JP2025501458A - 疾患の性特異的治療のためのnap - Google Patents

疾患の性特異的治療のためのnap Download PDF

Info

Publication number
JP2025501458A
JP2025501458A JP2024533944A JP2024533944A JP2025501458A JP 2025501458 A JP2025501458 A JP 2025501458A JP 2024533944 A JP2024533944 A JP 2024533944A JP 2024533944 A JP2024533944 A JP 2024533944A JP 2025501458 A JP2025501458 A JP 2025501458A
Authority
JP
Japan
Prior art keywords
day
pharmaceutical composition
disease
subject
nap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024533944A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025501458A5 (https=
Inventor
ゴゼス,イラナ
シャピラ,ガイ
ロビンツェバ,アレクサンドラ
カルモン,ギドン
ショムロン,ノーム
Original Assignee
ラモット アット テル アビブ ユニバーシティ, リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ラモット アット テル アビブ ユニバーシティ, リミテッド filed Critical ラモット アット テル アビブ ユニバーシティ, リミテッド
Publication of JP2025501458A publication Critical patent/JP2025501458A/ja
Publication of JP2025501458A5 publication Critical patent/JP2025501458A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2024533944A 2021-12-14 2022-12-13 疾患の性特異的治療のためのnap Pending JP2025501458A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163289174P 2021-12-14 2021-12-14
US63/289,174 2021-12-14
US202263306146P 2022-02-03 2022-02-03
US63/306,146 2022-02-03
PCT/IL2022/051314 WO2023112025A1 (en) 2021-12-14 2022-12-13 Nap for sex-specific treatment of diseases

Publications (2)

Publication Number Publication Date
JP2025501458A true JP2025501458A (ja) 2025-01-22
JP2025501458A5 JP2025501458A5 (https=) 2025-12-18

Family

ID=86773996

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024533944A Pending JP2025501458A (ja) 2021-12-14 2022-12-13 疾患の性特異的治療のためのnap

Country Status (9)

Country Link
US (1) US20250312408A1 (https=)
EP (1) EP4447994A4 (https=)
JP (1) JP2025501458A (https=)
KR (1) KR20240135692A (https=)
AU (1) AU2022410066A1 (https=)
CA (1) CA3240138A1 (https=)
IL (1) IL313226A (https=)
MX (1) MX2024006777A (https=)
WO (1) WO2023112025A1 (https=)

Also Published As

Publication number Publication date
EP4447994A1 (en) 2024-10-23
IL313226A (en) 2024-07-01
CA3240138A1 (en) 2023-06-22
WO2023112025A1 (en) 2023-06-22
AU2022410066A1 (en) 2024-07-25
MX2024006777A (es) 2024-08-06
KR20240135692A (ko) 2024-09-11
US20250312408A1 (en) 2025-10-09
EP4447994A4 (en) 2026-01-07

Similar Documents

Publication Publication Date Title
Cao et al. Advances in developing novel therapeutic strategies for Alzheimer’s disease
Chou et al. INPP5D regulates inflammasome activation in human microglia
Curcio-Morelli et al. Macroautophagy is defective in mucolipin-1-deficient mouse neurons
Bachurin et al. Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention
Vilchez et al. The role of protein clearance mechanisms in organismal ageing and age-related diseases
Ho et al. Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
Guo et al. Alzheimer's disease and retinal neurodegeneration
Caldeira et al. Microglia change from a reactive to an age-like phenotype with the time in culture
Bachmeier et al. Role of the cannabinoid system in the transit of beta-amyloid across the blood–brain barrier
Wang et al. Ursolic acid ameliorates amyloid β-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome
Teich et al. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse
US20100324079A1 (en) Medicament for prophylaxis and treatment of Alzheimer disease
Zhang et al. Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease
EP3897670A1 (en) Inhibitors of sarm1 in combination with neuroprotective agents
Morsy et al. Current and emerging pharmacological targets for the treatment of Alzheimer’s disease
Jia et al. Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid-β peptide-induced impairment of spatial learning and memory in rats
US20180217163A1 (en) Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
Olsson et al. Imatinib treatment and Aβ42 in humans
Straten et al. Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's disease
Xiao Levetiracetam might act as an efficacious drug to attenuate cognitive deficits of Alzheimer’s disease
Antony et al. Recent advances in Alzheimer’s disease therapy: clinical trials and literature review of novel enzyme inhibitors targeting amyloid precursor protein
JP2025501458A (ja) 疾患の性特異的治療のためのnap
Di Lucente et al. The impact of mild episodic ketosis on microglia and hippocampal long‐term depression in 5xFAD mice
HK40117549A (zh) 用於疾病的性别特异性治疗的nap
CN118678965A (zh) 用于疾病的性别特异性治疗的nap

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240808

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251210

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20251210