JP2025510774A5 - - Google Patents

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Publication number
JP2025510774A5
JP2025510774A5 JP2024556407A JP2024556407A JP2025510774A5 JP 2025510774 A5 JP2025510774 A5 JP 2025510774A5 JP 2024556407 A JP2024556407 A JP 2024556407A JP 2024556407 A JP2024556407 A JP 2024556407A JP 2025510774 A5 JP2025510774 A5 JP 2025510774A5
Authority
JP
Japan
Prior art keywords
fusion polypeptide
modified
domain
polypeptide according
inclusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024556407A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025510774A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2023/064886 external-priority patent/WO2023183892A1/en
Publication of JP2025510774A publication Critical patent/JP2025510774A/ja
Publication of JP2025510774A5 publication Critical patent/JP2025510774A5/ja
Pending legal-status Critical Current

Links

JP2024556407A 2022-03-24 2023-03-23 修飾fcドメインを有するsirp-alpha融合ポリペプチド Pending JP2025510774A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263323417P 2022-03-24 2022-03-24
US63/323,417 2022-03-24
PCT/US2023/064886 WO2023183892A1 (en) 2022-03-24 2023-03-23 Sirp-alpha fusion polypeptides with modified fc domains

Publications (2)

Publication Number Publication Date
JP2025510774A JP2025510774A (ja) 2025-04-15
JP2025510774A5 true JP2025510774A5 (https=) 2026-03-30

Family

ID=86054071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024556407A Pending JP2025510774A (ja) 2022-03-24 2023-03-23 修飾fcドメインを有するsirp-alpha融合ポリペプチド

Country Status (13)

Country Link
US (1) US20230365648A1 (https=)
EP (1) EP4499837A1 (https=)
JP (1) JP2025510774A (https=)
KR (1) KR20240162572A (https=)
CN (1) CN119546769A (https=)
AU (1) AU2023240361A1 (https=)
CA (1) CA3246192A1 (https=)
CL (1) CL2024002849A1 (https=)
CO (1) CO2024013909A2 (https=)
IL (1) IL315706A (https=)
JO (1) JOP20240212A1 (https=)
MX (1) MX2024011528A (https=)
WO (1) WO2023183892A1 (https=)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2816647T3 (es) 2012-01-17 2021-04-05 Univ Leland Stanford Junior Reactivos SIRP-alfa de alta afinidad
US10011660B2 (en) * 2012-04-30 2018-07-03 Medimmune, Llc Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
PL3575326T3 (pl) * 2012-12-17 2022-07-11 Pf Argentum Ip Holdings Llc Leczenie komórek chorobowych cd47+ z użyciem fuzji sirp alfa-fc
WO2016023040A1 (en) 2014-08-08 2016-02-11 Alexo Therapeutics International Sirp-alpha variant constructs and uses thereof
PL3180363T3 (pl) 2014-08-15 2020-02-28 Merck Patent Gmbh Białka fuzyjne immunoglobulin sirp-alfa
AU2016304794B2 (en) 2015-08-07 2021-07-15 ALX Oncology Inc. Constructs having a SIRP-alpha domain or variant thereof
CN116239698A (zh) * 2019-03-06 2023-06-09 江苏恒瑞医药股份有限公司 双功能融合蛋白及其医药用途
EP3976658A4 (en) * 2019-05-24 2023-06-07 Forty Seven, Inc. Regimes for co-administration of immunotherapeutic agents against c-kit and cd47
WO2020263830A1 (en) * 2019-06-25 2020-12-30 Gilead Sciences, Inc. Flt3l-fc fusion proteins and methods of use

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