JP2025512391A5 - - Google Patents
Info
- Publication number
- JP2025512391A5 JP2025512391A5 JP2024560376A JP2024560376A JP2025512391A5 JP 2025512391 A5 JP2025512391 A5 JP 2025512391A5 JP 2024560376 A JP2024560376 A JP 2024560376A JP 2024560376 A JP2024560376 A JP 2024560376A JP 2025512391 A5 JP2025512391 A5 JP 2025512391A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding domain
- multispecific antibody
- multispecific
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263330769P | 2022-04-13 | 2022-04-13 | |
| US63/330,769 | 2022-04-13 | ||
| US202263379100P | 2022-10-11 | 2022-10-11 | |
| US63/379,100 | 2022-10-11 | ||
| US202263382592P | 2022-11-07 | 2022-11-07 | |
| US63/382,592 | 2022-11-07 | ||
| US202363478881P | 2023-01-06 | 2023-01-06 | |
| US63/478,881 | 2023-01-06 | ||
| US202363480478P | 2023-01-18 | 2023-01-18 | |
| US63/480,478 | 2023-01-18 | ||
| PCT/US2023/065741 WO2023201309A1 (en) | 2022-04-13 | 2023-04-13 | Antibodies that bind pd-l1, pd-l2 and/or cd28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025512391A JP2025512391A (ja) | 2025-04-17 |
| JP2025512391A5 true JP2025512391A5 (https=) | 2026-04-22 |
Family
ID=88330395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024560376A Pending JP2025512391A (ja) | 2022-04-13 | 2023-04-13 | Ｐｄ－ｌ１、ｐｄ－ｌ２及び／またはｃｄ２８と結合する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230383012A1 (https=) |
| EP (1) | EP4508085A1 (https=) |
| JP (1) | JP2025512391A (https=) |
| CN (1) | CN119365490A (https=) |
| WO (1) | WO2023201309A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US11739144B2 (en) | 2021-03-09 | 2023-08-29 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and CLDN6 |
| US12365743B2 (en) | 2022-02-23 | 2025-07-22 | Xencor, Inc. | Anti-CD28 x anti-PSMA antibodies |
| WO2025090973A2 (en) * | 2023-10-27 | 2025-05-01 | Xencor, Inc. | Anti-trop2 x anti-pdl1 x anti-cd28 antibodies |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US459007A (en) | 1891-09-08 | Porte | ||
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| AU2004297616B2 (en) | 2003-12-04 | 2008-12-18 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| WO2007041635A2 (en) | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| EP2138478B1 (en) | 2007-04-17 | 2019-07-24 | Kao Corporation | Process for producing hydrogenolysis products of polyhydric alcohols |
| AU2011283694B2 (en) | 2010-07-29 | 2017-04-13 | Xencor, Inc. | Antibodies with modified isoelectric points |
| ES2758994T3 (es) | 2010-11-05 | 2020-05-07 | Zymeworks Inc | Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc |
| KR102211837B1 (ko) | 2013-01-14 | 2021-02-03 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| JP6594855B2 (ja) | 2013-03-15 | 2019-10-23 | ゼンコア インコーポレイテッド | ヘテロ二量体タンパク質 |
| EP3699195A3 (en) | 2014-03-28 | 2020-11-04 | Xencor, Inc. | Bispecific antibodies that bind to cd38 and cd3 |
| EA035419B9 (ru) | 2014-05-29 | 2020-08-07 | Мэкроудженикс, Инк. | Триспецифичные связывающие молекулы и способы их применения |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN109715663B (zh) | 2016-06-28 | 2022-11-25 | Xencor股份有限公司 | 结合生长抑素受体2的异源二聚抗体 |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| MA52212A (fr) * | 2018-03-30 | 2021-02-17 | Merus Nv | Anticorps multivalent |
| JP7789002B2 (ja) * | 2020-01-29 | 2025-12-19 | インヒブルクス バイオサイエンシズ インコーポレイテッド | Ｃｄ２８シングルドメイン抗体ならびにその多価および多重特異性の構築物 |
| CN113461824A (zh) * | 2020-03-31 | 2021-10-01 | 普米斯生物技术(珠海)有限公司 | 一种构建多特异性抗体的平台 |
| CA3192204A1 (en) * | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| US20220135684A1 (en) * | 2020-10-14 | 2022-05-05 | Xencor, Inc. | Bispecific antibodies that bind pd-l1 and cd28 |
-
2023
- 2023-04-13 CN CN202380046738.9A patent/CN119365490A/zh active Pending
- 2023-04-13 EP EP23722248.4A patent/EP4508085A1/en active Pending
- 2023-04-13 US US18/300,302 patent/US20230383012A1/en active Pending
- 2023-04-13 WO PCT/US2023/065741 patent/WO2023201309A1/en not_active Ceased
- 2023-04-13 JP JP2024560376A patent/JP2025512391A/ja active Pending
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