JP2025510161A - ガストリン放出ペプチド受容体（ｇｒｐｒ）のインビボイメージング及びｇｒｐｒ関連障害の治療のための放射性標識化合物 - Google Patents

ガストリン放出ペプチド受容体（ｇｒｐｒ）のインビボイメージング及びｇｒｐｒ関連障害の治療のための放射性標識化合物 Download PDF

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JP2025510161A
JP2025510161A JP2024556499A JP2024556499A JP2025510161A JP 2025510161 A JP2025510161 A JP 2025510161A JP 2024556499 A JP2024556499 A JP 2024556499A JP 2024556499 A JP2024556499 A JP 2024556499A JP 2025510161 A JP2025510161 A JP 2025510161A
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xaa
trp
peptide
peptide compound
gly
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JP2025510161A5 (https=
Inventor
－ シュヤン リン、クオ
ベナール、フランソワ
ワン、レイ
チャン、チェンシン
ブラタノビック、イビカ
チャン、チェンチェン
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Provincial Health Services Authority
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Provincial Health Services Authority
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
JP2024556499A 2022-03-25 2023-03-24 ガストリン放出ペプチド受容体（ｇｒｐｒ）のインビボイメージング及びｇｒｐｒ関連障害の治療のための放射性標識化合物 Pending JP2025510161A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263323831P 2022-03-25 2022-03-25
US63/323,831 2022-03-25
PCT/CA2023/050401 WO2023178449A1 (en) 2022-03-25 2023-03-24 Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders

Publications (2)

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JP2025510161A true JP2025510161A (ja) 2025-04-14
JP2025510161A5 JP2025510161A5 (https=) 2026-03-30

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JP2024556499A Pending JP2025510161A (ja) 2022-03-25 2023-03-24 ガストリン放出ペプチド受容体（ｇｒｐｒ）のインビボイメージング及びｇｒｐｒ関連障害の治療のための放射性標識化合物

Country Status (9)

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US (2) US12246076B2 (https=)
EP (1) EP4499663A1 (https=)
JP (1) JP2025510161A (https=)
KR (1) KR20250007523A (https=)
CN (1) CN119213011A (https=)
AU (1) AU2023239751A1 (https=)
CA (1) CA3246188A1 (https=)
IL (1) IL315057A (https=)
WO (1) WO2023178449A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025054727A1 (en) * 2023-09-13 2025-03-20 Provincial Health Services Authority Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
EP2198878A1 (en) 2008-12-18 2010-06-23 University Of Miami Polypeptide bombesin antagonists
ES2745635T3 (es) 2012-09-25 2020-03-03 Advanced Accelerator Applications Usa Inc Antagonistas de GRPR para la detección, diagnóstico y tratamiento del cáncer positivo para GRPR
WO2021068051A1 (en) 2018-11-13 2021-04-15 Provincial Health Services Authority Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
TWI878344B (zh) * 2019-09-17 2025-04-01 瑞士商諾華公司 放射性標記grpr拮抗劑之方法及其套組

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Publication number Publication date
US20240123099A1 (en) 2024-04-18
CA3246188A1 (en) 2023-09-28
CN119213011A (zh) 2024-12-27
KR20250007523A (ko) 2025-01-14
US12246076B2 (en) 2025-03-11
AU2023239751A1 (en) 2024-09-05
US20250195702A1 (en) 2025-06-19
EP4499663A1 (en) 2025-02-05
IL315057A (en) 2024-10-01
WO2023178449A1 (en) 2023-09-28

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