JP2557242B2 - Cleaning and disinfecting solution for dental treatment instruments - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to a dental treatment instrument, for example, a dental cutting instrument (dental steel bar, tungsten carbide bar, diamond bar, diamond disc, carborundum point, etc.), dental Polishing tool (silicon point,
White Alundum Point, Grinding Point, Grinding Wheel, Rubber Polisher,
Felt points, metal strips, etc.), dental end equipment (reamers, files, rubber burst toppers, mediast toppers, pluggers, sprayers, heat cutters, etc.), dental instruments (explorers, gray syrups, probes, etc.), It relates to a cleaning and disinfecting solution used for.

[Conventional technology]

The major infectious diseases in the oral region are roughly classified into those caused by bacteria and those caused by viruses. Bacterial factors include Pseudomonas aeruginosa infection, Vibrio parahaemolyticus, Staphylococcus aureus infection, resistant bacterium infection, tuberculosis, pneumonia, dysentery amoeba infection, overt syphilis, Chlamydia infection, and mycosis. In addition, depending on the virus, adenovirus causing laryngeal conjunctival fever, orthomyxovirus causing meningitis, paramyxovirus causing measles, etc.,
Picornavirus causing hand-foot-and-mouth disease, enterovirus causing rubella, herpes, rotavirus causing gastroenteritis, HB virus causing hepatitis B, EB virus causing infectious mononucleosis, cytomegalo with carcinogenicity Retrovirus (Human immunodeficiency virus) that causes viruses, AIDS, adult T-cell leukemia, etc.
and so on. There are two major routes that can be considered as the infection routes: the dental clinic and the dental laboratory. Contaminated blood, saliva, and bodily fluids are possible sources of infection.

First of all, in the case of a dental clinic, contaminated blood and saliva, as well as body fluid, adhere to dental cutting instruments, dental polishing instruments, dental end equipment, dental instruments, etc. Penetration from scratches on the fingers or nose. These are so-called "horizontal infections". On the other hand, "vertical transmission" refers to mother-to-child transmission before and after childbirth.

Secondly, in the case of a dental laboratory, when handling contaminated blood, saliva, and impression materials with body fluid adhered, dust scattering of model trimming, cutting dust scattering when repairing dentures, using an air gun, steam cleaner There is a "horizontal infection" during use.

Therefore, as a measure to prevent horizontal infection from such an infection route on a daily basis, wearing a white coat, rubber gloves, a mask, protective glasses, a hat, etc. It is disinfection and sterilization. The purpose of the disinfectant is to prevent infection until it gets tired, but its effect is desirable for all microorganisms from bacteria to viruses, so-called disinfection.

Next, the main disinfection methods that have been used conventionally are: 1. Heating method 1) Flame method 2) Dry heating method 3) High pressure steam method 4) Flowing steam method 5) Boiling method 6) Intermittent method 2. Gas method 1) Ethylene oxide method 2) Formaldehyde method 3. Chemical solution method 1) Alcohols (ethanol, isopropanol, etc.) 2) Phenols (phenol, cresol, etc.) 3) Aldehydes (glutaraldehyde, formalin, etc.) 4) Inverse soaps ( Benzalkonium chloride, benzethonium chloride, etc.) 5) Biguanide (chlorhexidine, etc.) 6) Chlorine compounds (sodium hypochlorite) 4. Radiation, UV irradiation, etc. are available.

Among these methods, the simplest and most commonly practiced method is the chemical solution method. Among them, those based on chlorine compounds (sodium hypochlorite) are the most common. This sodium hypochlorite is used as an aqueous solution, but its effective chlorine concentration must be 0.5% or more in order to be effective against almost all bacteria and viruses. According to the Japan Dental Association Magazine Vol. 39 No. 3, "Disinfection B"
When sodium hypochlorite is used for disinfection of hepatitis C virus and disinfection of AIDS virus, the effective chlorine concentration of 5000 ppm (0.5%) is 10 minutes at room temperature. Also Dental Technician Vol.15, No.
According to 8,1987, the concentration of chlorinated compounds (sodium hypochlorite) used is 0.002 to 0.5% for hepatitis B, and AIDS virus is far weaker infectiousness than hepatitis B virus. It is said that the same disinfection as for viruses is sufficient. In addition, according to Prosthodontic Outlook Vol. 70, No. 5, 1987, 0.5% sodium hypochlorite is recommended for 10 to 30 minutes for AIDS and hepatitis B in the case of chemical disinfection.

Therefore, the sodium hypochlorite aqueous solution having such an effective chlorine concentration has been used for a long time in dentistry for cleaning and disinfecting dental cutting instruments, dental polishing instruments, dental end equipment, dental instruments, etc. It is used. In particular, so-called "antiformin" is used in which sodium hydroxide is added to a sodium carbonate solution to precipitate out calcium carbonate by filtration to produce sodium hypochlorite.

[Problems to be solved by the invention]

However, there are the following problems when cleaning and disinfecting a dental treatment instrument using an aqueous solution of sodium hypochlorite.

The storage stability of effective chlorine concentration of sodium hypochlorite aqueous solution is very poor. Figure 1 shows the relationship between the effective chlorine concentration (%) of sodium hypochlorite aqueous solution and the number of days of storage (days) at 23 ° C and 37 ° C. The decreasing tendency of the effective chlorine concentration of the sodium hypochlorite aqueous solution is extremely large, and is about 60 days at 23 ° C and about 35 days at 37 ° C, which is less than 0.5% of the effective chlorine concentration required for medical disinfection as described above. The phenomenon occurs. This decrease in effective chlorine concentration has a bad influence on the disinfection effect, that is, when a phenomenon occurs that the effective chlorine concentration is below 0.5%, which is necessary for medical disinfection,
Without being aware of this, it is possible that they could have been infected with a serious infection assuming that they could have been disinfected.

The sodium hypochlorite aqueous solution is extremely corrosive to metals. For example, the effective chlorine concentration of sodium hypochlorite aqueous solution is 0.5, which is the minimum concentration required for medical disinfection.
% When a stainless steel (SUS 303) sample is dipped in an aqueous solution, air bubbles are generated on the surface of the stainless steel after about 1 minute 30 seconds and black rust is generated in about 16 minutes. When nickel-chromium alloy is dipped, air bubbles are generated on the surface in about 30 seconds and black rust is generated in about 2 minutes. Furthermore, tungsten carbide is more susceptible to rust than stainless steel or nickel-chromium alloys. Many of these metals are used in dental treatment equipment, and if they are not soaked at room temperature for 10 minutes or more, there is no sterilizing and disinfecting effect due to the sodium hypochlorite aqueous solution. Is a big problem in terms of rust.

The sodium hypochlorite aqueous solution has almost no dentin solubility regardless of the effective chlorine concentration. Here, dentin means enamel, dentin, and cement, and pulp is omitted. At the time of cutting and polishing of tooth material in a dental clinic, dental treatment equipment has adhesion of cutting dust of tooth material and strong clogging. Also in the dental laboratory, gypsum and the like will be clogged in the same instruments. If it is not possible to remove clogging and adhesion, the cutting and polishing abilities will deteriorate considerably.
This makes work in the dentist's office and technician's room very inefficient, wastes time and leads to cost up, and also the quality of treatment for the patient, which affects the quality of the prosthesis. .

[Means for solving problems]

As a result of intensive studies to solve the above problems, the present inventors have solved the problem by developing an aqueous solution in which chloramines and a chelating agent are mixed and dissolved instead of the sodium hypochlorite aqueous solution. The specific methods of solving each of the problems will be described below.

(1) The storage stability of the effective chlorine concentration of an aqueous solution in which chloramines and a chelating agent are mixed and dissolved is very stable as shown in FIG. FIG. 2 is a graph showing the relationship between the effective chlorine concentration (%) of an aqueous solution prepared by mixing and dissolving sodium-p-toluenesulfone chloramide and nitrotriacetate citrate trisodium salt and the number of days of storage (days). The concentration of available chlorine slightly increased with the number of storage days because the solvent water was evaporated. The reason is that chloramines are typical "bound chlorine". Bound chlorine is chlorine bound to ammonia or an organic nitrogen compound, and reacts with water to gradually generate hypochlorite. The aqueous solution of the present invention has a very good storage stability of effective chlorine concentration as compared with sodium hypochlorite because it has a so-called free generation chlorinated release effect. This means that if the initial effective chlorine concentration at the time of compounding is 0.5% or more, it will never fall below the minimum effective chlorine concentration of 0.5% required for medical disinfection in dentistry. Therefore, there is no serious infectious disease due to insufficient disinfection.

(2) An aqueous solution obtained by mixing and dissolving chloramines and a chelating agent does not corrode metals at all. For example, in the present invention, the effective chlorine concentration of the aqueous solution is set to 1.0%, and stainless steel (SUS 303), nickel-chromium alloy, and tungsten carbide are individually immersed. 2 at room temperature
No bubbles or rust were found even after storage for more than a month.
This indicates that even if a dental treatment instrument made of metal is immersed in an antiseptic solution having a sterilizing / disinfecting effect at room temperature for 10 minutes or more, it is completely safe for rust.

(3) An aqueous solution prepared by mixing and dissolving chloramines and a chelating agent has dentin solubility. There are three types of tooth substance: enamel, dentin, and cementum.
Enamel is 97% inorganic and 3 organic
%; Dentin 70% inorganic, organic 30%; cementitious 50% organic, 50% organic. Here, most of the inorganic components are calcium phosphate (apatite), and most of the organic components are amino acids (collagen). The tooth substance having such a composition needs to have dentin solubility, but the present inventors have succeeded in imparting dentin solubility by using a chelating agent.

The product of the present invention exhibits a strong decalcification action when the pH of the aqueous solution is 7 or more. That is, it combines with many metal ions such as calcium ions to form a water-soluble chelate compound. Therefore, the tooth substance can be easily melted. Further, since the aqueous solution of the present invention also has a protein coagulating action, it has the action of dissolving all tooth substances regardless of enamel, dentin and cement.

From the above, it is possible to easily remove the adhesion and clogging of tooth chips and gypsum when using the dental treatment instrument in the dental clinic or dental laboratory simply by immersing it in the aqueous solution of the present invention. Can be done. Therefore, it will dramatically improve the work efficiency in the dental clinic and dental laboratory, leading to a significant cost reduction in dentistry, and further improving the treatment of patients and the quality of prostheses. It has the advantage of being connected.

As the chloramines in the present invention, one or more selected from sodium-p-toluenesulfonchloramide (chloramine T), sodium benzenesulfonchloramide (chloramine B), and sodium xylenesulfonechloramide (chloramine X). used.
Among them, sodium-p-toluenesulfone chloramide (chloramine T) is particularly preferable. The blending amount of chloramines with respect to water is 1 to 20 parts by weight with respect to 100 parts by weight of water. If the content of chloramines is less than 1 part by weight, the effective chlorine concentration cannot be increased to 0.5% or more. If the blending amount exceeds 20 parts by weight, the chloramines cannot be dissolved even if heated to 30% or more.

Specific examples of the chelating agent in the present invention include ethylenediaminetetraacetate citrate, nitrilotriacetate citrate, hydroxyethylethylenediamine-N, N ', N'-triacetate citrate,
Diethylenetriamine pentaacetate, ethylenediamine-N, N'-diacetate, 1-
Hydroxyethylidene-1,1-diphosphite oxide, triethylenetetraamine-N, N, N ', N ", N, N
-Hexaacetate citrate, dimethylglyoxime, ethylenediamine tetraacetate citrate disodium salt, ethylenediamine tetraacetate citrate trisodium salt, ethylenediamine tetraacetate citrate tetrasodium salt, ethylenediamine tetraacetate citrate disodium 1 Calcium salt, ethylenediamine tetraacetate 1 sodium 1 iron salt, ethylenediamine tetraacetate 1 ammonium 1 iron salt, ethylenediamine tetraacetate 2 ammonium salt, hydroxyethylethylenediamine-N, N ', N'-rea Cetacetate trisodium salt, diethylenetriamine pentaacetate pentasodium salt, nitrilotria setetate citrate 3 sodium Salt, and the like. The chelating agents may be used either individually or in combination of two or more. The amount of the chelating agent mixed with water is 0.1 to 30 parts by weight with respect to 100 parts by weight of water. If the blending amount is less than 0.1 part by weight, the ability to form a chelate compound with a metal ion such as calcium becomes very weak, and it becomes difficult to dissolve the tooth substance. If the chelating agent content exceeds 30 parts by weight, the main cleaning / disinfecting agent cannot be dissolved even if heated to 30 ° C or higher.

It is possible to appropriately add an anionic surfactant, a cationic surfactant, a nonionic surfactant, a coloring agent, a fragrance, etc. to the aqueous solution in which the chloramines and the chelating agent are mixed and dissolved in the present invention. Absent.

〔Example〕

Examples and comparative examples in the present invention will be shown below. The present invention is not limited to the above. The evaluation items and evaluation methods are as follows.

(1) Storage stability of effective chlorine concentration; When chloramines are used, iodine liberated with hydrochloric acid and potassium iodide is titrated with sodium thiosulfate, and with sodium hypochlorite, liberated with acetic acid and potassium iodide. The effective chlorine concentration is measured by titrating the iodine with sodium thiosulfate, and the effective chlorine concentration immediately after production (initial effective chlorine concentration) is compared with the effective chlorine concentration after 1 month at 37 ° C.

(2) Metal corrosiveness: Approximately 10 ml of the solutions of Examples and Comparative Examples are placed in a test tube, and each point and the metal are immersed and the time (minutes) until rust is generated is recorded visually.

(3) Solubility in dentin: GC diamond point ff type bovine teeth were scraped and clogged and immersed in a test tube containing about 10 ml of the solutions of Examples and Comparative Examples for 24 hours.

Dental solubility (%) is a value obtained by dividing (initial adhesion amount / residual adhesion amount) by initial adhesion amount and multiplying by 100.

Examples 1 to 5 and 8 to 10 are examples in which chloramines are sodium-p-toluenesulfonchloramide, Example 6 is sodium xylenesulfonchloramide, and Example 7 is sodium benzenesulfonchloramide. It is an example. Examples 11 and 12 are sodium-p
-Toluene sulfone chloramide and sodium xylene sulfone chloramide are mixed and dissolved,
13 is an example in which sodium-p-toluenesulfonchloramide and sodium benzenesulfonchloramide are mixed and dissolved. Examples 1 to 7 and 11 are examples in which trisodium nitrilotriacitrate trisodium salt is used as a chelating agent, and Example 8 is N-hydroxyethylethylenediamine-N, N ', N'-triacetate citrate. Example 9 is an example using disodium trisodium salt, Example 9 is an example using diethylenetriamine pentaacetate pentasodium salt, and Example 10 is ethylenediamine-N,
This is an example using N'-diacetate citrate. Examples 12 and 13 are Nitrilotriacetate citrate trisodium salt and N-hydroxyethylethylenediamine-N,
This is an example in which N ', N'-triacetate trisodium salt is mixed and dissolved.

Example 2 is an example in which the content of sodium chloramine, sodium-p-toluenesulfonchloramide, is small, and the effective chlorine concentration is 0.7%, which is small, but exceeds the minimum effective chlorine concentration 0.5% required for medical disinfection. Further, Example 8 is an example in which the amount of sodium-p-toluenesulfone chloramide is large, and the effective chlorine concentration also increases in proportion. The examples are examples in which the amount of nitrilotriacetate citrate trisodium salt, which is a chelating agent, is small, and the amount of dentin dissolved is slightly reduced, but it can be said that it has a considerable effect in practical use. Examples 5, 6, and 7 are examples in which the amount of nitrilotriacetate citrate trisodium salt is large, but the amount of dentin dissolution is not extremely improved. This means that if the amount of the chelating agent blended reaches a certain level, the amount of dissolved dentin does not increase that much. Since chloramines are used in each of the examples, the initial effective chlorine concentration and the effective chlorine concentration after 1 month at 37 ° C. are almost the same or slightly increased. It is considered that the reason is that the effective chlorine concentration apparently increased due to the evaporation of water during storage. Further, in the above examples, no rust was found after immersion for 2 months.

Comparative Example 1 is an example using an aqueous solution of sodium hypochlorite. Regarding the storage stability of the available chlorine concentration, the initial available chlorine concentration was 1.8%, and it was 0.3% after 1 month at 37 ℃, and the minimum available chlorine concentration of 0.5% required for medical disinfection cannot be obtained. For metal corrosion, the metal used is 1-16
Occurrence of rust was observed in minutes. Furthermore, it has little dentin solubility.

[Effects of the Invention] The aqueous solution according to the present invention, in which chloramines and a chelating agent are dissolved in water, has solved the above-mentioned drawbacks from the root. The following effects can be obtained by cleaning and disinfecting a dental treatment instrument using the liquid of the present invention.

(1) Since chloramines are typical combined chlorine, effective chlorine necessary for sterilization is gradually released, so that the storage stability of the effective chlorine concentration is very good (see Fig. 2). Since this does not fall below the effective chlorine concentration of 0.5% required for medical disinfection, there is no risk of serious infection.

(2) No rust is observed even when metals such as stainless steel (SUS 303), nickel chrome alloy, and tungsten carbide are immersed in an aqueous solution in which chloramines and a chelating agent are dissolved. This means there is no risk of rust when cleaning and disinfecting dental treatment instruments.

(3) The aqueous solution in which the chloramines and the chelating agent are dissolved has dentin solubility. The chelating agent has a pH of 7 or more (alkali) in its aqueous solution and binds with many metal ions such as calcium ions to form a water-soluble chelating compound, which has a strong demineralizing effect on tooth and gypsum. Therefore, it is possible to easily remove the tooth substance and plaster attached to the dental cutting instrument, the dental polishing instrument, the dental end device, the dental instrument and the like. This will dramatically improve the efficiency of work in the dental clinic and dental technician room, which will lead to a significant cost reduction in dentistry, further improve the treatment of patients and the quality of prostheses. .

The cleaning and disinfecting solution obtained according to the present invention can be used not only for dentistry but also for other medical instruments.

[Brief description of drawings]

FIG. 1 is a diagram showing the relationship between the effective chlorine concentration (%) of an aqueous solution of sodium hypochlorite and the number of days of storage (days), and FIG. 2 shows the relationship between sodium-p-toluenesulfone chloramide (chloramine T). Effective chlorine concentration (%) and storage days (days) of an aqueous solution obtained by mixing and dissolving nitrilotriacetate citrate trisodium salt (Zonone NTT; manufactured by Daiichi Pure Chemicals)
It is a figure showing the relation with.

Claims (1)

(57) [Claims] 1. Sodium-p-for 100 parts by weight of water
1 to 20 kinds of chloramines selected from toluene sulfone chloroamide, sodium benzene sulfone chloroamide, and sodium xylene sulfone chloroamide
A cleaning and disinfecting solution for dental treatment instruments, characterized by containing 0.1 to 30 parts by weight of a chelating agent.