JP2690609B2 - contact lens - Google Patents

Description

TECHNICAL FIELD The present invention relates to a contact lens. More specifically, the present invention relates to a contact lens that is excellent in stain resistance and stain release property of a lens when worn.

[Prior Art] For contact lenses, polymethylmethacrylate, polyhydroxyethylmethacrylate, siloxanyl-based copolymers, etc. are used, and they have been used because of their strength, wettability, flexibility, and oxygen permeability. It was However, when using a contact lens, there is no contact lens that has a self-cleaning ability that does not adhere to dirt due to tears and easily detaches even if proteins or lipids adhere. Therefore, the contact lens wearer needs to clean the lens with a lens cleaning agent every day or at regular intervals, which is inconvenient to use.

In order to solve this, in recent years, it has been studied by copolymerizing a fluorine-containing monomer (see, for example, JP-A-51-5539).
No. 1, JP-A-54-29660, JP-A-61-73706) The stain resistance and stain removability are insufficient.

In addition, a copolymer using a fumarate-based monomer has been studied for the purpose of improving the drawbacks of the conventional (meth) acrylate-based monomer (see, for example, JP-A-61-176909, JP-A-62-50728, JP-A-62-106432, JP-A-62-160419, JP-A-62-212618, JP-A-62-39589, JP-A-62-235919 JP, JP-A-63-11908, JP-A-63-32518,
(JP-A-63-132216, JP-A-63-266422, JP-A-63-271411) Stain resistance and stain release are not satisfactory, and when a fluorine-containing monomer is used. It becomes difficult for dirt to adhere, but it adheres little by little, and once it adheres, it cannot be easily washed, so there is a problem that dirt accumulates during wearing.

[Problems to be solved by the present invention]

An object of the present invention is to provide a contact lens excellent in stain resistance and stain release in addition to the basic characteristics of the contact lens, namely strength, water wettability and enzyme permeability.

[Means for solving the problem]

As a result of intensive research to develop a novel contact lens that solves the above-mentioned problems, the present inventors have found that a fluorine-containing monomer having a specific structure is suitable for the purpose. The invention was completed.

That is, the present invention is a contact lens comprising a polymer obtained by polymerizing a fumaric acid ester represented by the following general formula (I) or a maleic acid ester as an essential component.

General formula (I) (In the formula, at least one of R ₁ and R ₂ is a general formula, Or Is a fluorocarbon group containing an —OH group (where n is an integer of 1 to 4, m is an integer of 2 to 8 and i is
Is 0 or 1, j is an integer of 1 to 7, k is an integer of 1 to 5, X is
Is hydrogen or fluorine. ). ) In the present invention, in the general formula (I),
R _1, R ₂ may be different even in the same, also, R _1,
One of R ₂ is a fluorocarbon group containing a —OH group, the other is a substituent other than that, for example, hydrogen, an alkyl group,
Hydroxyalkyl group, fluoroalkyl group, fluoroalkyl ether group, (In the formula, r is 2 or 3, and R ₃ , R ₄ , and R ₅ are substituents selected from a methyl group, a trimethylsiloxy group, a pentamethyldisiloxanyloxy group, and a methylbis (trimethylsiloxy) siloxy group. And a fumaric acid ester or a maleic acid ester which is a substituent selected from

The reason why the contact lens made of the copolymer using the monomer represented by the general formula (I) of the present invention does not easily attach dirt and the adhered dirt is easily released is not always clear. Compared with the case of simply mixing and copolymerizing a monomer containing fluorine, the fluorine atom and the hydroxyl group, which is a hydrophilic group, are present close to each other on the surface of the copolymer, so that the protein It is considered that contaminants such as lipids are hard to come close to the surface of the copolymer, and even if they are attached, their bonding state is extremely weak and they are easily released.

Although these monomers used in the present invention are novel, the corresponding fluorine-containing epoxy compound and fumaric acid or maleic acid can be prepared by a known method (for example, a collection of polymer papers, 42 [55] P.345. ~ 350 (1985), JP-A-61-73706).

For example, di (2-hydroperfluoroethyl glyceryl) fumarate and maleate corresponding thereto are added with 0.14 mol of potassium hydroxide to 1 mol of 2-hydroperfluoroethyl glycidyl ether, and under a nitrogen gas stream,
0.5 mol of fumaric acid was added little by little and reacted at a temperature of 70 to 90 ° C. After the reaction, the mixture was allowed to cool, diluted with chloroform and filtered, and the filtrate was washed with diluted alkaline water and then with saturated saline. After that, the chloroform layer is separated, a desiccant is added thereto for dehydration, and then the solvent is removed under reduced pressure to obtain.

The contact lens of the present invention is a copolymer of a monomer represented by the general formula (I) and a monomer copolymerizable therewith, wherein the monomer represented by the general formula (I) is 0.1 ~ 99.9
Used in the range of weight percent. If it is less than 0.1% by weight, the amount of stains attached increases and the removability of stains deteriorates, which is not preferable. The higher the content of these monomers, the less the adhesion of dirt and the better the releasability, but in consideration of the balance with other physical properties, it is used at 99.9% by weight or less.

Examples of the monomer copolymerizable with the monomer represented by the general formula (I) used in the present invention include trifluoroethyl acrylate, tetrafluoroethyl acrylate, tetrafluoropropyl acrylate, pentafluoropropyl acrylate and hexa Fluorobutyl acrylate, hexafluoroisopropyl acrylate, heptafluorobutyl acrylate, octafluoropentyl acrylate and other acrylic acid fluoroalkyl esters and corresponding methacrylic acid fluoroalkyl esters, fumaric acid fluoroalkyl esters, maleic acid fluoroalkyl esters and other fluorine Containing monomer,
For example, methyl methacrylate, ethyl methacrylate,
Methacrylates such as t-butyl methacrylate, n-butyl methacrylate, cyclohexyl methacrylate, and benzyl methacrylate, and corresponding acrylates, fumarates, maleates, and aromatic vinyls such as styrene, t-butylstyrene, and α-methylstyrene. Monomers such as compounds are used to impart hardness to contact lenses and increase mechanical strength. Among these monomers, trifluoroethyl methacrylate, hexafluoroisopropyl methacrylate, methyl methacrylate, cyclohexyl methacrylate, di-t-butyl fumarate, ditrifluoroethyl fumarate, dihexafluoroisopropyl fumarate and the like are preferable.

These copolymerizable monomers are generally used within the range of 3 to 95% by weight.

Further, a siloxane-based monomer or oligomer which imparts oxygen permeability to the contact lens is used. For example, the general formula (III) (In the formula, R ¹ and R ² are each hydrogen or a methyl group, and 1 is 1
An integer of 5 to 5 and m is an integer of 1 to 3), and examples of such a monomer include tris (trimethylsiloxy) silylpropyl methacrylate and bis ( Trimethylsiloxy) methylsilylpropyl methacrylate,
Examples include tris (trimethylsiloxy) silylethyl methacrylate, tris (trimethylsiloxy) silylbutyl methacrylate, tris (trimethylsiloxy) silylheptyl methacrylate, bis (trimethylsiloxy) silylpropyl methacrylate, and their corresponding acrylates.

General formula (IV) (R ⁵ and R ⁶ in the formula are each hydrogen or a methyl group, X ¹ ,
X ² , X ³ , X ⁴ , X ⁵ and X ⁶ are the same or different alkyl groups, halogenated alkyl groups or trimethylsiloxanyl groups, p and q are the same or different integers of 1 to 5, and n is 0. Alternatively, it is an integer of 1 to 100. ) Is a bifunctional organic siloxane monomer, and examples of such a monomer include 1,3-bis (3-methacryloxypropyl) -1,1,3,3-tetramethyldisiloxane. 1,3-bis (3-methacryloxypropyl) tetrakis (trimethylsiloxy) disiloxane, 1,5-
Bis (3-methacryloxypropyl) -1,1,3,3,5,5-
Hexamethyltrisiloxane, 1,3-bis (2-methacryloxyethyl) -1,1,3,3-tetramethyldisiloxane, 1,7-bis (3-methacryloxypropyl) -1,7-
Tetrakis (trimethylsiloxy) -3,5-tetramethyltetrasiloxane and corresponding acrylates α, ω-bis (3-methacryloxypropyldimethylsiloxy) 3,3,3 trifluoropropyl-methylpolysiloxane, α, ω -Bis (3-methacryloxypropyl)
Tetrakis (trimethylsiloxy) silyl 3,3,3 trifluoropropylmethylpolysiloxane, α, ω-bis (2-methacryloxypropyldimethylsiloxy) 3,3,
3 Trifluoropropylmethylpolysiloxane, α, ω
-Bis (3-methacryloxypropyl) dimethylpolysiloxane, α, ω-bis (3-methacryloxypropyl) tetrakis (trimethylsiloxy) silyldimethylpolysiloxane, α, ω-bis (2-methacryloxyethyl) dimethylpolysiloxane ,and so on.

General formula (V) (In the formula, R ₁ and R ₂ are hydrogen or a methyl group, R ₃ and R ′ ₃ are linear or branched divalent hydrocarbon groups having 2 to 7 carbon atoms, or p is 1 to 20 ₂ CH ₂ —O _p group, and R ₄ , R ₅ ,
R _'4 and R' ₅ are each a hydrocarbon group or a trimethylsiloxy group having 1 to 12 carbon _{atoms, R 6, R 7, R} '6 and R' ₇ each having 1 to 12 carbon atoms is a hydrocarbon group or It is a halogen-substituted hydrocarbon group, and R ₈ is 2 having 4 to 13 carbon atoms.
Valent hydrocarbon group, X is a -COO- group bonded to R ₈ or -NHC
Is an OO- group, l and l'are integers from 0 to 20, and m and n are integers from 0 to 100. ) Is a bifunctional organosiloxane oligomer.

These monomers or oligomers are used within the range of 3 to 95% by weight.

Further, fumaric acid ester and maleic acid ester having a siloxane group corresponding to the siloxane monomer represented by the general formula (III) are also copolymerizable and used in the range of 3 to 95% by weight.

Among these siloxane monomers or oligomers,
Tris (trimethylsiloxy) silylpropyl methacrylate (general formula III), α, ω-bis (3-methacryloxypropyl) dimethylpolysiloxane (n≈45 in general formula IV), hexamethylene diisocyanate to α,
ω-Bis (3-hydroxypropyl) dimethylpolysiloxane was added, and glycidyl methacrylate was further added (in general formula V, m =
N≈45, l = 1 ′ = 1) bis [tris (trimethylsiloxy) silylpropyl] fumarate and the corresponding malates are preferred.

Further, in order to further impart hydrophilicity to the contact lens to improve water wettability or to make it a water-containing soft contact lens, for example, methacrylic acid, acrylic acid, itaconic acid, 2-hydroxyethyl methacrylate, 2-hydroxyethyl methacrylate, Hydrophilic monomers such as hydroxyethyl acrylate, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate, glycerol methacrylate, polyethylene glycol methacrylate, N, N'-dimethylacrylamide, N-methylacrylamide and N-vinylpyrrolidone are used. .

These hydrophilic monomers are generally used within the range of 5 to 90% by weight.

Among these hydrophilic monomers, methacrylic acid, itaconic acid, 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, glycerol methacrylate and N-vinylpyrrolidone are preferably used.

In order to improve the dimensional stability of contact lenses, for example, ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethylolpropane trimethacrylate, pentaerythritol tetramethacrylate. A crosslinkable monomer selected from methacrylate, bisphenol A dimethacrylate, vinyl methacrylate, acrylic methacrylate and acrylates corresponding to these methacrylates, divinylbenzene, triacrylic isocyanurate and the like is used.

Among these, ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, and tetraethylene glycol dimethacrylate are preferably used, and these crosslinkable monomers are used within the range of 0.1 to 15% by weight. .

These copolymerizable monomers are combined to improve the balance of properties such as optical properties of contact lenses, oxygen permeability, mechanical strength, deformation recovery, dimensional stability in tear fluid and its change over time. Mixtures can be used.

For example, in the case of a hard contact lens, 40 to 85 parts by weight of siloxane-based monomer, 5 to 20 parts by weight of alkyl methacrylate, 5 to 15 parts by weight of hydrophilic monomer, 0.1 to 10 parts by weight of crosslinkable monomer. And a mixture in the range of 2 to 50 parts by weight of the monomer represented by the formula (I) of the present invention, and in the case of a hydrous soft contact lens, a hydrophilic monomer 70 to 98
Preference is given to parts by weight, 0 to 20 parts by weight of alkyl methacrylate, 0.1 to 10 parts by weight of crosslinkable monomers and 2 to 30 parts by weight of monomers of the formula (I) according to the invention.

The contact lens of the present invention comprises a monomer and a radical polymerization initiator which is usually used in a mixture, and heated.
It can be produced from a polymer polymerized by irradiation with ultraviolet rays by a cutting / polishing method or a casting method in which polymerization is performed in a mold. As the radical polymerization initiator, for example,
Peroxides such as benzoyl peroxide and lauroyl peroxide, and azo compounds such as azobisisobutyronitrile and azobisdimethylpareronitrile can be used. The amount used is usually a total monomer mixture of 10
It is in the range of 0.01 to 1 part by weight per 0 part by weight.

Further, in the photopolymerization, for example, a photosensitizer such as benzoin ethyl ether, benzoin n-butyl ether, benzoldimethyl ketal, acetophenone, α, α′-diethoxyacetophenone, and anthraquinone is added per 100 parts by weight of the total monomer mixture. , 0.05 to 3 parts by weight.

Further, the contact lens of the present invention can contain additives such as a colorant and an ultraviolet absorber, if desired.

〔Example〕

Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not limited to these Examples. The physical properties were determined as follows.

《Staining and detachability》 Journal of Japan Contact Lens Society, 23 P.10-14 (1981)
It was measured using the protein quantification method described in.

<Adhesion of dirt> Model lens (diameter
13mm, thickness 0.2mm, base curve 7.8mm, power 0.0) 2
Immerse the lens at 5 ° C for 20 hours, remove the lens, wash the lens surface with a certain amount of purified water, combine the washing solution with the dipping solution, quantify the residual protein content in this solution, and determine the difference from the initial protein content. The amount of protein adhering to each lens calculated and taken as the stain adhesion was determined.

<Dirt release property> The model lens was immersed in a protein aqueous solution adjusted to a concentration of 17 ppm at 25 ° C for 20 hours, taken out, and washed with purified water to prepare a model lens with dirt attached. The lens was immersed in a 0.75% sodium dodecylsulfate (abbreviated as SDS) aqueous solution at 40 ° C. for 24 hours to extract protein from the lens. Take out the lens and put a certain amount of SDS on the surface
After washing with an aqueous solution and combining with the extract, the amount of protein in this was quantified, and the value was taken as the stain release property.

Example 1 90 parts by weight of 2-hydroxyethyl methacrylate (hereinafter abbreviated as HEMA), bis (1,1,2,2-tetrafluoroethoxy-2-hydroxypropyl) fumarate (hereinafter TFHF
10 parts by weight of A) and 1.0 parts by weight of ethylene glycol dimethacrylate (hereinafter abbreviated as ED) are uniformly mixed, and 0.1 parts by weight of azobisisobutyronitrile (hereinafter abbreviated as AIBN) is dissolved, and the mixture is placed under vacuum. After degassing, inject it between two glass plates with a 5mm thick spacer,
Polymerization was performed by heating at 90 ° C. for 36 hours. A contact lens was produced from the obtained polymer by a cutting and polishing method. This lens was immersed in physiological saline for 48 hours to give a hydrous soft contact lens.

As a result of evaluating the stain adhesion and releasability of this lens, the amount of protein stain adhered was 0.3 μg / one lens, and the amount of stain detachment was 1.4 μg / one lens.

Comparative Example 1 In Example 1, 100 parts by weight of HEMA, 1.0 part by weight of ED,
A contact lens was manufactured from a polymer obtained by uniformly mixing and dissolving 0.1 part by weight of AIBN and polymerizing it, and after the same treatment as in Example 1, the stain adhesion and removability were evaluated. Is 1.5 μg / sheet, and the amount of dirt released is 0.3
It was μg / one lens.

Comparing Example 1 with Comparative Example 1, it is clear that the copolymer of the present invention is less likely to attach the protein and easily releases the attached protein.

Comparative Example 2 In Example 1, instead of THFFA, trifluoroethyl methacrylate containing only a fluorine atom (hereinafter,
A hydrous soft contact lens was produced from a polymer polymerized using 3FM. As a result of evaluating the stain adhesion and releasability of this product, as shown in Table 1, it is clear that the addition of 3FM does not improve the protein adhesion and the removability.

As is clear from the comparison between Example 1 and Comparative Examples 1 and 2, it can be seen that the copolymer of the present invention has very specific properties in terms of stain adhesion and releasability.

Example 2 90 parts by weight of methyl methacrylate (hereinafter abbreviated as MMA) and 10 parts by weight of THFFA were uniformly mixed, 0.1 part by weight of AIBN was dissolved and deaerated under vacuum, and then the same cast polymerization as in Example 1 was performed. Then, the mixture was poured into a glass cell and heated at 60 ° C. for 96 hours for polymerization. A contact lens was processed from the obtained polymer to obtain a hard contact lens. As a result of evaluating the dirt adhesion property and the detachability of this lens, as shown in Table 1,
It was difficult for dirt to adhere and was easy to remove.

Examples 3 and 4 In Example 2, instead of MMA, tris (trimethylsiloxy) silylpropyl methacrylate (hereinafter abbreviated as TSSMA) and 3FM were used, respectively, and polymerized with the compositions shown in Table 1 to obtain polymers. Got

A hard contact lens was produced from the obtained polymer, and the dirt adhering property and the releasing property were evaluated. As shown in Table 1, stains did not easily adhere and were easily removed.

Examples 5-8 Instead of THFFA in Examples 1 to 4, bis (4,4,
A polymer was obtained using 5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptane) fumarate (hereinafter abbreviated as FFBFA). A contact lens was produced from each of the obtained polymers, and the stain adhesion was evaluated. As a result, as shown in Table 1, it was difficult to adhere and the adhered stain was easily released, showing excellent performance. .

Example 9 99.9 parts by weight of THFFA and 0.1 part by weight of ED were polymerized to obtain a polymer. A contact lens was produced from the obtained polymer and immersed in physiological saline for 48 hours to give a hydrous contact lens.

As a result of evaluating the dirt adhering property and the removability of this lens, as shown in Table 1, the dirt adhering amount was remarkably small. The small amount of dirt removal is considered to be due to the extremely small amount of adhesion.

Example 10 FBHFA was polymerized with ED in the same manner as in Example 9 to prepare a contact lens. As a result of evaluating the dirt adhesion and releasability of this lens, it was found that it was as hard to adhere and easy to remove as THFFA.

Example 11 80 parts by weight of HEMA, 15 parts by weight of 2-hydroxypropyl methacrylate (hereinafter abbreviated as HPMA), 5 parts by weight of THFFA, ED1.5
Parts by weight, 0.1 parts by weight of AIBN are uniformly mixed and degassed under vacuum, then, about 30 g each is injected into a test tube with a length of 180 mm and an inner diameter of 16 mm, 8 hours at 40 ° C, 12 hours at 60 ° C, Polymerization was carried out by heating at 90 ° C for 48 hours. The obtained polymer was transparent and was uniform without optical distortion. This polymer is 5 mm thick and has a diameter of 12.
Cut the 7mm disk strip button and place it in the desiccator 2
After being dried for 4 hours, a contact lens was manufactured by a cutting / polishing method. The obtained lens was immersed in physiological saline for 48 hours to obtain a hydrous contact lens. As a result of evaluating the dirt adhesion and releasability of this contact lens, it was found that protein dirt was difficult to adhere, and the adhered dirt was also easily dislodged. The results are shown in Table 2. The swelling ratio of this polymer was 1.21.

Examples 12 to 13 Polymers were obtained in the same manner as in Example 11 except that the monomers of Example 11 were used and the mixed composition was changed to the composition shown in Table 2. A lens was made from the obtained polymer as a prototype, and the dirt adhesion and releasability were evaluated. The results are shown in Table 2.

Example 14 63 parts by weight of TSSMA, 25 parts by weight of THFFA, 12 parts by weight of MMA, 6 parts by weight of tetraethylene glycol dimethacrylate (hereinafter abbreviated as 4ED), 0.086 parts by weight of AIBN were uniformly mixed, and after deaeration under vacuum, Approximately 2 in a test tube with a length of 180 mm and an inner diameter of 16 mm
Inject 8 g each, 40 hours at 60 ℃, 48 hours at 90 ℃, 1 at 110 ℃
Polymerization was performed by heating for 0 hours.

The obtained polymer was transparent and had a Vickers hardness of 7.6, an oxygen transmission coefficient of 83 × 10 ⁻¹¹ ml · cm / cm ² , sec, and mmHg and was a uniform one without optical distortion. 5 mm thick, 1 diameter from this polymer
A 2.7 mm disc-shaped button was cut, dried in a vacuum desiccator for 24 hours, and then a contact lens was manufactured by a cutting and polishing method. The obtained hard contact lens was stored in a storage solution containing physiological saline and a nonionic surfactant for 1 week, and then the stain adhesion and releasability were evaluated. The results are shown in Table 2.

Example 15 A polymer was obtained in the same manner as in Example 14, except that the monomer used in Example 14 was used and the mixed composition was changed to the composition shown in Table 2. A lens was made from the obtained polymer as a prototype, and the stain adhesion and the releasability were evaluated. The results are shown in Table 2.

Examples 16 and 17 Polymerization was carried out in the same manner as in Example 11 except that FBHFA was used instead of THFFA in Examples 11 and 12. A contact lens was produced from the obtained copolymer, and the stain adhesion and releasability were evaluated. The result is
It is shown in the table.

Comparative Example 4 In Example 11, a polymer obtained by polymerizing with the monomer composition shown in Table 2 without using THFFA was obtained. A lens was manufactured from the obtained polymer, and the adhesion and detachability of stains were evaluated. The results are shown in Table 1. From Table 2, it is clear that the contact lens of the present invention does not easily attach proteins and easily removes the attached stains.

Comparative Example 5 A polymer was produced in the same manner as in Example 12, except that MMA was used instead of THFFA in Example 12. The obtained copolymer was processed into a lens, and its stain adhesion and releasability were evaluated.

Example 18 α, ω-bis (3-methacryloxypropyl) dimethylpolysiloxane (n in the general formula IV is about 45)
55 parts by weight, n-butyl acrylate 20 parts by weight, trifluoroethyl acrylate 15 parts by weight, THFFA 11 parts by weight, ED4
Parts by weight are uniformly mixed, 0.5 parts by weight of benzyl dimethyl ketal is dissolved in this, degassed in a vacuum, and this is molded with polypropylene to mold a lens (concave).
Then, a polypropylene mold (convex type) was placed on this, and irradiated with an ultraviolet lamp having a main wavelength of 350 nm to polymerize. The obtained lens was dipped in physiological saline for 2 days and stored, and then the stain adhesion and the releasability were evaluated. Adhesion when lysozyme is used as a model stain
The release property was 0.2 μg / sheet and the detachability was 1.4 μg / sheet.

Comparative Example 6 In the same manner as in Example 18, except that 5 parts by weight of n-butyl acrylate (25 parts by weight in total) and 6 parts by weight of methacrylic acid were used in place of 11 parts by weight of THFFA in Example 18, casting weight was the same. The lens was manufactured by law. The obtained lens was a soft soft lens having a hardness (IRHD) of 83. As a result of evaluating the dirt adhering property and the removability thereof, the dirt adhering property 2
μg / sheet, releasability was 0.9 μg / sheet.

[Advantages of the Invention] The contact lens of the present invention has a feature that stains such as proteins and lipids are less likely to be attached, and the attached stains are also easily removed, and when used as a hard contact lens and a soft contact lens. It is very useful because it is easy to wear, there is no fogging of the lens even if it is worn for a long period of time, there is no decrease in visual acuity, there is little damage to the cornea, and daily cleaning work is easy.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-2-79014 (JP, A) JP-A 63-11908 (JP, A) JP-A 63-32518 (JP, A) JP-A 50- 86588 (JP, A) JP 61-138613 (JP, A) JP 63-70221 (JP, A) JP 59-24825 (JP, A)

Claims (1)

(57) [Claims] 1. A contact lens comprising a polymer obtained by polymerizing a fumaric acid ester represented by the following general formula (I) or a maleic acid ester as an essential component. General formula (I) (In the formula, at least one of R ₁ and R ₂ is a general formula, Or Is a fluorocarbon group containing an —OH group (where n is an integer of 1 to 4, m is an integer of 2 to 8 and i is
Is 0 or 1, j is an integer of 1 to 7, k is an integer of 1 to 5, X is
Is hydrogen or fluorine. ). )