JP2540234B2 - Foaming composition for cleaning contact lenses - Google Patents

Description

TECHNICAL FIELD The present invention relates to a foamable cleaning composition for contact lenses, and more specifically to a foamable cleaning composition used by foaming in the form of a mousse. .

[Prior Art] For contact lenses, daily care is required to remove foreign matter and dirt adhering to the surface of the contact lens, sterilize it, and put it on the eye.

Generally, there are three types of contact lenses: a hard type, a gas permeable hard type, and a soft type. In terms of materials, polymethylmethacrylate is used for the hard contact lens, and polysiloxane, cellulose acetate butyrate ester, fluoropolymer, etc. are used for the gas permeable hard system. On the other hand, as the soft contact lens, methacrylic acid, methyl methacrylate, which is a homopolymer of hydroxyethyl methacrylate (HEMA),
It is known to use a HEMA-based copolymer having vinylpyrrolidone as a comonomer as a base polymer. Since these soft contact lenses are made of a particularly flexible material, they have an advantage that there is little feeling of foreign matter when they are worn.
Also, soft contact lenses and gas permeable contact lens systems with enhanced water content are good for cornea because they have excellent oxygen permeability.

However, contact lenses, especially soft contact lenses, may come into contact with eye tissues or tears during wearing, causing inorganic salts, proteins, fats, lipids, mucins, mucopolysaccharides, cholesterol-like substances, etc. to surface. Easy to adhere to. Therefore, it is necessary to effectively remove these stains without damaging the lens material or surface.When using, regularly clean the surface to remove the above deposits and disinfect. Will be needed.

Nonionic surfactants are good cleaning agents for gas-permeable hard contact lenses of polydimethylsiloxane type, but are not effective for cellulose acetate butyrate ester type, and especially to remove cholesterol-like substances sufficiently. I can't. Moreover, if the surfactant is used alone as a cleaning agent, it may affect the wettability of the lens and impair the wearing feeling.

However, by using an amphoteric surfactant in combination with the above-mentioned nonionic surfactant, a useful detergent for cellulose acetate butyrate can be obtained.

[Problems to be Solved by the Invention] By the way, since the above-mentioned conventional liquid cleaning agents are usually used for more than half a year, they must be managed cleanly and properly in order to keep the components stable and prevent contamination with bacteria and the like. There was a problem. In addition, since it is liquid, the container drips from the mouth of the container and the container is dirty and unclean; the opening and closing of the cap is troublesome; the cleaning liquid sticks to the cap, making it difficult to open the cap; There was also a handling problem such as "power is needed to do so."

The present invention solves these problems, has excellent cleaning ability for contact lenses, keeps a stable state with little change in components, prevents contamination, and easily foams into a mousse that is easy to handle. The present invention provides a foamable composition for cleaning a contact lens, which can be used as.

[Means for Solving the Problems] As a result of repeated studies to solve such problems, the present inventor has formulated a specific surfactant in a cleaning vehicle at a specific amount ratio, The inventors have found that a good mousse-like foam can be obtained by jetting, and have completed the present invention.

That is, the present invention relates to a foamable composition for cleaning a contact lens, which comprises the following components A and B.

(A) (1) Nonionic surfactant composed of polyoxyethylene-polyoxypropylene block copolymer; (2) General formula (In the formula, R ¹ has a monovalent hydrocarbon group having 6 to 24 carbon atoms; R
² and R ³ each represent an alkylene group having 1 to 4 carbon atoms;
X ¹ represents a hydrogen atom, an alkali metal atom or a —CH ₂ COOM ¹ group; X ² represents —COOM ² or Wherein M ¹ and M ² each represent a hydrogen atom, an alkali metal atom or a nitrogen atom-containing organic base group; and X ³ represents a hydroxyl group or a sulfur atom-containing acidic group that produces surface activity). Activator; (3) Ethanol or isopropyl alcohol; and (4) Washing solution 88-97% by weight of water, provided that (1) and (2)
Is 5 to 20 parts by weight per 100 parts by volume of the cleaning liquid,
And the weight ratio of (1) :( 2) is 1: 1 to 3: 1, and (3)
Is 5 to 25 parts by weight per 100 parts by volume of the washing liquid; (B) 3 to 12% by weight of propellant.

The cleaning foamable composition of the present invention comprises a cleaning liquid (A) and a propellant (B). (A) is one of two types of surfactants, that is, a nonionic surfactant (1)
And (2) which is a kind of amphoteric surfactant as a detergent component, and an alcoholic solvent (3) and water (4).

The polyoxyethylene-polyoxypropylene block copolymer (1) used in the present invention generally has a polyoxyethylene chain, which is a lipophilic portion, in the center, and a polyoxyethylene chain, which is a hydrophilic portion, is arranged on the left and right sides thereof. Is a linear terblock copolymer. The average molecular weight is preferably 1800 to 27,000, and particularly preferably in the range of 3,500 to 20,000 because of its cleaning ability. The ratio of the polyoxypropylene portion in the molecule is preferably 20 to 85% by weight from the viewpoint of cleaning ability,
Especially preferred is -60% by weight. On the other hand, if it exceeds 85% by weight, the affinity for water is lowered in the high molecular weight region. The molecular terminal is preferably a hydroxyl group.

The amphoteric surfactant (2) used in the present invention has the above general formula and is particularly effective for removing cholesterol-like substances. In the above general formula, R ¹
Is a lipophilic part, and when this length is balanced with the type and number of polar groups in the molecule, it shows good cleaning ability. Generally, it is a saturated or unsaturated hydrocarbon group or an alkyl group having 6 or more carbon atoms. Substituted aromatic hydrocarbon groups are preferred. X ¹ is preferably a hydrogen atom, sodium atom, —CH ₂ COOH or —CH ₂ COONa group. M ² is preferably a hydrogen atom or a sodium atom. X ³ is preferably a hydroxyl group.

Among the amphoteric surfactants of (2), the more preferable one is a dicarboxylic acid salt type, that is, X ¹ is —CH ₂ COOM ¹ and X ² is —.
It is of COOM ² , and is of the sodium salt type in which M ¹ and M ² are sodium atoms. Most preferred are quaternary ammonium type compounds of the formula:

(In the formula, R ¹ , R ² , and R ³ are as described above.) The feature of the present invention is that the specific surfactants (1) and (2), which are the detergent components, are fixed in the detergent vehicle. The total amount and the amount ratio are included. That is, the total amount of (1) and (2) in the vehicle is 5 to 20 parts by weight per 100 parts by volume of the vehicle. Here, "parts by weight per 100 parts by volume" means the number of g in 100 ml. If this amount is less than 5 parts by weight, a sufficient cleaning effect cannot be expected. On the other hand, 20
If it exceeds the weight part, it is difficult to eject from the nozzle of the aerosol can after storage for a long period of time, and good foam cannot be obtained.
The weight ratio of (1) and (2) is 1: 1 to 3: 1. By keeping the ratio of both within this range, a foam with good detergency can be obtained, and proteins, fats, lipids, mucopolysaccharides and cholesterol-like substances attached to contact lenses during wearing can be effectively washed. Can be removed.

The alcohol (3) used in the present invention serves both as an antiseptic and as a solvent, and is ethyl alcohol, isopropyl alcohol or a mixture of both, preferably isopropyl alcohol. In the present invention, the amount of (3) is also an important factor, and is 5 to 25 parts by weight, preferably 10 to 22 parts by weight, per 100 parts by volume of the above-mentioned detergent vehicle. If the amount of alcohols is less than 5 parts by weight, a sufficient antiseptic effect cannot be obtained, and the effect of dissolving lipids contained in tear fluid is reduced. On the other hand, if it exceeds 25 parts by weight, the lens may be affected depending on the material of the contact lens.

The cleaning liquid used in the present invention is (1) above,
The components (2) and (3) and the balance (4) water. Pure water such as distilled water or deionized water is used as water.

The cleaning liquid may contain a bactericide for sterilizing the contact lens and for storing the cleaning liquid itself or the foamable composition in an aseptic state. As the bactericide, sorbic acid, EDTA disodium salt, EDTA trisodium salt,
Examples thereof include benzalkonium chloride.

The propellant (B) used in the present invention is a component for foaming the cleaning foamable composition of the present invention into a mousse by spraying. As propellants, CFCs, LPG,
Examples include butane, butylene, and a mixture thereof, and a mixture of these and dimethyl ether, but they are easily available, easy to handle, and have no adverse effect on the environment.
LPG is preferred.

The amount of propellant is 3-12% by weight of the foamable composition,
The preferred range varies depending on the kind of the foaming agent, but is generally 4 to 10% by weight. When the amount of the propellant is less than 3% by weight, the foaming state of the liquid is poor, and the propellant is consumed before the liquid is completely ejected, so that the cleaning agent vehicle cannot be completely used up. On the other hand, if it exceeds 12% by weight, the sprayed composition foams too much and the texture of the foam becomes rough.

The cleaning foamable composition of the present invention can be produced and filled as follows, for example. That is, after the respective components of the detergent vehicle are uniformly mixed, the excess is carried out. A pressure-resistant can such as an aerosol can is prepared, the inside of the can is thoroughly cleaned, and then a predetermined amount of a cleaning agent vehicle is filled. The valve and spout are then mounted on the can and filled with a predetermined amount of propellant. All of these steps are carried out while maintaining aseptic conditions, and finally a needle is attached.

[Effects of the Invention] The foamable composition of the present invention is applied to all contact lenses regardless of whether they are hard or soft, not limited to the material of the range. Since it foams into a shape, liquid does not flow from the palm during cleaning, it is easy to wash as a foam, the container does not get dirty, the cap can be simplified, etc.
Easy to handle. In addition, because it is kept in an airtight container that is isolated from the outside air, it maintains a stable state with little change in components, keeps the sterilization state without propagating bacteria in the can, and suppresses bacterial contamination of contact lenses. Can clean contact lens effectively, fresh and clean for a long time.

[Examples] Hereinafter, the present invention will be described with reference to Examples and Comparative Examples.
The invention is not limited by these examples.

Examples 1 to 4 and Comparative Example The washing solutions of Examples 1 to 4 and Comparative Example were prepared under the aseptic conditions according to the blending amounts shown in Table 1. The surfactants S-1A, S-1B and S-2 used here were as follows.

S-1A: polyoxyethylene-polyoxypropylene linear block copolymer, average molecular weight: 11,500, polyoxypropylene: 30% by weight S-1B: copolymer similar to S-1A, provided that the average molecular weight:
6,350, polyoxypropylene: 50% by weight S-2: amphoteric surfactant represented by the following formula 95% by weight of each of the aerosol cans having the same shape and the same volume, in which the mixed liquids having the compositions shown in Table 1 are stirred and mixed until they are uniform, and the inside is cleaned in advance by mixing.
It was filled so that Then, LPG was pressurized and filled so as to be 5% by weight and the gas pressure in the can at 25 ° C. was 3 kg / cm ² G.

A jetting experiment was conducted on the cleaning foamable composition thus prepared and filled. The compositions of Examples 1 to 4 were satisfactorily sprayed and had good foam breakage, and the obtained foams were fine and fine in texture. On the other hand, the composition of Comparative Example was slightly difficult to spray the contents, and the foam state was not good.

In addition, when the same injection experiment was carried out after storing at 45 ° C. for 3 months, the compositions of Examples 1 to 4 obtained the same good mousse-like foaming as those after preparation and filling, but The example composition was difficult to jet.

Next contact lens L-1 to L with dirt components
-3 was used to examine the cleaning ability of the compositions of Examples 1-4.

L-1 Silicone rubber system L-2 Acetic acid butyric acid cellulose ester system L-3 HEMA-Vinylpyrrolidone-Ethylene glycol methacrylate copolymer system First, the contact angle of the above-mentioned contact lens with water to water was measured. Then, this lens was placed on the palm with the concave surface facing upward, and 2 ml (about 0.1 g as a cleaning liquid) of foam was sprayed onto the lens surface of each of the foamable compositions of Examples 1 to 3 with a finger. Rubbed and washed.
The contact angle of the lens after cleaning was measured. The results are shown in Table 2. The lens after washing was transparent and clean as a result of visual observation, and the lens was not damaged by washing.

Claims (1)

(57) [Claims] 1. A foamable composition for cleaning a contact lens, which comprises the following components A and B: (A) (1) Nonionic surfactant composed of polyoxyethylene-polyoxypropylene block copolymer; (2) General formula (In the formula, R ¹ has a monovalent hydrocarbon group having 6 to 24 carbon atoms; R
² and R ³ each represent an alkylene group having 1 to 4 carbon atoms;
X ¹ represents a hydrogen atom, an alkali metal atom or a —CH ₂ COOM ¹ group; X ² represents —COOM ² or Wherein M ¹ and M ² each represent a hydrogen atom, an alkali metal atom or a nitrogen atom-containing organic base group; and X ³ represents a hydroxyl group or a sulfur atom-containing acidic group that produces surface activity). Activator; (3) Ethanol or isopropyl alcohol; and (4) Washing solution 88-97% by weight of water, provided that (1) and (2)
Is 5 to 20 parts by weight per 100 parts by volume of the cleaning liquid,
And the weight ratio of (1) :( 2) is 1: 1 to 3: 1, and (3)
Is 5 to 25 parts by weight per 100 parts by volume of the washing liquid; (B) 3 to 12% by weight of propellant.