JP2595356B2 - Analyzer having automatic correction coefficient setting means for measured values - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method of automatically setting a correction coefficient of a measured value in an automatic analyzer represented by an electrolyte analyzer.

2. Description of the Related Art An electrolyte analyzer is known as a device for measuring the ion concentration in a liquid using an ion electrode method. In this electrolyte analyzer, a sample such as serum or urine is placed in a container such as a sample cut, and the sample in this container is sucked into the device and guided to a measurement electrode unit, and an electrode potential corresponding to the ion concentration is detected. The control unit calculates and measures the ion concentration of the specimen based on the electrode potential.

Generally, in order to obtain a correct measurement value, an analyzer needs to measure a calibration solution having a known concentration before measuring a specimen and calibrate a calibration curve.

However, as with the detector of a general analyzer, the output of the electrode of the detector used in the electrolyte analyzer also fluctuates due to factors such as time, so a calibration solution with a known concentration is measured before measuring the sample, Although it is necessary to calibrate the calibration curve, in the case of an apparatus such as an electrolyte analyzer for measuring a serum sample, the calibration liquid is generally an aqueous solution for various reasons, and the composition other than the target substance is serum. It is not such a composition.

Serum is not used as a calibration solution because of the following problems.

1) It is difficult to obtain.

2) Saving after adjustment does not work.

3) Not easy to use.

However, since the calibration solution and the serum have different component compositions than the target component, the true value of the concentration of the target component in the serum cannot always be measured only by calibrating with the calibration solution. In particular, when the electrode becomes dirty or deteriorates, this difference becomes conspicuous.

Recently, standard serum has become commercially available as a standard substance in which the true value of the concentration of electrolyte is indicated in serum. By using this, it became possible to set a correct calibration curve with a substance of the same composition as the sample while avoiding the above-mentioned problems, so if you want to measure the true value of the electrolyte concentration of the sample, It has become necessary to correct the measured values obtained by measuring the standard serum.

In the present invention, the meanings of the terms of the standard substance and the calibration solution are as follows.

The standard substance refers to a substance having a composition other than the target component close to that of the sample, and the concentration of the target component being valued to a value close to the absolute value by a public organization such as an academic society. For example, there are standard serum, standard blood and the like.

The calibration liquid is a solution having a known concentration of the target component other than the standard substance, which is measured by the device manufacturer to use for preparing a calibration curve of the device. As an example, when performing a correction work using a standard serum in the electrolyte analyzer, Y
= A · X + B (where X: measured value, Y: correction value), and this correction formula is input and stored in the control unit of the apparatus in advance, and the correction coefficients A and B are calculated by calculation. And calculates the calculated correction coefficients A and B by the control unit in the apparatus.
They are stored in a RAM or the like and set.

FIG. 4 is a flowchart specifically showing a processing procedure of a correction coefficient setting method in a conventional correction method of a measured value using a standard serum.

In correcting the measurement values using the standard serum, the user must use three sample serums H, M, and L having different ion concentrations of high, medium, and low for five sample cups for each serum H, M, and L. And set these 15 sample cups on the turntable of the autosampler of the device (step). At this time, the calibration operation of the measurement using the calibration solution is completed.

Next, the user gives an instruction to start measurement by operating the keyboard, and supplies an input signal for starting measurement to the control unit (CPU) of the apparatus (step). In response to the input signal, the operation of measuring the ion concentration of the three standard sera H, M, and L is automatically performed sequentially and automatically, and the results are displayed and printed out at the same time (step). This measurement operation is automatically repeated until all the standard sera H, M, and L put in the 15 sample cups are completed. Then, when the measurement operation is completed for all of the standard serums H, M, and L put in the 15 sample cups, in a step, it is determined whether or not the measurement value needs to be corrected based on the measurement result. You. That is,
The user determines whether correction of the measured value is necessary according to a predetermined criterion by comparing the printed out result of the measurement with the true value (standard value) attached to the standard serum. The criteria are as follows.

Whether or not the difference between the standard value of the standard serum and the average value of the five measurement results of the standard serum is within the range of the following values for each of the ion concentrations of the three standard sera of H, M, and L: . No correction is required if it is included.

Na: within ± 1.5 mmol / l K: within ± 0.1 mmol / l Cl: within ± 1.5 mmol / l If it is determined that there is no need for correction in the step, all steps of setting the correction coefficient are completed.

On the other hand, if it is determined in the step that the user needs to perform the correction, in the step, the user uses the predetermined calculation formula to calculate the correction coefficients A and B in the correction formula Y = A × X + B. Performed by technique. The formula for calculating the correction coefficient is as follows.

a = -b Here, X1: standard value of standard serum H X2: standard value of standard serum M X3: standard value of standard serum L Y1: average value of measurement results of standard serum H Y2: average value of measurement results of standard serum M : Average value of the measurement results of standard serum L In the step, when the correction coefficients A and B are calculated by the procedure, then in the step, the calculated correction coefficients A and B are calculated by the user's keyboard operation. It is input to the control unit of the device. The control unit of the apparatus reads the input correction coefficients A and B by the CPU, transfers the correction coefficients A and B to the RAM, and stores them (step). Thus, the input and setting of the correction coefficients A and B to the device are completed.

Problems to be Solved by the Invention In general, in an analyzer, a calibration solution is an aqueous solution, and a composition other than a target substance is not a composition like serum. Therefore, as described above, apart from a calibration procedure using a known calibration solution,
It has been necessary to measure the standard serum to determine the correction coefficient, and to correct the measured value of the sample using the correction coefficient.However, the conventional correction coefficient setting method uses the standard serum ion concentration measurement to calculate the measured value. Judgment of the necessity of correction, determination and input of correction coefficients A and B to the device when correction is necessary.
All settings were made manually by hand. Therefore, it is impossible to automate the procedure of the operation and processing for setting the correction coefficient, and an operation error may occur during the operation and processing by the procedure. In addition, since the user determines whether or not correction is necessary by a technique, a determination error may occur, and an objective determination may not be obtained.
Furthermore, since the correction coefficient is calculated and calculated by the user using a technique, the calculation takes time and effort, and the handling becomes extremely complicated. In addition, there is a problem that a calculation error easily occurs because of the manual calculation. Such a problem frequently occurs not only in the electrolyte analyzer but also in other automatic analyzers that need to correct the measured value using a correction formula, such as a blood gas analyzer.

The present invention has been proposed in view of the above points. After automatic calibration with a calibration solution in an analyzer, measurement of a standard substance and measurement of a standard substance are performed using a plurality of standard substances having known concentrations in a measurable concentration range. It is necessary to automatically perform a series of operations and processing procedures from the necessity of value correction, the calculation of the correction coefficient when it is necessary, and the input and setting of the calculated correction coefficient to the device. Aim.

Means for Solving the Problems The above object is to collect a sample from a sample container, calculate a concentration of the target substance based on a measurement unit for detecting the concentration of the target substance and a detection signal thereof, and control each unit. A control unit;
In an analyzer consisting of a display unit that displays the calculation results such as concentration and a power supply unit that supplies electric energy to each unit, after automatic calibration with a calibration solution, a plurality of standard substances with known concentrations in the measurable concentration region are displayed. Using the standard value of the standard substance whose concentration is known, the measured value measured by the measuring unit, and the control unit based on a preset reference value to compare the necessity of correction of the measured value. The determination is achieved by the analysis device, wherein when a correction is necessary, a correction coefficient of a correction formula set in the device is calculated and stored in the control unit based on the determination signal. . In this case, according to one configuration of the present invention, after standard values of a plurality of standard materials of known concentrations are input to the control unit and stored, the concentrations of these standard materials are measured a predetermined number of times, and the measurement is performed. The control unit calculates the average value of the values, compares and calculates the difference between the average value and the standard value, and determines whether the difference is within a predetermined range with respect to a preset reference value. An automatic correction coefficient setting method is employed in which the presence or absence of correction of the measured value is determined based on the measured value.

Further, according to the present invention, when it is necessary to correct the measured value, after calculating and storing the correction coefficient of the correction formula in the control unit, the correction formula set in the control unit at the time of measuring the concentration of the sample is used. An automatic correction coefficient setting method of a measured value in an analyzer characterized by automatically correcting a measured concentration value is characterized.

Action After the true values (standard values) of a plurality of standard materials with known concentrations are input to the device, a predetermined number of measurement operations are started for each standard material, and the average value and standard value of the measurement results and a preset reference value The presence or absence of correction of the measured value is automatically determined based on the above. If it is determined that correction is necessary, a series of calculation procedures are automatically and sequentially performed in the control unit of the apparatus based on a predetermined calculation formula, and a correction coefficient of the correction formula set in the device is calculated. You. The calculated correction coefficient is stored in the RAM of the control unit, and the automatic setting of the apparatus ends. Thereafter, the measured value of the concentration of the sample is automatically corrected to the true value by the correction formula having the automatically set correction coefficient.

Embodiments Hereinafter, embodiments of the present invention will be described with reference to the drawings.

FIG. 1 is a block diagram showing a specific example of an electrolyte analyzer to which an automatic correction coefficient setting method according to the present invention is applied, and FIG. 2 is a block for explaining signal transmission / reception operations centered on a control unit thereof. FIG.

An autosampler 10 is provided at a sample aspirating position of the apparatus main body, and a turntable 11 is rotatably mounted thereon. In the circumferential direction of the turntable 11, sample cups 12 containing sample or standard serum are mounted at predetermined pitch intervals. The turntable 11 is step-fed at intervals of the arrangement pitch of the sample cups 12.

A sampling nozzle 13 for sucking a sample is supported at a position corresponding to a sample suction position above the turntable through a septum 14 so as to be vertically movable. Sampling nozzle
13 is raised or lowered by the operation of the nozzle up / down mechanism 15. The sampling nozzle 13 is an electrode 16 for measuring the ion concentration.
Are connected integrally. The sample flow path of the nozzle 13 communicates with the measurement electrode unit 16. The nozzle 13 is provided with the K, Na, and Cl ion electrodes 16A, 16B, and 16C of the measurement electrode unit 16, and the reference electrode unit 1
6D, it is connected to the roller pump 18 through the flow sensor 17, and a predetermined amount of the sample is sucked from the sample cup 12 into the nozzle 13 by the forward rotation in the sample suction direction (clockwise direction in the figure).

Further, the nozzle 13 is connected to the three-way valve 19 through the septum 14.
A and 19B, and are connected to the containers of the calibration liquids 1 and 2 through the three-way valves 19A and 19B, respectively. Three-way valve 19
A and 19B are opened and closed and switched by a signal from the control unit 21.

The calibration liquid sucked by the nozzle 13 fills the measurement electrode unit 16 when measuring the ion concentration. Calibration solution 2 is a three-way valve
When 19B is opened to the nozzle 13 side and the roller pump 18 is rotated forward, it is sucked into the nozzle 13 through the valve 19B and the septum 14, guided to the measurement electrode unit 16 and filled. The reference electrode liquid 16 is previously filled in the reference electrode portion 16D by the forward rotation of the roller pump 18. At this time, the three-way valves 19A and 19B are both closed. The three-way valves 19A and 19B are controlled to open and close so that one is closed and the other is open.

The signals of the ion electrodes 16A, 16B, 16C, the reference electrode 16D, and the flow sensor 17 of the measurement electrode unit 16 are A / D-converted by the analog-to-digital conversion unit 20, then input to the control unit 21, and processed by the CPU 21A. Is done. The result is displayed on the display
At the same time as being displayed on 22, it is printed out from the printer unit 23.

A keyboard 24 is connected to the control unit 21 so that various operation signals are given to the control unit 21 by a key operation of a user. The control unit 21 includes a CPU 21A, a ROM 21B, and a RAM 21C. The CPU 21A, ROM 21B, and RAM 21C of the control unit 21
Input port and output port Connected through. Analog ports
A digital converter, that is, an A / D converter 20 is connected. A keyboard 24 is connected to the input port. The input ports are connected to sensors 25 of the mechanism of the apparatus.

On the other hand, a display unit 22, that is, an LED display 22 is connected to the output port. Printer port for output port
23 are connected. A drive circuit 26 of the mechanism is connected to the output port.

In FIG. 1, reference numeral 27 denotes a power supply unit that supplies drive power to the control unit 21 and each unit.

The apparatus to which the present invention is applied has the above configuration.
An outline of the basic operation is as follows.

First, when power is turned on to the apparatus, drive power is supplied to each unit from the power supply unit 27, and the CPU 21A receives RO power by supplying drive power.
Subsequent operations are started according to the program stored in M21B. Next, an output port is selected by a port selection signal output from the CPU 21A, and the motor, the solenoid valve, and the like of the mechanism are initialized by resetting the output port. This sets the device in use.

[Calibration] The calibration operation of the apparatus is performed prior to the measurement of the ion concentration of the sample serum and the automatic setting of a correction coefficient described later.

The calibration start signal is sent to the control unit 21 by operating the keyboard 24.
Is input, the input port is selected by the port selection signal sent from the CPU 21A, and a calibration start signal is sent to the control unit 21 via this input port. Next, an output port is selected by a port selection signal, and a drive signal is sent from the CPU 21A to the three-way valve 19B and the roller pump 18 via the data bus and the output port. When the three-way valve 19B and the roller pump 18 are turned on by this drive signal, the calibration liquid is sucked into the measurement electrode unit 16 through the nozzle 13. Thereafter, the three-way valve 19B and the roller pump 18 are closed and stopped in response to the OFF signal sent through the output port. Then, an electrode potential corresponding to the ion concentration of the calibration liquid 2 is detected by each of the electrodes 16A to 16C of the measurement electrode unit 16. This electrode potential is subjected to A / D conversion by the A / D converter 20 and then input from the input port to the CPU 2 via the data bus.
The data is read into 1A, transferred to the RAM 21C, and stored. this
The data value of the electrode potential stored in the RAM 21C is E2.

Next, an output port is selected by a port selection signal, and a drive signal and an open signal are sent from the CPU 21A to the roller pump 18 and the three-way valve 19A via the data bus and the output port for a certain period of time. When the three-way valve 19A is opened and the roller pump 18 is turned on, the calibration liquid 1 is sucked into the nozzle 13 through the septum 14, and the measurement electrode 16
It is led to. Thereafter, a signal is output from the CPU 21A to the three-way valve 19A and the roller pump 18 through the data bus and the output port, and the three-way valve 19A closes and the roller pump 18 stops. Then, each ion electrode of the measurement electrode section 16
The electrode potential corresponding to the ion concentration of the calibration liquid 1 is detected by 16A to 16C. This electrode potential is subjected to A / D conversion by the A / D converter 20, and then read from the input port to the CPU 21A of the control unit 21 via the data bus, transferred to the RAM 21C, and stored. This stored data value of the electrode potential is
E1.

 Thus, the calibration operation is completed.

[Measurement of Sample Serum] After setting the sample cup 12 containing the sample serum on the turntable 11 of the autosampler 10 and inputting a measurement start instruction from the keyboard 24, the signal of the measurement start is input. CPU21A from port via data bus
And the measurement sequence starts.

First, a nozzle down signal is sent from the CPU 21A to the output port via the data bus. This nozzle descent signal is given to the nozzle up / down mechanism 15 via the mechanism section and the drive circuit 26,
The nozzle 13 descends to a predetermined position. When the nozzle 13 descends to a predetermined position, a sensor (not shown) below the nozzle detects this and turns on. The sensor ON signal is sent from the input port to the CPU 21 via the data bus. Then, the CPU 21A outputs a stop signal to the nozzle up / down mechanism 15 via the output port and the drive circuit 26, and stops the lowering of the nozzle 13. At this time, the tip of the nozzle 13 is
It has been inserted into the sample serum in 12.

Next, a signal is output from the CPU 21A to the drive circuit 26 via the output port for a certain period of time. A drive signal is sent from the drive circuit 26 to the roller pump 18 in response to the input signal. When the roller pump 18 is turned on for a certain period of time, the sample serum in the sample cup 12 is sucked by the nozzle 13 and guided to the measurement electrode unit 16 therefrom. Thereafter, when the roller pump 18 is stopped by a stop signal from the CPU 21A, the operation of aspirating the sample serum by the nozzle 13 ends.

When the aspiration of the sample serum is completed, a nozzle up signal is supplied from the CPU 21A to the nozzle up / down mechanism 15 via the output port and the drive circuit 26. When the nozzle 13 moves up to a predetermined position, the sensor above the nozzle is turned on, and the signal is sent from the input port to the CPU 21A via the data bus. The CPU 21A receives the input signal and gives a signal for stopping the rising of the nozzle to the nozzle up / down mechanism 15 via the output port and the drive circuit 26.

After the nozzle 13 stops, each ion electrode of the measurement electrode section 16
The electrode potential corresponding to the ion concentration of the sample serum is detected by 16A to 16C. The electrode potential output from the electrode section 16 is subjected to A / D conversion by the A / D converter 20 and then read from the input port to the CPU 21A via the data bus, and
The data is transferred to the M21C and stored. The data value of the stored electrode potential is represented as EX.

Next, an ON signal is output from the CPU 21A to the three-way valve 19A and the roller pump 18 via the output port and the drive circuit 26 for a certain period of time, and the roller pump 18 is turned on at the same time as the three-way valve 19A is opened. When the roller pump 18 is turned on,
Standard solution 1 is nozzle 1 via three-way valve 19A and septum 14.
It is sucked into 3 and guided to the measurement electrode unit 16.

When the sample serum is led to the measurement electrode section 16, the electrode potential corresponding to the ion concentration of the calibration liquid 1 is detected by the ion electrodes 16A to 16C. The electrode potential output from the measurement electrode unit 16 is A / D converted by the A / D converter 20,
The data is read from the input port to the CPU 21A via the data bus, transferred to the RAM 21C, and stored. The stored data value of the electrode potential is represented as E1 '.

Next, the data value E2 stored in the RAM 21C at the time of the above calibration,
CP based on E1, the data values EX and E1 'stored at the time of measurement, and the known concentration C2 of calibration solution 2 and concentration C1 of calibration solution 1.
The following equation is calculated in U21A, and the measurement result CX of the ion concentration of the sample serum is calculated.

CX = C1 · (C2 / C1) ^D The measurement result CX is output to the output port via the data bus, and is displayed on the LED display 22 through the output port. At the same time, the measurement result CX is output to the output port via the data bus, and is printed out from the printer unit 23 through this output port.

After that, a signal is sent from the CPU 21A to the drive circuit 26 through the data bus and the output port, and the drive signal from the drive circuit 26 turns on the motor of the autosampler 10 and turns the turntable 11 into the array of the sample cups 12. One step is sent at a pitch interval corresponding to the pitch.
Then, based on the signal from the CPU 21A, the turntable 11
Feed operation stops. Next, the above-described sequence for measuring the ion concentration of the sample serum is continuously performed.

The above sequence of measuring the ion concentration is sequentially and continuously repeated, and the ion concentration is continuously and automatically measured for all of the sample sera of the sample cups 12 arranged on the turntable 11.

Next, a specific processing procedure of the automatic correction coefficient setting method according to the present invention will be described with reference to the flowcharts of FIGS.

When using the apparatus, there is a case where a correction work is performed in which the measured value of the ion concentration of the standard serum or the like actually measured is matched with the standard value (true value) of the known ion concentration using the standard serum or the like. In this case, the correction coefficients A and B in the correction formula (regression formula) Y = A.X + B are set according to the following procedure using the standard serum whose ion concentration is known as described above. The correction formula Y = A.X + B is stored and stored in the RAM 21C of the control unit 21 in advance.

First, in a step, a standard value (true value) of a known ion concentration attached to three kinds of standard sera H, M and L having different ion concentrations of high, medium and low is determined by operating the keyboard 24 by the user. It is input to the control unit 21. Then, CP
The input port is selected by the port selection signal output from U21A, the input standard value is read by the CPU 21A from the input port via the data bus in a step, and the read standard value is transferred to the RAM 21C, and the standard serum is read. Next, in a step, three sample cups 12... Each containing a standard serum are set on the turntable 11 of the autosampler 10 in steps (H), (M), and (L). You. At this time, the above-described measurement calibration operation has already been completed. Thereafter, in a step, the user operates the keyboard 24 to input an instruction to start measuring the ion concentrations of the standard serums H, M, and L. The measurement start instruction input signal is read from the input port to the CPU 21A via the data bus, and thereafter, the same sequence of the ion concentration measurement as shown in the above “Sample serum ion concentration measurement” is performed on the standard serum H, M , L in order.

That is, in the step, for the standard serums H, M, and L under the control of the CPU 21A, suction from the sample cup 12 by the nozzle 13 → introduction of the measurement electrode unit 16 → detection of the electrode potential → A / D conversion → ion concentration The above-described basic operation sequence of the ion concentration measurement up to the calculation... Is executed. This measurement is performed successively five times on three sample cups 12... Each of the standard serums H, M, and L. The measurement results are as follows.

Standard serum H: YH1, YH2, YH3, YH4, YH5 Standard serum M: YM1, YM2, YM3, YM4, YM5 Standard serum L: YL1, YL2, YL3, YL4, YL5 Measurement results calculated by this CPU 21A are data The signal is output to the output port via the bus.
This is represented on the D display 22. At the same time, the data is output to the output port via the data bus, and is printed out by the printer 23 via the output port. The measurement results of these standard sera H, M, and L are transferred to the RAM 21C,
It is stored in a dedicated storage address (step).

Standard serum H, M, L in three sample cups 12 ...
If the continuous measurement is not completed five times for each, the above measurement operation is automatically repeated (step).

When the five consecutive measurements are completed, the CPU 21A
The average values YH, YM, and YL of the measurement results are the standard serum H,
The calculation and calculation are sequentially performed for M and L as shown in steps (1) and (2). The calculation result is as follows.

Standard serum H: ▲ ▼ = (YH1 + YH2 + YH3 + YH4YH5)
/ 5 Standard serum M: ▲ ▼ = (YM1 + YM2 + YM3 + YM4YM5)
/ 5 Standard serum L: ▲ ▼ = (YL1 + YL2 + YL3 + YL4YL5)
/ 5 When the average values ▲ ▼, ▲ ▼, ▲ ▼ of the five measurement results for the standard serum H, M, L are calculated,
The standard serum H stored in the RAM 21C in the step,
Standard values XH, XM, XL of M and L, and average values ▲ ▼, ▲ ▼, ▲ ▼ of the five measurement results of the standard serum,
The CPU 21A determines whether or not the measured value needs to be corrected based on a reference value for determination stored in the ROM 21B in advance.
Is determined.

In the determination, in the steps (1) and (2), the difference B between the standard values XH, XM, XL of the standard serums H, M, L and the average values ▲, ▼, ▲ of the five measured values
H, BM, and BL are sequentially calculated. The calculation result is as follows.

Standard serum H: BH = | ▲ ▼ -XH | Standard serum M: BM = | ▲ ▼ -XM | Standard serum L: BL = | ▲ ▼ -XL | In steps, BH, BM, and BL are sequentially calculated. Then, in the following steps, the respective differences BH, BM, and BL are stored in the ROM 21B as standard values K.
Are compared and determined by the CPU 21A. When all the differences BH, BM, BL are within the range of the reference value K, ie, BH <K, BM <K, BL <
When K, it is determined that the measurement result satisfies the standard. If it is determined that the standard is satisfied, the CPU 21A outputs to the output port via the data bus that there is no need to correct the measured value. The output result is printed out by the printer 23 via the output port and is notified to the user. Then, a series of processes regarding the automatic setting of the correction coefficient ends.

As the reference value K stored in the ROM 21B, for example, the following numerical values are given.

Na: within ± 1.5mmol / l K: within ± 0.1mmol / l Cl: within ± 1.5mmol / l No correction is required if all the values of BH, BM, and BL are within this range. That is, it is determined that there is no need to set the correction coefficient, and the series of processes according to the present invention is completed.

On the other hand, if any one of BH, BM, and BL does not fall within the range of the reference value K in step and, the CPU 21A determines that the measurement result does not satisfy the reference.

If it is determined that the measurement results do not meet the criteria, the CP
Under the control of U21A, the next process step of the automatic correction coefficient setting is executed using the above-described correction coefficient calculation formula. Through this series of processing steps, the correction coefficients A and B in the correction equation Y = A.X + B are automatically calculated and calculated.

That is, by executing the processing of the steps 21 in FIG. 3B, the standard values XH, XH
Average of M, XL, average of measured values ▲ ▼, ▲
The average values of ▼, ▲ ▼, and a and b are automatically and sequentially calculated and calculated automatically. Then, the calculated a,
Based on b, the correction coefficients A and B are sequentially and continuously calculated by the CPU 21A (step). The correction coefficients A and B calculated by the CPU 21A are stored in the RAM 21C in the step.
And stored in a dedicated address.

As described above, all the series of processes and procedures of the automatic correction coefficient setting are completed. Thereafter, the automatically set correction coefficient A,
The measurement value of the sample serum is automatically corrected to a true value in the control unit 21 by a correction formula using B as a slope and a Y intercept, that is, a regression line formula Y = A × X + B, and the corrected true value is calculated. It is displayed and printed out.

In the above embodiment, an example in which the present invention is applied to an electrolyte analyzer has been described.However, the present invention is not limited to this. The present invention can be widely applied to an apparatus that needs to determine whether or not to perform correction and calculate and set a correction coefficient when correction is performed. In addition, not only standard serum but also other standard substances with known concentrations can be selected and used in various ways according to the apparatus mode and the like. Furthermore, in the examples, the concentration is high as an example of the standard substance,
5 for each using three standard sera different from medium and low
Although the measurement is performed every time, the number and the number of times of measurement are not limited to the standard serum of the present invention, and the number and the number of times of measurement are variously changed and set according to the measurement mode and the like. It is possible.

Further, the correction coefficient in the correction equation is also A,
When used as a correction expression for a quadratic expression or another functional expression, not limited to B2, several types of correction coefficients such as A, B, C... Can be used. Such cases are also included in the technical scope of the present invention.

Effects of the Invention As described above, according to the present invention, measurement of a standard substance is performed only by inputting a true value (standard value) of a standard substance having a known concentration into an apparatus and performing an operation of starting measurement of the standard substance. A series of processes and procedures from the need for correction of the measured values of the reference material, the calculation of the correction coefficient when correction is necessary, and the input and setting of the calculated correction coefficient to the device are performed in a preset program. Therefore, since all of them can be automatically executed, the process of setting the correction coefficient can be simplified or omitted, and the efficiency of the process can be improved. Therefore, time and labor for handling the apparatus can be saved. In addition, when correction is required, no special knowledge or skill is required, anyone can easily perform accurate correction, and all the series of processing required for correction can be automatically performed. Mistakes can be completely prevented. Therefore, accurate measurement accuracy can be managed.

Further, there is an advantage that a user without special knowledge or skill can be provided with an accurate determination as to whether correction is necessary.

[Brief description of the drawings]

FIG. 1 is a block diagram showing a specific example of an electrolyte analyzer to which the present invention is applied, FIG. 2 is a block diagram for explaining signal transmission / reception operations centered on the control unit, and FIG. (B) is a flowchart showing a specific procedure of processing and execution of the automatic correction coefficient setting method according to the present invention, and FIG. 4 is a flowchart showing a conventional correction coefficient setting method. 21: Control unit, 21A: CPU, 21B: ROM, 21C: RAM, H, M, L: Standard serum (standard substance).

Claims (3)

(57) [Claims] 1. A measuring section for collecting a sample from a sample container and detecting the concentration of the target substance, a control section for calculating the concentration of the target substance based on the detection signal and controlling each section, In an analyzer configured by a display unit that displays a calculation result and a power supply unit that supplies electric energy to each unit,
After the automatic calibration using the calibration solution, using a plurality of standard substances of known concentrations in the measurable concentration area, the standard value of the standard substance of which the concentration is known, the measurement value measured by the measurement unit, and a preset value. The control unit compares and determines whether or not the measurement unit needs to be corrected based on the reference value, and when correction is necessary, a correction coefficient of a correction formula set in the device based on the determination signal. Is calculated by the control unit and stored. 2. A plurality of standard substances having known concentrations are measured a predetermined number of times, and an average value of the measured values is calculated by the control unit, and a difference between the average value and the standard value is compared and calculated. The analyzer according to claim 1, wherein the presence or absence of correction of the measured value is determined based on whether the difference falls within a predetermined range with respect to a preset reference value. 3. When it is necessary to correct the measured value, the control unit calculates and stores a correction coefficient of the correction formula, and then calculates the concentration according to the correction formula set in the control unit when measuring the concentration of the sample. The analyzer according to claim 1, wherein the measurement value is automatically corrected.