JP2025513929A5 - - Google Patents

Info

Publication number
JP2025513929A5
JP2025513929A5 JP2024563327A JP2024563327A JP2025513929A5 JP 2025513929 A5 JP2025513929 A5 JP 2025513929A5 JP 2024563327 A JP2024563327 A JP 2024563327A JP 2024563327 A JP2024563327 A JP 2024563327A JP 2025513929 A5 JP2025513929 A5 JP 2025513929A5
Authority
JP
Japan
Prior art keywords
cancer
inhibitor
ras
subject
farnesyltransferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024563327A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025513929A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2023/061079 external-priority patent/WO2023209073A1/en
Publication of JP2025513929A publication Critical patent/JP2025513929A/ja
Publication of JP2025513929A5 publication Critical patent/JP2025513929A5/ja
Pending legal-status Critical Current

Links

JP2024563327A 2022-04-28 2023-04-27 がんの処置のためのras阻害剤とファルネシルトランスフェラーゼ阻害剤との組合せ Pending JP2025513929A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22305636 2022-04-28
EP22305636.7 2022-04-28
EP22306602.8 2022-10-21
EP22306602 2022-10-21
PCT/EP2023/061079 WO2023209073A1 (en) 2022-04-28 2023-04-27 Combination of ras inhibitors and farnesyltransferase inhibitors for the treatment of cancers

Publications (2)

Publication Number Publication Date
JP2025513929A JP2025513929A (ja) 2025-04-30
JP2025513929A5 true JP2025513929A5 (https=) 2026-04-28

Family

ID=86378289

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024563327A Pending JP2025513929A (ja) 2022-04-28 2023-04-27 がんの処置のためのras阻害剤とファルネシルトランスフェラーゼ阻害剤との組合せ

Country Status (5)

Country Link
US (1) US20250262211A1 (https=)
EP (1) EP4514356A1 (https=)
JP (1) JP2025513929A (https=)
KR (1) KR20250002557A (https=)
WO (1) WO2023209073A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4719410A1 (en) * 2023-05-31 2026-04-08 Kura Oncology, Inc. Farnesyltransferase inhibitors for treatment of kras-dependent cancers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140335077A1 (en) * 2013-05-07 2014-11-13 Leonard Girnita Compositions and Methods for the Treatment of Cancer Using IGF-IR Antagonists and MAPK/ERK Inhibitors
US11331312B2 (en) * 2014-04-25 2022-05-17 Memorial Sloan-Kettering Cancer Center Treatment of H-Ras-driven tumors
US20230285498A1 (en) * 2020-08-07 2023-09-14 City Of Hope Treatments for cancers having kras mutations

Similar Documents

Publication Publication Date Title
Grimes et al. Conjunctival melanoma: current treatments and future options
Blecua et al. The DNA methylation landscape of hematological malignancies: an update
Jain et al. Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities
Oettle et al. Adjuvant therapy in pancreatic cancer: a critical appraisal
Jin et al. Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions
CN105120663A (zh) 用于利用羧胺三唑乳清酸盐治疗对先前化学治疗药物和靶向药物具有获得性耐药性的癌症的方法和组合物
JP2020523354A5 (https=)
Souglakos et al. Multicenter dose-finding study of concurrent capecitabine and radiotherapy as adjuvant treatment for operable rectal cancer
JP2019506392A5 (https=)
JPWO2022269525A5 (https=)
JP2025513929A5 (https=)
Dabney et al. Molecular pathways and targeted therapy in cholangiocarcinoma
Malakar et al. The role of BRAF inhibitors in the management of ameloblastoma: a literature review
Li et al. Unraveling the role of TP53 in colorectal cancer therapy: from wild-type regulation to mutant
Jin et al. Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment
Kawai et al. Phase I/II study of preoperative chemoradiotherapy with TEGAFIRI for locally advanced rectal cancer
JP2025026846A5 (https=)
Ning et al. Anti‐PD‐L1 antibody TQB2450 combined with tyrosine kinase receptor inhibitor AL2846 for immunotherapy‐refractory advanced hepatocellular carcinoma and esophageal squamous cell carcinoma: A prospective phase 1b cohort study
Zhou et al. Advances in immunotherapy and targeted therapy for pancreatic cancer
JPWO2022182857A5 (https=)
Yu et al. Radiotherapy in the preoperative neoadjuvant treatment of locally advanced rectal cancer
Lee Disease modifying agents of myeloproliferative neoplasms: a review
Chan et al. CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis
White et al. Infigratinib for the treatment of metastatic or locally advanced cholangiocarcinoma with known FGFR2 gene fusions or rearrangements
Yoon et al. Sunitinib malate synergistically potentiates anti-tumor effect of gemcitabine in human bladder cancer cells