, the blood collection tube is crushed and at least the blood is collected. A vacuum blood collection device, comprising: a tube crushing device that causes blood in the blood collection tube to flow into the blood container in the vicinity of a connection portion with the container. 2. The vacuum blood collection device according to claim 1, wherein a blood collection stop device for stopping the blood collection operation to said blood container by clamping and closing said blood collection tube at a blood collection end stage is connected to said tube crushing device. apparatus. 3. The vacuum blood collection apparatus has a tube crushing block capable of pressing the blood collection tube, and the tube crushing block presses and closes the blood collection tube in a first stage of the pressing operation. The vacuum blood collecting apparatus according to claim 1, further comprising: a part; and a pressing flat part configured to crush the blood collection tube over a predetermined length range in a second step following the first step.