JP2515937B2 - Skin protectant and manufacturing method thereof - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin protectant which penetrates skin and protects human skin from irritants and pollutants.

[0002]

BACKGROUND OF THE INVENTION Conventionally known skin protectants generally include emollients, ointments and creams such as those used for long term treatment of the skin of ataxic senile and paraplegic or quadriplegic patients. . Such emollients, ointments and creams have also been applied to wrinkles, dry or cracked skin of the skin exposed to sweat stimuli, and pressure sensitive areas and also for the treatment of stoma. A typical emollient ointment or cream contains water and hydrophobic lanolin, paraffin oil, beeswax, and white petrolatum that forms an oil film on the skin that promotes rehydration of the epithelium by partial retention of water.

Many of the humectants contain wax esters such as whale wax lanolin and beeswax. Some contain steroid alcohols such as cholesterol and other lanolin alcohols. Fatty alcohols are also often used, including lauryl, cetyl, oleyl and stearyl alcohols with triglyceride esters including animal and vegetable oils and fats.

Silicone oils are commonly used to modify petroleum jelly and mineral oils and to obtain the desired wetting performance. These materials, with the exception of water,
The main carrier used in cosmetic emulsions,
It serves primarily to hold other emollients. They normally hydrate the keratin as they remain on the skin surface and prevent water from being supplied by the underlying tissues of the skin to evaporate into the surroundings by a hydrocarbon barrier. This commonly used amount of hydrocarbon oils and waxes inhibits the penetration of more effective ingredients into the skin as disclosed herein.

In all of these prior art compounds, some components treat the skin surface with little or no penetration of the skin and are generally removed by simple washing procedures. One of the prior art compounds (see US Pat. No. 5, OOO, 938) is capable of penetrating the skin and forming an active protective membrane on the upper epithelial layer (stratum corneum).

[0006]

However, to form an effective barrier between the surface of the skin and the subepithelial layer to protect the skin from most commonly used acids or alkaline substances, alcohols and cleansing agents. There is no known skin protectant that can do the above.

The present invention has such a protective effect and can be applied to the skin easily and quickly, and
An object of the present invention is to provide a skin protective agent having a good feeling in use.

[0008]

SUMMARY OF THE INVENTION The present invention is summarized as follows.
Water, propylene glycol, sorbit, glycerin,
A novel skin protectant containing ingredients such as stearic acid, cocoa butter, liquid paraffin, ascorbyl stearate, and silicone oil, which improves the penetration of the active ingredient into the skin and improves the emulsification and pH control factors. It is a skin protectant containing the above-mentioned components in a preferable ratio so as to exert a function.

Such skin protectants are preferably subjected to a dispersion medium such as a gas at a suitable pressure to produce a light weight foam, the light weight foam being predominantly aqueous skin protection. Bubbles in the agent.

More specifically, in the present invention, propylene glycol 2.5-3.
5% by weight, sorbit 0.9 to 1.9% by weight, glycerin 2 to 3.5% by weight, stearic acid 2.5 to 3.5% by weight, cocoa butter 0.8 to 1.25% by weight, liquid paraffin 0.8-1.25% by weight, ascorbyl stearate 0.5-1.1% by weight, silicone oil 0.5-1.1
A skin protectant which is a mixture containing 65% by weight and 65 to 70% by weight of water. In a preferred embodiment, the mixture is a foamable skin protectant pressurized with gas, more preferably 3 to 5 kg / cm ² , and particularly preferably 4.2.
Pressurized with kg / cm ² (60 PSI) gas
The cans are effervescent skin protective agent, characterized in that it is enclosed in the form of bubbles lightweight aqueous.

Examples of the silicone oil include methyl polysiloxane. The gas is liquefied petroleum gas of about 19.5% or isobutane of about 16.50.
% And about 3% propane are preferred. As water, purified water is preferable.

By using such a skin protective agent, it is possible to prevent the penetration of dust, oil and grease into the skin. The present invention also provides a method for producing the skin protectant. This method comprises the following steps. (A) A step of mixing sorbit, stearic acid, cocoa butter, liquid paraffin, ascorbyl stearate, and silicone oil to form a first mixture. (B) A step of increasing the temperature of the first mixture to 60 to 80 ° C., preferably about 70 ° C., and stirring the mixture until it becomes uniform. (C) A step of adding water, propylene glycol, and glycerin to the first mixture that has been heated and mixed to form a second mixture. (D) The temperature of the second mixture is raised to 60 to 80 ° C, preferably about 70 ° C, and the temperature of the second mixture is set to 30 to
Cooling to 50 ° C, preferably about 40 ° C and stirring this second mixture until homogeneous. (E) Cooling this mixture to room temperature, preferably to about 20 ° C. (F) Cans pressurized with gas, preferably 3
~5kg / cm ^2, particularly preferably 4.2 kg / cm ²
Encapsulating in a can pressurized with gas at a pressure of (about 60 PSI) . The gas is liquefied petroleum gas of about 19.5.
%, Or about 16.50% isobutane and about 3% propane.

The effervescent form of the skin protectant described above is
The final product can also be prepared as a non-pressurized skin protection cream by increasing the content of some of the ingredients and omitting the pressurization by the gas.

The formulation of this cream is propylene glycol 2.5-3.5% by weight, sorbit 0.8-1.2.
% By weight, glycerin 3-5% by weight, stearic acid 4-6
% By weight, cocoa butter 0.8-1.2% by weight, liquid paraffin 0.8-1.2% by weight, ascorbyl stearate 0.8-1.2% by weight, silicone oil 0.8-1.2
% By weight and 80-87% by weight of water. Similar to the effervescent skin protectant, the silicone oil may be methylpolysiloxane, and the water is preferably purified water.

In addition to the above components, components that are generally incorporated in a skin protectant, such as fragrances, may be incorporated as long as the effects of the present invention are not impaired.

[0016]

The skin protective agent of the present invention quickly penetrates into the skin and forms a protective film that acts as a barrier between the skin surface and the highly sensitive subepithelial layer. This barrier is used for most acid and alkaline substances. It protects the skin from alcohols and most of the commonly used cleaning agents and can remove dirt, stains, coloring pigments, glues, greases, oils, etc. much easier than ever before. it can.

Furthermore, the ingredients of this skin protectant protect the skin against cracks, contact allergies and mild irritation. The product is a small foam and contains a small amount of this ingredient. It becomes absorbed into the skin and becomes colorless and disappears shortly after use, but usually remains in an effective protective position in the skin for 5 hours after use, and is not removed by repeated washing during this period.

[0018]

The preferred form of the invention consists of a mixture of several components in a substantially aqueous composition, the active ingredients propylene glycol, sorbitol, glycerin, stearic acid, cocoa butter, liquid paraffin, ascorbyl stearate. And silicone oil such as methyl polysiloxane.

These ingredients together make up about 1 of the total formulation.
3.5% by weight, about 67% by weight of the total formulation is water and the remaining about 19.5% by weight is 3% propane and 16.50% by weight isobutane.

The formulation of the above components is about 3% by weight of propylene glycol, about 1% by weight of sorbit, about 3% by weight of glycerin, about 3% by weight of stearic acid, about 1% by weight of cocoa butter,
Liquid paraffin about 1% by weight, ascorbyl stearate about 0.5% by weight, silicone oil about 1% by weight and water about 67% by weight.

The above components are suitably mixed as described below and a dispersion medium such as a gas, for example liquefied petroleum gas about 19.5%, gas pressure 3-5 kg / cm ² , preferably.
Serving at 4.2 kg / cm ² (about 60 PSI) results in the production of light cellular foam that emerges upon introduction of gas bubbles into the skin protectant upon pressurization.

This effervescent skin-protecting agent has cellular bubbles formed of gas and liquid, in which small gas bubbles are contained in a small amount of liquid, and a small amount of skin-protecting agent. Can be effectively swollen and diluted to control the amount of effervescent skin protectant used on the skin, with several components penetrating well into the skin, forming a barrier between the skin surface and the sensitive subepithelial layer be able to.

Effervescent skin protectants are non-toxic, colorless, non-greasy and, moreover, diluted as foam and absorbed rapidly by the skin so that they are not visible shortly after use. This product allows the skin to maintain a perfect feel,
It also allows the skin to breathe and sweat, all of which are desirable properties.

In order to prepare the above-mentioned formulation, a specific step is indispensable. In this step, (1) sorbit, stearic acid, cocoa butter, liquid paraffin, ascorbyl stearate and silicone oil are mixed to prepare a first step. Forming a mixture, (2) increasing the temperature of the first mixture to about 70 ° C. and stirring until the mixture is uniform, (3) adding to the heat-mixed first mixture,
Adding water, propylene glycol and glycerin to form a second mixture, (4) increasing the temperature of the second mixture to about 70 ° C., cooling the second mixture to about 40 ° C. and homogenizing Stirring the second mixture until about 20 minutes.

The mixture thus formulated is then enclosed in a pressure vessel in the presence of a dispersion medium such as the gas mentioned above, for example liquefied petroleum gas, which dispersion medium is in the foamed form of the skin protectant. It can be induced and released from the pressurized container in a very fine foamy form. The effervescent skin protectant thus formed and dispersed gives a very dry and unique feel when used on the skin.

The novel effervescent and highly effective skin protectant and its method of preparation have been disclosed herein. When this effervescent skin protectant is applied to the skin of, for example, a human hand, it quickly penetrates into the skin and forms a protective film that acts as a barrier between the skin surface and the sensitive subepithelial layer.
This barrier protects the skin from most acids, alkaline substances, alcohols and most of the commonly used cleaning agents and keeps dirt, stains, pigments, glues, greases, oils, etc. Even much easier to wash away.

Furthermore, the components of this effervescent skin protectant are:
Protects the skin against cracks, contact allergies and mild irritation.This product is a small foam and has a small amount of this component.It is quickly absorbed into the skin and becomes colorless and invisible shortly after use. But after normal use 5
It remains in an effective protective position in the skin for a period of time and is not removed by repeated washings during this time.

It has been found that the amounts of the components mentioned above can be varied within certain limits without changing the effectiveness of this formulation. For example, the formulation is propylene glycol 2.5-3.5 wt%, sorbit 0.9-1.9 wt%, glycerin 2-3.5 wt%, stearic acid 2.
5 to 3.5% by weight, cocoa butter 0.8 to 1.25% by weight,
Ascorbyl stearate 0.5-1.1% by weight, silicone oil 0.05-1.1% by weight and water 60-70
It may contain wt%.

Within the above ranges, the components are mixed and processed in the same manner as described above, and the product is processed through pressure and encapsulation steps. The lightweight effervescent component composition resulting from the introduction of gas bubbles in these processes allows a small amount of effervescent skin-protecting agent to penetrate the skin surface, and provides a barrier between the skin surface and the sensitive subepithelial layer. An active protective film is formed in the upper layer of the epithelium to provide the

The preferred effervescent form of the skin protectant described above also increases the content of some of the above-identified components and eliminates the pressurization by the gas, thus adding no end product. It can also be prepared as a pressure skin protection cream.

The formulation of this cream is propylene glycol 2.5-3.5% by weight, sorbit 0.8-1.2.
% By weight, glycerin 3-5% by weight, stearic acid 4-6
% By weight, cocoa butter 0.8-1.2% by weight, liquid paraffin 0.8-1.2% by weight, ascorbyl stearate 0.8-1.2% by weight, silicone oil 0.8-1.2
% By weight and 80-87% by weight of water, preferably
Propylene glycol 3% by weight, sorbitol 1% by weight,
Glycerin 4% by weight, stearic acid 5% by weight, cocoa butter 1% by weight, liquid paraffin 1% by weight, ascorbyl stearate 1% by weight, silicone oil 1% by weight and water 8
It is 2% by weight.

To make this cream, sorbit, stearic acid, cocoa butter, liquid paraffin, ascorbyl stearate and silicon oil were placed in a first container as a premix batch and mixed, which was brought to about 70.degree. Heating, mixing the batch until homogeneous, placing the heated premix batch in a second vessel, adding water and propylene glycol and glycerin, and heating to about 70 ° C.,
The mixture is then cooled and the mixing is continued for about 20 minutes until the mixture is at about 40 ° C. and the batch is homogeneously mixed, which is then sealed in a non-pressurized container such as a jar. do it. Since this non-pressurized skin protection cream has substantially all the properties of the above-mentioned effervescent skin protection agent, it can be preferably used.

To apply the present invention to creams, the water content is increased compared to the foamed form and propylene glycol,
Slightly increase the content of glycerin and stearic acid. It has a high water content and allows the cream to be applied thinly and widely to the skin, whereby a small amount of active ingredient is
It is supplied to a large skin area and penetrates the skin surface to form a protective layer on the epithelium upper layer.

Although a skin protectant for skin protection treatment and two steps for preparing it have been described, various changes and modifications in this formulation and steps are possible without departing from the scope of the invention. It will be apparent to those skilled in the art.

<Effect test of the skin protectant of the present invention> As an example, propylene glycol 3% by weight, sorbitol 1% by weight, glycerin 3% by weight, stearic acid 3% by weight, cacao butter 1% by weight, liquid paraffin 1 The effect of the foaming skin protectant composed of wt%, ascorbyl stearate 0.5 wt%, methylpolysiloxane 1 wt%, purified water 67 wt% and liquefied petroleum gas 19.5% is shown below.

(1) Safety Test After subcutaneously injecting 0.2 ml of liquid base oil of the foaming skin protectant of this Example into 10 rats of each sex, 15 rats were subcutaneously injected.
Mortality and pathological clinical findings were observed after minutes, 1, 2, 4 hours and then daily for 14 days.

As a result, no mortality or pathological findings were observed.

(2) Evaluation of duration of protective layer formed on human skin: The skin protective agent of the present example mixed with the fluorescent substance deoxycycline was applied to the skin of 10 hands, and the hands were wet. Washed,
Fluorescence reflection was measured after 1, 2, 3, 4 hours after drying with a paper towel. Between each measurement he did his usual work.

Table 1 shows the average values of the measured values inside and outside the hand.

[0040]

[Table 1]

From this result, under the conditions of this experiment, the life of the protective layer decreases slowly with the time,
After a lapse of time, it was found that about 50% was retained even after washing 4 times in total.

<3> Sulfuric acid resistance test The backs of four Shirako rabbits weighing about 3 kg were divided into eight sites, four were used as control sites, and 0.2 g of the skin protectant of this example was applied to the remaining sites. I massaged it and rubbed it into my skin. After rinsing with distilled water for 5 minutes, 1m
1% of 10% or 20% sulfuric acid was added, and after 1, 4, 24 hours, and 3 days, the presence or absence of skin reaction, the development of erythema and the development of edema were evaluated.

The presence or absence of skin reaction was evaluated by-or +, and the expression of erythema or edema was evaluated by the 4-point method. The results of sulfuric acid concentration of 10% are shown in Table 2, and the results of 20% are shown in Table 3.

[0044]

[Table 2]

[0045]

[Table 3]

From these results, it was found that the application of the skin protectant of the present invention can prevent rough skin caused by 10% sulfuric acid. This effect is not impaired by washing with water. Further, it was found that when the sulfuric acid concentration is 20%, the skin becomes rough, but the degree thereof can be reduced as compared with the case where the skin protective agent is not applied.

[0047]

INDUSTRIAL APPLICABILITY The skin protectant of the present invention can be applied to the skin easily and quickly, since it is absorbed by the skin, it does not affect the feel, and the composition used is small. The skin can breathe and sweat. Further, the skin protectant of the present invention forms a barrier between the skin surface and the subepithelial layer when used on the skin, and is resistant to water and detergent for about 3 to 5 hours after use, and thus it is free from dust and dirt. In addition to protecting the skin from pigments, pastes, greases, oils, etc., it can protect the skin from cracks, contact allergies, and mild chemically induced inflammation.

Claims (7)

(57) [Claims] 1. Propylene glycol 2.5 to 3.5% by weight, sorbit 0.9 to 1.
9% by weight, glycerin 2 to 3.5% by weight, stearic acid 2.5 to 3.5% by weight, cocoa butter 0.8 to 1.25% by weight, liquid paraffin 0.8 to 1.25% by weight, stearin A skin protectant which is a mixture containing 0.5-1.1% by weight of ascorbyl acid, 0.5-1.1% by weight of silicone oil and 65-70% by weight of water. 2. The skin protectant according to claim 1, wherein the mixture is pressurized with a gas. 3. The mixture according to claim 2, wherein the mixture is a gas.
Therefore , an effervescent skin protectant characterized in that it is enclosed in a pressurized can in the form of a lightweight aqueous foam. 4. The skin protective agent according to claim 2, wherein the gas is liquefied petroleum gas. 5. Propylene glycol 2.5 to 3.5% by weight, sorbit 0.8 to 1.2% by weight, glycerin 3
-5% by weight, stearic acid 4-6% by weight, cocoa butter 0.
8 to 1.2% by weight, liquid paraffin 0.8 to 1.2% by weight, ascorbyl stearate 0.8 to 1.2% by weight,
Silicon oil 0.8-1.2% by weight and water 80-8
A skin protectant containing 7% by weight. 6. A method for producing the effervescent skin-protecting agent according to claim 2, wherein (a) sorbit, stearic acid, cocoa butter, liquid paraffin, ascorbyl stearate and silicone oil are mixed, and Forming a mixture, (b) increasing the temperature of the first mixture to 60 to 80 ° C. and stirring until the mixture becomes uniform, (c) adding the first mixture to the heat mixture, Adding water, propylene glycol and glycerin to form a second mixture, (d) increasing the temperature of the second mixture to 60-80 ° C and cooling the second mixture to 30-50 ° C. , a step of stirring the second mixture until uniform, the mixture step of cooling to room temperature, the process of encapsulating the cans pressurized by (f) which gas (e) How. 7. The method for producing an effervescent skin protective agent according to claim 6, wherein the gas is liquefied petroleum gas.