JP2025513019A - 疾患の治療のためのリファブチン類似体 - Google Patents

疾患の治療のためのリファブチン類似体 Download PDF

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Publication number
JP2025513019A
JP2025513019A JP2024559583A JP2024559583A JP2025513019A JP 2025513019 A JP2025513019 A JP 2025513019A JP 2024559583 A JP2024559583 A JP 2024559583A JP 2024559583 A JP2024559583 A JP 2024559583A JP 2025513019 A JP2025513019 A JP 2025513019A
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Japan
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alkyl
optionally substituted
independently
aryl
halogens
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Pending
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JP2024559583A
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English (en)
Japanese (ja)
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JP2025513019A5 (enExample
Inventor
アントライゲス、ケビン
ブーロット、マリリン
イー. デール、グレン
ドフェール、オリヴィエ
ギツィンガー、マルク
ロチウロ、セルジオ
メゴ、マチュー
トレボスク、ヴィンセント
ヴィラント、ニコラス
Original Assignee
バイオヴェルシス アクチェンゲゼルシャフト
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Publication of JP2025513019A publication Critical patent/JP2025513019A/ja
Publication of JP2025513019A5 publication Critical patent/JP2025513019A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024559583A 2022-04-11 2023-04-06 疾患の治療のためのリファブチン類似体 Pending JP2025513019A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22167670 2022-04-11
EP22167670.3 2022-04-11
PCT/EP2023/059154 WO2023198597A1 (en) 2022-04-11 2023-04-06 Rifabutin analogs for the treatment of disease

Publications (2)

Publication Number Publication Date
JP2025513019A true JP2025513019A (ja) 2025-04-22
JP2025513019A5 JP2025513019A5 (enExample) 2026-03-25

Family

ID=81306910

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024559583A Pending JP2025513019A (ja) 2022-04-11 2023-04-06 疾患の治療のためのリファブチン類似体

Country Status (7)

Country Link
US (1) US20250235434A1 (enExample)
EP (1) EP4508053A1 (enExample)
JP (1) JP2025513019A (enExample)
CN (1) CN118974060A (enExample)
AU (1) AU2023251806A1 (enExample)
CA (1) CA3253889A1 (enExample)
WO (1) WO2023198597A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025132358A1 (en) * 2023-12-21 2025-06-26 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of infectious diseases
EP4696694A1 (en) 2024-08-14 2026-02-18 BioVersys AG Antibiotic rifabutin analogs
EP4696695A1 (en) * 2024-08-14 2026-02-18 BioVersys AG Antibiotic rifabutin analogs
WO2026062070A1 (en) * 2024-09-18 2026-03-26 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of infectious diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
PT102807A (pt) 2002-07-09 2004-01-30 Inst Nac De Engenharia E Tecno Derivados n-substituidos de rifabutina uteis como agentes antimicrobianos, processo para a sua preparacao e sua utilizacao como medicamentos

Also Published As

Publication number Publication date
CN118974060A (zh) 2024-11-15
EP4508053A1 (en) 2025-02-19
WO2023198597A1 (en) 2023-10-19
CA3253889A1 (en) 2023-10-19
US20250235434A1 (en) 2025-07-24
AU2023251806A1 (en) 2024-09-12

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