JP2025506681A - 組み換えアデノ随伴ウイルスによる血管新生amdにおけるcst変動の低減方法 - Google Patents

組み換えアデノ随伴ウイルスによる血管新生amdにおけるcst変動の低減方法 Download PDF

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JP2025506681A
JP2025506681A JP2024548391A JP2024548391A JP2025506681A JP 2025506681 A JP2025506681 A JP 2025506681A JP 2024548391 A JP2024548391 A JP 2024548391A JP 2024548391 A JP2024548391 A JP 2024548391A JP 2025506681 A JP2025506681 A JP 2025506681A
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eye
unit dose
raav particles
weeks
administration
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JP2025506681A5 (https=
JPWO2023158990A5 (https=
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ジョアンナ ドゥ,
アダム トゥルプク,
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アドヴェラム バイオテクノロジーズ, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
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    • A61K38/00Medicinal preparations containing peptides
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    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61K9/0048Eye, e.g. artificial tears
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts or implants
    • AHUMAN NECESSITIES
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14145Special targeting system for viral vectors
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/22Vectors comprising a coding region that has been codon optimised for expression in a respective host

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  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2024548391A 2022-02-16 2023-02-14 組み換えアデノ随伴ウイルスによる血管新生amdにおけるcst変動の低減方法 Pending JP2025506681A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263310865P 2022-02-16 2022-02-16
US63/310,865 2022-02-16
US202263316705P 2022-03-04 2022-03-04
US63/316,705 2022-03-04
PCT/US2023/062531 WO2023158990A1 (en) 2022-02-16 2023-02-14 Method of reducing cst fluctuation in neovascular amd by a recombinant adeno-associated virus

Publications (3)

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JP2025506681A true JP2025506681A (ja) 2025-03-13
JP2025506681A5 JP2025506681A5 (https=) 2026-02-24
JPWO2023158990A5 JPWO2023158990A5 (https=) 2026-02-24

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JP2024548391A Pending JP2025506681A (ja) 2022-02-16 2023-02-14 組み換えアデノ随伴ウイルスによる血管新生amdにおけるcst変動の低減方法

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EP (2) EP4479098A1 (https=)
JP (1) JP2025506681A (https=)
KR (1) KR20240161978A (https=)
AU (1) AU2023221321A1 (https=)
CA (1) CA3244250A1 (https=)
IL (1) IL314762A (https=)
MX (1) MX2024010002A (https=)
WO (1) WO2023158990A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118718181A (zh) 2019-06-05 2024-10-01 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20171334T1 (hr) 2011-04-22 2017-11-17 The Regents Of The University Of California Virioni adeno-povezanog virusa s kapsid varijantom i postupci njihove upotrebe
CN110546257B (zh) 2017-03-17 2024-03-01 阿德夫拉姆生物技术股份有限公司 用于增强基因表达的组合物和方法
FI4027983T3 (fi) * 2019-09-11 2026-02-03 Adverum Biotechnologies Inc Silmän neovaskulaaristen sairauksien hoito afliberseptiä koodaavilla aav2-varianteilla
WO2021050094A1 (en) * 2019-09-11 2021-03-18 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

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IL314762A (en) 2024-10-01
AU2023221321A1 (en) 2024-09-26
EP4479098A1 (en) 2024-12-25
KR20240161978A (ko) 2024-11-13
EP4682163A3 (en) 2026-04-15
EP4682163A2 (en) 2026-01-21
CA3244250A1 (en) 2023-08-24
MX2024010002A (es) 2024-11-08
WO2023158990A1 (en) 2023-08-24

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