JP2025506993A - 病理スライド画像を分析する方法及び装置 - Google Patents

病理スライド画像を分析する方法及び装置 Download PDF

Info

Publication number
JP2025506993A
JP2025506993A JP2024552307A JP2024552307A JP2025506993A JP 2025506993 A JP2025506993 A JP 2025506993A JP 2024552307 A JP2024552307 A JP 2024552307A JP 2024552307 A JP2024552307 A JP 2024552307A JP 2025506993 A JP2025506993 A JP 2025506993A
Authority
JP
Japan
Prior art keywords
patch
pathology slide
information
machine learning
learning model
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024552307A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025506993A5 (https=
Inventor
ユ，ドングン
ソン，サンフン
オク，チャンヨン
チョン，ウォンギョン
チョ，スイク
ペン，ギョンヒョン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lunit Inc
Original Assignee
Lunit Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020230017338A external-priority patent/KR20230130536A/ko
Application filed by Lunit Inc filed Critical Lunit Inc
Publication of JP2025506993A publication Critical patent/JP2025506993A/ja
Publication of JP2025506993A5 publication Critical patent/JP2025506993A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/82—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/774—Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03—Recognition of patterns in medical or anatomical images

Landscapes

  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • Medical Informatics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Biomedical Technology (AREA)
  • Software Systems (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Databases & Information Systems (AREA)
  • Artificial Intelligence (AREA)
  • Computing Systems (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Quality & Reliability (AREA)
  • Image Analysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Computational Linguistics (AREA)
JP2024552307A 2022-03-03 2023-02-16 病理スライド画像を分析する方法及び装置 Pending JP2025506993A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20220027211 2022-03-03
KR10-2022-0027211 2022-03-03
KR10-2023-0017338 2023-02-09
KR1020230017338A KR20230130536A (ko) 2022-03-03 2023-02-09 병리 슬라이드 이미지를 분석하는 방법 및 장치
PCT/KR2023/002241 WO2023167448A1 (ko) 2022-03-03 2023-02-16 병리 슬라이드 이미지를 분석하는 방법 및 장치

Publications (2)

Publication Number Publication Date
JP2025506993A true JP2025506993A (ja) 2025-03-13
JP2025506993A5 JP2025506993A5 (https=) 2026-02-19

Family

ID=87850835

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024552307A Pending JP2025506993A (ja) 2022-03-03 2023-02-16 病理スライド画像を分析する方法及び装置

Country Status (4)

Country Link
US (2) US12530874B2 (https=)
EP (1) EP4489011A4 (https=)
JP (1) JP2025506993A (https=)
WO (1) WO2023167448A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4489011A4 (en) * 2022-03-03 2025-08-06 Lunit Inc METHOD AND APPARATUS FOR PATHOLOGICAL SLIDE IMAGE ANALYSIS
CN117831612A (zh) * 2024-03-05 2024-04-05 安徽省立医院(中国科学技术大学附属第一医院) 基于人工智能的gist靶向药物类型选择预测方法及系统
CN120431990B (zh) * 2025-07-07 2025-11-04 杭州华大生命科学研究院 功能单元预测模型构建方法及预测方法、装置及电子设备

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014140070A2 (en) 2013-03-14 2014-09-18 Ventana Medical Systems, Inc. Whole slide image registration and cross-image annotation devices, systems and methods
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
KR101879207B1 (ko) * 2016-11-22 2018-07-17 주식회사 루닛 약한 지도 학습 방식의 객체 인식 방법 및 장치
US10713794B1 (en) * 2017-03-16 2020-07-14 Facebook, Inc. Method and system for using machine-learning for object instance segmentation
WO2019172901A1 (en) * 2018-03-07 2019-09-12 Google Llc Virtual staining for tissue slide images
US10957041B2 (en) * 2018-05-14 2021-03-23 Tempus Labs, Inc. Determining biomarkers from histopathology slide images
CA3109279A1 (en) * 2018-05-24 2019-11-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Predicting cancer recurrence from spatial multi-parameter cellular and subcellular imaging data.
US12165743B2 (en) * 2018-11-09 2024-12-10 The Broad Institute, Inc. Compressed sensing for screening and tissue imaging
US20220180975A1 (en) * 2019-01-28 2022-06-09 The Broad Institute, Inc. Methods and systems for determining gene expression profiles and cell identities from multi-omic imaging data
KR20220015367A (ko) * 2019-05-31 2022-02-08 프리놈 홀딩스, 인크. 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템
KR102155381B1 (ko) * 2019-09-19 2020-09-11 두에이아이(주) 인공지능 기반 기술의 의료영상분석을 이용한 자궁경부암 판단방법, 장치 및 소프트웨어 프로그램
KR102068279B1 (ko) * 2019-10-04 2020-01-20 주식회사 루닛 이미지 분석 방법 및 시스템
KR102068277B1 (ko) * 2019-10-04 2020-02-11 주식회사 루닛 이미지 분석 방법 및 시스템
KR102166835B1 (ko) * 2019-10-28 2020-10-16 주식회사 루닛 신경망 학습 방법 및 그 장치
KR102170297B1 (ko) * 2019-12-16 2020-10-26 주식회사 루닛 조직병리체학 데이터의 해석 정보를 제공하는 방법 및 시스템
US12300006B2 (en) * 2019-12-23 2025-05-13 The Regents Of The University Of California Method and system for digital staining of microscopy images using deep learning
US11830227B2 (en) * 2020-05-12 2023-11-28 Lunit Inc. Learning apparatus and learning method for three-dimensional image
US20210358571A1 (en) * 2020-05-13 2021-11-18 Tempus Labs, Inc. Systems and methods for predicting pathogenic status of fusion candidates detected in next generation sequencing data
KR20210139195A (ko) * 2020-05-13 2021-11-22 주식회사 루닛 의학 데이터로부터 바이오마커와 관련된 의학적 예측을 생성하는 방법 및 시스템
EP4154163A1 (en) * 2020-05-18 2023-03-29 Genentech, Inc. Pathology prediction based on spatial feature analysis
CN115698335A (zh) * 2020-05-22 2023-02-03 因斯特罗公司 使用机器学习模型预测疾病结果
KR102246319B1 (ko) * 2021-01-07 2021-05-03 주식회사 딥바이오 병리 검체에 대한 판단 결과를 제공하는 인공 뉴럴 네트워크의 학습 방법, 및 이를 수행하는 컴퓨팅 시스템
US20220261988A1 (en) * 2021-02-18 2022-08-18 Lunit Inc. Method and system for detecting region of interest in pathological slide image
US12488893B2 (en) * 2021-02-18 2025-12-02 Lunit Inc. Method and system for training machine learning model for detecting abnormal region in pathological slide image
US11482319B2 (en) * 2021-03-09 2022-10-25 PAIGE.AI, Inc. Systems and methods for processing electronic images to determine testing for unstained specimens
EP4489011A4 (en) * 2022-03-03 2025-08-06 Lunit Inc METHOD AND APPARATUS FOR PATHOLOGICAL SLIDE IMAGE ANALYSIS
US20240257910A1 (en) * 2023-01-30 2024-08-01 Research & Business Foundation Sungkyunkwan University Method and electronic device for predicting patch-level gene expression from histology image by using artificial intelligence model

Also Published As

Publication number Publication date
EP4489011A1 (en) 2025-01-08
US12530874B2 (en) 2026-01-20
US20260120281A1 (en) 2026-04-30
WO2023167448A1 (ko) 2023-09-07
US20230281971A1 (en) 2023-09-07
EP4489011A4 (en) 2025-08-06

Similar Documents

Publication Publication Date Title
US12073948B1 (en) Systems and methods for training a model to predict survival time for a patient
Schneider et al. Integration of deep learning-based image analysis and genomic data in cancer pathology: A systematic review
JP7100336B2 (ja) デジタル病理学のために、画像を処理し、処理された画像を分類するためのシステムおよび方法
JP7827688B2 (ja) 機械学習技術を使用したデジタル病理画像における特徴の異種性の評価
JP2025506993A (ja) 病理スライド画像を分析する方法及び装置
AU2021213131B2 (en) Systems and methods for processing electronic images for biomarker localization
JP7260119B2 (ja) 一般化疾患検出のために電子画像を処理するためのシステムおよび方法
JP2022530280A (ja) デジタル病理学のための処理された画像に関するスライドを調製するために画像を処理するためのシステムおよび方法
JP2018504674A (ja) 早期癌予知のための計算病理学システム及び方法
JP2024510955A (ja) 染色されていない標本のテストを判定するために電子画像を処理するシステム及び方法
Zhao et al. Inferring single-cell spatial gene expression with tissue morphology via explainable deep learning
Tan et al. Robust and interpretable prediction of gene markers and cell types from spatial transcriptomics data
KR20230130536A (ko) 병리 슬라이드 이미지를 분석하는 방법 및 장치
KR20230026950A (ko) 병리 슬라이드 이미지로부터 예측된 종양 함량에 기초하여 검사와 관련된 가이드를 제공하는 방법 및 장치
US20250252760A1 (en) Method and apparatus for analyzing pathological slide images
KR20230100571A (ko) 병리 슬라이드 이미지에 기초하여 종양 순도를 예측하는 방법 및 장치
JP2024546649A (ja) 病理検体に対する判断結果を提供する人工ニューラルネットワークの学習方法、及びこれを行うコンピューティングシステム
Rehman et al. Computational approach for counting of SISH amplification signals for HER2 status assessment
US20240212146A1 (en) Method and apparatus for analyzing pathological slide images
EP4654125A1 (en) Method and device for analyzing pathology slide image
KR20240069618A (ko) 병리 슬라이드 이미지를 분석하는 방법 및 장치
EP4283623A1 (en) Method and device for evaluating quality of pathological slide image
US20250069691A1 (en) Method and apparatus for providing examination-related guide on basis of tumor content predicted from pathology slide images
Hu et al. STEP: Deciphering Spatial Atlas at Single-Cell Level with Whole-Transcriptome Coverage
KR20260046606A (ko) 병리 슬라이드 이미지를 분석하는 방법 및 장치

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260209

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20260209